Download - Molecular hydrogen biomed-applications-888
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Molecular Hydrogen “An idea and pharmaceutical whose time has come” a food and nutraceutical ….
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Molecular Hydrogen “An idea whose time has come” History
Historical applications:-Dirigible-until the Hindenberg Incident-Hydrogenation of oil-until vascular incidents-Inert and non toxic-useless in biomedical-Industrial gas for welding, petroleum refining,
and industrial chemical engineering-No historical medical uses prior to 1976
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Molecular Hydrogen “An idea whose time has come”
The paradigm shifts
First hint of useful bio-activity:
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Molecular Hydrogen “An idea whose time has come”
Early roadblocks
-Fyfe and Dole publish in AAAS “Science”-University sees hyperbaric hydrogen as insurance
liability ,“a bomb”, and orders apparatus to be deconstructed.
-No interest by medical or private industry to put molecular hydrogen into any product pipeline
-Inertness of molecular hydrogen questioned
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Molecular Hydrogen “An idea whose time has come”
Safety to humans established
-Molecular hydrogen finds application in diving gas mixtures
-Still considered inert and biomedically useless-Safe long term use established….GRAS
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Molecular Hydrogen “An idea whose time has come”hyperbaric H2 physiological effects
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Molecular Hydrogen “An idea whose time has come”hyperbaric H2- 3 decades after seminal paper
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Molecular Hydrogen “An idea whose time has come”
Hydrogen water
-Spas market special spring waters as therapeutic-H2 levels at homeopathic levels of 4-6 ppm-Easily dismissed as a mineral water with an added
placebo effect-Investigation begins to separate fact from fancy
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Molecular Hydrogen “An idea whose time has come”Fringe medicine publishes data
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Molecular Hydrogen “An idea whose time has come”Explosion of interest begins
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Fig.?1 Illustration of the generation and scavenging systems of reactive oxygen species (ROS) in mitochondria. Superoxide radical anions (<ce:glyph name="rad"/> O<ce:inf loc="post"> 2</ce:inf> <ce:sup loc="post"> ?</ce:sup> ) are generated by the...
Shigeo Ohta
Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases
Biochimica et Biophysica Acta (BBA) - General Subjects Volume 1820, Issue 5 2012 586 - 594
http://dx.doi.org/10.1016/j.bbagen.2011.05.006
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Molecular Hydrogen “An idea whose time has come”Future directions
-Hydrogen water at 4-6ppm has benefits
-Lactulose produces H2 in gut but benefits are skewed by poor bioavailability and catabolism by other microflora
-Inhaled H2 poses explosion hazards to dwellings, requires contracts and specialized equipment
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Molecular Hydrogen “An idea whose time has come”
Future directions
-What if there were a simple way to increase bioavailabilty with no need for dispensing equipment or hazards of explosive gases?
-What if the delivery mode was marketable as food or food supplement that would slowly diffuse molecular hydrogen into body fluids, lungs and tissues of all descriptions?
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Molecular Hydrogen “An idea whose time has come”
Future directions
INVENTOR : JOHNSON , MORRIS, F. , whose complete address is of SW34-01-16-W2, BOX 10, BEAUBIER , SASKATCHEWAN , CELL PHONE 701-240-9411, email [email protected] CANADA Method to use a stable foam composed of bubbles of various food/ supplement/ cosmetic/ pharmaceutical substances to increase the bio-availability of otherwise inert molecular hydrogen gas for medically useful health maintenance , health promotion, anti-aging and generalized disease process interference purposes in biological living systems in a manner which manages regulatory and insurance risks and impediments to mass commercialization.
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Molecular Hydrogen “An idea whose time has come”
Future directions
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Molecular Hydrogen “An idea whose time has come”
Future directions
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Molecular Hydrogen “An idea whose time has come”
Future directions
-With the protection of a pending patent would a modest amount of capital launch products and be easily scaleable with contract manufacturing and find distribution channels?
-Would capital partner invest to expand the IP package to include beverages and cosmeceuticals and nutraceuticals?
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Molecular Hydrogen “An idea whose time has come”
Future directions-Proposed manufacturing at Food Centre and POS
pilot plant in Saskatoon , Saskatchewan-Business offices in Saskatoon and Lake Alma ,
Saskatchewan-Equity and royalty swap for risk capital.
Morris Johnson, SW34-01-16W2, Box 10Beaubier, Sk., Canada, 701-240-9411