Download - U78-5672 ID:434500-5
U78-5672 ID:434500-5
A 4-year-old girl had persistent hematuria (microscopic) found by routine urinalysis. Patient has been symptom free. Been investigated with no good information revealed. Probable diagnosis Focal glomerulonephritis.
IF
• IgG –Negative.
• IgA –Negative.
• IgM –Negative.
• C3 –Negative.
• Fibrinogen –Negative.
Interpretation
• The minimal findings are compatible with “idiopathic (essential) hematuria” or with “benign familial hematuria”.
• Persistent “fetal type glomeruli” are a feature of early cases of “Alport’s syndrome”, these can be seen in infantile kidneys with persistent fetal lobulation of the cortex.
• The absence of focal proliferative changes in glomeruli mitigates against a diagnosis of focal glomerulonephritis.
DIAGNOSIS
• Needle biopsy of kidney showing a few persistent “fetal Glomeruli” renal glomeruli and occasional red cell casts within renal tubules.
EM82-5343
Glomerulonephritis (open renal biopsy).
IF
• IgG – Negative.
• IgA – Negative.
• IgM – Negative.
• C3 – Negative.
• Properdin – Negative.
DIAGNOSIS
• Probable “Progressive Hereditary Nephritis” (Alport’s syndrome).