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Lymphatic system
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Anatomy mathematics
•Cancer = bad cells = Bad inter cellular junctions
= cells slip away
Slipping away cells = A PROBLEM.Clearing process = Lymphatics
= Veins
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Anatomy mathematics
•Lymphatic capillaries = Blind end
•= endothelium
• + overlapping junctions
• + vesicular system
•+ anchoring filaments
•+ Valves
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Anatomy mathematics
•Lymph node = Fibrous skeleton(Capsule+
trabiculae)
• + Reticular stroma Reticulocytes+Rfibers
+
Lymphoid tissue
+ Sinuses subcapsular,trabicular and medullary
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Direction of lymph flow through a
lymph node
Afferent lymphatic vessel
Subcapsular sinus
Trabecular or perinodular sinus
Medullary sinus
Efferent lymphatic vessel
Thoracic duct
Left subclavian vein
General circulationRoss and Pawlina, p. 419
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capsu
lecap
sule
sub
capsu
lar sinu
s
sub
capsu
lar sinu
s
cortexcortex deep cortexdeep cortexmedullamedulla
hilus hilus (w/ artery and vein)(w/ artery and vein)
medullarymedullarysinussinus
medullarymedullarycordcord
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Anatomy mathematics
•Lymphoid follicle = germinal center + Outer lymphocytes
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capsulecapsule
sub
capsu
lar sinu
s
sub
capsu
lar sinu
s
cortexcortex
reticular cellreticular cell
endothelial cellsendothelial cells(easiest to see lining the inner wall, (easiest to see lining the inner wall, but they line the capsule as well)but they line the capsule as well)
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Anatomy mathematics
•Lymphoid follicle = Lymphoid nodule
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germinalgerminalcentercenter
lymphoblastslymphoblasts
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medullarymedullarycordcord
medullarymedullarysinussinus
macrophagemacrophage
reticular cellreticular cell
lymphocyteslymphocytes
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medullarymedullarysinussinus
medullarymedullarycordcord medullarymedullary
sinussinustr
abec
ula
trab
ecul
a
(con
nect
ive
tissu
e)
(con
nect
ive
tissu
e)
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high endothelial venuleshigh endothelial venules
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red pulpred pulp
centralcentralarteryartery
PALSPALS
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Splenic red pulp
•Some anatomy mathematics
•Red pulp = sinusoids + splenic cords
•Splenic cords = billroth columns
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Splenic cords and sinuses
Ross and Pawlina, p. 427
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Splenic Circulation
Splenic artery Splenic vein
PALS: Periarterial (periarteriolar) lymphatic sheath
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capsulecapsule
red pulpred pulp
white pulpwhite pulp
trabeculatrabecula(connective tissue)(connective tissue)
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lumen of cryptlumen of crypt
stratified squamous epithelium
stratified squamous epithelium
secondary folliclessecondary folliclesw/ germinal centersw/ germinal centers
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cortexcortex
medullamedulla
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cortexcortex(immature T lymphocytes)(immature T lymphocytes)
medullamedulla(mature T lymphocytes)(mature T lymphocytes)thymic (Hassal’s)thymic (Hassal’s)
corpusclescorpuscles
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