exponential technologies schb #acssandiego
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8/3/2019 Exponential Technologies SCHB #ACSSanDiego
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SCHB Joseph Sabol Monday, March 26, 2012
Oral Session
Exponential Technologies: Disruptive Influences and Rapid Advancements in Chemistry - PM Session
Location: San Diego Convention Center Monday March 26, 2012
Room: Room 26B
Cosponsored by: CEPA, COMSCI
Organizers: Lisa Butters
Presiders: Lisa Butters
Duration: 1:30 pm - 4:20 pm
Pres Time Pub # Presentation Title
1:30 pm
Introductory Remarks
8/3/2019 Exponential Technologies SCHB #ACSSanDiego
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1:35 pm 6
Digital biology: Life under Moore's Law
Raymond McCauley, Genomera, Inc., Mountain View, CA 94041, United States
The ability to read DNA is in the midst of an unprecedented exponential change. The Human Genome
Project took about $300 million and 11 years to complete, we now do for under $5000 in a week, and
there's no end in sight. What are the practical applications of this technology? What are the technical
and economic trends driving this revolution? How can small, agile companies ride along? And where are
we going next?
2:05 pm 7
Broadband magnetic signatures of solvated chemistries
Bennett M. Butters, Nativis, Inc., United States
A low temperature SQUID (super conducting quantum interference device) based approach to
broadband molecular interrogation is discussed with an emphasis on the technical basis for detection,
signal analysis, and the usefulness of acquired data. Also, presented are the analytical results of selected
materials and the implications to biochemistry.
2:35 pm 8
Nanostructured materials for large and small molecule selectivity
Robert Meagley, ONE Nanotechnologies, LLC, Berkeley, CA 94710, United States
We describe work ongoing at ONE Nanotechnologies, LLC to create and refine chemoselective films for
application as recognition elements in several sensor platforms. Organic materials and nanocomposites
have been developed that allow gas phase and liquid phase detection of explosives and chemical agents.
Very high surface area interfaces are achieved through processes suitable for high volume manufacture.
Novel strategies enabling high molecular weight precursors to be used in a plasma enhanced deposition
mode will be shown. Highly structured surfaces shown to have significant capability to recognize
individual proteins from mixtures will be presented and implications for advanced biomarker sensing
will be discussed. The thrust of this work illustrates the value of an interdisciplinary approach to
advanced material design and integration in devices.
3:05 pm
Intermission
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3:15 pm 9
Sequencing DNA by looking at it: Seeing chemistry with atoms rather than ensembles of atoms (or,
"Why I left a full professorship to join a startup")
Andrew Bleloch, Halcyon Molecular, Redwood City, CA 94063, United States
The development of highly multiplexed sequencing reactions via clonal oligonucleotide clusters has
provided the means to reduce the cost of sequencing by roughly five orders of magnitude over the last
six years. This "next generation" sequencing has enabled sequencing as a basic tool to inquire the state
of DNA variation, the transcriptional levels of the multitude of RNAs, the location of transcriptional
cofactors, and many other molecular characteristics that can be expressed as an oligonucleotide. This
presentation will summarize the technology and showcase several vignettes of current biological and
medical interest.
3:45 pm 10
Next generation sequencing: Redefining growth beyond Moore's Law
Scott D. Kahn, Illumina, Inc., San Diego, CA 92121, United States
The development of highly multiplexed sequencing reactions via clonal oligonucleotide clusters has
provided the means to reduce the cost of sequencing by roughly five orders of magnitude over the last
six years. This "next generation" sequencing has enabled sequencing as a basic tool to inquire the state
of DNA variation, the transcriptional levels of the multitude of RNAs, the location of transcriptional
cofactors, and many other molecular characteristics that can be expressed as an oligonucleotide. This
presentation will summarize the technology and showcase several vignettes of current biological and
medical interest.
4:15 pm
Concluding Remarks