kevin baker asad mansoor welcome to 181l section 14 room 430
DESCRIPTION
Read the lab manual BEFORE lab Be ON TIME to class PARTICIPATE Complete the assignments (online, etc) Participate Think, evaluate, investigate, understand ExpectationsTRANSCRIPT
Kevin BakerAsad Mansoor
Welcome to 181LSection 14 Room 430
This lab is about you:Thinking, Evaluating, Investigating and Understanding
This lab is NOT about you:Showing up, jumping through hoops and
leaving
We are not synchronized with the lectures, but cover ‘same’ material
Welcome to 181L
• Read the lab manual BEFORE lab• Be ON TIME to class• PARTICIPATE• Complete the assignments (online, etc)• Participate• Think, evaluate, investigate, understand
Expectations
• Phones, etc• Food and drinks• C’mon, really?• Code of Conduct http://deanofstudents.arizona.edu/studentcodeofconduct
Expectations
• Info found in syllabus• Assignments• Online assessments/tutorials 10%• In-class quizzes 15%• Lab-based assignments 50%• Projects and Reports 25%
Grading
• Absences must be excused through Asya Roberts in BSE 109• Arriving late/leaving early is absent• Make-up labs are labs. Only current week• Miss 2 labs and you should drop, or we’ll do it
Attendance
• Just do YOUR work• Plagiarism agreement p xii• Link http://deanofstudents.arizona.edu/codeofacademicintegrity/
Plagiarism
• Class webpage:http://blc.arizona.edu/courses/181lab
• Click ‘Create 181L Account’• Our section number is ‘14’• Let me know about you• ‘Bio181L_Go’ is best way to do online homework• Links available under ‘course software’
181L
181L
181L
Molecules and the Tao of the Molecular World
Molecules and the Tao of the Molecular World
Molecules and the Tao of the Molecular World
Molecules and the Tao of the Molecular World
How molecules feel, and the world they live in
Molecules and the Tao of the Molecular World
• Observe the forces acting on and between macromolecules
Molecules and the Tao of the Molecular World
• Observe the forces acting on and between macromolecules • Make deductions about molecular world from observations
Molecules and the Tao of the Molecular World
• Observe the forces acting on and between macromolecules • Make deductions about molecular world from observations• Become familiar with computer representations of molecules
Molecules and the Tao of the Molecular World
• Observe the forces acting on and between macromolecules • Make deductions about molecular world from observations• Become familiar with computer representations of molecules• Begin to think of biological molecules as real, with distinctive surfaces.
Atoms: They’re how life works
DNA: C, H, N, O, P, [Mg++]RNA: C, H, N, O, P, [Mg++]Protein: C, H, N, O, (S), (P), [traces]Membranes: C, H, N, O, P, (S)
It’s pretty simple, really…
What cannot be done with assemblages of these atoms* cannot be done by living
organisms, nor their cells, nor their spit, etc.
Who Am I?• At birth, # protons = # electrons• Atoms seek completion• Mostly it means 8 in the outer ‘shell’• Hydrogen and Helium are two
ColorsYou’ll need
to know thesefor NEXT week
ColorsRED also means ‘negative’
Blue also means ‘positive’
Dependent on:# protons (+ve charge)Distance e- from nucleus
Slide courtesy of Cara Gibson
A Little JargonBonds/Interactions
Covalent bond: shared pair of electrons* Non-polar bond: equal sharing; “greasy” Polar bond: doesn’t share well with others Hydrogen bond: Hydrogen interaction-- partial(+) H atom attracted to partial(-) oxygen or nitrogen Ionic bond: attraction between opposites
Dependent on:# protons (+ve charge)Distance e- from nucleus
Slide courtesy of Cara Gibson
Looking at Water
Looking at WaterH2O
Looking at WaterH2O
HO
H
Looking at WaterH2O
HO
H
Looking at WaterH2O
HO
H
+
+
-
Looking at Water
To your StructViewers!Desktop => Bio181L_Go
Hydrophobicity (non-polar covalent bonds)
Water is disordered - when lipids present, water molecules arrange in more ordered way.
Clumping together of fat molecules reduces amount of water that has to be ordered.www.steve.gb.com/science/membranes.html
Slide Courtesy of Cara Gibson
How to draw molecules
Carbon Hydrogen Oxygen NitrogenFigure is from Lab Manual p. 0-5
Things to do today…Demonstrate that you get it :
Surface tensionHydrophobicity & your worldHeat helps (molecular movement)Size Matters
Things to do today…• Assessor• primary online tool for labs• You’ll use it today in lab• Many homework assignments
Things to do today…• Assessor• primary online tool for labs• You’ll use it today in lab• Many homework assignmentsThink, Evaluate, Investigate and
Understand
Groups• Tao_MCB181L• Enter assigned group name• Periodically change ‘jobs’• THINK!!!!!!!
AtroxWillardiViridisCerberusCerastesTigrisMolossus
Molecules and the Tao of the Molecular World
• Observe the forces acting on and between macromolecules • Make deductions about molecular world from observations• Become familiar with computer representations of molecules• Begin to think of biological molecules as real, with distinctive surfaces.
Alcohol vs. Water• “If this is true…”• Densities:
• Which one is closest to water?• Oil/Water and/or Salt Water/water
MeOH = 791EtOH = 789PrOH = 803BuOH = 810
Ethanol vs. Water
•Which is bigger/heavier?•Which evaporates/distills first?•Why...?
Clean Up• Oil waste in the hood• Ethanol waste in sink• Anything too messy, throw away• Leave the lab as you found it
Non-newtonian fluids for fun
Running on waterCornstarch on a subwoofer
HomeworkDUE BEFORE 10 PM MONDAY!
1. ‘181 Intro 11’2. ‘Molecular World’ tutorial3. Crossword (2) OR Vocabuwary
Molecules and the Tao of the Molecular World
HomeworkDUE BEFORE 10 PM MONDAY!
1. ‘181 Intro 11’2. ‘Molecular World’ tutorial3. Crossword (2) OR Vocabuwary
Quiz next week’s WILL include information from this week’s lab/assignments
and next week’s lab
HomeworkStart the homework early
e-mail me with questions