Where’s it all going?

Future Tech

23

• Sensor Tech (Wearables, Hearables, Remote / Environmental)

• Data Tech (AI, Big Data, Real Time Analytics)• NeuroTech (EEG, fMRI)• Neurostim Tech (tXCS, tRNS, DBS, CNS, TUS,

FUS, TMS)• Biofeedback Tech (EDA, Heart, Temp, Breath)• Bio Tech (Genetics, Biome)

12 MAJOR AREASOF TRANSFORMATIVE TECHNOLOGY

• Biostim Tech (Vagus Nerve, Peripheral Nerves)• Perception Tech (VR, AR)• Sleep Tech (Monitoring, Improvement)• Healthy Spaces Tech (Design, Air, Water,

Lighting, Materials)• App Tech (Gaming, Gamification, Apps, Social,

Behaviour)• Robotics / Carebots

Sensors

Neuro-feedback

Neuro-stimulation

Sleep

Apps

Biotech

Data & AI

Bio-Feedback

Bio-Stimulation

Perception

Healthy Spaces

5

COST OF US STRESS($300BN)

COST OF LOW EMPLOYEE

ENGAGEMENT ($550BN WW)

MEDITATION$1BN US

PREVENTATIVE HEALTH$534BN WW

WELLNESS REAL ESTATE$118.6BN WW

DEPRESSION, STRESS, & ANXIETY DRUGS

$22BN WW

WORKPLACE WELLNESS$43.3BN US

NEUROTECH$8.4BN WW

SLEEP TREATMENT$50BN WW

WELLNESS TOURISM

$563.2BN WW

MENTAL HEALTH TREATMENT

$89BN US

CORPORATE TRAINING

$360BN WW

WEARABLES80MN Units WW

(18.4% CAGR)

FITNESS& MIND/BODY

$542BN WW

HEALTHY EATING & WEIGHT LOSS$647BN WW

ADDICTION TREATMENT

$35BN US

PERSONAL DEVELOPMENT

$10BN US

EMOTION DETECTION RECOGNITION

$6.72BN

ALTERNATIVE MEDICINE

$199BN WWYOGA

$27BN US

THE TRANSFORMATIVE TECH MARKET:A HIDDEN MULTI TRILLION DOLLAR CATEGORY

We’ve come a long way!

Professional Grade

Less expensive

Consumer Tech

And more…

And more…

And more…

And more…

And yet more…

Real DIY

My Favorite –No More

Woof

Ethics and Technology

Claims about Commercial Wearable Brain Technologies Iris Coates McCall, Chloe Lau, Nicole Minielly, and Judy IllesNeuroethics Canada, Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, CanadaCorrespondence:jilles@mail.ubc.cahttps://doi.org/10.1016/j.neuron.2019.03.026

Category Claim Frequency Percent of total Example

Wellness

Relieve stress/anxiety 17 10% “myBrain Technologies built a new drug-free, easy-to-use, and perfectly safe solution to stress” (MyBrain Technologies MeloMind)

Improve sleep quality 17 10% “Because the Sleep Shepherd lets you directly control your brain rate, you can naturally build a better, healthier sleep cycle that allows you to fall asleep faster, stay asleep longer, and have more energy during the day” (Sleep Shepherd Blue)

Improve general wellness 16 9% “Versus provides a path to wellness through brain exercises” (Versus) Augment meditation/relaxation 11 6%

“Muse: the brain sensing headband will elevate your meditation experience. It gently guides your meditation through changing sounds of weather based on the real-time state of your brain” (InteraXon Muse)

Increase self-awareness 9 5% “Introducing Lowdown Focus Brain Sensing Eyewear™ with the Smith Focus App to help you develop a heightened sense of self-awareness” (Smith LowDown Focus) Improve mood 4 2% “If you want to improve your mood… Omni is for you” (Omni) Lose weight 1 0.6% “Modius uses neuro-technology to make weight loss easier by reducing your appetite and cravings” (Modius)

Enhancement

Assist with self-regulation/neurofeedback 19 11% “The FocusBand headset and app provides neurofeedback, a proven method to train the brain” (FocusBand)

Increase concentration/focus 15 9% “The drug free way to learn to focus” (Narbis) Improve general cognition 13 8% “A smart headset helps you to achieve peak mental fitness” (Brainlink) Increase efficiency/productivity 9 5%

“Mindset can give suggestions on how to improve your productivity: schedule emails during your downtime, and save your best hours for your deep work sessions” (Mindset)

Support learning/training 7 4% “Halo Sport accelerates how fast people learn skills like golf, piano, triathlon, clarinet, and CrossFit” (Halo Sport) Boost physical performance 5 3% “Enhance your mental/physical performance with photobiomodulation” (Vielight) Enhance Memory 5 3% “Enhance your memory, logic and other cognitive skills” (Neeuro’s Senzeband)

Practical Applications

Perform research 7 4% “NeuroDEV offers neurotechnology that extends beyond hospitals and research facilities, giving developers and professionals the opportunity to access affordable brainwave technology and integrate it with their own applications for the purpose of research, monitoring brain waves and improving brain health” (Vielight Neuro Alpha)

Control technology 4 2% “Control machines with the power of your mind and make science fiction a reality today” (Emotiv)

Create art 2 1% “Whether commanding drones or wheelchairs, creating music or art, or adapting digital experiences to real time emotions, the interface between the brain and computer has never been easier” (Emotiv Insight)

Promote safety 1 0.6% “Our wearable technology prevents microsleeps by providing accurate alertness measurements in real-time to operators and drivers so they can take charge when it comes to safety” (SmartCap Technologies)

Health

Improve a medical condition 5 3% “Some conditions where Bellabee has been used include: Anxiety problems, Sleep disorders, Stress-related issues, Concentration problems, ADD and ADHD issues (attention deficit disorders), PTSD (post-traumatic stress disorder)” (Bellabee)

Promote autonomy after disability 4 2%

“The proof of concept software connects a wearable display with an EMOTIV Insight Brainware headset to show how a person with severe mobility restrictions, such as amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, could regain more independence” (Emotiv Insight)

Total 171 100

Category

Claim

Frequency

Percent of total

Example

Wellness

Relieve stress/anxiety

17

10%

“myBrain Technologies built a new drug-free, easy-to-use, and perfectly safe solution to stress” (MyBrain Technologies MeloMind)

Improve sleep quality

17

10%

“Because the Sleep Shepherd lets you directly control your brain rate, you can naturally build a better, healthier sleep cycle that allows you to fall asleep faster, stay asleep longer, and have more energy during the day” (Sleep Shepherd Blue)

Improve general wellness

16

9%

“Versus provides a path to wellness through brain exercises” (Versus)

Augment meditation/relaxation

11

6%

“Muse: the brain sensing headband will elevate your meditation experience. It gently guides your meditation through changing sounds of weather based on the real-time state of your brain” (InteraXon Muse)

Increase self-awareness

9

5%

“Introducing Lowdown Focus Brain Sensing Eyewear™ with the Smith Focus App to help you develop a heightened sense of self-awareness” (Smith LowDown Focus)

Improve mood

4

2%

“If you want to improve your mood… Omni is for you” (Omni)

Lose weight

1

0.6%

“Modius uses neuro-technology to make weight loss easier by reducing your appetite and cravings” (Modius)

Enhancement

Assist with self-regulation/neurofeedback

19

11%

“The FocusBand headset and app provides neurofeedback, a proven method to train the brain” (FocusBand)

Increase concentration/focus

15

9%

“The drug free way to learn to focus” (Narbis)

Improve general cognition

13

8%

“A smart headset helps you to achieve peak mental fitness” (Brainlink)

Increase efficiency/productivity

9

5%

“Mindset can give suggestions on how to improve your productivity: schedule emails during your downtime, and save your best hours for your deep work sessions” (Mindset)

Support learning/training

7

4%

“Halo Sport accelerates how fast people learn skills like golf, piano, triathlon, clarinet, and CrossFit” (Halo Sport)

Boost physical performance

5

3%

“Enhance your mental/physical performance with photobiomodulation” (Vielight)

Enhance Memory

5

3%

“Enhance your memory, logic and other cognitive skills” (Neeuro’s Senzeband)

Practical Applications

Perform research

7

4%

“NeuroDEV offers neurotechnology that extends beyond hospitals and research facilities, giving developers and professionals the opportunity to access affordable brainwave technology and integrate it with their own applications for the purpose of research, monitoring brain waves and improving brain health” (Vielight Neuro Alpha)

Control technology

4

2%

“Control machines with the power of your mind and make science fiction a reality today” (Emotiv)

Create art

2

1%

“Whether commanding drones or wheelchairs, creating music or art, or adapting digital experiences to real time emotions, the interface between the brain and computer has never been easier” (Emotiv Insight)

Promote safety

1

0.6%

“Our wearable technology prevents microsleeps by providing accurate alertness measurements in real-time to operators and drivers so they can take charge when it comes to safety” (SmartCap Technologies)

Health

Improve a medical condition

5

3%

“Some conditions where Bellabee has been used include: Anxiety problems, Sleep disorders, Stress-related issues, Concentration problems, ADD and ADHD issues (attention deficit disorders), PTSD (post-traumatic stress disorder)” (Bellabee)

Promote autonomy after disability

4

2%

“The proof of concept software connects a wearable display with an EMOTIV Insight Brainware headset to show how a person with severe mobility restrictions, such as amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, could regain more independence” (Emotiv Insight)

Total

171

100

Are the Claims Supported by Evidence?

“We identified a link to research or a resource to support associated claims for 33 of the 41 devices, but we only found a link to one or more relevant peer-reviewed research papers for 8 of the device claims overall. Of the remainder, 29 had links to citations to general science research and scientific concepts. For example, one website discussed how tDCS may, in general, improve cognitive functioning but did not explicitly say their device did so. Other links were to user testimonials, gray literature, company/in-house research, or peer-reviewed literature that was irrelevant to the device or claim at hand.

Technology to Share Today

Photobiomodulation

• Photobiomodulation therapy is defined as the utilization of non-ionizing electromagnetic energy to trigger photochemical changes within cellular structures that are receptive to photons. Mitochondria are particularly receptive to this process. At the cellular level, visible red and near infrared light (NIR) energy are absorbed by mitochondria, which perform the function of producing cellular energy called “ATP”. The key to this entire process is a mitochondrial enzyme called cytochrome oxidase c, a chromophore, which accepts photonic energy of specific wavelengths when functioning below par.

Mechanism

• The current and widely accepted proposal is that the low level visible red to near infrared light (NIR) energy is absorbed by mitochondria and converted into ATP for cellular use. In addition, the process creates mild oxidants (ROS), which leads to gene transcription and then to cellular repair and healing. The process also unclogs the chain that has been clogged by nitric oxide (NO).[1] The nitric oxide is then released back into the system. Nitric oxide is a molecule that our body produces to help its 50 trillion cells communicate with each other. This communication happens by transmission of signals throughout the entire body. Additionally, nitric oxide helps to dilate the blood vessels and improve blood circulation.

BioStrap

• What makes us different?Most wearables utilize a very basic heart rate monitor, counting only that a beat occurred. Our approach is different – instead of checking your pulse at all times, we check while you’re still, allowing us to capture high-fidelity, raw PPG waveforms. These waveforms are the same kind that your doctor uses to evaluate your heart’s health. That’s why our device is being utilized by doctors and clinicians to monitor their patients.

Raw PPG: The source code to your health.Our clinical-quality PPG sensor allows us to gather extremely precise heartbeat data. Biostrap captures over 2,000 heartbeats every 24 hours. Every single pulsewave is analyzed for 29 different parameters, then analyzed against all of your other heartbeats from the last 24 hours.

Influencing the Future

Future TechSlide Number 212 MAJOR AREASOF TRANSFORMATIVE TECHNOLOGYTHE TRANSFORMATIVE TECH MARKET:A HIDDEN MULTI TRILLION DOLLAR CATEGORYWe’ve come a long way!Professional GradeLess expensiveConsumer TechAnd more…And more…And more…And more…And yet more…Real DIYMy Favorite – No More WoofEthics and TechnologySlide Number 17Are the Claims Supported by Evidence?Technology to Share TodaySlide Number 20PhotobiomodulationMechanismSlide Number 23BioStrapSlide Number 25Slide Number 26Slide Number 27Influencing the Future