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Kevin BakerAsad Mansoor
Welcome to 181LSection 14 Room 430
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This lab is about you:Thinking, Evaluating, Investigating and Understanding
This lab is NOT about you:Showing up, jumping through hoops and
leaving
We are not synchronized with the lectures, but cover ‘same’ material
Welcome to 181L
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• Read the lab manual BEFORE lab• Be ON TIME to class• PARTICIPATE• Complete the assignments (online, etc)• Participate• Think, evaluate, investigate, understand
Expectations
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• Phones, etc• Food and drinks• C’mon, really?• Code of Conduct http://deanofstudents.arizona.edu/studentcodeofconduct
Expectations
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• Info found in syllabus• Assignments• Online assessments/tutorials 10%• In-class quizzes 15%• Lab-based assignments 50%• Projects and Reports 25%
Grading
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• Absences must be excused through Asya Roberts in BSE 109• Arriving late/leaving early is absent• Make-up labs are labs. Only current week• Miss 2 labs and you should drop, or we’ll do it
Attendance
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• Just do YOUR work• Plagiarism agreement p xii• Link http://deanofstudents.arizona.edu/codeofacademicintegrity/
Plagiarism
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• Class webpage:http://blc.arizona.edu/courses/181lab
• Click ‘Create 181L Account’• Our section number is ‘14’• Let me know about you• ‘Bio181L_Go’ is best way to do online homework• Links available under ‘course software’
181L
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181L
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181L
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Molecules and the Tao of the Molecular World
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Molecules and the Tao of the Molecular World
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Molecules and the Tao of the Molecular World
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Molecules and the Tao of the Molecular World
How molecules feel, and the world they live in
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Molecules and the Tao of the Molecular World
• Observe the forces acting on and between macromolecules
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Molecules and the Tao of the Molecular World
• Observe the forces acting on and between macromolecules • Make deductions about molecular world from observations
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Molecules and the Tao of the Molecular World
• Observe the forces acting on and between macromolecules • Make deductions about molecular world from observations• Become familiar with computer representations of molecules
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Molecules and the Tao of the Molecular World
• Observe the forces acting on and between macromolecules • Make deductions about molecular world from observations• Become familiar with computer representations of molecules• Begin to think of biological molecules as real, with distinctive surfaces.
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Atoms: They’re how life works
DNA: C, H, N, O, P, [Mg++]RNA: C, H, N, O, P, [Mg++]Protein: C, H, N, O, (S), (P), [traces]Membranes: C, H, N, O, P, (S)
It’s pretty simple, really…
What cannot be done with assemblages of these atoms* cannot be done by living
organisms, nor their cells, nor their spit, etc.
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Who Am I?• At birth, # protons = # electrons• Atoms seek completion• Mostly it means 8 in the outer ‘shell’• Hydrogen and Helium are two
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ColorsYou’ll need
to know thesefor NEXT week
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ColorsRED also means ‘negative’
Blue also means ‘positive’
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Dependent on:# protons (+ve charge)Distance e- from nucleus
Slide courtesy of Cara Gibson
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A Little JargonBonds/Interactions
Covalent bond: shared pair of electrons* Non-polar bond: equal sharing; “greasy” Polar bond: doesn’t share well with others Hydrogen bond: Hydrogen interaction-- partial(+) H atom attracted to partial(-) oxygen or nitrogen Ionic bond: attraction between opposites
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Dependent on:# protons (+ve charge)Distance e- from nucleus
Slide courtesy of Cara Gibson
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Looking at Water
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Looking at WaterH2O
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Looking at WaterH2O
HO
H
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Looking at WaterH2O
HO
H
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Looking at WaterH2O
HO
H
+
+
-
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Looking at Water
To your StructViewers!Desktop => Bio181L_Go
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Hydrophobicity (non-polar covalent bonds)
Water is disordered - when lipids present, water molecules arrange in more ordered way.
Clumping together of fat molecules reduces amount of water that has to be ordered.www.steve.gb.com/science/membranes.html
Slide Courtesy of Cara Gibson
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How to draw molecules
Carbon Hydrogen Oxygen NitrogenFigure is from Lab Manual p. 0-5
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Things to do today…Demonstrate that you get it :
Surface tensionHydrophobicity & your worldHeat helps (molecular movement)Size Matters
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Things to do today…• Assessor• primary online tool for labs• You’ll use it today in lab• Many homework assignments
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Things to do today…• Assessor• primary online tool for labs• You’ll use it today in lab• Many homework assignmentsThink, Evaluate, Investigate and
Understand
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Groups• Tao_MCB181L• Enter assigned group name• Periodically change ‘jobs’• THINK!!!!!!!
AtroxWillardiViridisCerberusCerastesTigrisMolossus
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Molecules and the Tao of the Molecular World
• Observe the forces acting on and between macromolecules • Make deductions about molecular world from observations• Become familiar with computer representations of molecules• Begin to think of biological molecules as real, with distinctive surfaces.
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Alcohol vs. Water• “If this is true…”• Densities:
• Which one is closest to water?• Oil/Water and/or Salt Water/water
MeOH = 791EtOH = 789PrOH = 803BuOH = 810
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Ethanol vs. Water
•Which is bigger/heavier?•Which evaporates/distills first?•Why...?
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Clean Up• Oil waste in the hood• Ethanol waste in sink• Anything too messy, throw away• Leave the lab as you found it
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Non-newtonian fluids for fun
Running on waterCornstarch on a subwoofer
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HomeworkDUE BEFORE 10 PM MONDAY!
1. ‘181 Intro 11’2. ‘Molecular World’ tutorial3. Crossword (2) OR Vocabuwary
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Molecules and the Tao of the Molecular World
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HomeworkDUE BEFORE 10 PM MONDAY!
1. ‘181 Intro 11’2. ‘Molecular World’ tutorial3. Crossword (2) OR Vocabuwary
Quiz next week’s WILL include information from this week’s lab/assignments
and next week’s lab
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HomeworkStart the homework early
e-mail me with questions
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