high alert medication program - hospital quality institute · high alert medication program...
TRANSCRIPT
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High Alert Medication Program
Nicholas Kostek, RPh, MS
Pharmacy Quality and Patient
Safety Coordinator
Kaiser Permanente, Northern
California
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Disclosure
• Nicholas Kostek has indicated that he has no relevant
financial relationships to disclose in regard to the content of
this presentation.
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Objectives
• Review the development and implementation of a high-
alert medication program at Kaiser Permanente
• Discuss factors in your practice environment that can
contribute to the occurrence of medication errors
• Demonstrate how medication error and near miss data
can be used to identify opportunities for improving
patient safety
• Describe the application of system strategies to reduce
medication administration errors with IV heparin and
improve patient outcomes
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Kaiser Permanente - 2012
• 9.1 million members
• 8 regions serving 9 states and the District of Columbia
• 37 medical centers (with hospitals)
• 618 medical offices and other outpatient facilities
• 17,157 physicians
• 175,668 employees (including 49,034 nurses)
• $50.6 billion operating revenue
• $2.6 billion net income
• $169.4 million invested in health research
• 1,070 articles published in peer reviewed journals
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Kaiser Permanente - 2012
Northwest Region Portland, OR
Vancouver, WA
484,349 members
Northern
California Region 3,403,871 members
Southern
California Region 3,594,848 members
Colorado Region Denver / Boulder, CO
Colorado Springs, CO
Pueblo, CO
540,442 members
Hawaii Region 224,591 members
Ohio Region Cleveland, OH
Akron, OH
86,338 members
Mid-Atlantic Region Washington, DC
Maryland
Virginia
481,755 members
Georgia Region Atlanta, GA
233,880 members
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Preventable Medication Errors
Add Text Here – Hospital A
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More Tragic Consequences
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And More…
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High Alert Medication Program
(HAMP) Goals
• Eliminate harm
• Promote standardization
• Monitor performance
• Generate ongoing system improvements
• Ensure sustainability
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HAMP Program Components
• Identification of High Alert
drugs
• Independent double checks
• Specialized HAMP labeling
• Standardization of drugs,
concentrations and
procedures
• Use of premixed IV
solutions
• Elimination of unapproved
abbreviations
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High Alert Program Description
• Standardized order sets and protocols
• Segregation of high alert drugs
• “Clinical Data Categories”
• “Smart” IV pumps
• Staff training & testing for competency
• Universal application
• Regional oversight
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High Alert Medications
“High alert medications are those medications
involved in a high percentage of errors and/or
sentinel events as well as medications that
carry a higher risk for abuse or other adverse
outcomes.”
The Joint Commission Standard MM.01.01.03. CAMH Update 2, September 2012.
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High Alert Medications
• More frequently involved in serious
medication errors
• Narrow margin of safety
• Increased risk of harm if an error should
occur
• Generally recognized as problematic
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High Alert Medications
• Heparin and argatroban* infusions
• Insulin infusions and U-500 insulin*
• Neuromuscular blocking agents (e.g., succinylcholine, vecuronium, rocuronium, etc.)
• Cytotoxic chemotherapy agents
• Concentrated electrolytes (sodium injection >0.9%; potassium injection >0.4mEq/mL)
• Magnesium sulfate infusions (>100 mL)
• Alteplase (Activase)and tenecteplase (TNKase)*
• Vinca alkaloids (vinCRIStine, vinBLAStine, vinorelbine) • Bortezomib (Velcade) injection*
• Parenteral nutrition solutions (TPN, PPN)*
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High Alert Medications
• Epoprostenol (Flolan)*
• All opiate infusions (including PCA)
• Epinephrine, isoproterenol, norepinephrine and phenylephrine* infusions
• Medications administered via intrathecal route
• Medications administered via epidural route
• Neonates: all doses of IV and oral medications (except for oral doses of vitamins and/or iron)
• Pediatrics: all adult HAMP drugs; all medications used for procedural sedation except when administered by anesthesia provider; all IV medications in critical care areas (including ED); and digoxin (all routes)
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Standardized Concentrations
• Heparin 100 units/mL
• Insulin 1 unit/mL
• Magnesium sulfate 40 mg/mL
• Epinephrine 8 mcg/mL
• Norepinephrine 16 mcg/mL
• Isoproterenol 4 mcg/mL
• Morphine sulfate 1 mg/mL
• Meperidine 10 mg/mL
• Hydromorphone 0.2 mg/mL
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Independent Double Check
“A procedure in which two authorized, qualified practitioners will separately check each component of the work process. For example, one person calculating a medication dose for a specific patient and a second individual independently performing the same calculation (not just verifying the calculation) and matching the results. A pharmacist will be consulted in the event that agreement cannot be reached.”
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Independent Double Checks
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Independent Double Checks
• Five “rights”
• IV pump settings
• Volume standardization
• Label accuracy
• IV tubing connections
• Site of line insertion
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A Culture of Safety
• Awareness, understanding, and ownership of medication safety at all levels of the organization
• Mindset of constant vigilance and situational awareness to prevent medication errors
• Emphasis on identification of system faults and latent errors
• A “just culture” where individuals are treated fairly when errors occur
Adopted from Spath
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Barriers
• Crisis management
• Short time-line
• Complex program
• Need for physician, staff and labor partner
engagement
• Multiple facilities covering a large
geographical area
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Close Calls
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Patient Harm
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Key Success Factors
• Leadership support
• Regional coordination and oversight by the Regional Medication Safety Committee
• Involvement of labor partners, medical group and staff from all levels of the organization
• Standardized procedures, high alert medication list, order sets and protocols
• Program sustaining activities such as monthly medication safety calls, staff education and testing for competency, monthly observation audits and coaching
• Notification and investigation of all HAMP errors, data analysis and reporting
• Comprehensive approach – CPOE, BCMA, “Smart” infusion pumps, KP MedRite program, Nurse Knowledge Exchange
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Sustainability – The Future
• Thinking and attitudes change with the process and outcome over time
• The systems surrounding the changes become an integrated or mainstream process
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SustainabilityTools
• Actionable measurement (process audits) • Standardized ongoing competencies • Intensive analysis of events to identify trends • Continue work to support a “Just Culture” • Identify and control drift and workarounds • Ongoing review of the HAMP policy • Share experiences internally and externally
• Interregional HAMP assessment • Webinar sharing conferences • “Docushare” intranet site for policies and tools • HAMP collaborative calls • HAMP presentations both within and outside KP
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Do Not Try This At Home
• Wait for a disaster to occur • Take a narrow approach • Leave the staff or patient out of the solution • Fail to plan for sustainability and control “drift” • “Set it and forget it”
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High Visibility
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THE INFORMED PATIENT
By LAURA LANDRO
Hospitals Tackle High-Risk Drugs To Reduce Errors
March 5, 2008; Page D1 Hospitals are taking steps to prevent errors in the use of so-called high-alert medications -- those that, when
given in the wrong dose or used incorrectly, have the highest risk of seriously harming or even killing a patient.
Many of the high-alert medications are the most essential to hospitals. Among them are drugs to prevent blood
clots, sedate patients, relieve pain and stabilize diabetics. But incorrect use of these drugs can lead to disasters,
such as the accidental overdoses of heparin, an anticlotting drug, that killed three infants at an Indiana hospital
in 2006 and threatened the newborn twins of actor Dennis Quaid this past November.
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2012 NCAL HAMP Errors
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Top Drugs
Heparin 117
hydromorPHONE 34
TPN/PPN Per Protocol 25
Morphine 19
Fentanyl 17
Insulin 13
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Heparin Infusion Errors
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Heparin Infusion Error Rate
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Add Text Here
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Heparin Infusion Error Types
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Add Text Here
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Cardiac Heparin Nomogram
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Cardiac Heparin Protocol UFH (Unfractionated Heparin) Infusion
Dosing Nomogram Based on Anti-Xa Results
NOTE: Obtain Anti-Factor Xa assay 6 hours after initiating infusion.
Anti-Xa Results (units/mL)
Bolus dose (units)
Hold Infusion (minutes)
Rate Change (units/hour)
Repeat Anti-Xa assay (hours)
Less than or equal to 0.1
3,000 units No Increase by 100 units/hour
6 hours
0.11-0.4 (Target Range)
None No None 6 hours one time, then every AM while on heparin IV infusion
0.41-0.8 None No Decrease by 50 units/hour
6 hours
0.81-0.92 None *30 minutes Decrease by 100 units/hour
6 hours
0.93-1.4 None 60 minutes Decrease by 150 units/hour
6 hours
Greater than 1.4 None 60 minutes Decrease by 300 units/hour
STAT Anti-Xa in 2 hours
Call Attending Physician with 2 hours Anti-Xa result
Repeat Anti-Xa in 6 hours or per Physician order
* For Anti-Xa results obtained less than 12 hours after initiation of TNKase, do NOT discontinue or decrease infusion unless significant
bleeding or anti-Xa greater than 0.92 units/mL.
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Heparin Improvement Project
Phase 1 - Initial pharmacy involvement Protocol with dosage algorithm managed by RN with pharmacist
available for consultation
Phase 2 - Increased collaboration and communication RN calls pharmacy with every anti-Xa level to discuss dosage
adjustments using algorithm
Phase 3 – Proactive Pharmacy Consultation Pharmacy monitors anti-Xa levels and calls RN to discuss dosage and
rate changes
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Medical Center Heparin Pilot
IV Heparin Dosing Adjustment % correct initial boluses administered
% correct adjustment boluses based upon anti-Xa result
% correct infusion adjustments based upon anti-Xa result
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Initial Heparin Bolus
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Heparin Adjustment Bolus
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Heparin Infusion Adjustment
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Pharmacy Management
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July 2012 Education for the ancillary departments (pharmacy, nursing,
lab) and physicians
September 2012 “Heparin per Pharmacy” protocol – Pharmacist monitors
heparin therapy, orders lab tests and places orders for dosage and rate adjustments
New Epic tools for staff including heparin order set, patient lists, anticoagulant flow sheet, heparin accordion report, clinical in-basket messaging for labs
Placeholder established in all IV heparin order sets
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Protocol Evaluation
• For Cardiac and Non-Cardiac Protocols reviewed % patients therapeutic after 1st Anti-Xa level
% of patients therapeutic after 24 hours
Average # of adjustments to therapeutic level (includes first bolus/initial rate)
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Comparison to SCAL Protocol
2011 IV Heparin Improvement Project
% Therapeutic
within 1st Anti-Xa
% Therapeutic
within 24 Hours
SCAL Pharmacy Protocol
(Range 0.3 – 0.7) N = 985
46%
66%
NCAL Nursing Protocol
(Range 0.3 – 0.7) N = 778
41%
56%
2012 IV Heparin Improvement Project
October – December 2012 (N = 829)
NCAL Pharmacy Non-Cardiac
Protocol (Range 0.3 – 0.7)
49%
78%
NCAL Pharmacy Cardiac
Protocol (Range 0.11 – 0.4)
48%
82%
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Heparin Events
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Next Steps
• Perioperative heparin workflow
• Improvement of Anti-Xa turn around time Standardize lab draw and lab delivery workflows
• Evaluation of robustness of cardiac and non-cardiac nomograms Weight based protocol?
• Review nomenclature of heparin protocols
• Standardization of the SCAL heparin protocol
• Leverage NCAL and SCAL practices to improve workflows
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Barriers
• The “silo” effect
• Resource allocation
• Competencies and
training
• Workflow changes
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Questions?
Nicholas Kostek, RPh, MS
Regional Pharmacy Quality and
Patient Safety
Kaiser Permanente, Northern
California
(510) 625-3715
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