drug forms peter johnson schin, newcastle, uk work done in prodigy 3 project by chris wroe, medical...
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Drug Forms
Peter Johnson
SCHIN, Newcastle, UK
Work done in Prodigy 3 project
By Chris Wroe,
Medical Informatics Group, Manchester University, UK
Motivation
• Decision support• Chronic disease management guidelines• Computer needs to be able to answer questions
such as :-• “Is this patient on an inhaled steroid for asthma?”• “on a sustained release tablet for angina?”• Implies machine has explicit categorisation of
drugs by Indication, Chemical structure, Route of admin, Form, etc.
Patient on
•Becodisks• Dry powder for inhalation, disks containing 8 blisters of beclometasone dipropionate
• 100 micrograms/blister
Forms proposed
Spray. Dermal Spray. Inhalant. . Inhalant Powder. . . Inhalant Powder Capsule. . Nasal Inhalant. . Oral Inhalant. Nasal Spray. Spray with Adaptor. Powder Spray. . Inhalant Powder. . . Inhalant Powder Capsule
Inhaled steroid for asthma
Route – implies some formsAerosol, Dry powder Drug class
Indication
‘Form’ in reality
Route of administration
Physical Form
+ Administration Action
+ Administration Device
Inhaled Powder Form for chewing Delivered by applicator
Route taxonomy. topical to conjunctiva. topical to ear. topical to nose. topical to skin. topical to scalp. topical to oral mucosa. . buccal. sublingual. topical to teeth. oral (passing through oral cavity). rectal. vaginal. intravenous. intrathecal. intraperitoneal. inhaled to lung. . inhaled to lung via nose. . inhaled to lung via mouth
Drug form taxonomy . aerosol . bar . cake . disk . foam . gel . . jelly . gum . liniment . liquidEmulsion . lotion . ointment . particulate . . bead . . crystal . . flake . . granule . . pellet . . powder . . suppository
. paste . patch . pillShaped . . caplet . . capsule . . tablet . . . lozenge . . . pastille . . troche . semiSolidEmulsion . . cream . solution . . aqueous . . . elixir . . . syrup . . oil . stick . suspension . wafer
Device taxonomy. spray device
. drug applicator
. drug dropper device
Process/Action taxonomy. Douching. Rinsing
. Irrigating
. Spraying
. Liquid installing
. . Infusing
. . Irrigating
. Chewing
. Inhaling
. Ingesting
4 hierarchies of ‘form’
By Route. 'inhaled to lung form'
. . 'Inhalation Solution'
. . 'Nasal Inhalant'
. . 'Oral Inhalant'
. . 'Inhalant Powder'
. . . 'Inhalant Powder Capsule‘
By Action
By Physical Form. 'Solid'
. . 'Powder'
. . . 'Powder Spray'
. . . . 'Inhalant Powder'
. . . . . 'Inhalant Powder Capsule'
. . . 'Powder for Reconstitution‘
By Device
'Sustained Release Buccal Tablet'
Intermediate Representation :
MAIN tabletHAS_PHARMACOKINETICS sustained releaseHAS_ROUTE buccal
'Sustained Release Buccal Tablet' First parent : Form classification
Form classification:
'Solid‘
. 'Pill‘
. . 'Tablet‘
. . . 'Sustained Release Buccal Tablet'
From form taxonomy:
pillShaped . . caplet . . capsule . . tablet . . . lozenge . . . pastille . . troche
'Sustained Release Buccal Tablet’ second parent : Route classification
Route classification
. 'oral mucosa form'. . 'buccal form'
. . .'Sustained Release Buccal Tablet'
From route taxonomy
Route. topical to conjunctiva. topical to ear. topical to nose. topical to skin. topical to scalp. topical to oral mucosa
. . buccal
n.b. Pharmacokinetics – sustained release is another classification concept
Where now?
• Preliminary work• Quick classification of the leaf terms supplied• Intermediate nodes from Prodigy work
Chris Wroe [[email protected]]http://www.cs.man.ac.uk/mig/people/wroec/index.html