epidemiology of the dramatic spread of diabetes mellitus worldwide; influence of helicobacter...

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EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh., MSc. Randa M. Nasrat, MBBCh., MD. Salwa A.M. Nasrat, BSPT.

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Page 1: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS

WORLDWIDE;

INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY.

Abdullah M. Nasrat, MBBCh., MSc.

Randa M. Nasrat, MBBCh., MD.

Salwa A.M. Nasrat, BSPT.

Page 2: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF

DIABETES MELLITUS WORLWIDE;

INFLUENCE OF HELICOBACTER

PYLORI&A SUGGESTED STRATEGY.

Page 3: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

Helicobacter pylori

Page 4: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

THE ANTIBIOTIC VIOLENCE AGAINST

HELICOBACTER PYLORI

Page 5: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

Helicobacter pylori

Page 6: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,
Page 7: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

HELICOBACTER PYLORI

The Commonest Cause Of Fire Inside The Stomach

Guilty, Not Guilty, or Innocent!!

Page 8: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

Helicobacter pylori remains

a worldwide medical challenge

This fact made the medical world believe that H. pylori eradication should be

a necessary attempt.

Page 9: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

The flare up of a lot of medical problems related to H. pylori through immune

or different unknown reasons

indicates that

the current eradication therapies are inadequate to control all the problems related to

the stomach bug.

Page 10: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

The high costs, bacterial resistance and the severe side effects are major drawbacks of

these treatments;

More efficient, economic and friendly drugs need to be

developed.

Page 11: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

H. pylori colonized the stomach since an immemorial time;

As if both the stomach and the bug used to live together in peace

harmless to each other.

What could this mean !!

Page 12: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

The Unbeatable Challenge

A Highly Talented Natural Ability

Of

The Organism To Survive.

What this could also mean !!

Page 13: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

After more than 20 years of extensive research;

(Unfair blind) The harm is worse

&

The matter is still dilemma

A scientific stop is becoming mandatory,

To achieve an evaluation of some misconceptions about H. pylori itself.

Page 14: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

H. pylori

Is it

Biologic or Pathologic

Protective or Destructive

Defensive or Offensive

Useful or Harmful

Page 15: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

H. pylori

Is it

Natural ExistenceOr

Abnormal Existence

Page 16: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

H. Pylori Eradication

Is it

Necessary and Possibleor

Unnecessary because Impossible

Page 17: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

H. Pylori Antibiotic Eradication

Is it

Efficientor

Inefficient

Page 18: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

The Resistant H. pylori Strains

Are they

Resistant because Drastic

or

Emigrant therefore Resistant

Page 19: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

Are they

Really Aggressive,

or

Just Panic

Page 20: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

H. pylori

Is it

Guilty, Not Guiltyor

Innocent

Page 21: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

The answers of these questionnaires are scattered here and there and far

over there.

Page 22: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

H. pylori have colonized the stomach since an immemorial time; Falush et al, 2003.

H. pylori in human populations is common and persistent; Guruge et al, 1998.

H. Pylori prevalence is high, complications in stomach were minor; Cataldo et al, 2004.

Re-infection with H. pylori is un-avoidable; McPhee et al, 1996.

H. Pylori is not just a bad bug in all instances; Farinha et al, 2005.

Should we kill or Should we save H. pylori; Hunt et al, 2001.

Page 23: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

If the knowledge of these answers are coalesced together, the picture is then complete.

Page 24: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

H. pylori was re-discovered nearly before two decades.

The fight against H. pylori by antibiotics has been nearly over the past

two decades.

The flare up of medical dilemmas related to H. pylori has been nearly during the last

two decades.

Page 25: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

The complications related to H. pylori before being attacked by antibiotics

were limited to the stomach& in minor incidence.

WHILE

The complications of H. pylori after the antibiotic attack flared up& exceeded the limits of the stomach.

Page 26: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

H. pylori protects the gastric wall from its acid if it goes in excess

&

It protects the stomach from absence of the acid during absence of food

Page 27: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

The antibiotic aggression against H. pylori,

whatever aggressive can never defeat it.

Page 28: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

Epidemiology

Page 29: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

H. Pylori Existence

In developing countries

Early 2000: 70-80%

Late 2000: over 90%

Page 30: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

H. Pylori Existence

In developed countries

Early 2000: below 50%

Late 2000: over 50%

Page 31: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

Incidence of

DM

Page 32: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

In developing countries

Early 2000: below 23%

Late 2000: above 25%

Page 33: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

In US now

Every third person is Diabetic

Page 34: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

Pathogenesis

Page 35: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

Accumulation of profuse toxic amounts of ammonia in the colon constitutes a

biological stress to the body which could lead to stress diabetes.

Page 36: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

Administration of traditional oral

hypoglycemic pills to a stressed pancreas

means an insistence to flog a tired horse leading to turn a potential

condition into an established chronic illness

with consequent dramatic spread of DM

all over the world.

Page 37: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

This explains the prevalent observation that most of the diabetic patients in the world

are inadequately controlled in spite of regular follow up of medications.

Page 38: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

PATIENTS

RESULTS&

CONCLUSIONS

Page 39: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

The scientific interest of this study includes

18 Newly Discovered Adult DM Patients

With frank history of H. pylori dyspepsia

Page 40: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

The diabetic condition has been successfully& permanently corrected

in 17 patients.

BY

Page 41: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

BY

Mere natural eradication of H. pylori, colon care and colon clear.

Page 42: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

Bio-Organic Acids

Page 43: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

Potent Natural Purgative

Page 44: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

CONCLUSION

Page 45: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

The concept of biological stress considered in this study in leading to

DM is not just hypothetical.

As upon the basis of this concept the newly-discovered diabetic condition has been successfully& permanently

corrected in good number of patients.

Page 46: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

In the light of recent findings and statistics,

a revision of the current guidelines for the management of

H. pylori and newly discovered DM

may be needed.

Page 47: EPIDEMIOLOGY OF THE DRAMATIC SPREAD OF DIABETES MELLITUS WORLDWIDE; INFLUENCE OF HELICOBACTER PYLORI& A SUGGESTED STRATEGY. Abdullah M. Nasrat, MBBCh.,

THANK YOUVERY MUCH

&