lymphatic system. anatomy mathematics cancer = bad cells = bad inter cellular junctions = cells slip...
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Lymphatic system
Anatomy mathematics
•Cancer = bad cells = Bad inter cellular junctions
= cells slip away
Slipping away cells = A PROBLEM.Clearing process = Lymphatics
= Veins
Anatomy mathematics
•Lymphatic capillaries = Blind end
•= endothelium
• + overlapping junctions
• + vesicular system
•+ anchoring filaments
•+ Valves
Anatomy mathematics
•Lymph node = Fibrous skeleton(Capsule+
trabiculae)
• + Reticular stroma Reticulocytes+Rfibers
+
Lymphoid tissue
+ Sinuses subcapsular,trabicular and medullary
Direction of lymph flow through a
lymph node
Afferent lymphatic vessel
Subcapsular sinus
Trabecular or perinodular sinus
Medullary sinus
Efferent lymphatic vessel
Thoracic duct
Left subclavian vein
General circulationRoss and Pawlina, p. 419
capsu
lecap
sule
sub
capsu
lar sinu
s
sub
capsu
lar sinu
s
cortexcortex deep cortexdeep cortexmedullamedulla
hilus hilus (w/ artery and vein)(w/ artery and vein)
medullarymedullarysinussinus
medullarymedullarycordcord
Anatomy mathematics
•Lymphoid follicle = germinal center + Outer lymphocytes
capsulecapsule
sub
capsu
lar sinu
s
sub
capsu
lar sinu
s
cortexcortex
reticular cellreticular cell
endothelial cellsendothelial cells(easiest to see lining the inner wall, (easiest to see lining the inner wall, but they line the capsule as well)but they line the capsule as well)
Anatomy mathematics
•Lymphoid follicle = Lymphoid nodule
germinalgerminalcentercenter
lymphoblastslymphoblasts
medullarymedullarycordcord
medullarymedullarysinussinus
macrophagemacrophage
reticular cellreticular cell
lymphocyteslymphocytes
medullarymedullarysinussinus
medullarymedullarycordcord medullarymedullary
sinussinustr
abec
ula
trab
ecul
a
(con
nect
ive
tissu
e)
(con
nect
ive
tissu
e)
high endothelial venuleshigh endothelial venules
red pulpred pulp
centralcentralarteryartery
PALSPALS
Splenic red pulp
•Some anatomy mathematics
•Red pulp = sinusoids + splenic cords
•Splenic cords = billroth columns
Splenic cords and sinuses
Ross and Pawlina, p. 427
Splenic Circulation
Splenic artery Splenic vein
PALS: Periarterial (periarteriolar) lymphatic sheath
capsulecapsule
red pulpred pulp
white pulpwhite pulp
trabeculatrabecula(connective tissue)(connective tissue)
lumen of cryptlumen of crypt
stratified squamous epithelium
stratified squamous epithelium
secondary folliclessecondary folliclesw/ germinal centersw/ germinal centers
cortexcortex
medullamedulla
cortexcortex(immature T lymphocytes)(immature T lymphocytes)
medullamedulla(mature T lymphocytes)(mature T lymphocytes)thymic (Hassal’s)thymic (Hassal’s)
corpusclescorpuscles