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,}lum*n M*tmrinln Trcnnf,tr Agr*cmentfVit$-$snHPTII pnrtn*re'hip * AIYI-Gen Study
NfH - tt$Africa furrdcd re*eareh
ln *grecrmemt berr*.ew thc RfifrIFIF-bIT nnd rhe pe"$vltlER rhi* is m rtque*t tCI trnnsftr MAIfSKIAL:
MATSRIAL; Flumatr Senomic. IINA.
S*fitti$sp,pi
pR$\iIX)fiR:'{hirrcipal lnt"csr:iggt61 rmponsibl* for the pr*ject fmmr whir:h tlm statsrj*l erigi**tes
ItHclpffinr:rl principal lnrestigatur responsible for the praject rvh*rc the research dat,a n'iil be generat*d
&HCIFIEI'IT $C,IH}'{TI$TS: $uier*isrs &'#rkirrg in the Ssup *f th* Rf;CIFIHNT tc gene,,rate the dats f$rthe *pecified project
MATRRIAI-: Reftrx m the speeifrc hir*ngical sample* ns detuilsd in Appcndix A to this agrc*rnsnt whi*hdmsribns the n{ttuxt of thg projs*t
The FIISVIFff.R asks thar rhs RffiCff{H}'lT and the REC]$ffiNT SCIF}ilTIST$ ntp,se r* the tullowinghe,fcr* ths RECtplf;NT receiws the MATtrRIAL;
1. .fhe ahsrrs MATSRIAL li,s the pftl$$ry cf the PRSV:IDnR" *nd is rnnde av*ilfrble for a specific
Buqpe$F {ffien*,ruting frnrrtin!\rtetabochip dnt$ $n fh* "tarnp}es $retvidsd}"
?. T-!{fi$ M,AtERlAt IS }$f;'f F$R U$H IH Iil-IMAN S{JBJtr{:T$.
3. Th* &tATHRIdrtrl will bs used for the stated pulpose anly'
4. Tihe MATIIRtrAL will be Esed s$ described in App+ndix A unly. ASy olh*r use of theMATHKIAL requires the FRsvlllHR,* written Cffi$$srr*t end an anrend$ent frumr th& relw*nt Resds#ctl&thie* C*nnmittee.
i. ThB r1*ta genernred hy tge tu{.ATHRIAL' sns$ it kas Uon *sed'a* d*scrib*d in Aopnudix A, *hnlltie rehined b.y rhn RII*trPIHNT ibr * lirnitsd time only AND will tre $snt ts tlrg P$"tl\FryS$ fbr use in fhepublic d*m*ln ***o*diog ttl *:stiprlat*d pro*;es* nf {he \s,its*{F"{HFT}t },tr3Africa fuftdnd' ptr'trershipprugru*_ rne RH*lffinfir: *ill refo requ*$r$ f$r access rn tbe dara ro the appr*priate wirs.tN,DHPT[{i*o***ftip cwrnmitree,on u'Lriqh ttle FR$VIIIER t"ill hat'c representation'
s. The ${ATH}I"IAI* wi}l not be {brther r$irrritrurnd t<; orhern. Any MAT:ERIAI" let] $1dsr nftsr thestipulated experirnent* huvs bs€n **u*ludsd will trs kxrpt unril **mpletlnn cf thE p*lject and vvill thes bs*lemtr*ye*|. a"r agr'*ed h*tween the purties.
7. the n"EffIFtFHT w"il[ *r}t puhlixh nny *f the elat* genernt*d.
g. Any futrATHRtAI- d*livered pl*rsufln{ to rhis Agr*ernent is underrttlsd to'be expe,rimental fu}ga{ffe agsmny hnve hsf;srdsus prqxntie*. The MATES"trAL is of human ori$rn and may pose unknewnan6 unrecegrrined heatth *r s,afery ii"sfts. l'he RSCIFIENT will handle the MATH'RIAI., using appraprinttprccedrxes*fir humun.s$ur$e matsri*ls" Ti{F. PR,SVffiJfiR MAKEti NCI &HPRSSEN'I'ATIONS ANI}fumxrf$$ Nff w*,RRANT{H.$ t:l' ANV KfNn. HITr{ER S}{FRuS$HD #K }MFLiHD. THHRH ARHHS MHPRE$$, #R ft!{FtIEI} K,AR,R,ANTIII$ C}F MER.C}TANTASILITY T}R FITNITSS F$H A
[.4R FL3'ltFt]$*i, t}R "fl{AT :lrtlH $SE OF TIIH h.{ATHRI.AL trSlt'L NOT INFRINfiH ANY
pATgNT, flt}Fyltt{}}trT, T&,qDHh{ARK* SR flT}IHX p}l.f}pRIHTAR.Y R.l$I:r,TS, Unlvwx $r*hibitcd byI,nw" ttSCIpIHN? &ss$$t*$ nlt tiufoility fcff Glainrx fur d**nages *Sa{nsr it tt3' ih,ird pnrtierr w"hich m$f erlp*frsm ths Nse" sr{;rgge *r disposal *S the MA'l-llRXAL'except tlint, t+ fhe exterrt permitt*d by law, th$:FR$\TiltrR *haXl b$ tiehle i$ the H"H,CIpI}INT whsr* the darnage is ea*sed fo3r the gr*$* ne$lig***e orwillftrl rnisenndu*t sf ttre FR"#VtrI)I3R'
$. The Marerial prnvid*d hy the FI{S\iIruHR. tuxfituti*n ',pitl b* ds-identified. The HHSnFffi!{TInsrituri*n u,rill nct be pretided rviitr any infcrr.mnti*n that cculd be used 't* idmrttfu tlw rubjrms lb*mrs/hslTl the MATHIq,IA; was e+llecr6d' ulihnxgh,thcr FROV$SI$R Inxtitution-r*ley t*t*in s,*snfi-dentinl linkiu tlrr xutrje*t,s ident1ty. lqteithsr $I"H#IPISN'I Xnsrituti#I'l rlsr H"fTCIFIENT Scienti*ts *hnll mel*e .anyatrernpf$ ts, d$*emills t$re id*ntity of, tk*r* *erhj*cts, CIr is ${.}trtnef ths subje*ts" $hr:-llld * hums$ subjeut*om *'honr 5' ,-{TERIAI- **as cfllle*ted nhject t* t}rc uss set rfunh herpin, then the H"HCtrPImKIr lrhc$tutisn&gfees tCI prrwptly *ornpxy with FR{}'v'fi}nR Institr*ti*n*s Sequest t{} rstt$Tr} *r destr*uv ;my such sa.rnple"
l$, Rf;,*IFIhI'lT essess irr a$* lh* h{ATItRIAl.. in * s*fe $}s$nss snd in cornpni*ncs wiih ellappliuablc l*w* and reguluti*rn"s. pft"ft\rl$trR rusrra*ts th*t it heg *btcin*d any In*titrrt'ianal Review fiuand*r-Erhirls #.*rnr*ittee atr1trrr*r.al r*quir*S ftrr ttre tr*nsfsr af ehis Mf\THRIAI-.
11, lrhe ItfiClF{H}*T and pR{}\J}SSR. tl$ks re*pues{t}ilitv ra the authsnticify r# th* ethie* *pFr*vet*er.tificares {Appen<tix B} and exporr, irnporr certifi*ate* {ApXr*-*dix f,} 6** reqreired by nnd'in, s**$fdfi{tcqwith the lswn *f the*r r*sp**tive cuunlries.
l?. Ttris Agpeernenr lrill temlinnt* up{)n c*mpletirn nf RffifiIFIS}$'F trnstiruicr#* use sf tnlc Materialfire Farties ogr*e thnt the prcr.{si*ns of th,is Agr*ern-e*t sre inlend*d t+ h*r l*te.r'pret*d ffid implet*erttnd *ons t* compny r+1ttll ntt *x,plicahle larr** govurnrrr*ofa$ ruXen and reglrlatin*s; hCIrt'erper, if it is Smteflnirrsdthnt am5. prnvisinn ;f -# Agreenrerrt liil'rlrrt in *ue,h *ornplianceo *r if an lrlsr'iftItionat Review F*aid <xother *Lmpanrhte l*ody tltrj*,:ts ro fire tsn$$ trf tliis Agreement ry tht: provisiun or u*s of the ?Hnt*iial**tlren ths Far*ies agr$s to muti*fu' tlrat prur.fsis$n $r thix ,S.gre*{flent .ss as f# hs in ctmplirmee *}r t* bnuc*eptahre tg sugh In*tituti*nal Revielv, Il*nrd. If *us,h rnndi{i**tiutr ie $,ot p*asibte, cr pra*ti*a}n ur if, thepurtien arc unrrhlfi tr] s*r€e $F(l{r rke r*odiscati*n m'he r.twdso [h*n either Far-W fi]e$ irnmediatetytcnninate thi* *.gn"gernent. ptK)\{SfiH. fn*tituti*xr .qhrill ,lrate tlr* r'ight rn tenvri*ate tkis &gge*rn*nt f+rany rss$$n :i*rtuiing HH,trIPI$NT tns*ttt*totrls hrs-eeh *t nny *f.itx *blig*tl*ns srr{E$Ffisibitfuies $nder*rls -qg,reeraefit- afifr s,gch hne*sh is nct umed within thi#y d*y* crf 3eueipt *f written .notie} ,f.romFIf$VInfiR Insrirurion" {Jpan teyminnti** ftrr nmy rr}*ss{r the RHC[FI,Ht\i"f lnstitutiun wifi, at SR{}]"f$fifi'Instituti*n's dis*retinn, eiiher stufisu En refurn CIr ds$trsy any remnirring Molerial in ac*<lrdnr,rce rs{thaspllsahle I*w* snd rsgrulnt*(lnx'
t*he FRS$I$HR nnd HHfftr.pIHNT rru*t *.igp hr*Ie **gie* $f thix letts,r wnd refum one niglwd oopy tc theFROVlmffiR" The PRt)ldlAHR vrill then ssnd ths MATHRIAI".
FRCIVInHJ{ INSSRMA:I'I$N nnd A'UTtff}K"lf;S.D $I$}'l ATURS
Fr$vidsr: Fraf" Mieh*le H.mnsny-Frcvid*r snxxtsst detnils,: @- {} I t4fl$$l I 4Provider Organimtirw: l'isticnal Heslth Lab*ratury'$mricesFrorriderAdsrees: Sepattr**nr sf l{twnan Saneties, Rnsm tfig l#stkirr* Pit*lrfcrd Brlitding Natls$slf{eatth Labcrct*ny $enriee*, flsnanrfbnteim, lt}frS, $uutfu Africa
3$ April 2{i 1i
Delte$ignnnuec'f Frwider
Namq *f Auth*rised Sf{iciul:Title uf Auth*ri*ed Sffl*iah
ff*r 3$ignaturc *f Authori.tscl t]ffleinl
#^si$ *{4d-r**-" edd"ldfl S-ttd- e,{ir*S-{ {sre$***lRECIFIE}fT- XN FSRMATI$H NNd +TIJTfT.sRIf;Hn' $IfSN&TTJR.H
fte+ipient: ilr vfi&en*a Raxhbrcok ,'-q]-]tx, vkrss]rh*mr l: $3$-?S4-g$$gnecident ss$tast detsils: XsLSSftiffiL#kS-[, Xhrq$tLtl.mshi$us*lnsm*Sg' f a;
Recipi*.nt {kganis*ti*n: l}mir'*rsity *f Ca]i fornia- DnvisReeipicnt Addre*s: tlFgA Techlxil*gies dl#r$
43134 {}BSF45t F{*nelth $rd*,1:tes l}riveUn iverxr'f,r' *i trel'ifcxuin, - ffi*vistr}avizu t-4 SSSI$
t nJa"*c=e^ lffi %1?$igpntt*re*f Rwipiel* Ilat* U
[.]itle
Nsme of Authuri$ed, $fFrci*l1'lltle of. Authorised #{fi eisl;
,APPcndix A
Alnn and ot{e*tivet sf tke Pnof*ct
Titl* of th* Ressflrnh rpr*jeetr ldemtifiestien *f S*netic Mafker* *f $be*i11-Risk und B{}dy'
cnrnpnritiem in $ $*$th Afti*an Hlnck F*p*lnti*tl.
Th* o"*usll nim nf th* propcs*d f,ers*rsh is to identify gcn*tie mnrhsr-t nf nb0**tg'ric*r *n s
$eutk Afrimn s$*ck popntntlun {e*rcgtvsrs nf fhe,&t?{} enhort}
To achieve drix- we 1p'ill study the genetic populatitln c{ffittibuti+ns *f't}:e Ht?$ *nregiver s*hort'
t* aid *ptimgl des,ign *f tke sss$*int*$n studies. &'r will tlaen: p*r{brm ar.l ***ei*isti*n study,
{b*using crn la;ci ass{r*.imted with erhesity measur** {e.g, Bady ffi*l$s ind*x {BMI}, h$rry fut 9{s,
wsist t* hip eire*rnfurencr] in Sur*p*armn fn u*mfkm if thes* l*rci are ximilnr,ty ass*ciat*d with
nhesity iisk in Afri*mn, u*ing ths, Flurnan Cnrdi*Metaboctrip {Il}umir*a}"
AilMl F,in* mstr l**i pr*vi*g.sly ess${iieted with hody e*mptsiti*s} to ss$es$ tlle ns-q*ci*ti$u in nn
African pqprlation" anEl identify the c.andidete regi$n$ flt the$s ltlci nxing ths dets CIbtained frsrn
the Dardi*htletabouhiP.
Brief desrriPtlon cf th* Pr$ccf
$be*ity ir s **nsidernbls rink feet$r fi:r the developlxrfflt sf ntnrernl chr*ni*, fi$n*
crmsnu*icstrle diseases {C.hTffiC}, sn* i* bec*ming ffitrrs prevalwt in devektptng cCImrlries
such a s$uth Akicn- Atrth*ugh smvir*nm*,ntnl fhst*rs lmv*r n e*nsidsr*ble irrnpact on *besity
rj*k it *trsa; ha* * g*n*ti*; u$mFrffis$t {B*durtho et *}", lsqs; W:nrdle et n[-. g(]*$]. The,siu$y tlf
sy*drorni*l ohesity hn-s pmrvided ${rrafi insighr iru* tkr gene*irt c'&us$}i *f *he*ity *nd ge*nlne-
wide a*suciation studies tGwA$) havs provic,h:d ttrrrher evideerse fcrr r;smrx*n *b*sity risk
lu'ui. Alt cufFent #wA$ ftrr twdy c*mpelniiion srnd *tre*ity nrw hasd sil fi$f,t'&frieam
p*pul*tierns. with an explicit defisit $f Af:riean*centri* res*ar*tr, s"lnc the identi{i*sti*n *'ll
*s$$el vnrjunt* in g**etic *nsouis*isn studie,q in Africun srrlrrF$ is mmu eft'i*islt, hec*u*s
linkag* d{*eqr:itib;ium {Ls) *xists nvnr a +homer gerrn*nic distnnse" Fur{hcrmnrd, thn
m*raholi* f$11ssq$eriss$ nf eibesity are highly dependant *u trcdy fat dis$it?$titn sn*sthnic
difl',eren*es in h*cly:*$mp$$i{i*n *re well d*currrentsd {Cr$wttter srnd F*rris, 2S1$1. The
fhstsrs *nrterfying thes* di{f-,erences n.re *or fi*t{y underst**d nnd t*r$r* is an uxpl'i*it *hr}*fsll
in Afr"jcan*focu,sed re*carch int* ge*etic fnetors f*r ahesity,and b*cly wnnpmsitian' Alth*ugh
v*riatiun witfiin and sronrnd num,emrur genrtie luci hes tieen ssstlnintsd "nith eihesiqr, heritability is
not fully explairred by our su{renr kmwle*lge of genetic tnriation. 'fhis *tudy will ttilize sv*iluble
tCIrrgi{udinal dnt* to ss$r*h for n:Ble*,ulnr uhs*ity rixk {hcts}r$ &cr$$$ t**e li'fe-e$u'r.qs *nd will tie the {ir*t
stutl5'.sgi** kind fo*using stt fi blsclq S*uth Attisan sahnrt {StESi'
F*rtiotpnnt* iu the Fr*ieetEthnitlty: $H &nnfu {$*uth Atiican Slsck}Rele*rg1t pbenutype dstg: Sody mass ind*x {SMI}, body tht;srii welist l* hip *ireurnference
F,rseis* tlmcrlptiun sf thefff;ntsrinl {c+uld hs in tsb-ls fomnat}:Numfuer of r*mpl*s: 1ff34Qtnant r sf ms*€risl per *nnrptn: ?5-50FI *t' S0lrgfpl tlNA :$ftffipl#s in tr I Dnep rvell- 'r$ufidbottorn PCR plates.
Hthics *ppraval fi,nstitntfinn*l rcde nnd numherli #Itva*anue eertif'"reatte fnr WIT$*INSryTFIpnrtrrer$ttip: SerurNri* mnd ffinvinrnnrenr Risk Fa*t*rs ,fbf Cnrdi*metah+li* Ilisess* in Afiriesns
ffi:fffi:-Tffi ffi H: i:YJnT:l proj ecr: "' rdentiricar inn *r Gen$ric Mnrkers a r sbes tty R isk andB*dy C-urnp*siti*n in a $mrth Afbic*n Slssk ptppultti*n," (t*rtitTf,sts n$ffiber; Mt?{}647)-msth s*rti fientes trttached-
Ilafc nnxlyeis nmd dsta *knring **at*gy: To he desided *nc* ctffix is rm$eissdo datn rvill hennalSmed uning pt,INK {}Ian'nrd Univer$ity frnewnr*}.
flwner*ftip cf Srtx nnd IP: Letter nt'imresr m puhlish stttr*he.S.
Intent tr p-trbfi*h {in *uetxdance with Writs-trlt}HPT$ H}Africa fun*ed resesrch prntereels}:ref*r abcve
Finansiat irnplicntians * Prulviqler will gay fur scrvices rendered blr$N,4 Te*;hreol*gie* Ctttu
A.ppendlx S
Cop'y nf serai*$ approval ssrfificates
L. Frorn pruvitler;n. Appr*valt* csllect the sarnplesb, A$prcval for their: use in this pruject
3. Frorn recipient:6. N6t requird {R*eipient i* n Seru"i** Frovidex * s}l data gnnernted will he retrmGd
tc Pr*qid€r mnd after *n agreed ti*:e peri+rd fhe clata will be rernCIr,ed freirn thtrreCipient, dsteb*sel
.{,ppcn$ix ff
L*gal drxlum*nts nx r:eq*i:md fruffi the $SNtlR snd RHCTPIHNT countrie*s.S. EtrpsrtF*.fmit fronr thu S*uth Af,riean National ffepartrn*m uf H,ealth
INFORMATION SHEET Birth to Twenty participants
Re-consenting around historical blood and DNA samples
Historical blood samples You have been a part of the Birth to Twenty cohort since 1990, now over 20 years. We have collected data on the Birth to Twenty participants at 16 time points. At some of these time points you provided consent for us to collect blood samples from you to test for health indicators such as blood sugar (glucose), cholesterol, vitamin D, calcium, etc. These blood samples are stored at the University of the Witwatersrand with only a unique number identifier so your name is not attached to the sample. The information linking you name to the unique number identifier is locked away in the study offices with strict access control and is not made available to the people working on your blood sample.
In the future we may run additional tests on the stored blood samples, but we will not do so without the approval of the Human Research Ethics Committee of the University of the Witwatersrand. Historical DNA samples From the blood samples we collected from you in 2003/2004 you consented to us extracting DNA (the inherited material in your cells) so that this DNA could be used for studies that look for genes/changes in DNA that are involved in causing diabetes, obesity and cardiovascular diseases, and for studies to understand how the DNA works (we call this epigenetic studies). DNA studies give us information about how your body works and also whether you are more likely to get certain conditions or diseases. It will also tell us about your ancestry (your family) and about the way that your body uses medications (we call this pharmacogenetics). Just as for the blood samples, all DNA samples are stored in a safe place at the University of the Witwatersrand and strict control access. If at some future date we realize there are other studies that we would like to carry out on your DNA samples, such tests would only be performed if permission is given to us by the Human Research Ethics Committee of the University of the Witwatersrand. Your identity will be anonymous as your sample will be identified by a number (as described above). Blood and DNA sample management The scientists who do the research will generate information (data) which will be placed in databases. Some of the information in the databases will be shared with other scientists, possibly around the world. These scientists will not have access to your name and therefore the data will not be linked back to you. It is possible that we may send small amounts of the DNA out of the country where tests will be done that we cannot easily do in South Africa, but that would give us valuable information for our studies. Benefits The discoveries that come from the studies on your DNA will not be of direct benefit to you and will not be communicated back to you. The discoveries may lead to information that will help us in the future to diagnoses disease, understand who is most likely to get ill and how different people behave when they are given medication. The DNA belongs to you and we are the keepers of the DNA. You may withdraw your sample at any time. Risks Since the DNA of every person is different, it is possible that if someone tested your blood and compared it to the data in the databases, they could conclude that the two samples come from the same person. However, this is unlikely given the procedures in place that protect your samples.
CONSENT SHEET
The information around the blood and DNA samples taken from me in the past is clear and that the purpose is for me to inform the study what they can or cannot do with these samples. I acknowledge that all procedure/tests on the stored blood and DNA samples have been or will be approved by the Human Research Ethics Committee of the University of the Witwatersrand.
YES NO I am in agreement that my DNA may be stored and used for the purposes described above.
YES NO I am in agreement that the data generated from my DNA may be made available in a public domain without any identifiers.
YES NO I agree that a small bit of my DNA may be sent out of the country if the research cannot easily be done in South Africa.
YES NO I understand that every time a new study is done on my DNA, permission will be obtained from the ethics committee for the study to make sure that it is used only for the purposes stated above.
YES NO I understand that I will not benefit directly from the research done on my DNA.
YES NO I understand that I may withdraw from the study at any time.
YES NO RESEARCH ASSISTANT: Printed Name Signature/Mark or Thumbprint Date and Time PARTICIPANTS _____________________________________________________________________ Printed name Signature/Mark or Thumbprint Date and Time WITNESS: (If applicable) Printed Name Signature/Mark or Thumbprint Date and Time
MRC/Wits Developmental Pathways for Health Research Unit Department of Paediatrics
School of Clinical Medicine Faculty of Health Sciences
University of the Witwatersrand, Johannesburg 17th July 2011
The Chair Human Ethics Research Committee University of the Witwatersrand, Johannesburg Dear Professor Cleaton-Jones,
Re-consenting Birth to Twenty cohort participants around historical blood and DNA samples
When Birth to Ten transitioned to Birth to Twenty and the Bt20 cohort and the Bone Health sub-cohort was formed, the HERC approved protocols that entailed the collection of blood and DNA samples for the analyses linked to non-communicable disease (obesity, bone health, diabetes, etc). The participants are now 21 years of age and we wish to re-consent them around the management and use of biological samples collected. Below are the information and consent sheets. We are asking the participants to consent to the following:
• I acknowledge that all procedure/tests on the stored blood and DNA samples have been or will be approved by the Human Research Ethics Committee of the University of the Witwatersrand.
• I understand that every time a new study is done on my DNA, permission will be obtained from the ethics committee for the study to make sure that it is used appropriately.
• I am in agreement that my DNA may be stored and used for the purposes described. • I am in agreement that the data generated from my DNA may be made available in a
public domain without any identifiers. • I agree that a small bit of my DNA may be sent out of the country if the research
cannot easily be done in South Africa. • I understand that I will not benefit directly from the research done on my DNA. • I understand that I may withdraw from the study at any time.
We piloted the re-consent procedure with 10 biological parents of the Bt20 cohort. The re-consent procedure included:
• Power-Point on genetics and core concepts presented by a masters-level research assistant in both English and Zulu.
• Question & Answer session. • Information sheet distributed and discussed as a group. • Question & Answer session. • Individual consent in private with a trained research assistant.
The response from the pilot study was extremely positive. The participants understood and appreciated the presentation; they understood the information sheet and 100% consented to all of the points above. I seek permission from the HERC to approve the re-consent documents and procedure. Shane Norris
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Licensed Content Publisher American Society for Nutrition
Licensed Content Publication The American Journal of Clinical Nutrition
Licensed Content Title The five-level model: a new approach to organizing body-composition research.
Licensed Content Author Z M Wang, R N Pierson, Jr, S B Heymsfield
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The five-levels of human body composition
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The Identification of Genetic Markers of Obesity Risk in a SouthAfrican Black population
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Licensed content publication International Journal of Epidemiology
Licensed content title Cohort Profile: Mandela's children: The 1990 birth to twenty studyin South Africa:
Licensed content author Linda Richter, Shane Norris, John Pettifor, Derek Yach, NoelCameron
Licensed content date 06/01/2007
Type of Use Thesis/Dissertation
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Title of your work The Identification of Genetic Markers of Obesity Risk in a SouthAfrican Black population
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Expected publication date Jul 2016
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Requestor Location Venesa PillayHoneyridge EstateDuring Street
Johannesburg, Gauteng 1724South AfricaAttn: Venesa Pillay
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Billing Address Venesa PillayHoneyridge EstateDuring Street
Johannesburg, South Africa 1724Attn: Venesa Pillay
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Questions? [email protected] or +1-855-239-3415 (toll free in the US) or+1-978-646-2777.
NATIONAL HEALTH LABORATORY SERVICE University of the Witwatersrand, School Of Pathology
Division Human Genetics
Practice No.: 005200296 Hospital Street, Johannesburg 2001 PO Box 1038, Johannesburg 2000
Telephone: +27-11-489-9223/9211 Telefax: +27-11-489-9226 /9209/ 9499
Prof A Christianson 489-9211/9239 Prof A Krause 489-9219 Prof H Soodyall 489-9208 TothePostgraduateCommitteeChair
29March2016
REPORTOFTURNITINASSESSMENTFORPLAGIARISMStudent:VenesaPillay(Studentnr.9504731W)Degree:PhD(HumanGenetics)Title:TheIdentificationofGeneticMarkersOfObesityRiskinaSouthAfricanBlackPopulationIwishtoconfirmthatthePhDthesishasbeensentthroughTurnitin.ThestudentandIwentthroughthereportverycarefully.Therewaslittleofnote,andthesoftwareonlypickedupusualphrasesandwordstringscommoninourfield-thisdidnotoccuroften,andwasdeemedacceptable.ForChapter2,aslightlyhigherlevelwasdetected–thisisduetothischapterbeingbasedonanoriginalresearcharticle,writtenbythestudent,solelycontributingtowardstheresearchforthisPhDstudy.Therefore,thistoowasdeemedacceptable.IamcontentthatthereisnoplagiarisminthethesishandedinbyMsPillay.Pleasedonothesitatetocontactmeshouldyourequireanyfurtherinformation.KindRegards
--ZanéLombard,PhDPhDSupervisorDivisionofHumanGeneticsNationalHealthLaboratoryService&UniversityoftheWitwatersrandTel:+27114899475|Fax:+27867656304|Email:[email protected]