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Essentials of Human Anatomy & Physiology
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slides 12.1 – 12.22
Seventh Edition
Elaine N. Marieb
Chapter 12The Lymphatic System
and Body Defenses
Lecture Slides in PowerPoint by Jerry L. Cook
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The Lymphatic System
Slide 12.1Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Consists of two semi-independent parts
• Lymphatic vessels
• Lymphoid tissues and organs
• Lymphatic system functions
• Transport fluids back to the blood
• Play essential roles in body defense and resistance to disease
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Lymphatic Characteristics
Slide 12.2Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Lymph – excess tissue fluid carried by lymphatic vessels
• Properties of lymphatic vessels
• One way system toward the heart
• No pump
• Lymph moves toward the heart
• Milking action of skeletal muscle
• Rhythmic contraction of smooth muscle in vessel walls
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Lymphatic Vessels
Slide 12.4aCopyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Lymphatic collecting vessels
• Collects lymph from lymph capillaries
• Carries lymph to and away from lymph nodes
Figure 12.2
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Lymph
Slide 12.5aCopyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Materials returned to the blood• Water• Blood cells• Proteins
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Lymph
Slide 12.5bCopyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Harmful materials that enter lymph vessels
• Bacteria
• Viruses
• Cancer cells
• Cell debris
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Lymph Nodes
Slide 12.6aCopyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Filter lymph before it is returned to the blood
• Defense cells within lymph nodes
• Macrophages – engulf and destroy foreign substances
• Lymphocytes – provide immune response to antigens
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Lymph Nodes
Slide 12.6bCopyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Figure 12.3
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Flow of Lymph Through Nodes
Slide 12.8Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Lymph enters the convex side through afferent lymphatic vessels
• Lymph flows through a number of sinuses inside the node
• Lymph exits through efferent lymphatic vessels
• Fewer efferent than afferent vessels causes flow to be slowed
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Other Lymphoid Organs
Slide 12.9Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Several other organs contribute to lymphatic function
• Spleen
• Thymus
• Tonsils
• Peyer’s patchesFigure 12.5
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The Spleen
Slide 12.10Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Located on the left side of the abdomen
• Filters blood
• Destroys worn out blood cells
• Forms blood cells in the fetus
• Acts as a blood reservoir
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The Thymus
Slide 12.11Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Located low in the throat, overlying the heart
• Functions at peak levels only during childhood
• Produces hormones (like thymosin) to program lymphocytes
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Tonsils
Slide 12.12Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Small masses of lymphoid tissue around the pharynx
• Trap and remove bacteria and other foreign materials
• Tonsillitis is caused by congestion with bacteria
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Peyer’s Patches
Slide 12.13Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Found in the wall of the small intestine
• Resemble tonsils in structure
• Capture and destroy bacteria in the intestine
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Mucosa-Associated Lymphatic Tissue (MALT)
Slide 12.14Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Includes:
• Peyer’s patches
• Tonsils
• Other small accumulations of lymphoid tissue
• Acts as a sentinal to protect respiratory and digestive tracts
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Body Defenses
Slide 12.15aCopyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• The body is constantly in contact with bacteria, fungi, and viruses
• The body has two defense systems for foreign materials
• Nonspecific defense system
• Mechanisms protect against a variety of invaders
• Responds immediately to protect body from foreign materials
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Body Defenses
Slide 12.15bCopyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
•Specific defense system
• Specific defense is required for each type of invader
• Also known as the immune system
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Nonspecific Body Defenses
Slide 12.16Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Body surface coverings
• Intact skin
• Mucous membranes
• Specialized human cells
• Chemicals produced by the body
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Surface Membrane Barriers –First Line of Defense
Slide 12.17aCopyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• The skin
• Physical barrier to foreign materials
• pH of the skin is acidic to inhibit bacterial growth
• Sebum is toxic to bacteria
• Vaginal secretions are very acidic
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Surface Membrane Barriers –First Line of Defense
Slide 12.17bCopyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Stomach mucosa
• Secretes hydrochloric acid
• Has protein-digesting enzymes
• Saliva and lacrimal fluid contain lysozyme
• Mucus traps microogranisms in digestive and respiratory pathways
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Defensive Cells
Slide 12.18aCopyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Phagocytes (neutrophils and macrophages)
• Engulfs foreign material into a vacuole
• Enzymes from lysosomes digest the material
Figure 12.6b
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Defensive Cells
Slide 12.18bCopyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Natural killer cells
• Can lyse and kill cancer cells
• Can destroy virus-infected cells
Figure 12.6b
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Inflammatory Response -Second Line of Defense
Slide 12.19Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Triggered when body tissues are injured
• Produces four cardinal signs
• Redness
• Heat
• Swelling
• Pain
• Results in a chain of events leading to protection and healing
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Functions of the Inflammatory Response
Slide 12.20Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Prevents spread of damaging agents
• Disposes of cell debris and pathogens
• Sets the stage for repair
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Steps in the Inflammatory Response
Slide 12.21Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Figure 12.7
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Antimicrobial Chemicals
Slide 12.22aCopyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Complement
• A group of at least 20 plasma proteins
• Activated when they encounter and attach to cells (complement fixation)
Figure 12.8
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Antimicrobial Chemicals
Slide 12.22bCopyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Complement (continued)
• Damage foreign cell surfaces
• Has vasodilators, chemotaxis, and opsonization
Figure 12.8
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Antimicrobial Chemicals
Slide 12.22cCopyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
• Interferon
• Secreted proteins of virus-infected cells
• Bind to healthy cell surfaces to inhibit viruses binding