Download - Wake Up and Smell the Caffeine
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04/22/23 Caffeine 1
Wake Up and Smell the Caffeine
Psychology 2800
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04/22/23 Caffeine 2
Introduction The most popular psychoactive
drug in North America How many people here DO NOT
ingest caffeine?
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04/22/23 Caffeine 3
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04/22/23 Caffeine 4
Introduction That includes:
Coffee 130 mg Tea 40 mg Soft Drinks (colas) 30 – 90 mg Cold and Headache medications
15 – 50 mg Rev ?, probably about 100 mg Chocolate! 50 – 100 mg Wake up pills 100 – 500 mg
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04/22/23 Caffeine 5
Introduction Almost always taken orally,
absorbed in small intestine. Crosses all barriers Absorbed more slowly from cold
beverages Less than 2% is excreted
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04/22/23 Caffeine 6
Metabolism Half life is between 30 min and 3.5
hr Metabolism slowed by birth control
pills Sped up by broccoli! 2x faster in smokers
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04/22/23 Caffeine 7
Metabolism That was with adults (well not kids
anyway) Different deal in kids and infants
85% excreted 4 DAY half life Different pathways and
metabolism than in adults More similar to non-humans
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04/22/23 Caffeine 8
Neurophysiological Effects. Like alcohol, we don’t know! Might block adenosine
Neuromodulator that inhibits firing So, caffeine disinhibits? High doeses block benzodiazipine
receptors
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04/22/23 Caffeine 9
Neurophysiological Effects Might cause release of epinephrine Causes smooth muscles to relax,
striate muscles to contract Decreases airway resistance
Good for asthma, colds Constriction of blood vessels to the
brain Dilation other places
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04/22/23 Caffeine 10
Neuropshysiological Effects Not sure if it helps performance
Does reduce drowsiness,boredom. Increases FA levels, could be
performance enhancing, especially for long athletic events. Controlled substance.
Increases time in light sleep Stages 1 and 2 Can counteract barbiturates.
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04/22/23 Caffeine 11
Effects on Nonhumans Small doses increase SMA Large doses do the opposite Increases FR responding
Affects timing Increases suppressed behaviour. Generalizes to coke, not to
amphetamine.
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04/22/23 Caffeine 12
But, how does that first cup make you feel? Humans are great at discriminating
1.8 mg, about a sip of coffee!! Caffeine makes us:
Energized Focused Motivated Same in non users
All at low-moderate doses (20-200 mg) About a cup of coffee.
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04/22/23 Caffeine 13
Could I ever use a coffee Tolerance
Sustained use leads to more adenosine receptors
Whole deal changes if big dose given to non users.
Withdrawal Headache Flu like symptoms Bad attitude in general 100 mg a day, most all of us!
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04/22/23 Caffeine 14
Reinforcing Properties Hard to get animals to self-
administer Will prime cocaine use Lots of variation in us
Task demands Caffeine experience.
Demand is relatively inelastic. Late 1970s, 6 bucks a pound.
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04/22/23 Caffeine 15
Bad Stuff Cancer? Caffeinism OD?
30-80 cups of coffee Reproduction
Chromosomal damage? Toxicity
Cardiac effects? Depends on method
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04/22/23 Caffeine 16
Beware the International Coffee Conspiracy!