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Evaluation of shortness of breath: how to avoid pitfalls and make a timely diagnosis Gyorgy Mundruczo, MD Pulmonary and Critical Care Medicine Bozeman Health Deaconess Hospital

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Page 1: Evaluation of shortness of breath: how to avoid …...Evaluation of shortness of breath: how to avoid pitfalls and make a timely diagnosis Gyorgy Mundruczo, MD Pulmonary and Critical

Evaluation of shortness of breath: how to avoid pitfalls and make a

timely diagnosis

Gyorgy Mundruczo, MD

Pulmonary and Critical Care Medicine

Bozeman Health Deaconess Hospital

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July 18, 2016

Page 3: Evaluation of shortness of breath: how to avoid …...Evaluation of shortness of breath: how to avoid pitfalls and make a timely diagnosis Gyorgy Mundruczo, MD Pulmonary and Critical

December 31, 2016

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February 3, 2017

Page 5: Evaluation of shortness of breath: how to avoid …...Evaluation of shortness of breath: how to avoid pitfalls and make a timely diagnosis Gyorgy Mundruczo, MD Pulmonary and Critical

Dyspnea: dys (bad) + pnoe (breathing)

Dyspnea: a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity (ATS)

Perhaps the most common manifestation of lung disease

Distinct sensations include effort/work, chest tightness, air hunger and an unpleasant urge to breathe

Dyspnea can be a normal sensation in heavy exertion or at extreme elevation

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Receptors

Centralnucleus tractus solitarius in the medulla, >thalamus >insular cortex and limbic systems

Peripheralchest wall mechanoreceptors: muscle spindles and tendon organs –sense muscle tension and contraction > ant. horn cells >somatosensory cortex

Chemoreceptorshypercapnia or severe hypoxia

Lung receptorsmyelinated and unmyelinated (C) fibers via vagus nerve

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Lung-heart axis

Lungs (upper and conductive airways, parenchyma, diaphragm)

Heart (systolic, diastolic dysfunction, valvulopathies, intracardiac shunts)

Pulmonary vasculature (pulmonary HTN, PE, shunts)

• CaO2= 1.36xHbxSaO2/100 +0.0031xPaO2

• SaO2= C(HbO2)/(C(HbO2)+C(Hb) x100

• DO2= COx(1.39xHbxSaO2+(0.003xPaO2))

• PaCO2= VCO2x0.863 /VA

Page 9: Evaluation of shortness of breath: how to avoid …...Evaluation of shortness of breath: how to avoid pitfalls and make a timely diagnosis Gyorgy Mundruczo, MD Pulmonary and Critical

Evaluation: the tools

• History and physical

• Pulse oximetry (at rest and with exercise)

• Imaging (CXR, CT chest)

• Pulmonary function testing (spirometry, complete PFTs, CPET)

• Cardiac evaluation (echo, right/?left heart cath)

• Serologies

• Tissue biopsy

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H & P

• Smoking/occupational/environmental history

• Family history

• Medication use history

• Examination: lung sounds, expiratory time, persistent rales/crackles always indicate pathology

• Upper airway wheezing >not too concerned

• Clubbing

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Pulse oximetry

• Low Hb >easier to saturate, elevated Hb>the opposite

• Methemoglobinemia and carboxyhemoglobinemia can cause falsely elevated SpO2

• Cool extremities can increase Hb’saffinity to O2 and underestimate tissue hypoxia

• Tremor can affect the pulse oximetry reading >use the earlobes

• Allow time to equilibrate

• Check at rest and with exercise

• 95-100% -probably normal

• </= 94% probably impaired

• Dropping O2 sats with exercise suggests supply<demand=abnormal

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Imaging

Start with a CXR –may be more sensitive than a CT scan for detecting increased markings

CT chest w/o contrast usually adequate for evaluating parenchymal lung disease >pattern recognition: IPF or not?

The radiologist may under-read CXRs and CTs in subtle lung disease: “no acute cardiopulmonary findings”; possibility of inter-observer bias

CTA/VQ scan for evaluation for PE

VQ: low/intermediate/high probablility

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Spirometry/PFTs

• Look at the flow-volume loop

• “normal range” 80-100% predicted >normal is 95-100% predicted

• Spirometry and lung volumes need to be supportive of each other

• “significant” post-bronchodilator response is 12%/200cc increase in FEV1 or FVC per ATS

• Obstruction and restriction in the same person can result in changes in the opposite direction, may lead to pseudo-normalization

• DLCO, DLCOcor, DLCO/VA >I look at the DLCO(DLCOcor)

• MIP, MEP –effort dependent, fraught with measurement errors

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Cardiac evaluation

• BNP >released from the ventricles, causes vasodilation and natriuresis

• Echocardiography >equivalent of a coin-flip when it comes to

RVSP, unless there are right chamber abnormalities associated with elevated estimated pressures

• Right heart catheterization >measure the pulmonary

artery pressures and the PCWP

• Left heart catheterization -in select cases

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Polysomnography

• OSA may contribute to pulmonary hypertension

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Serologies

• Autoimmune and inflammatory,

• Infectious serologies

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Lung biopsy/sampling

• Tissue biopsies

– Bronchoscopic (tissue and cultures, cell count with diff)

– Trasthoracic needle

– Open lung (VATS, thoracotomy)

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Lead time bias

• ???

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Pre-test probability

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Effects of ageing on the lungs

• ???

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Lung disorders seen my practice

Treatable/curable

• COPD, asthma*

• Sarcoidosis

• Hypersensitivity pneumonitis*

• Bronchiectasis*

• Eosinophilic bronchitis

Not a great prognosis• Bronchiolitis obliterans• NSIP*• IPF• LAM• Sjogren’s• Cryptogenic organizing pneumonia*• Wegener’s granulomatosis• Other vasculitides• MAC• Pulmonary hypertension*• Recurrent laryngeal nerve paralysis • Malignancy*• Yet unspecified lung disease

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Treatment strategies

• Will treatment make patients feel better or live longer?

• Appropriate immunizations

• Exercise program, nutrition

• Trial of meds for a period of time –if not effective (or not essential for longevity) may be OK to stop

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Patient examples.

Page 24: Evaluation of shortness of breath: how to avoid …...Evaluation of shortness of breath: how to avoid pitfalls and make a timely diagnosis Gyorgy Mundruczo, MD Pulmonary and Critical

Patient examples..

Page 25: Evaluation of shortness of breath: how to avoid …...Evaluation of shortness of breath: how to avoid pitfalls and make a timely diagnosis Gyorgy Mundruczo, MD Pulmonary and Critical

Patient examples…

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Patient examples….


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