Event Proceedings

Flow Chemistry India 2019 Agenda Day 1

Scientific Session ISession Chair: Rajeev Rehani, Sr VP & Global Head -API R&D, Dr Reddy’s Laboratories Ltd

08:00 Registration

10:10 Introduction of Resource Persons & Memento Presentation

10:25 Group Photograph

10:45 Coffee Break and Networking in Exhibition Area

11:15 Expanding Chemical Synthesis by Utilizing Flow ChemistryIan R Baxendale, Chair of Synthetic Chemistry, Durham University, United Kingdom

09:50 Inaugural Address Richard Jones, Secretary, Flow Chemistry Society, Switzerland

09:30 Opening of Conference & Introduction to SELECTBIOSanjay Bajaj, Managing Director, Select Biosciences India Pvt Ltd

09:40 Welcome AddressVijay Kirpalani, Founder President, Flow Chemistry Society-India Chapter

11:50 API Manufacture in Africa Exploiting Continuous ProcessingPaul Watts, Research Chair in Microfluidic Bio/Chemical Processing, Nelson Mandela University, South Africa

Scientific Session IISession Chair: Kishan Gurram, MD, Sravathi Advance Process Technologies P Ltd &

Former Site Head & Director, SABIC Research & Tech Center

13:00 Lunch Break and Networking in Exhibition Area

12:25 Some Mistakes and Triumphs in Continuous ProcessingMalcolm Berry, Director of Chemistry, GlaxoSmithKline, United Kingdom

15:45 Coffee Break and Networking in Exhibition Area

16:30 End of First Day of Conference

14:00 Sustainable and Green Chemical Manufacturing via Continuous FlowAnil Kumar, Professor, IIT-Bombay, India

16:15 Rapid and Multigram Synthesis of Vinylogous Esters under Continuous Flow: An Access to Transetherification and Reverse Reaction of Vinylogous EstersNirmala Mohanta, Research Scholar, Indian Institute of Science Education and Research, Pune, India

Scientific Session IIISession Chair: Nitesh Mehta, Co-Founder & Director, Green ChemisTree Foundation

16:22 MnO2@Fe3O4 MNP: An Efficient and Recyclable Heterogeneous Catalyst for Benzylic sp3 C-H OxidationAkanksha Pandey, Research Scholar, Institute of Science Education and Research, Pune, India

14:35 Application of Continuous Flow Reactors for the Controlled Performance of Hazardous Processes -From R&D to ProductionCharlotte Wiles, CEO, Chemtrix BV, The Netherlands

Oral Presentations

15:10 Toward Continuous Production of Fine Chemicals Using Flow Fine SynthesisShu Kobayashi, Professor, The University of Tokyo, Japan

16:00 Exploiting Segmented Flow Chemistry in Modern Compound Library SynthesisAndrew Mansfield, Head of Flow Chemistry, Syrris, United Kingdom

Flow Chemistry India 2019 Agenda Day 2

11:00 Coffee Break & Networking in Exhibition Area

09:30 Experiences with Industrial Flow ChemistryKumar Oza, CCO, Pi-Process Intensification Experts LLP, India

09:00 The Use of Continuous-flow Reactors for Gas-liquid TransformationChristopher Hone, Principal Scientist, CCFLOW, Research Center Pharmaceutical Engineering, Austria

12:30 Non Chemistry Aspects of Flow ChemistryRobert Ashe, Managing Director, A M Technology, United Kingdom

12:00 Automated Multistep Flow Synthesis for the Rapid Optimisation of Medicinal Chemistry LeadsGary Tarver, Team Leader, University of Dundee, United Kingdom

Scientific Session IV Session Chair: Srinivas Oruganti, Director, Dr Reddy’s Institute of Life Sciences

10:00 Continuous Manufacturing in a CRO @ ANTHEMKarunanidhi G, Deputy General Manager, Anthem Biosciences Pvt Ltd, India

Scientific Session V Session Chair: KVS Ram Rao, CEO - CSM Division, PI Industries Ltd.

11:30 Progress and Challenges for Continuous Manufacturing ResearchAlastair Florence, EPSRC, CMAC, University of Strathclyde, United Kingdom

10:30 Performing an Exothermic Reaction using Flow Chemistry - A Case StudyPrashil Lakhete, Scientist, SABIC Research & Technology Center, India

13:00 Lunch and Networking in Exhibition Area

Scientific Session VI14:00 Flow Spectrum & Interactive Session

18:00 End of the Conference

17:55 Vote of Thanks

15:15 Pharmaceutical Continuous Manufacturing (PCM)Atul Dubey, Director - PCM, USP-Rockville, USA

16:00 Coffee Break and Networking in Exhibition Area

16:20 Enabling Green Chemistry Using Flow ChemistryDhileep Krishnamurthy, Chief Scientific Officer, Zhejiang Nhu Co. Ltd, China

16:50 Process Improvements Using Flow ChemistryGanesan Balakrishnan, Research Director, Syngene International Ltd, India

17:20 Continuous Manufacturing and Key Global API Guidelines - A PerspectiveVenkatesh Katgeri, Senior General Manager – RA API - Regulatory Affairs, Glenmark Pharmaceuticals Ltd, India

17:50 Closing Remarks

Scientific Session VII Session Chair: Manjinder Singh, Senior Director - API R&D, Cipla Ltd, India

Scientific Session VIII Session Chair: M C Sriraman, Founder Chairman, Flow Chemistry Society - India Chapter

15:30 Process Intensification for Crystallization, Filtration and Washing in Flow ChemistryNicolaas F Viets, CEO, SoliQz, The Netherlands

14:45 Opportunities for Continuous Manufacturing in Fine and Speciality Chemicals IndustrySurendra Bhatia, Director, Ascenza Agro SA, Spain

Flow Chemistry India 2019 Speakers’ Biography

Ian R Baxendale

Dr Ian R Baxendale, Chair of Synthetic Chemistry, Durham University, United King-dom. He obtained his PhD under the supervision of Prof. Pavel Kocovsky at the Univer-sity of Leicester. He then moved to a postdoctoral position with Prof. Steven V. Ley at the University of Cambridge. In 2003 he was awarded a Wolfson Royal Society Fellowship. In 2008 he was promoted to a Senior Research Associate in the Department of Chem-istry and then in 2009 was awarded a Royal Society University Research Fellowship. In 2012 he moved to Durham to take up the Chair of Synthetic Chemistry. His current research interests are the design and implementation of new enabling technologies such as Flow Chemical Synthesis (FCS), Synthesis Automation Methodologies (SAM), micro-wave reactors and immobilised reagents and scavengers to expedite complex chemical syntheses.

Paul Watts

Dr Paul Watts, Research Chair in Microfluidic Bio/Chemical Processing, Nelson Man-dela University, South Africa. He started his career as a lecturer at the University of Hull in 2002, being promoted to full professor in 2011. At the University of Hull he led the micro reactor and flow technology group. In February 2013, he moved to Nelson Mandela Uni-versity to hold the distinguished position of ‘Research Chair in Microfluidic Bio/Chemical Processing’. He has published of over 120 highly cited papers. He strongly believes that scientists should conduct research that impacts society; the biggest project underway involves the local production of key drugs as the morbidity and mortality from major dis-eases are much more devastating in Africa than in other regions of the world. The vision is that new technology will be used within South Africa to manufacture generic drugs; this could create jobs and a new manufacturing industry within the country.

Vijay Kirpalani

Mr Vijay Kirpalani, Founder President, Flow Chemistry Society-India Chapter. Mr. Vijay Kirpalani, Founder President, Flow Chemistry Society – India Chapter has obtained his B.E. (Chemical Engg.) from Maharaja Sayajirao University, Baroda. He is also a CEO, Pi-Process Intensification Experts LLP; former Ex. Director of Sharon Bio-Medicine Ltd. Director ChemSphere Consultants P. Ltd. He is expert in Process Intensification, Flow Chemistry, Bio-catalysis, Process Design & Execution (of cGMP HPAPI / API / Pharma Formulation, Chemical, Fine-Chemical, Biotech & Nanotech Facilities), QbD, PAT, Reg Affairs. He has Experience with an extensive repertoire of process technologies that have been developed and commercialized across over 125 grass-roots plants with > 200 processes in 14 countries. He had also Worked with BARC (Bhabha Atomic Research Center), Bharat Petroleum, IPCL , United Phosphorous Ltd. , Baroda Productivity Council, etc. He has been instrumental in setting-up 28 Flow Chemistry based plants ( from 1 to 5 telescoped reactions) .

Richard Jones

Mr Richard Jones, Secretary, Flow Chemistry Society, Switzerland. Mr Richard has been working actively with the Flow Chemistry Society since its creation in 2010 and is currently acting Secretary. Mr Richard is the CEO and co-founder of Thale-sNano Energy Inc, as well as the CEO of InnoStudio, a scientific incubator company. Before this,Mr Richard was CEO of ThalesNano where he completely overhauled the product line, doubling the number of new instruments and greatly extending the number of countries ThalesNano sells into.He joined ThalesNano in 2004 where he started as Chief Research Chemist, helping to develop the chemistry on the H-Cube® and other flow reactors. Prior to ThalesNano, Mr Richard was at Biofocus Discovery and worked on the synthesis of several Kinase and GPCR inhibitor based compound libraries. Mr Richard studied chemistry at the University of Bristol where he graduated with honors in 1999. He has over 20 scientific papers, books, and patents specializing in flow chemistry to his name.

Charlotte Wiles

Dr Charlotte Wiles, CEO, Chemtrix BV, The Netherlands .He started her research in the area of continuous flow synthesis in 2000. she obtained her PhD in 2003 entitled ‘Microreactors in organic synthesis’. This was followed by 5 years of Post Doctoral re-search into the rapidly developing field of continuous flow synthesis, specifically in the area of heterogeneous catalysis for small molecule synthesis. In 2008, Dr Charlotte Wiles joined Chemtrix BV as a Senior Chemist where she worked on the commercialisation of lab-scale micro reactor apparatus. In 2010 she was promoted to Chief Technology Officer within Chemtrix BV and in 2013 to CEO, where she continues to research and develop continuous flow systems and solutions for industrial partners; with more recent developments focusing on industrial flow reactors, suited towards the development of flexible tonne-scale production plants, in cooperation with 3M and DSM. Over the course of her research career, Dr Charlotte has published more than 60 peer-reviewed articles, several book chapters and in 2011 published a book ‘Micro reaction technology in organic synthesis’.

Anil Kumar

Dr Anil Kumar is currently a Professor at IIT Bombay, in the Department of Chemis-try, Center for Excellence in Nanoelectronics, National Center for Photovoltaic Research and Education and National Center for Excellence in Technologies for Internal Security. His group’s research interest are in the area of continuous flow processes and printable optoelectronic devices based on conjugated polymers. In this direction, the main focus is on the development of handheld explosive sensors, electrochromic devices, thin film optoelectronic devices and transparent conductor etc. They have developed a state of the art continuous flow process lab and also conduct regular training programs and work-shops in Continuous Flow Process to train the next generation of human resources in this important emerging technology. Based on the processes, he started a company “Sycon Polymers India Pvt Ltd” (http://sycon.in/Home) and another start-up is in pipeline. His group also has developed many technologies including the transfer of technology in the domain of handheld explosive sensors and continuous flow processes. For his contri-bution in this field, he has been awarded the 2017 NASI-RIL Platinum Jubilee National Award for application-oriented innovations. Apart from research, his other hobbies are teaching, sports, technical financial analysis, magic, and music. He has developed an outreach program based on “Science & Magic” to promote teaching and practice of sci-ence among students and research scholars of different grades and has been conducting such workshops around the country.

Malcolm Berry

Dr Malcolm Berry, Director of Chemistry, GlaxoSmithKline, United Kingdom.He BSc 1st Hons, PhD, DIC, FRSC. Dr. Berry has done his PhD from Imperial College (1993) and 28 years’ experience working in the pharmaceutical industry as an organic chemist. He is the best known as one of the leading innovators in the field of continuous processing for small molecules. 2010-2019, he led the first multistage continuous process to an API in the GSK manufacturing network, as far as he can tell, the first across the industry. The new process was filed with regulatory agencies in Europe and USA in the 4th quarter 2018. Dr. Berry also has considerable experience of working with the emerging technol-ogies team at FDA, and EDQM, EMA, PMDA regarding the registration and implementa-tion of continuous processes for API. He is also contributing to ICH Q13, draft guidance on continuous manufacturing.

Shu Kobayashi

Dr Shu Kobayashi, Professor, The University of Tokyo, Japan. He studied at The Uni-versity of Tokyo, receiving his Ph.D. in 1988 working under the direction of Professor T. Mukaiyama. Following an initial period as an assistant professor, he was promoted to lecturer then associate professor at Science University of Tokyo (SUT). In 1998, he moved to the Graduate School of Pharmaceutical Sciences, The University of Tokyo, as a full professor. In 2007, he was appointed to his current position as professor of organic chemistry in the Department of Chemistry, Faculty of Science, The University of Tokyo. Professor Kobayashi held various visiting professorships, including the Uni-versite Louis Pasteur, Strasbourg (1993), Kyoto University (1995), Nijmegen Universi-ty (1996), Philipps-University of Marburg (1997), Paris Sud (2010), and ESPCI (2016). Professor Kobayashi has wide-ranging research interests that include the development of new synthetic methods and novel catalysts, organic reactions in water, solid-phase and flow synthesis, total synthesis of biologically interesting compounds, and organome-tallic chemistry. He has held numerous named lectureships and is a recipient of many prestigious awards, including the Chemical Society of Japan Award for Young Chemists (1991), Springer Award in Organometallic Chemistry (1997), IBM Science Award (2001), Organic Reactions Lecturer (2002), Nagoya Silver Medal (2002), Mitsui Chemical Catal-ysis Science Award (2005), JSPS Prize (2005), the Arthur C. Cope Scholar Award from the American Chemical Society (2006), Howard Memorial Lecturer (2006), C.S. Hamilton Award (2006), Merck-Cambridge Lecturer (2007), Boehringer Ingelheim Lecturer (2009), Humboldt Research Award (2013), Green Chemistry Minister of Education Award (2013), Green Chemistry Minister of Education Award (2013), Honorary Professor, Wuhan Insti-tute of Technology (2013), TUM-IAS Honorary Hans Fischer Senior Fellow (2013), Honor-ary Professor, Wuhan University of Technology (2014), Association for the Advancement of Science(AAAS) Fellow (2015), Toray Science and Technology Prize (2016), Honorary Professor, Hebei Engineering University (2016), Negishi Award (2018), Chemical Society of Japan Award (2019), The T.-Y. Luh Lectureship Award (2019).

Andrew Mansfield

Mr Andrew Mansfield, Head of Flow Chemistry, Syrris, United Kingdom. After graduat-ing with a degree in Applied Chemistry Mr Andrew moved into the research sector work-ing for a range of Pharmaceutical companies including Roche, Napp, Parke-Davis and Pfizer. From an early point in his career he began to specialise in new enabling chemical technologies and automation specialising in high throughput synthesis and purification and flow chemistry. At Pfizer Mr Andrew led the flow chemistry initiative working across research projects and process groups to integrate flow chemistry in Pfizer’s workflow. During this time that Mr Andrew undertook an industrial secondment in Prof. Steve Ley’s group developing his knowledge in the flow field. After the Pfizer (Sandwich) site closed Mr Andrew took his expertise and ran his own consultancy company developing batch to flow processes, training and working with flow chemistry apparatus manufactures to develop their technology and develop in-house applications. Mr Andrew moved to Syrris in early 2015 first in a technical role to develop flow chemistry applications, moving into Product Management before taking the position as Head of Flow Chemistry Products expanding his role to cover Syrris’ complete flow chemistry portfolio.

Christopher Hone

Dr Christopher Hone, Principal Scientist, CCFLOW, Research Center Pharmaceutical Engineering, Austria He studied his Master’s degree in Chemistry at the University of Southampton. As part of his degree, Chris worked within the robotic synthesis team within discovery chemistry at Syngenta. Subsequently, Chris moved to the Institute of Process Research and Development (iPRD) at the University of Leeds for his doctoral studies, working under the supervision of Dr Richard Bourne, Prof Frans Muller and Prof Steve Marsden. His thesis focused on the development of kinetic models through the utilization of continuous flow reactors. On completion of his PhD, Dr Chris moved to Graz, Austria, for a postdoctoral position in collaboration with AstraZeneca within the research group of Prof C. Oliver Kappe. Dr Chris is now a Principal Scientist, working under the scientific leadership of Prof Oliver Kappe, within the Center for Continuous Flow Synthesis and Processing (CCFlow) at the Research Center for Pharmaceutical Engineering (RCPE). Dr Chris’s main research focus is on the development of multiphase flow processes. Chris works closely with industrial partners Lonza, AstraZeneca and Janssen for the transfer of processes from the laboratory scale to commercial implementation.

Kumar Oza

Dr Kumar Oza, CCO, Pi-Process Intensification Experts LLP, India. Mr Oza presently a Jt. Mg. Director at Toyota Chemical Industries Pvt. Ltd and CTO at i-Chess Chemicals P. Ltd. He has a rich experience of more than 37 years in IAEC (Bom) P. Ltd, Toyota Chemical Industries Pvt. Ltd., and Specialist in Process Intensification, Flow-Chemistry, Ion-Exchange resins manufacture & applications.

Karunanidhi G

Dr Karunanidhi G, Deputy General Manager, Anthem Biosciences Pvt Ltd, India.

Prashil Lakhete

Dr Prashil Lakhete, Scientist at SABIC Research & Technology Center, Bangalore.He has 8+ years of experience in scale up and process engineering field. He is M. Tech Chemical Engineering from IIT Hyderabad (2013)

Alastair Florence

Dr Alastair Florence, EPSRC, CMAC, University of Strathclyde, United Kingdom .He is Director of the EPSRC Future Manufacturing Research Hub in Continuous Manufactur-ing and Advanced Crystallisation (CMAC), leading the multidisciplinary academic team as well as partnerships with NPL and leading international groups through I2APM. He is PI on the associated CMAC Doctoral Training Centre that has to date recruited over 50 PhDs across the collaborative academic network and also leads the new world-class CMAC National Facility within the Technology and Innovation Centre (TIC) at Strathclyde. The facility offers access for academic and industrial users to state-of-the art processing, analysis and characterization facilities. His research interests lie in the science and tech-nology associated with continuous crystallisation, physical form control and advanced characterisation of pharmaceuticals. This spans polymorphism, solvate, co-crystal and salt formation and structural investigations of amorphous systems. Alastair has extensive experience in the formation of pharmaceutical particles in continuous processes using a range of technologies as part of the CMAC programme.

Gary Tarver

Dr Gary Tarver, Team Leader, University of Dundee, United Kingdom.He studied at the University of Sheffield and completed his PhD under the supervision of Varinder K. Ag-garwal in 1997. His first appointment was as a medicinal chemist at Organon labs at Newhouse, Scotland. In 2004 he moved into a scale up and optimisation role leading a team of chemists in scale up, route evaluation, reaction optimisation and technology development. In 2010 he moved to Cyclofluidic Ltd. where he worked to develop the flow chemistry portion of a fully automated closed-loop flow chemistry system. In 2017 he moved to NewPath molecular developing flow chemistry methods and chemical auto-mation. In 2018 he moved to the Drug Discovery Unit of the University of Dundee where he is Team Leader of the Synthetic Methodologies team which covers roles such as flow chemistry, scale up chemistry, plate based chemistry and new technologies.

Robert Ashe

Mr Robert Ashe, Managing Director, A M Technology, United Kingdom. He is a Chemi-cal Engineer with over 40 years’ experience in chemical plant design and operation. He co-founded AM Technology (AMT) 17 years ago to specialize in reactor design and con-trol. For the past 10 years, the company has specialised in flow reactors and are now the global leader in actively mixed flow reactors. AMT have won awards for innovation from the Institution of Chemical Engineers and a Kirkpatrick Honour Award which is granted for noteworthy chemical-engineering technology. Mr Robert has contributed to and authored numerous articles, papers, patents and conferences on the subject of flow chemistry. He is currently the managing director of AMT but remains actively involved in flow reactor research and development.

Surendra Bhatia

Dr Surendra Bhatia, Director, Ascenza Agro SA, Spain. Dr Surendra Bhatia serves as Director, Ascenza Agro SA, Spain, having experience of over 35 years in process development studies of Crop Protection Chemicals, Fertilisers, Veterinary and Pharma intermediates. Dr. Bhatia studied at Cambridge consultants for 3rd Generation R&D Man-agement and converted customer requirements into QFD and vice versa. He worked at reputed organizations like Rallis India Ltd as Assitant Manager process development and served as a part of Leadership team for Indofil Chemical, Hikal Industries and Sapec Agro SA. His expertize are in the areas of Process Development in Organic Chemistry (Heterocyclic and Green Chemistry, Emulsion Polymerization and botanical Extracts). Dr. Surendra has been awarded seven patents on process development studies of crop pro-tection chemicals, involved in documentation of analytical method developments using GLP guidelines.

Atul Dubey

Dr Atul Dubey, the Director of Pharmaceutical Continuous Manufacturing (PCM) USP-Rockville, USA at USP. He is responsible for the development of USP’s approach to address the unique requirements specific to continuous manufacturing. He has signif-icant experience in pharmaceutical process engineering research and development in continuous manufacturing. He has a proven track record of working with subject matter experts to identify and resolve technical issues in areas like drug product manufacturing. He received his Ph.D. in Mechanical Engineering from Rutgers University in 2007. His research has been published in several journal articles and book chapters on topics like continuous mixing, granulation and tablet coating. At USP, his interests are to advocate for quality of products manufactured through PCM, facilitate capability development in industry through training, and identify opportunities for development of new quality stan-dards to help the industry.

Dhileep Krishnamurthy

Dr Dhileep Krishnamurthy, Chief Scientific Officer, Zhejiang Nhu Co. Ltd., China

Ganesan Balakrishnan

Dr Ganesan Balakrishnan, Research Director, Syngene International Ltd, India. A sci-entist with excellent managerial skills and a proven track record of successful implemen-tation of 25+ projects at commercial level (from concept to commercialization including Waste Management). Currently working with Syngene International Ltd as Research Di-rector in the Chemical Development Group leading the Polymer and Specialty Materials, Technology Transfer and Analytical R&D Groups.

Venkatesh Katgeri

Dr Venkatesh Katgeri, Senior General Manager – RA API - Regulatory Affairs, Glenmark Pharmaceuticals Ltd. India. Dr.Venkatesh Katgeri has done M.Sc, PhD (Chem-istry-Mumbai University), MBA, PGPMX (IIM-Indore). He has about 5 years in manu-facturing experience as a shopfloor supervisor. A great learning of being part of a team having common objectives, a great insight into the importance of process development for a smooth technology transfers. About 5 years in API QA, helped me get a holistic view of API manufacturing by dealing with API customers audits, Vendor audits, Consultants and Regulators. Since 2002, got an opportunity to learn in the filed of API regulatory. It re-emphasized the major role of process development, technology transfer, process validations in Regulatory affairs.He is heading a wonderful team, who are collectively re-sponsible for handling customer queries, Global regulatory submissions and deficiencies and Life cycle management.

Nicolaas F Viets

Dr Nicolaas F Viets, CEO, SoliQz, The Netherlands. Dr Nicolaas Viets have over 25 years of business experience in the Oil & Gas, and (petro) chemical industries in both technical and commercial roles at Shell, Dow and DSM. Since 2008 he lead several prod-uct and business innovation platforms.

Speakers’ Abstract 

Expanding Chemical Synthesis by Utilizing Flow ChemistryIan R BaxendaleChair of Synthetic Chemistry, Durham University, United KingdomFlow chemistry and continuous processing techniques are now widely accepted by industry. Academia’s new task is to expand the versatility of chemistries with a focus of applying directly adoptable reaction sequences, including more multi-step telescoped transformations. Our groups mission is therefore to generate processes which enable the direct scaling of common and challenging reaction to a continuous production format. This necessitates a more holistic consideration of the whole processing sequence including greater consideration of solvents, regents and waste streams. In this presentation we will describe some of the reactions classes and new chemical processes which we have developed aimed at delivering specific target molecules at moderate scales in an academic laboratory environment.

API Manufacture in Africa Exploiting Continuous ProcessingPaul WattsResearch Chair in Microfluidic Bio/Chemical Processing, Nelson Mandela University, South AfricaWhile Africa has a variety of companies that formulate medicines it does not have any form of pharmaceutical industry that manufactures the active pharmaceutical ingredients (APIs) with the consequence that these need to be imported from overseas. This results in increased drug costs making medications unaffordable to most patients in Africa as they fall in the low-middle income bracket. To this effect, we are working on developing local drug manufacturing capacity in Africa using continuous flow technology, with the goal of lowering the cost of drugs, improving drug accessibility and ultimately improving Africa’s health. We are developing cost effective and efficient continuous flow synthetic processes towards a variety of drugs to demonstrate that they can be manufactured at lower cost in Africa.

Some Mistakes and Triumphs in Continuous ProcessingMalcolm BerryDirector of Chemistry, GlaxoSmithKline, United KingdomA few innovative case studies on continuous processing, including feedback from regulatory agencies regarding visits to our facility at GSK and comments on the regulatory dossiers.

Sustainable and Green Chemical Manufacturing via Continuous FlowAnil KumarProfessor, IIT-Bombay, IndiaContinuous flow process provides a potential alternative to batch synthesis because of its inherent advantages such as very efficient heat exchange, high batch to batch reproducibility, fast mixing, high throughput, safety, and the ability to do multistep telescoping synthesis. Due to these advantages, these processes have been referred to as the most promising “Sustainable and Green Technology”. In fact, continuous flow processes are projected to be the “CHEMICAL FACTORIES” of tomorrow. Continuous flow processes also provide an “On-Demand” synthesis with complete control over reproducibility, size, shape and these parameters can be achieved at various scales (lab synthesis to pilot to bulk production) with excellent reproducibility. This opens up the opportunity for synthetic chemists to prepare materials with precise control over critical molecular design parameters. It also enables one to carry out material synthesis at higher temperatures that were outside the domain of an organic synthetic lab. We have been exploring continuous flow processes for the synthesis of conjugated polymers, nanoparticles and nanofibers, catalysis for heterogeneous processes etc. In this presentation, I will review some of the recent advances in these directions and some results from our laboratory.

Application of Continuous Flow Reactors for the Controlled Performance of Haz-ardous Processes - From R&D to ProductionCharlotte WilesCEO, Chemtrix BV, The Netherlands

Toward Continuous Production of Fine Chemicals Using Flow Fine SynthesisShu KobayashiProfessor, The University of Tokyo, JapanAs a synthetic method, flow processes have several advantages over batch in terms of environmental compatibility, effi-ciency, and safety. Wastes derived from work-up processes can be minimized or omitted altogether by performing organic transformations in flow. Equipment for chemical manufacturing can be designed to be smaller, which would enable signifi-cant savings in space and costs. In addition, the differences between batch and flow reactors, which are the large surface to volume ratios and the rapid mixing/quenching of reagents, should make chemical productions safer and more efficient. While continuous-flow practices have been adopted in the petrochemical and bulk chemical industries, its application in fine chemical production is limited. It was believed that synthesis by flow methods could be applicable for the production of simple gasses such as ammonia, but was difficult to apply to the preparation of complex molecules such as active pharmaceutical ingredients (APIs). This lecture will discuss recent advances in organic synthesis enabled by continuous-flow methods. In particular, the development of heterogeneous catalysts in multi-step continuous-flow reactions (sequential-flow reactions) for the synthesis of complex organic molecules will be highlighted.

Exploiting Segmented Flow Chemistry in Modern Compound Library SynthesisAndrew MansfieldHead of Flow Chemistry, Syrris, United KingdomThe pharmaceutical industry continues to go through changes both in its approach to drug discovery and in the way, it uses new enabling technologies. The constant demand to deliver new drugs to market is the driver to adopt new strategies to improve the speed through early discovery to production and to the point of care. One of the major challenges faced today in drug discovery programs is the increasing demand to deliver a continuous supply of active compounds, generally novel and structurally diverse, in increasing numbers and in shorter timelines. The use of continuous flow technology in the chemical synthesis of libraries allows the exploration of novel reaction windows to deliver a wider chemical space and more compound diversity over traditional methods. The technique enables the rapid optimization of synthetic protocols, access to reactions that were formerly avoided because of scale or safety concerns, telescoped reactions avoiding purification between steps and ready-made scale-up strategies. This presentation illustrates how flow chemistry technology has enabled the synthesis of a range of structurally diverse compounds across a range of chemistries with the benefits of automation and reaction control.

The Use of Continuous-flow Reactors for Gas-liquid TransformationChristopher HonePrincipal Scientist, CCFLOW, Research Center Pharmaceutical Engineering, AustriaGases are inexpensive and atom efficient reagents for organic synthesis. However, gases are often underutilized, or avoided altogether, in conventional organic synthesis due to the challenges associated with handling gases and pressurized chemis-try. The unique characteristics of continuous-flow reactors, such as fast heat and mass transfer, precise control over the re-action parameters and the easiness of scale-up which facilitate safe operation under elevated temperatures and pressures, enable many of the challenges associated with gas-liquid transformations to be overcome. The intensification of chemical reactions by using continuous-flow reactors has emerged as key enabling technology for process enhancement and for re-ducing the environmental impact of chemical processes.Continuous flow reactors in our laboratory have been successfully applied in organic transformations using gases such as O2, H2, CO and CHF3.[1-5] In this lecture examples from our own research will be presented to make the argument that gas-liquid transformations can indeed be safely handled on large scale employing continuous-flow reactors - whilst providing highly convincing synthetic and manufacturing benefits

Experiences with Industrial Flow ChemistryKumar OzaCCO, Pi-Process Intensification Experts LLP, India

Continuous Manufacturing in a CRO @ ANTHEMKarunanidhi GDeputy General Manager, Anthem Biosciences Pvt Ltd, India

Performing an Exothermic Reaction using Flow Chemistry - A Case StudyPrashil LakheteScientist, SABIC Research & Technology Center, India

Progress and Challenges for Continuous Manufacturing ResearchAlastair FlorenceEPSRC, CMAC, University of Strathclyde, United Kingdom Continuous manufacturing is seeing increased adoption in industry with a number of products now supplied via this approach. With a wide range of capabilities available for flow synthesis, workup, crystallization, isolation, drying, for-mulation and secondary processing of finished product available across lab and commercial scales there is increas-ing focus on the successful integration of unit operations, coupled with robust modelling, online measurement and advanced control techniques. The talk aims to provide an overview of developments in continuous manufacturing research, highlighting recent progress across continuous drug substance and drug product processing activities. In addition to recent updates from the industry demand led research programme at the UK Continuous Manufactur-ing and Advanced Crystallisation (CMAC) Manufacturing Research Hub, highlights from other major UK industrial research programmes (Remedies and ADDoPT) will be presented. The challenges and opportunities arising from increased need for digital design and manufacturing methods will be highlighted as well as selected areas where scientific and technological gaps remain.

Automated Multistep Flow Synthesis for the rapid Optimisation of Medicinal Chemistry LeadsGary TarverTeam Leader, University of Dundee, United Kingdom Automated multistep flow chemistry is a powerful method to explore two and three dimensional medicinal chemistry space. In the talk a number of case studies will be presented that have used this approach to optimise medicinal chemistry leads. The challenges and opportunities of this approach will be discussed and compared with traditional approaches.

Non Chemistry Aspects of Flow ChemistryRobert AsheManaging Director, AM Technology, United KingdomThree ubiquitous features of chemical processing are time, temperature and mixing. The influence of these factors on out-comes depends on the nature of the chemistry. Although small reactors offer better mixing and heat transfer by default, the size of industrial reactors is usually dictated by production needs. Typically this means reactors in the size range of 1-20 m3. At this scale limitations in heat transfer and mixing performance are encountered. The trade-off between performance and productivity primarily stems from the fact that batch reactors only process one volume at a time. Flow reactors by contrast can process hundreds or thousands of reactor volumes without interruption. This has important implications for both performance and productivity.Historically much of the interest in flow chemistry has focussed on performance. The primary aim of this work has been to achieve better chemistry outcomes in terms of yield, purity and raw material use. Improved productivity has received l ess attention but is also an important area. The benefits generally relate to non-chemistry factors around capital cost, energy consumption, land use, fugitive emissions, permitting, overheads etc. The versatility and high working capacity of large batch reactors suits industry needs and particularly in the context of multi-step synthesis and campaign production.To serve in a general purpose high throughput role, flow reactors need to match the throughput and versatility of batch re

actors. The engineering principle that most effectively addresses this need is a cascade of stirred stages. This is scalable and allows most types of fluid mixtures to be handled over a wide range of reaction times. Systems of this type have been used for centuries by coupling multiple stirred tanks together and the background theory is covered in Octave Levenspiel’s book ‘Chemical Reaction Engineering’. This is an important area for AM Technology and extensive work has been done on multistage systems within a single vessel. This approach overcomes the complexity and practical difficulties of multi tank solutions.Batch reactors often handle work-up operations in addition to the reaction. Replacing one batch reactor with 2 or more items of flow equipment to address work up might appear to be a drawback. Continuous work-up technologies however are well developed and generally offer small footprints, lower energy costs and better separation.Chemical manufacturing technology has seen little change for several centuries. Given the pressures today on margins and the need to reduce envi-ronmental impact it is inevitable that a greater variety of hardware solutions will be employed in the future. Some operations will always be done in batch and particularly where there are sticky materials or serious fouling problems. In other cases flow reactors with extreme mixing or heat transfer capabilities will be used to deliver better chemistry outcomes. Between the two are opportunities for versatile high throughput flow systems which deliver moderate to good improvements in chemistry outcomes but substantial reductions on non-chemistry costs.

Opportunities for Continuous Manufacturing in Fine and Speciality Chemicals In-dustrySurendra BhatiaDirector, Ascenza Agro SA, SpainQuite a few of important intermediates for active ingredients in Agrochemicals and API which have been produced by use of batch processes resulting in issues related to environment, quality and safety. Recent developments in China/India have led to shortage in the availability of these intermediates for the production of finished products and have resulted in high prices as well due to wider gaps in demand and supply. Chemistry of some of the fine chemicals and speciality products can be exploited for the development and production by continuous manufactur-ing processes.

Pharmaceutical Continuous Manufacturing (PCM)Atul DubeyDirector -PCM, USP-Rockville, USAPharmaceutical Continuous Manufacturing (PCM) marks a paradigm shift for the industry. As of today, five products have FDA approval to be manufactured using CM processes, and several others are under review. While branded manufacturers of small molecule finished oral solid dosage forms were the first to adopt PCM, the technology may also find applications in generics, drug substance, and biologics manufacturing in the future. However, there are significant challenges to overcome when it comes to technology suitability for different products, implementation, quality assurance, and risk.USP provides pub-lic quality standards for the pharmaceutical, dietary supplement and food industries. Driven by its commitment to advocating for quality, USP works with manufacturers, research institutes and regulatory agencies around the world to ensure availability of public standards to improve global health. The USP PCM program aims to refine and develop standards for continuous manufacturing, provide training and support to industry, and facilitate idea exchange amongst the various stakeholders. This presentation will highlight some of these initiatives.

Process Intensification for Crystallization, Filtration and Washing in Flow ChemistryNicolaas F VietsCEO, SoliQz, The Netherlands

Enabling Green Chemistry Using Flow ChemistryDhileep KrishnamurthyChief Scientific Officer, Zhejiang Nhu Co. Ltd., China

Process Improvements using Flow ChemistryGanesan BalakrishnanResearch Director, Syngene International Ltd, IndiaFlow chemistry helps in “taming difficult processes” to give product with consistency in quality and quantity. The unit opera-tions e.g. nitration; in flow chemistry give excellent process control ensuring consistent product quality.

Continuous Manufacturing and Key Global API Guidelines - A PerspectiveVenkatesh KatgeriSenior General Manager – RA API - Regulatory Affairs, Glenmark Pharmaceuticals Ltd., IndiaContinuous manufacturing is an emerging field for the APIs. This talk is intended to share the perspectives on the following :-• How do the current of API specific guidelines, address the concept of continuous manufacturing.• What do guidance related to Process validation guidelines, ICH Q7, “Life cycle management guidances have

to say on the Continuous manufacturing concepts.• What do the global regulators have to say on continuous manufacturing.

Oral Presentation - AbstractsRapid and Multigram Synthesis of Vinylogous Esters under Continuous Flow: An Access to Transetherification and Reverse Reaction of Vinylogous EstersNirmala Mohanta and BoopathyGnanaprakasamDepartment of Chemistry, Indian Institute of Science Education and Research, Pune, IndiaVinylogous esters receiving a significant attention from the organic chemist as these compounds are considered as a versatile and reactive key intermediates in many chemical transformations due to their ability to undergo FGI.1Thewidespread applications in the synthesis of natural products,2bioac-tive molecules,3 andmaterials4make β-keto-vinylogousesters promising precursor in synthetic organic chemistry.At present, there is an increasing demand for pharmaceutical industries to develop economic pathways for the synthesis of new chemical entities as well as essential medicines to treat the lethal diseases in our society. To fulfill the demand of bioactive molecules on a large scale; continuous flow chemistry can be proven as an important asset.Flow devicesare the viaducts between the bench chem-istry and process engineer. Additionally,this technology provides reduced reaction times, higher selec-tivities, and the possibility to safely use hazardous intermediates and gaseous reactants.Herein, we developedan environmentally benign approach for the synthesis of vinylogous esters from 1,3-diketone and its reversereaction under continuous-flow has been developed with alcohols in the presence of in-expensive Amberlyst-15 as a catalyst.5 Thismethodology is highly selective and general for a range of cyclic 1,3-dicarbonyl compounds which gives a library of linearalkylated and arylatedvinylogous esters in good to excellent yield under solvent and metal free condition. Furthermore, thelong-time experiment in a continuous-flow up to 40 h afforded 8.0 g of the vinylogous ester with a turnover number (TON) =28.6 and turnover frequency (TOF) = 0.715 h−1 using Amberlyst-15 as a catalyst. Besides, continu-ous-flow sequentialtransetherification of vinylogous esters with various alcohols has been achieved in high yield. Reverse reaction of vinylogous esterin the presence of environmentally benign water and amberlystresults hydrolysis to ketone under continuous-flow process. The aforementioned results will be presented.

MnO2@Fe3O4 MNP: An Efficient and Recyclable Heterogeneous Catalyst for Ben-zylic sp3 C-H OxidationAkanksha Pandey and Boopathy GnanaprakasamDepartment of Chemistry, Institute of Science Education and Research, Pune, India.Designing a sustainable chemical process for the functional group transformation is one of the formi-dable challenges in organic synthesis.1Homogeneous catalystssuch as Cr, Mn, Co, Bi, Ru, Rh and Fe are reported with several advantages for the direct transformation of methylene groups to afford ketone.However, there are several limitations exists in this transformation, for example; decomposition of the metal catalysts, the lack of regio- and stereoselectivity, exothermic reactions, the problems of catalyst extraction and recycling as well as product purification make them less ideal for the synthesis of fine chemicals where product contamination with heavy metal is highly undesirable in large scale synthesis.2 Hence heterogenization of the catalyst is essential to overcome through these plights and the development of a more sustainable and cost-effective process is of critical interest for the indus-try in order to reduce safety risks and to afford improved synthetic routes for larger scale reactions. Besides these factors, scalable of TBHP mediated reaction under batch is highly unsafe which makes them undesirable in batch process. To this direction, continuous flow has several advantages includes, mass transfer, easy scale-up, safe to operate elevated temperature and pressure reaction and shorter reaction time. Hence, we envisioned for the TBHP mediated benzylic sp3 C-H oxidation of ethers and methylene to esters and ketones. Herein, we prepared MnO2@Fe3O4 nanoparticles with an average size at 49-85 nm and studied benzylic sp3 CH oxidationethers and methylenein batch as well as in continuous flow.Optimised a series of reaction conditions results direct oxidation of aromatic benzyl compounds to aromatic ketones and (benzyloxy)benzene derivatives to its respective ester in high yield.This strategy offers the opportunity for using heterogeneous MnO2@Fe3O4 nanoparticles as a magnetically retrievable catalyst without any loss of its activity upto12 cycles to integrate presented cat-alyst into continuous flow condition for the scale up. All the above research findings will be presented.

ExhIbItIon SPonSorS

Inkarp Instruments Private Limited was established in the year 1985 by Mr. S. Balu. Through its history of more than 28 years the company has grown to be reputed suppliers of scientific / analytical instruments with a formi-dable Pan-India presence. Inkarp serves the need of customers in phar-maceutical and biotech Industries, hospitals and clinical diagnostic labs, universities, research institutions and government agencies. We aspire to be a scientific Instrument company where quality is deliverable, technolo-gies are innovative, and products are affordable with a reach transcending all boundaries.

Mettler Toledo is a leading global manufacturer of precision instruments and services for use in laboratories and manufacturing.They offer weigh-ing, analytical and inspection solutions along our customers’ value chain.They manufacture high-end products including industrial scales, laboratory balances, Rainin pipettes and process analytics equipment. They help cus-tomers to streamline processes, enhance productivity, reach compliance with regulatory requirements and optimize cost.

They are a group of Chemical Engineers and Scientists specialized in Pro-cess Intensification for the API and Fine-Chemical Industries with 30+ years of industrial and research experience. With experience of over 100 grass-roots projects in 14 countries, they are also evolved in the techniques to handle hazardous reactions and reagents.

Syrris creates automated products for research and development chem-ists and is a world leader in flow chemistry, microreactor and automation technology. Syrris products are used in a wide variety of applications and laboratories including process, discovery, crystallization, process safety, scale-up and many more.

Sawant Pumps in collaboration with world’s leading manufacturers has been providing a wide choice of solutions for frequent use in different types of Chemical, Pharmaceutical, Agrochemical, Petrochemical and Polyester Industries and most of R&D centers in India.

CMAC’s vision is to revolutionise the way pharmaceuticals and high value products are made. The approaches developed and adopted within CMAC have been developed through close collaboration with industry and the sup-port of its Tier 1 partners, which includes GlaxoSmithKline, AstraZeneca, Bayer, Lilly, Novartis, Pfizer, Roche and Takeda. Established in 2011, the CMAC has a £150m funding portfolio and currently comprises more than 130 staff and researchers, including academics, post docs, and more than 45 PhD students, as well as an experienced support team.

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Techsol Engineers is a solution provider in the field of Process and Instru-mentation. We are an innovative company and continually emphasize on our motto of “Listen to customer”. Whether the customer is in need of any products, technical expertise or any technical services –we want to listen to the customer and would like to offer our knowledge/ expertise/ services so that the customer’s requirement is met.

Chromatopak as a company is in a business exclusively dedicated to chro-matography and in particular, the consumables, accessories and spares that go with a Liquid Chromatograph (LC)or a Gas Chromatograph (GC).Our major areas of expertise is of course the chromatography column…but we are a one-stop for almost any accessory that you would need right from conception of an analytical method upto the final chromatograpy run.

GMM Pfaudler Limited is a leading supplier of engineered equipment and systems for critical applications in the global chemical and pharmaceutical markets.Our success is based on close and continuing interaction with our customers, application engineering expertise, innovation, customer support and a competitive cost structure.

Established in the year 2007, an ISO 9001:2015 Certified, CRISIL rated and having CE marking for various products, PCI Analytics Pvt. Ltd. is Mumbai/India based leading manufacturers, suppliers & exporters of wide range of laboratory scientific and research equipment and instruments. These comprise, AAS Accessories, FTIR Accessories, Gas Generator, Gas Purifi-cation Panel, HPLC Column Oven, Digital Gas Flow Meter, HPLC Accesso-ries and Laboratory Equipment.