Download - Photodynamic Therapy
Photodynamic Photodynamic TherapyTherapy
PhototherapyPhototherapy
The first who used the light: The first who used the light: Egyptians, Indians, Chinese and Egyptians, Indians, Chinese and Grecee Grecee
1815. Carvin1815. Carvin
1822. Sniadecki1822. Sniadecki
1903. D. N. Finsen: Nobel Prize1903. D. N. Finsen: Nobel Prize
PhotochemotherapyPhotochemotherapy
Indians: Psoralea corylifoliaIndians: Psoralea corylifolia
Egyptians: Ammi majusEgyptians: Ammi majus
PDT historyPDT history
1900. Oscar Raab1900. Oscar Raab
1905. H. von Tappeiner take in the PDT1905. H. von Tappeiner take in the PDT
HematoporphyrinHematoporphyrin
1841. Sherer1841. Sherer
1867. Thudicum1867. Thudicum
1871. Hoppe- Seyler 1871. Hoppe- Seyler
HematoporphyrinHematoporphyrin
1924. Policard1924. Policard
Auler and BanzerAuler and Banzer
Figge and co workers: photodiagnosisFigge and co workers: photodiagnosis
Why do some photosensitiziers Why do some photosensitiziers localize selectively in tumors?localize selectively in tumors?
Tumors have a larger interstital volume than normal tissuesTumors have a larger interstital volume than normal tissues
Tumors often contain a larger fraction of macrophages than normal tissuesTumors often contain a larger fraction of macrophages than normal tissues
Tumors have a leaky microvasculatureTumors have a leaky microvasculature
Tumors have poor lymphatic drainageTumors have poor lymphatic drainage
The extracellular ph is low in tumorsThe extracellular ph is low in tumors
Tumors contain a relatively large amount of newly synthesized collagenTumors contain a relatively large amount of newly synthesized collagen
Tumor tissue contains many receptors for lipoproteinsTumor tissue contains many receptors for lipoproteins
PDT treatmentPDT treatment
Use photosensitizing solution
Collect in cancer
Irradiate Selective tumour collapse
Porfirin Porfirin
PDT mechanismPDT mechanism
Energy transport Energy transport reactive oxygen reactive oxygen
PDT mechanismPDT mechanism
Electron passing Electron passing free radical free radical
photosensitizing Activation with light
Introduce photosensitizing into the
cell
release reactive oxygen
end free radical
tissuenecrosis or apoptozis
PDT mechanism
Other tumour therapyOther tumour therapy
SurgerySurgery
disadvantage: - can’t remove total the cancerdisadvantage: - can’t remove total the cancer
- matastasis- matastasis
Radio- and chemotherapyRadio- and chemotherapy
disadvantage: - to hight degree damage disadvantage: - to hight degree damage
- resistance- resistance
Photodynamic TherapyPhotodynamic Therapy
Advantage Advantage
- selective destruction- selective destruction
- not develop resistance- not develop resistance
DisadvantageDisadvantage
- only use surface cancer- only use surface cancer
- cell of small size- cell of small size
Other field of applicationOther field of application
- ArteriosclerosisArteriosclerosis
- Germ, virus inanctivationGerm, virus inanctivation
- Gum inflammationGum inflammation
- Blood sterilizationBlood sterilization
- Water purificationWater purification
Thank you for your patienceThank you for your patience