U78-5672 ID:434500-5

A 4-year-old girl had persistent hematuria (microscopic) found by routine urinalysis. Patient has been symptom free. Been investigated with no good information revealed. Probable diagnosis Focal glomerulonephritis.

IF

• IgG –Negative.

• IgA –Negative.

• IgM –Negative.

• C3 –Negative.

• Fibrinogen –Negative.

Interpretation

• The minimal findings are compatible with “idiopathic (essential) hematuria” or with “benign familial hematuria”.

• Persistent “fetal type glomeruli” are a feature of early cases of “Alport’s syndrome”, these can be seen in infantile kidneys with persistent fetal lobulation of the cortex.

• The absence of focal proliferative changes in glomeruli mitigates against a diagnosis of focal glomerulonephritis.

DIAGNOSIS

• Needle biopsy of kidney showing a few persistent “fetal Glomeruli” renal glomeruli and occasional red cell casts within renal tubules.

EM82-5343

Glomerulonephritis (open renal biopsy).

IF

• IgG – Negative.

• IgA – Negative.

• IgM – Negative.

• C3 – Negative.

• Properdin – Negative.

DIAGNOSIS

• Probable “Progressive Hereditary Nephritis” (Alport’s syndrome).