Frodo Links Dishevelled to thep120-Catenin/Kaiso Pathway: DistinctCatenin Subfamilies Promote Wnt Signals

Park et al. Dev Cell. (2006)

McCrea et al. Biochim Biophys Acta. (2006)

Linear structural representation of catenin family proteins

McCrea et al. Biochim Biophys Acta. (2006)

Signaling pathways and interactions involving p120-catenin

A) Cadherin stability

B) Phosphorylation

C) Transcription

D) Small G protein

E) Inflammation / proliferation

van Roy et al. Nat Rev Cancer. (2005)

Molecular complexes of Kaiso and LEF/TCF with armadillo proteins in the nucleus

BTB/POZ-ZF: Broad complex, Tramtrack, Bric a brac(BTB) or poxvirus and zinc finger (POZ)-ZF. Implicated in tumorigenesis.

Kaiso: Transcriptional repressor and binds tothe methylated sequence mCGmCG

or the nonmethylated sequence CTGCNA.

Daniel et al. Biochim Biophys Acta. (2006)

Model depicting the E-cadherin–catenin cell adhesion complex and signaling pathways

Daniel et al. Biochim Biophys Acta. (2006)

Schematic representation of p120ctn and its nuclear binding partner Kaiso

Frodo interacts with Dishevelled to transduce Wnt signals

Nat Cell Biol. (2002)

Two Frodo/Dapper Homologs Are Expressed in the Developing Brain and Mesoderm of Zeb

rafish

Dev Dyn. (2004)

The involvement of Frodo in TCF-dependent signaling and neural tissue development

Development. (2004)

A Vertebrate Homolog of the Cell Cycle Regulator Dbf4 Is an Inhibitor of Wnt Signaling Req

uired for Heart Development

Dev Cell. (2005)

Vertebrate homologues of Frodo are dynamically expressed during embryonic developmen

t in tissues undergoing extensive morphogenetic movements

Dev Dyn. (2006)

Frodo comes into Wnt signaling

Brott BK and Sokol SY. Differentiation. (2005)

A role for Frd1, a Dsh-associated protein, in Wnt signaling

Interaction between p120-Catenin and Frodo

Frodo Regulation of the xKaiso Target Gene, xWnt-11

Wnt11 KCS : Kaiso consensus site CTGCNA

Inhibition of Kaiso:DNA Association by Frodo

Figure S1.

Frodo Partially Rescues Kaiso-Induced Gastrulation Failures

Kaiso Wnt11

PCP

Dsh-∆DEPFrodo

p120

Kaiso

: blastopore

Frodo Depletion Destabilizes p120ctn while Frodo Overexpression Stabilizes p120ctn

Dsh Regulates p120-Catenin Protein Stability

Wnt-Ligand Induced Signaling Inhibits Kaiso:Promoter Association

Figure S3.

Dsh Regulates p120-Catenin Protein Stability

Model of the Frodo/p120-Catenin/Kaiso Signaling Module in Relation to Wnt LigandActivation of Frizzled/LRP Coreceptor

Frodo Inhibits Rho A Activity

Figure S4.

Frodo ?