esteban cheng-ching, mdestenosis carotídea asintomática. estenosis carotídea asintomática....

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Esteban Cheng - Ching, MD Neurolog í a Vascular Neuro - Intervenci ó n Endovascular Premier Health Clinical Neuroscience Institute Departamento de Neurolog í a - Wright State University Stroke Medical Director Good Samaritan Hospital

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Page 1: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

Esteban Cheng-Ching, MDNeurología Vascular

Neuro-Intervención Endovascular

Premier Health Clinical Neuroscience Institute

Departamento de Neurología - Wright State University

Stroke Medical Director – Good Samaritan Hospital

Page 2: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

Caso clínico

Page 3: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke
Page 4: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke
Page 5: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

Aterosclerosis carotídea

Page 6: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

Factores de riesgo para estenosiscarotídea

Page 7: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

Diagnóstico

Page 8: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

Tratamiento

Page 9: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

EAC

Page 10: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

Angioplastía-Stent

Page 11: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

•Sintomático vs Asintomático

•Grado de estenosis

•Intervalo desde el último evento

Factores Importantes

Page 12: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

•VACS (VA Cooperative Study)

• 19.4% 11.7%7.7%

•ECST (European Carotid Surgery Trial)

• 26.5% 14.9%

11.6%

Estenosis carotídea sintomática

Page 13: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

NASCET (North American Symptomatic Carotid Endarterectomy Trial)

Page 14: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

NASCET

Estenosis ≥70%

•26%•9%

17%

Estenosis carotídea sintomática

Page 15: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

NASCET con estenosis 70-99%

Page 16: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

NASCET

•Tomar en cuenta

Estenosis carotídea sintomática

Page 17: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

NASCET

Estenosis 50-69%

•22.2% 15.7% 6.5%

Estenosis carotídea sintomática

Page 18: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

NASCET estenosis 50-69%

Page 19: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

NASCET estenosis <50%

Page 20: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke
Page 21: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke
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SAPPHIRE (stent and angioplasty with protection in patients at high risk for endarterectomy):

Page 23: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

SAPPHIRE

4.8% 9.8%

EAC vs Angioplastía/Stent

Page 24: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

CREST (carotid revascularization, endarterectomy vs stent trial)

Page 25: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

CREST

•Sin diferencias: 7.2% A/S vs 6.8% EAC, (p=0.51)

(4.1% vs 2.3%, p=0.01)

(2.3% vs 1.1%, p=0.03)

•2% con EAC vs 2.4% con A/S

EAC vs Angioplastía/Stent

Page 26: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

EAC vs Angioplastía/Stent

Page 27: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

Favorece A/S en pacientes <70 a, y EAC en pacientes >70 a.

EAC vs Angioplastía/Stent

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Page 29: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

Recomendaciones para pacientessintomáticos con estenosis (≥ 70%)

Page 30: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

Angioplastía / Stent

Page 31: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

ACAS (Asymtomatic Carotid Atherosclerosis Study)

ACST (Asymptomatic Carotid Surgery Trial)

2%

0.34%

Estenosis carotídea asintomática

Page 32: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

Estenosis carotídea asintomática

Page 33: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis)

Tratamiento médico

Page 34: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

Tratamiento medico

Page 35: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke
Page 36: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

Guías

Page 37: Esteban Cheng-Ching, MDEstenosis carotídea asintomática. Estenosis carotídea asintomática. SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke

Nuestro paciente

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