Photodynamic Photodynamic TherapyTherapy

PhototherapyPhototherapy

The first who used the light: The first who used the light: Egyptians, Indians, Chinese and Egyptians, Indians, Chinese and Grecee Grecee

1815. Carvin1815. Carvin

1822. Sniadecki1822. Sniadecki

1903. D. N. Finsen: Nobel Prize1903. D. N. Finsen: Nobel Prize

PhotochemotherapyPhotochemotherapy

Indians: Psoralea corylifoliaIndians: Psoralea corylifolia

Egyptians: Ammi majusEgyptians: Ammi majus

PDT historyPDT history

1900. Oscar Raab1900. Oscar Raab

1905. H. von Tappeiner take in the PDT1905. H. von Tappeiner take in the PDT

HematoporphyrinHematoporphyrin

1841. Sherer1841. Sherer

1867. Thudicum1867. Thudicum

1871. Hoppe- Seyler 1871. Hoppe- Seyler

HematoporphyrinHematoporphyrin

1924. Policard1924. Policard

Auler and BanzerAuler and Banzer

Figge and co workers: photodiagnosisFigge and co workers: photodiagnosis

Why do some photosensitiziers Why do some photosensitiziers localize selectively in tumors?localize selectively in tumors?

Tumors have a larger interstital volume than normal tissuesTumors have a larger interstital volume than normal tissues

Tumors often contain a larger fraction of macrophages than normal tissuesTumors often contain a larger fraction of macrophages than normal tissues

Tumors have a leaky microvasculatureTumors have a leaky microvasculature

Tumors have poor lymphatic drainageTumors have poor lymphatic drainage

The extracellular ph is low in tumorsThe extracellular ph is low in tumors

Tumors contain a relatively large amount of newly synthesized collagenTumors contain a relatively large amount of newly synthesized collagen

Tumor tissue contains many receptors for lipoproteinsTumor tissue contains many receptors for lipoproteins

PDT treatmentPDT treatment

Use photosensitizing solution

Collect in cancer

Irradiate Selective tumour collapse

Porfirin Porfirin

PDT mechanismPDT mechanism

Energy transport Energy transport reactive oxygen reactive oxygen

PDT mechanismPDT mechanism

Electron passing Electron passing free radical free radical

photosensitizing Activation with light

Introduce photosensitizing into the

cell

release reactive oxygen

end free radical

tissuenecrosis or apoptozis

PDT mechanism

Other tumour therapyOther tumour therapy

SurgerySurgery

disadvantage: - can’t remove total the cancerdisadvantage: - can’t remove total the cancer

- matastasis- matastasis

Radio- and chemotherapyRadio- and chemotherapy

disadvantage: - to hight degree damage disadvantage: - to hight degree damage

- resistance- resistance

Photodynamic TherapyPhotodynamic Therapy

Advantage Advantage

- selective destruction- selective destruction

- not develop resistance- not develop resistance

DisadvantageDisadvantage

- only use surface cancer- only use surface cancer

- cell of small size- cell of small size

Other field of applicationOther field of application

- ArteriosclerosisArteriosclerosis

- Germ, virus inanctivationGerm, virus inanctivation

- Gum inflammationGum inflammation

- Blood sterilizationBlood sterilization

- Water purificationWater purification

Thank you for your patienceThank you for your patience