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Rodrigo Rodriguez MD ,medical director and cofound-er of International Bio Care
Hospital and Medical Center, is aninternationally acclaimed and widelyrespected physician with a succesfulacademic career, and many researchpapers, symposia and conferencesin his curriculum. He decided a quar-ter century ago to enter the eld ofnutritional, immune and integrativetherapies. With postgraduate studiesin the US, Canada and Germany hehas researched, implemented andpioneered modalities that are now
becoming standard therapies. He isone of the most recognized expertsin the integrative medicine world andhas devoted his time and experienceto bringing together advanced andhigh-tech medical achievements.
Our TreatmentPhilosophy
IBC Hospitals general treatment approachis based on these concepts:
1. The uniquely individual biochemistry of the patient.
2. The development of treatment programs (protocols) takingthis unique individualized biochemistry into account.
3. A multifactorial, integrative, succesive, restorative approach aiming at:
Detoxication and dietary adjustment. Balancing of the neuro-endocrinological (hormonal) systems. Regulation and restoration of the various components of the immune defense
system. An all-out attack on pathogens with the fullest possible range of modalities with
an emphasis on natural, non-toxic methods. Exhaustive review of dental health to ensure the absence of infectious foci and
the presence of mercury amalgams and other potentially toxic materials. Fostering of a healing psychological milieu.
IBC Hospital is aware that no two patients are exactly alike, so that no two treaments (in application or response) are exactly alike. We are interested not in treating
disease persebut in helping our patient heal him/herself.
Integrative diagnostics and clinical applications are bringing about long-term survivals andmany cases of complete success in advanced disease conditions around the world.
IBC Hospital is the home of many breakthrough therapies that were researched andeveloped to safe and effective levels never before achieved.
The IBC staff notes that its maximum effort is aimed at restoring wellness and controlinmost of the metabolic conditions we have treated in thousands of patients from sometwo dozen countries over a quarter century.
With a professional bilingual staff at all levels, from medical to nursing, from administrative to transportation, we all strive to create a caring and nurturing environment for thpatient. IBC Hospital has accumulated for over 25 years the experience and know-howto implement and successfully manage one of the major integrative health centers inthe world.
We emphatically believe thatmedical intervention should
be comprehensive andintegrative that one part isnot more important than theother and some therapies
should be implemented onlyafter certain goals have
been reached.
The
Bio Care System
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International Bio Care Hos-pital and Medical Centerwithmore than a quarter-century of dedi-cated experience in the eld fullls
your quest for a total treatment centerin which all forms of state-of-the-arttherapies integrative medicine,with a strong bias toward natural
treatments are available for themanagement of a full range of dis-eases, chronic metabolic disorders,immunological conditions and geneticchallenges.
Years of professional experi-ence have thrust International BioCare Hospital into world prominenceas a leader in the development andapplication of individualized, integrat-ed (custom-made) programs in themanagement of all forms of disease
and pathological conditions.
Long-term survivors fromaround the world have helped bringrenown to our veteran, licensed, bilin-gual medical staff, our support teamof research scientists and physiciansfrom around the world.
The caring environment of ev-eryone connected with InternationalBio Care Hospital from drivers tokitchen personnel to nurses and our14-member medical staff and ourtrack record of long-term recoveriesmake our fully accredited facility yournatural choice for a healing and treat-
ment center.
The International Bio-Care Systemis a full package of health-orientedservices that focus on the individualstotal well-being embracing the bestin hospitalized care, state-of-the-artdiagnostics and monitoring, preven-tive health maintenance and a fullline of metabolic pharmaceuticals,
supplements and health products.
International Bio Care Hospitaland Medical Center offers:
Full in-house hospital services,including room and board, intensivecare unit, nurses station and tele-phone communication, cable colortelevision, personalized in-roomnursing when necessary. Organic kitchen and dining roomwhich prepares meals both for in-house patients and outpatients aswell as visitors and loved ones.
Our Medical Nutrition Departmentdirector is continually adding newdietary approaches to our alreadyhighly respected dining services.
On-site laboratories for utilizationof state-of-the-art diagnostics includ-ing high resolution digital medicalmicroscopy. Augusti test (reticuloendothelialprole), a 9-parameter immunologi-cal performance test. The Augustitest has become a major monitor ofcancer activity and immune perfor-mance, offered exclusively by Inter-national Bio Care Hospital. Outpatient services for the lessseriously challenged, including acomfortable and fully staffed generaltreatment area. VIP suites for outpatients andfamilies in spacious accommodationsattached to the medical center. In-house television channel forpatient orientation on therapies andtreatments and for special videoevents. Fully equipped operating room. Individual consultation ofces formedical staff. Transportation to and from SanDiego International Airport and fromhotels and motels. Laundry, exercise, mail and secu-rity services. Full dental and other medicalspecialties available.. On-site X-ray and ultrasound di-agnostics.
IBC Hospital and Medical CenterYour best option in integrative healthcare
International Bio Care Hospitamaintains around-the-clock medicaand nursing services, chauffeur avaiability during working hours every daand has a full complement of kitcheand maintenance personnel trainedto cater to patient needs. Our modern facilities are located only twentminutes from San Diego InternationaAirport.
Our modern, semiprivaterooms are equipped with telephonecolor television with US channels
an in-house, closed-circuit television channel for patient educatioprograms, intercom and private
bathroom. A security safe, securecomputer port with high-speed internet connection in every room, maiinternational telephone and FAXservices are available as well as anInternet access kiosk for browsingand e-mail needs.
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NUTRITIONAL MEDICINE.IBC Hos-
pital remains at the forefront in offering
dietary support and the proper balanceof oral/intravenous administration of vi-
tamins, minerals, enzymes, amino acids,essential fatty acids, herbal extracts and
other nutrients to achieve balanced body
chemistry (homeostasis) and as immunesystem modulators. Germanium, sele-
nium, and coenzyme Q10 are amongmany broad-spectrum nutrients in usein addition to mega-vitamins, minerals,
enzymes and herbs.
DETOXIFICATION/COLON THERAPY.
Recognizing the extreme importance ofsound gastrointestinal tract function, IBC
Hospital applies numerous detoxication
techniques including fasting, enemas,and human ora replacement therapy
as an integral part of metabolic treat-
ments.
COMPREHENSIVE ANTIOXIDANTTHERAPIESThe balancing, supple-menting, and enhancing of antioxidants,
which selectively destroy or inhibittoxic oxygen factors (free radicals),
has been a major IBC Hospital research
endeavor.
LIVE CELL THERAPY. IBC Hospital
is the major center where continuingresearch, development and application
of fresh cell therapy techniques (sub-
dermal or intramuscular suspensionsof birth related animal tissues) as pio-
neered early in the 20th century by thelate Paul Niehans MD of Switzerland are
in place for regeneration, rejuvenation
and endocrine balancing.
LAETRILE THERAPY. IBC Hospital
has researched and applied amygdalin
(laetrile, vitamin B17), both intravenouslyand orally, as important anticancer
agents.
EDTA CHELATION TREATMENTS.
EDTA, mans miracle molecule, is ad-ministered intravenously and by supposi-
tory for the chelation (clawing out) of
toxic heavy metals and minerals as partof a program of detoxication, improved
circulation, immune enhancement, and
the inhibition of free radicals.
CHONDROITIN SULFATES.Revolutionary techniques to improve
blood ow, treat arteriosclerosis, and
help prevent heart disease include thesesubstances.
ACUPUNCTURE & ACUPRESSURE.Dr. Richard Park, in charge of acu -
puncture/acupressure therapies also
provides metabolic breathing exercisesto enhance the function of acupuncture/
acupressure while also oxigenating theblood. These techniques are useful in
pain control, diagnostics, immune en-
hancement, and endocrine balancing.
BIOELECTRICAL REPOLARIZATION
of tumors based on Dr. Nordenstroms
research in Sweden is a major modalityresearched by IBC Hospital staff.
INTEGRATED STANDARD
TREATMENTS.Standard medical pro-
cedures and substances are integratedinto total integrative programs with heavy
metabolic support for individual andspecial needs.
SPECIALIZED THERAPIES.
Specialized state-of-the-art programs,developed from high technology re-
search centers, all from our globalresearch connections, are available as
newer modalities in immune-building,
anti-malignant or homeostasis-manag-ing activity.
AUTOLOGOUS DENDRITIC CELL
VACCINES, An exciting new experi-
mental therapy, vaccines made from
a patients own tumor cells and "den-dritic" immune cells are customized and
administered to the patient as "smartbombs" which entrap and destroy ma-
lignancies.
This novel high-tech approach is non-toxic and provides an entirely new
dimension to cancer therapy. (see also
Integrative Medicine for the Treatmentof Cancer.)
WHOLE-BODY HYPERTHERMIA,
which consists of the elevation of the
core temperature of the body achievedby circulating the blood through a high-
tech heat-exchange device, has provid-
ed positive results in advanced cancer.(see special section)
ULTRAVIOLET BLOOD IRRADIATION
THERAPY (U.B.I.T.), also known as pho
toluminescence, photo-oxidation, anextracorporeal photophoresis, in whic
UV treatment of blood helps improvmicrocirculation and oxygenation of tis
sues, stimulates the immune system
and has powerful antiviral, antibacteriaand antiinammatory properties. It ca
also reduce the size and inammatoractivity of large tumors. (see speciasection)
ADVANCED OXIDATIVE THERAPIESOzone and advanced oxidative agents
hyperbaric oxygen, and oxygen-releas
ing molecules are some of the mosadvanced oxidative agents for nontoxi
antiviral, antibacterial and antifunga
management. IBC has its own hyperbaric oxygen chamber. It is also the
major center for the administration o
concentrated atomic oxygen in theform of BiOx, which is a major oxidativ
therapy available intravenously and asublingual drops.
We are integrating all
of progressive med
standard and integrain the management o
generative diseas
International Bio Care Hospital through its yearsof experience with research associations and
institutions around the world has made avail-
able one of the most comprehensive integrativetherapy programs.
IBC Hospital understands the uniqueness of eachpatient at different stages and has found that
successive, individualized, integrative, restorative
protocols are the way to success.
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There are 8 full-time and part-time
physicians on staff and a support team
of hundreds of consultants from Mexicoand the United States. Nonresident
physicians from around the world havehospital privileges at IBC Hospital.
IBC Hospital has a licensed and reg-istered nursing staff for its inpatient and
outpatient facilities and sixty supportpersonnel. The hospital maintains ongo-ing orientation videotapes and a bureau
of speakers who present instructional
programs.
Special programs for rejuvenation, im-mune system enhancement, longevity
and promotive health are available at
IBC Hospital and Medical Center.
With the theme adding years to your
life and life to your years, IBC pio-neered live cell therapy-based programs
in which hormone balancing through the
use of extracts of birth-related animalendocrine tissues is the centerpiece of
a total program including:
Laboratory workup with advanced
blood, urine and stool proles, as wellas food sensitivity and immunological
panels.
Intravenous feed-
ing and oral nutritional
programs with a strongemphasis on antioxi-
dants, which offer totalsupport and restora-
tion to the seriously
challenged patient.
Specic anti-agingcompounds such asGerovital (GH3) and longevity-inducing
medications, including human growth
hormone, Regeneresen, ginseng, ginkgobiloba. All can be integrated into easily
complied-with, highly successful therapy.
EDTA chelation therapy, which not
only helps protect the circulatory systemfrom plaque buildup and detoxies the
body of minerals and metals, but also
properly balances calcium and enhanceslive cell injections.
Cosmetic and/or restorative surgerywhere necessary or desired.
Accommodations for patients seeking
rejuvenation/longevity programs are
available at the VIP suites attached tothe hospital or at comfortable hotels and
motels on both sides of the border.
The IBC staff encourages the public to
take advantage of existing diagnostic
and treatment modalities now so thatpromotive health can become a reality
for the many instead of the few.
For the past quarter-century,
International Bio-Care Hospital andMedical Center has been facing the ever-
present question of whether to embarkon so-called alternative or integrative
therapies or follow mainstream, conven-
tional or orthodox therapies.
In conventional oncology the
concept of making the body less toxic,improving diet and nutrition and regulat-
ing the immune system while treating
the malignancy is still widely regarded
as an unimportant aspect of medicalcare.
The belief that medication alone
can and should reverse disease andcure a patient without any consideration
of the bodys own defense and recovery
systems still dominates the medicalmentality.
In standard oncology, there i
no treatment which is not deleterious t
the immune system or the overall hosdefense of the patient. In our concep
the foundation of any form of therapyshould be the restoration of the biolog
cal capacities of the host with specic
emphasis on the immune system. Supported by the recovery of the patient
own defense mechanisms medicaintervention in the form of specitherapies can then take place. Such
an approach in due time hopefull
will lead the patient to a better quaity of life and improved longevity.
This is the concept of Integrativ
Medicine. We emphatically believe
that medical intervention should bcomprehensive and successive
one part is not more importan
that the other and some therapieshould be implemented only afte
certain goals have been reached
For example, to give chemo
therapy to a patient who recentlunderwent surgery will only worsen hi
appetite, strength and wellbeing, reduc
ing defense systems and the chances osuccessful outcome.
In standard radiotherapy programs, statistics show that the higher the
dose of radiation, the higher the tumora
response. However, the same statisticprove that higher doses mean less sur
vival. This means that we must strike abalance between how aggressively we
attack the tumor and how much sup
port we give the body or at least howmuch assault our biological systems ca
endure.
INTEGRATIVE MEDICINE FOR THE
TREATMENT OF CANCERby Rodrigo Rodriguez MD, Medical Directo
International Bio Careuses only the nestproducts available,
looking always for quality,performance recordand natural sources.
Only the best productswill be used and prescribed
by our doctors.
Creating a Health Team with patientand doctors alike, careful planning,understanding and commitment are thefoundation of the Bio Care System
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Another important concept to
understand is that a healthy body with
an intact defense system does not de-velop cancer. So the mere fact of cancer
presence denotes a failure, mutation, orbiological change important enough to
trigger such a diagnosis.
If we continue to follow the con-
cept that the elimination of the tumormass brings cure, we will continue tosee the recurrence of cancer which is
one of the consistent outcomes of con-
ventional oncology. The fact is that whena breast tumor, for example, is removed
we are far from solving the problem. Sothe lump is not the disease and that
should be the conclusion.
In an integrative model we follow
four major principles: restoring the best
possible biological conditions throughnutrition, rest and exercise; detoxifying
the body; regulating the immune system;
and using a wide array of modalities, al-ternative and conventional alike, against
the malignant process itself.
We stress the concept of bio-
chemical individuality - no two patientsare treated identically. Since each
patient is different and each patients
response to cancer let alone its therapyis also different, we individualize our
therapies.
The concept of biological indi-
viduality is easy to grasp since we haveindividual genetic pools that are not iden-
tical other than in identical twins, and we
are raised under different circumstances,climates, diets, etc. We are exposed
to different immunological challenges
throughout our lives with unique biologi-
cal experiences.
We are exposed
to different pol-lutants and tox-
ins. Finally, ourindividual mental attitudes give stress a
personal touch that impacts on each and
every one of us.
Much attention in recent yearshas focused on dietary considerationsin chronic disease yet, just as there
is no one-treatment-ts-all therapeutic
approach to cancer, neither is thereone-diet-ts-all, and we must be as at -
tentive to individuality in diet as we areto individuality in therapy.
In critical cancer patients, inten-sive crisis nutrition can only be attained
by intravenous feeding that will deliver
to the blood all the critically necessarynutritional elements in an immediate and
efcient way. It is easy to understand that
patients with cancer are malnourished bylack of appetite, depression and medical
interventions such as surgery, chemo-therapy and poor digestion.
The mere satisfaction of nutri-tional needs represents a major step
toward well-being and the recovery of
biological capacities.
This is a concept well supported
by research at major medical schools.Intravenous nutrition rapidly improves
white blood cell (WBC) performance al-lowing restoration and enhanced activity
of a key element in ghting cancer: cel-
lular immune performance.
Supplementation by mouth is
also a common method of managing
less critical cases.
Detoxication is a major tool if thebody is to be able to function properly.
Each function of the body is regulated by
our genetic information system throughspecic enzymes. A toxin is dened as a
substance that impairs or blocks enzymeperformance.
It is imperative to rid as many
foreign and toxic substances from thesystem as possible, a problem of enor-
mous signicance in cancer.
To detoxify the body we use,
among other things, specialized diets,juice fastin g, coffee enemas, chelat -
ing agents, replacement of friendly
bacteria and any other approach orsubstance required. Coffee enemas,
often regarded as controversial yet of
comparatively ancient pedigree even inWestern medicine, help render the small
intestine alkaline, detoxify the liver andhelp restore bowel regularity.
Of no less importance is thecareful exploration of the body to look
for sources of toxic debris, organic or
inorganic. Infectious focci, dental healthand removal of mercury amalgams are
all of primary importance.
Toxic oxygen breakdown prod-
ucts free radicals have to beneutralized or blocked, a process which
can largely be carried out with nutrients
known to have free radical-blockingthat is, antioxidant activity.
Our approach is to utilize a baseline
special blood test to measure oxidative
antioxidant activity in the blood. Antoxidant substances in general use are
SOD (superoxide dismutase), catalaseglutathione, butyrate, selenium, NAC
(N-acetyl-cysteine) and vitamins A, C
and E, Beta Carotene, to mention onlthe more prominent from a growing lis
The controversial compound laetrile isamong other things, an antioxidant.
Immune regulation involves
complex process (by some denitionthere are several immune systems
whereby internal defense mechanismare made aware of the presence of al
tered cells or tumors which are growin
wildly in the body.
Malignant processes may isolat
themselves by building a protein sheataround themselves or, as Nordenstrom
proposed, by creating an electrica
eld, making them unrecognizable tthe immune system, which otherwise
would attack them. We must overcomethis blockage by the administratio
of proteolytic enzymes as a rst-ran
weapon, or by electrical repolarizatioof the tumor.
Live cell or cellular therapy (being slowly accepted in orthodox circle
as fetal cell transplantation therapy
after being cold-shouldered for years) ia highly effective approach to long-term
immune regulation.
It consists of intramuscular o
subdermal injections of cellular suspensions of animal embryonic or other birth
related tissue. Since these kinds of sus
pensions are obtained from embryos o
Integrative MedicIntegrative MedicineWe emphatically believe thatmedical intervention shouldbe comprehensive and suc-cessive; one part is not moreimportant than the other and
some therapies should beimplemented only after certain
goals have been reached.
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other birth-related tissues in early stages
of pregnancy, they provoke no allergicresponses. The varied positive effects of
such injections have a start-up period ofseveral weeks and an endurance of up
to six months. Live cell injections have a
hormone balancing effect on the body ingeneral, a balancing effect on immunity
and some specic anticancer activity.
The direct assault on cancer
is carried out not only with such time-
tested substances as laetrile (amygdalin,
Vitamin B17), but also with a growingnumber of nutrients and herbal-derivedcompounds, combinations and extracts
which have solid research behind them.
New alkaloids are now available in com-binations that can induce the death of
cancer cells while protecting immune
cells, thus creating a brighter horizon forthe use of herb extracts in the treatment
of cancer.
These essentially nontoxic anti-
cancer compounds, together with a totalmetabolic program of dietary change,
detoxication and immune system regu-
lation, provide us with effective therapiesnot only virtually free of unpleasant side
effects but accompanied by higher en-
ergy levels, better appetite and overallimproved biological performance.
Of course, we can and do utilizesubstances from the orthodox arma-
mentarium when feasible and practical.Ongoing research has shown that a
nutritionally based metabolic program
actually enhances the effects of che-motherapy and radiation should either
of these modalities be c alled for.
Two relatively new therapies
requiring individual attention and which
have shown great promise at our hospi-tal are whole body hyperthermia and
autologous dendritic cells Results ofthese techniques have been particularly
heartening in advanced cancer cases
where the extension or severity of thecase needs intensive, more aggressive
protocols.
Whole body hyperthermia con-
sists of heating the patients body by cir-culating blood through a heat-exchange
device. This is a modern expression of
the ancient observation that cancer cellscannot stand high temperatures to which
normal cells are otherwise insensitive.
High heat sets off a cascade of intracel-lular events in cancer cells leading to
apoptosis or programmed cell death.
During this procedure the patient is se-dated in order to tolerate the increased
heat and allowed a recovery period rang-
ing from a few hours to ve days.
IBC is also pioneering the useof "autologous" meaning "made from
self" - vaccines against the cancer pro-
cess, particularly those made from therecently discovered structures called
"dendritic" cells (DCs). DC's are known
to entrap tumor cells and expose them toa patient's immune system for destruc-
tion.
By lenghtening and enhancingtumor control through human immune/
defense systems while remaining com-
pletely free of side effects over long peri-ods of use, this is the most nature-similar
way of controlling malignant growths.
It has been learned that DCs
elongated appendages in certain
cells can actually pick up normal cellsand migrate with them to Iymph nodes
where they can be exposed to a highconcentration of immune system cells.
DCs can stimulate a responsein which
the immune system increases the activ-ity of T-cells which help ght cancer and
viruses.
The procedure involves drawing
from the patient blood containing mature
and immature DCs and tumor cells. Abiochemist induces the maturation and
activation of DCs in the presence of pro-teins derived from the patient's tumor.
At this point a weapon has beencreated which administered to the pa-
tient, will act as a cellular vaccine - a
"smart bomb" - which will actively seekout, entrap and expose to the immune
system tumor cells developed at every
stage of malignancy.
The vaccine, being non-toxic,sterile and customized from the patient's
own blood, is thus a safe and effective
form of t herapy.
International research and
knowledge exchanges provide informa-tion and resources from around the world
and access to new modalities, products
and experiences that enrich and widenthe expectation of good results in the
hard battle against cancer.
Our anticancer program oslow drip infusions, direct injections
oral and sublingual nutrients, specialize
diet and detoxication normally takethree weeks, a period we call the crisi
phase.
The three-week segment is de
signed to interfere with at least one fucycle of malignant-cell replication a
process which hopefully will remove the
patient from the crisis stage.
After the initial three-week intensive-therapy phase, the patient iprovided with a program of protocol
and dietary changes to be followed a
home.
The arguments between alter
native and orthodox medicine shouldvanish with the understanding that meta
bolic illnesses are part of a multifactoriaand complex scenario.
Real medicine is unitarian - addresses the health and well being o
whole individuals. There are no such
things as different medicines or evenmedical specialties; these are man-made
concepts which help to understand how
the body works in health and disease. Inreality any attempt to treat only a part o
a patient will encounter a far less thandesired outcome.
Every effort to integrate the differing avenues of medicine, alternative
or conventional, old and new, East o
West, homeopathic or allopathic, etcwith the well-being and respect for ou
patients, needs in mind can only lead t
better, more substantial and longer-lasting results.
Integrative MedicIntegrative Medicine
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Hippocrates routinely buried
patients in the desert sand to elevate
their core body temperature in an at-tempt to cure disease. In the middle
1800s a German physician, Dr. WilliamBush, noted spontaneous remission of
sarcomatous tumors in patients who
sustained prolonged fever episodes. Dr.W. C. Colley at the turn of the century
injected cancer patients with differenttoxins to create articial fever with goodresults, and Dr. Julius Wagner-Jauregg,
an Austrian physician, was awarded the
Nobel Prize in Medicine in 1927 for hissuccessful work using malaria serum
fever induction in patients plagued withsevere complications of syphilis.
Hyperthermia represents a natu-ral approach in combating disease since
it involves inducing an exaggerated ver-
sion of the bodys own fever state.
Medical research found tha
induced hyperthermia has damagin
effects on cancerous cells and infectious agents, but the technical limitatio
in elevating body temperature in an accurate, consistent, and reproducible wa
was a major obstacle to accomplishin
this goal in humans despite the excitingresults obtained in experimental obser
vations.
Many infectious agents are
sensitive to heat particularly, but no
restricted to, human immunodeciencvirus (AIDS), Hepatitis C virus and
Lymes disease which die due to heashock before the normal human biolog
is altered.
Summarizing, we observe tha
the articial elevation of body tempera
ture either through normal physiolog(fever) or by induction (medical hyper
thermia) is an important healing factor in
the management and treatmenof several infectious processe
and in the treatment of canceMedical hyperthermia can b
applied in cases where norma
fever response is not presenbecause of the inability of th
host to react to the illness. O
key importance, medical hyperthermia is carried out unde
controlled circumstances, time
and parameters, making it safe and accurate therapeuti
tool.
Medical Hyperthermia
MEDICALHYPERTHERMIAA treatment option in the eldsof oncology and infectious diseasesby Victor Loustaunau, MD
Hyperthermia, from the Greek
words hyper,meaning high, and ther-mos,meaning temperature, can simply
be dened as the elevation of the body
temperature.
The physiological and biological
mechanisms of hot-blooded mammalsincluding humans demand that the body
maintain a temperature that is normallyabove that of the external environment.
However, it is important to note that the
same functions can only successfullyoperate within very narrow t emperature
margins.
Our bodies have developed
highly sophisticated heating and cooling
systems to maintain a stable tempera-ture within the narrow margins required
regardless of environmental conditions.The process that attempts to maintain a
steady internal thermic balance is called
homeostasis.
There are only a few physi-
ological conditions in which the thermicbalance is changed: winter hibernation,
egg-setting hens, and fever. Only fever
is a physiological thermic resource inhumans.
Fever acts as a defense mecha-
nism against a number of processes,
mostly related to either infections or thepresence of abnormal proteins in the
bloodstream called pyrogenes.
One of the most immediate physi-
ological effects of fever is the accelera-
tion of metabolic processes in general.Fever increases oxygen uptake and
renders white blood cells more aggres-sive against bacteria, fungi or viruses.
By making the cells more permeable,
white blood cells are able to dischargeinto the bloodstream more aggressive
substances against infectious organismsand increase their phagocytic (destruc-tive) capability.
Fever within physiological limitscan have many benecial effects and will
not produce any harm to normal cellsthat are able to cope with the higher
metabolic demand. Human cells under
specic metabolic conditions, such ascancer cells or infected cells, can be
seriously challenged by thermic stress
and may even be killed by it.
In summary, fever should be
seen as an important physiological de-fense mechanism against disease.
BACKGROUND INFORMATION
Because of the empirical obser-
vation that the healing process is often
preceded or accompanied by febrileepisodes, the induction of thermic eleva-
tion has been attempted as a cure for
thousands of years. In recent centuriesthere were reports of cures of cancer and
cases of syphilis, which improved spon-taneously after severe fever episodes
that were caused by other infections.
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Necrosis involves damage to the cell
by an external factor such as an injury,
infectious agent, or immune reactionand in fact is the cell death phenomenon
that we have commonly recognized andunderstood.
Apoptosis or programmed celldeath is characterized by a degradation
of the cell with shrinkage and fragmenta-tion triggered from within. Genetic mate-rial in each cell has information codes
that allow the cell to evaluate its own
functions.
Hyperthermia isone of the major
apoptosis induc-
ers. This is whyremission of can-
cer has been em-
pirically seen afterfebrile episodes
and more recent-
ly under inducedtemperature el-
evation.
The damage and
changes produced by hyperthermia canbe enhanced with the use of substances
that can further the metabolic problems
of cancer cells. Vitamin C, glucose,low-dose chemotherapy and low-dose
radiation therapy have been pointed to
as important adjuvants for a more effec-tive therapeutic outcome.
It has been proven that in pa-tients with resistance to chemotherapy,
whole body hyperthermia can reinstitut
drug efcacy. It is widely recognize
and scientically proven that whole bodhyperthermia renders cancer cells mor
sensitive to chemotherapy. This allowthe use of milder forms of chemotherap
at lower doses and hence with fewer side
effects and complications.
The same is true for radiatiotherapy: whole-body hyperthermia casubstantially increase the possible dam
age to the cancer cell with the use o
radiation. And again it is possible to usfewer radiation sessions, with shorte
times and lower doses in general, andstill obtain good results with milder side
effects.
Infectious disease: The ratio
nale for the use of whole body hyper
thermia begins with nature itself: Fever ithe most immediate reaction to infectio
and at the same time one of the bes
known and earliest recognized defensmechanisms.
Under normal circumstance
many infectious agents that were or sti
are important plagues of mankind can bdamaged and destroyed at temperature
that are easily tolerated by normal hu
man cells.
The causative agents of huma
immune deficiency syndrome virushepatitis C virus and Lymes disease
are among the most notorious infectiouagents that due to their susceptibility t
heat have become important targets o
this method.
Medical Hyperthermia
METHODS
It wasnt until the 1970s when
Dr. Parks, a cardio thoracic surgeon,reported success in using an extra cor-
poreal technique to conduct more thanone thousand whole body hyperthermia
sessions for the treatment of cancer.
During the following two decades manyadditional studies have been conducted
and documented.
The use of external sources of
heat creates uneven heat distribution in
the body and burns are not uncommon.The extra corporeal technique involves
circulating blood through a closed circuitdevice. Extra corporeal circulation with
the help of a pump will carry the blood
through a heat exchange unit. Heat willbe transferred to the blood and then
recirculated into the body.
Utilizing the cardiovascular sys-
tem for inducing hyperthermia from the
inside out has the inherent advantageof creating an extremely uniform heat
distribution throughout the body.
During the procedure the pa-
tient, under mild sedation, is continu-ously monitored. The information from
thermometers in the body is fed back to
the computer that controls the heat ex-change unit. Because of this feedback
mechanism the core body temperature
can be consistently and reliably adjustedwith an accuracy of one tenth of a de-
gree.
In a routine treatment protocol tempera-
ture will be raised to a constant plateau
that lasts 60 to 90 minutes at a tempera-ture of 42 C (108F).
Once the procedure is termi-
nated the patient is transferred to his/her
room, monitored and assisted throughthe following hours until the next day by
specially trained nursing staff.
CRITERIA FOR ENTERING THE
HYPERTHERMIA PROGRAM
The available medical informa-tion and experience have proven that
medical Whole Body Hyperthermia hastwo major classes of patients as potential
beneciaries: cancer patients and those
with chronic progressive viral infections,mainly HIV and Hepatitis C patients.
Cancer: There are many formsof cancer in which hyperthermia can play
a major role and lead to a successful
result: Hyperthermia by itself can havelethal effects against certain forms of
cancer, and in an integrative protocolin which other nontoxic modalities are
used this method is a major adjunctive
therapy.
Cell death is a fundamental
phenomenon of organisms occurringnaturally as part of embryo development,
in cell turnover in adults and as a result
of injuries and pathological processes.There are two fundamental types of cell
death necrosis and apoptosis.
Medical Hyperthermia
Utilizing the cardiovascularsystem for inducing hyper-
thermia from the inside outhas the inherent advantage ofcreating an extremely uniformheat distribution throughout
the body.
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It is highly recommended that any
metabolic disturbances detected beforehyperthermia be placed under control
before this metabolism-challenging pro-
cedure is done.
Patients normally undergo in-tegrative metabolic protocols before
and after whole-body hyperthermia in
order to enhance the positive aspectsand results to be expected from such a
comprehensive program.
FINAL CONSIDERATIONS
Hyperthermia has a long history
of use in medicine in the treatment of avariety of diseases. Recently we have
seen a resurgence of its importance asa potential treatment option in the man-agement of chronic illness in the elds
of oncology and infectious diseases.
Medical Hyperthermia
CLINICAL APPLICATION
Candidates for whole-body hy-
perthermia are carefully evaluated notonly in terms of the main diagnosis but
also their general, nutritional and overallcondition and specically their lung and
heart functions.
Careful clinical diagnosis and
staging of the disease with all possibleelements to establish the status of theillness will provide necessary informa-
tion to allow both patient and physician
to evaluate changes in the disease in anobjective and systematic manner. This
is vital in the planning of adjunctive andfuture therapies that will bring about a
successful outcome.
Radiological studies, such as CT
scans, MRI, and other X-Ray images,
are helpful elements with which to judgechanges in the progression of a tumor.
Laboratory ndings are also important
factors in this assessment, particularlytumor markers in blood.
In the case of viral infections
modern laboratory techniques can
provide accurate information such asviral load quantication, antibody titer
elevation and immunological reactions
to the disease which provide importantfeedback to support or modify the treat-
ment program.
Patients are placed in a hospital
environment prior to the whole-bodyhyperthermia procedure. Medical evalu-
ation is started at once.
Before the actual procedure
begins the anesthesiologist places the
patient under mild sedation. Two otherphysicians carry out the procedure with
the assistance and help of two nurses.The entire process takes approximately
4 to 6 hours.
After the procedure, the patient
is under constant observation with aphysician and a private duty nurse duringthe rest of the day and night. Other than
the effects of sedation patients should
not expect any discomfort and normallysleep over the following hours.
Laboratory tests may show
some changes following hyperthermia,
similar in nature to those observed afterhigh fever. However, as in fever, these
changes will return to normal in a few
days and scientic studies prove theyare inconsequential.
The day after the treatment mostpatients feel as they would feel after a
normal febrile episode: tired, sleepy, andwith mild aches and pains. All these
symptoms are mild enough not to require
any specic medication.
Thanks to careful surveillanc e
and monitoring during the procedurepatients rarely experience any discom-
fort. After a day, they normally resume
the level of activity they had before thetreatment.
Medical Hyperthermia
Results from well formulated basic sc
entic studies and subsequent clinica
studies have demonstrated that heat aa therapeutic option is a viable alterna
tive. Heat therapy can be a tool whiccan be offered to many, but state-of
the-art technology, a professional staf
well trained in these protocols andprudent patient screening must rst be
developed in order to implement a safenontoxic procedure.
Chronic viral infections are th
other group of diseases in which treatment options at present are not only lim
ited but unfortunately are accompanieby short-term results. The prevalenc
of AIDS and Hepatitis C in the curren
world population provides the challengto seek effective alternatives to manag
and arrest the progression of these po
tentially fatal conditions.
We cannot stress enough th
importance of an accompanying protocoof detoxication, nourishment, immun
augmentation and overall well being athe foundation for more sophisticated
forms of therapy.
The nal determinat ion of th
value of this therapy in a particular cas
can only be decided by the interactionof doctor and patient together with the
appropriate analysis of clinical and labo
ratory ndings.
Those diseases that medicines donot cure are cured by knife, those
that the knife does not cure arecured by re, and those that re
does not cure must be considered
incurable.
Hippocrates
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Advanced Diagnostic Assessmen
ADVANCED DIGITAL MICROSCOPY
IBC has been a world pioneer inthe use of digitalized, high-resolution,
phase-contrast optical microscopy forrapid monitoring and evaluation of condi-
tions. It has also been a research center
utilizing two of the blood tests particularlydesigned to use such an essay: the
"clot retraction" and "Iive cell" bloodtests or CRT and LCA.
The advanced medical micros-
copy used at IBC whose research anddevelopment involved IBC principals
over many years, it is a state-of-the-art system, including digitalization and
video monitor, which allows the clini-
cian to gather a tremendous amount ofinformation in a short period of time.
Sometimes erroneously called"darkeld microscopy" a reference
to one of its modes the system uses
drops of capillary blood expressedfrom the ngertip for the utilization
of the clot-retraction and live-cell tests,although the system is well tted for
medical microscopy in general.
The darkeld mode allows many
elements of blood not clearly visible in
the brighteld mode to come into clearview. At better than 15,000 magnica-
tion, the practitioner may see numerous
factors of living, circulating blood includ-ing red blood cells, white cells, platelets,
yeast forms, chylomicrons, cholesterolcrystals, bacteria, mycoplasma and
other structures.
"Live Cell analysis" hence allows the
physician to see in color and at extremely
high optical magnication a patient'sresponse to diet, medications and patho-
gens. Such evaluations allow for weeklyand even daily patient monitoring and
arguably diagnosis.
The more vintage "clot retraction"test, which has had various names, is uti-
lized at lower magnication to examine
the clotting factors in dried blood.
It has been determined that an
essential element in this test is the se-rum's response to "free radicals," which
are molecular breakdown products
common in the processes of oxidationand inammation. These compounds
which are normally generated by meta-bolic activity of the body can increase
substantially in a number of conditions
ranging from inammation to cancer.
ADVANCED DIAGNOSTIC ASSESSMENTAdvanced Digital Microscopy and the Augusti ReticuloEndothelial Prole, a peek into the future of diagnostics. bySalvador Chavarn, MD.
A theory that's gaining suppoholds that Cancer is
fundamentally a geneticdisease in which the normalgenetic mechanisms that
control cellular growthmaturation and senescence
have been disrupted.
They can also increase when the normalanti-oxidant system either fails or loses
efciency due to the presense of toxins
(tobbaco) or disease.
The appearance of coagulatedblood can indicate many pathological
conditions and/or the body's response
to therapies and healing.
Images from both CRT and LCA;
are digitally collected to produce picturesthat can be analyzed by the doctor with
the patient for his understanding of the
procesess and the result of the therapies.Hard copies will form part of the patient's
le for follow-up and comparison.
Experience has shown thatcertain conditions which would laterplague the patient in a visible, clinical
way were rst observed via the CRT
and LCA before standard laboratorytests detected them. Hence, the tests,
properly done with the advanced mi-
croscopy system, are often predictiveas well as diagnostic.
THE AUGUSTI
RETICULO ENDOTHELIAL PROFILE
Another state-of-the-art diagnos
tic tool that allows the clinician and thepatient not only to determine the status o
the condition but to follow the respons
to different programs is the "Reticuloendothelial Prole," also called the Augus
Test in recognition of the French scientis
who rst described, later standardizedand until today continues to improve th
test: Dr. Yves Augusti.
Normal red & white blood cells.Clumping of cells due t o enzyme deciencand resulting in poor blood ow.
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Advanced Diagnostic Assessment
In this test, blood serum from
the patient is incubated at 9 different pHlevels (acid-alkaline) that will precipitate
different types of serum protein (alpha-
globulins). When any of these proteinsis abnormally abundant or scarce, it will
give, in the rst case, a turbid or an ex-
traclear solution in the latter.
These values, read by specialequipment, give us an overall perfor-
mance prole of important functions of
the body, such as the immune system,the liver, in ammatory processes, aller-
gies and even cancer.
The Augusti Test becomes even
more important in the follow-up treat-
ment, since it reacts to the same.
Different kinds of processes canbe followed as they increase in severity
or improve due to different programs
and critically important factors such asimmune performance, to the severity of
the inammatory process, reactivity to
allergic factors and activity or remissionof cancer can be all analyzed in order
to determine what direction future treat-
ments should take.
Many thousands of cases attest
to the performance and reliability ofAugusti's Reticulo Endothelial Prole.
Normal
High protein profile due to inflammatorymalignancy.
The development of vaccinesagainst disease has been one of med-
icine's high-water marks. And now
there is a new era in vaccinology whichincludes customized vaccines made
from tumors and traditionally prepared
cells that stimulate immune responses(Antigens).
Cancer is one of the areas whereresearch groups associated with Inter-
national BioCare Hospital (IBC) have
seen the most potential for DendriticCell (DC's) manipulation and response.
Science has shown that cells derivedfrom the specialized white blood cells
called Lymphocytes and Monocytes
produce tentacle-like elongations whichtrap tumor cells and expose them to the
immune system for destruction. They
are called Dendritic cells (DC's). Manyfactors in modern life may affect the
maturation process of DC's, renderingthe body more susceptible to the growth,
maturation and proliferation of tumo
cells. Every individual's cancer is unique
Therefore, the most effective treatment ione customized to a particular disease'
genetic conguration. By capturing thgenetic information of tumors, we ar
able to use DC's to trigger a desired im
mune response.
The Challenge of Cancer:Individual Cancer and Mutations.
Humans normally produce can
cer cells throughout their lives. Malignan
cells exposed to a healthy, active immune system will either be attacked and
destroyed (Phagocytosis) or geneticallprogrammed for self destruction (Apop
tosis).
Genetic mutations and chro
mosomal abnormalities are commonl
associated with human cancers. Unfortunately, since the genetic mutation
leading to the development of cance
are often random events, every patient'tumor can contain a unique repertoire o
antigens. The characteristic of humacancer requires each patient's immun
system to recognize the specic ant
gens present.
It is in this area of unique genetiprole, and the genetic mutations of eaccancer, that we capitalize our ability to
make Autologous Dendritic cell (DC's
cancer vaccines. The RNA-loaded DC'vaccine is customized to the unique an
tigen repertoire of each patient's tumoequipping the immune system to recog
nize and ght that particular disease.
DENDRITIC CELL (DC) VACCINESBushwhacking cancer from within
by Javier Vazquez, MD
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Dendritic cell vaccines
Combining tumor cell-specicdendritic cell vaccines with atotal program which marshalsthe immune system in manyother ways while detoxifyingthe body, providing essentialnutrients and modulating theimmune system can stimulatethe natural process of healingto provide particularly impres-sive responses against degen-
erative diseases that plagueour times.
Because these vaccines include the
entire genetic repertoire of the patient's
tumor, they preclude the need to identifyor isolate specic tumor antigens. Thus,
with DC's vaccines, we can treat thosepatients without known tumor antigens
or those from whom insufcient tumor
material can be obtained, making themsuitable for the vast majority of cancer
patients.
Creating a Personalized Cancer
Vaccine:
The procedure involves drawingblood, from the patient. RNA-loaded
DC's vaccines start with precursors ofthe patient's DC's which, when matured
for the vaccine, are currently considered
the most effective antigen-presentingcells within the immune system. We are
then able to amplify tumor RNA from the
patient, whether from the primary tumorsite, distant metastatic sites, or from
tumor cells present in the circulation,
and transfect the patient's DC's with thepatient's tumor RNA.
This process offers the ability
for most cancer types at any stage of
disease to be target opportunities forthis cancer vaccine. At this point we
have created a weapon which, when in-
jected to the patient, will act as a cellularvaccine a "smart bomb" in modern
defense parlance.
Unique Advantages:
Dendritic cells transfected with RNA-encoding tumor antigens have been
shown to stimulate potent immune cell
responses equal or superior to othercompeting approaches.
The vaccine is completely Autologous,
potentially offering maximum safety with
practically no side-effects.
The vaccine targets the entire antigenicrepertoire of the tumor including "private
mutations" unique to the patient.
Formulation requires no specialized
manipulation maximizing patient partici-
pation (warm vial at room temperature,load syringe, inject).
International BioCare Hospital
is proud of its association with researchcenters from around the world whichhave brought to our patients this novel
and rational treatment program which is
so much in tune with the workings of theimmune system.
AUTOIMMUNE DEGENERATIVEDISEASES
Multiple Sclerosis, Lupus, Rheumatoid Arthritis and related condition
by Michael L. Culbert ScD
An important area of degenerative dis-
ease is one in which the defense or im-
mune system, far from being dormant oracting too slowly, manifests an increased
reactivity while at the same time ignoring
the normal target of its action ("non-self")
and instead turns on the self-compo-nents of our own bodies.
The result is autoimmune dis-
ease.
The immune system may be lik-
ened to a watchdog; a key virtue of theanimal is its ability to distinguish familiar
residents from intruders. The watchdog
that is dozing during a burglary is of nobenet to its master. Likewise, a dog s o
vicious that it does not distinguish be-
tween resident and visitor but may attackboth is an equal problem. This is what
happens in immune dysregulation.
Our immune systems develop
from the earliest infancy: as soon as weare born there are literally thousands
of "immunological challenges" we face
externally and even internally webreathe, eat or come in contact with them
in many ways through different organ
or tissues. That is, from the point of birtwe are under attack.
In the first weeks to month
following birth we are more or less pro
tected through the substances calledantibodies passed onto us from ou
mother's milk and which teach our de
veloping immune systems to distinguisself from non-self. These substance
even allow certain microbes to live and
thrive in certain organs because they areuseful, but others will be attacked and
expelled from the body.
So our immune system will grow
up with us, serving as a rst line of defense against disease. But various fac
tors can disrupt the normal maturation
process of that system: excessive use oantibiotics at an early age, replacement o
mother's milk by "formula" milk, the lacof or deciency in certain vital nutrient
such as essential fatty acids (EFAs), othe use of drugs and medications whic
may have a short-term benet but a long
term negative effect on the system.
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Autoimmune degenerative diseases Autoimmune degenerative disease
All these elements may play a
role in the development of autoimmuneand "atopic" diseases.
From asthma to multiple sclero-sis, from lupus to rheumatoid arthritis,
immune diseases share in common a
high reactivity of the immune system with
a self target.
While medicine in general hasalways tried to curb the activity of the
immune system in general with the useof so-called immune suppressor drugs,
we believe that the treatment should
be directed toward helping the immunesystem respond in a more normal way
and to try to direct its activity against
non-self components.
In all immune disorders effortsmust be made to regulate a
dysregulated immune systemto again become an essential
part of our defense systemwhile restoring vitality to af-fected organs and tissues
Our treatment protocol for MS is
designed with various factors in mind:
The possible origins of the dis-
ease, the complications and problemsthe disease may produce, and specic
responses, such as the myelin sheath in
MS and the joints in rheumathoid arthri-tis. Each autoimmune disease normally
has its own most affected tissue or or-gan.
Even though the causes of
degenerative disease are obscure, weconsider that among the more important
ones are the immune system dysregula-tions in which one's own antibodies are
activated against various parts of the
body, such as the myelin sheath in MSor the collagen system. Indeed, since
collagen is an integral part of the con-
nective tissue which is the matrix whichsupports virtually every cell in the body-
we can say that it is universally located in
the body- collagen disease may producesymptoms in virtually every organ in the
body - from the skin to the liver to thekidneys.
Another theory of the origin ofautoimmune disease is that the antibody
response is triggered by viruses and that
in the presence of an altered immunesystem antibodies target tissues in what
are called "cross reactions".
With the increasing evidence
that viruses and/or mycoplasmas maybe "triggers" in these conditions, oxida-
tive agents can play essential roles in
therapy since they attack both.
In our protocols we are interested
in even subclinical infections -as in s uch
commonplace problems as infected
teeth and sinuses. Dysfunctional im
mune systems also allow the proliferation of Candida yeast and other microbia
infestations.
Once a diagnosis is in, oxidative thera
pies become key players since antibiotitherapy is counter-indicated. One of the
most effective of these agents, chlorine
dioxide, can both dismantle the viral omycoplasmic "trigger" and also relieve
the stress that infectious diseases ca
produce on an already overwhelmedimmune system. Ozone, hyperbaric oxy
genation and other oxidative substance
may also help in this process
We are interested insubclinical infections as insuch commonplace chronicproblems as infected teethand sinuses. Dysfunctionalimmune systems also allowthe proliferation of Candidayeast and other microbial
infestations. We also look forsources of toxic substances a
tobacco or mercury llings.
While IBC is not claiming "cure"
in MS or in rheumatoid arthritis,Sjogren's syndrome, lupus and other
autoimmune conditions in which "self"attacks "self" and all of which have re-
sponded favorably to IBC's treatments
its developing track record speaks foritself:
IBC protocols have been utilized,often with signicant results, in autoim-
mune disease in general and multiple
sclerosis (MS) in particular, with con-siderable experience developed in the
latter condition. In fact, over the yearspatients who were unable to walk due to
the deleterious effects of MS have been
able to regain that function.
Lives are lengthened, symptoms
are mitigated, suffering declines orceases, organ function is renewed.
In all autoimmune disorders,efforts must be made to regulate a dys-
regulated immune system as well asrestoring vitality to affected organs and
tissues.
Cytokines in rheumatoid arthritis
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Autoimmune degenerative diseases
Optimal nutrition is providedas an important part of
the protocol. A key part inreversing the symptomsand restoring the normal
functioning of the immunesystem is provided by
essential nutrients that aresystematically depleted in the
so-called "western diet".
Our treatment program includes
providing alternative targets. For ex-
ample, certain snake venom derivativesdeect antibodies from normal tissue.
Several of these natural antigens packsuch a powerful punch that they can
shock and jumpstart the immune system
without any side effects to the host. Beevenom has also been positively used
with the same rationale in mind.
The use of live cell therapy (LCT)
helps reprogram the behavior of the
immune system to avoid the derangedresponse which produces the antibodies.
Since our main objective is to restore thehealth of the immune system, any effort
to restore its normal reactivity and its
ability to differentiate self from non-selfbecomes critical in obtaining a healthier
and long-lasting result.
Live cell therapy also helps repair
damaged neurological cells, joints, or
other organs affected so that symptomsare rst slowed and later reversed.
Optimal nutrition is provided as an
important part of the protocol. A key part
in reversing the symptoms and restoringthe normal functioning of the immune
system is provided by essential nutrients
that are systematically depleted in theso-called "western diet". With healthful
eating in mind as a central part of the
therapy program we start our patients onan intravenous protocol that will ll the
gap in the shortest time possible.
Daily intravenous nourishment
provides the missing or decient miner-als, vitamins, co-factors and essential
nutrients. A gluten-free diet is highly rec-
ommended and a vegetarian-oriented
diet rich in essential fatty acids, particu-
larly omega- 3 fatty acids and vegetable
protein and important phytochemicalssuch as lignans, are the foundation on
which long-term supplementation andlifestyle changes will provide healthy
living.
The treatment program is ac-
companied by a tailored detoxication
regimen and a special dietary program tohelp the body achieve peak performance
in ghting the disease while repairing
damage.
We cannot stress enough the
importance of a serious comprehensivein-house treatment program that can be-
gin changing the course of degenerativedisease. Our program that extends from
10 days to 2 weeks typically addresses
the different areas discussed in order torestore normal responses and behavior
in the immune system as well as heal
damaged tissue.
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Victor Loustaunau, MD
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In the 1980s patients and doctors
alike faced a completely new problem.All of a sudden and without any expla-
nation young people who in other times
would have been considered strong,healthy and very productive became
ill. The new illness did not follow a spe-
cic pattern but rather was a number ofsymptoms that altogether did not seem
to make much sense --at least to theeyes of physicians at that time.
Patients were also disoriented.Young professionals at the top of their
careers fell ill and became tired, de-
pressed, lost interest in all activity andgradually lost their jobs, social status and
even family lives. Worse, medical profes-
sionals failed to diagnose the problemand usual laboratory tests came back
consistently normal.
All this, along with a wide variet
of neurological signs, caused physician
to take the easy way out: The problemis in your mind, you will get over it; you
need a vacation and if all this fails loofor psychological help and take Prozac
they said.
What nobody seemed to unde
stand at the time was that we were facinga new entity, a number of illnesses somehow connected with the failure of the
immune system -- a new dysregulation
of this very important defense mechanism.
With the rst cases at our hos
pital, doctors immediately noticed tha
young, supposedly active people wereundergoing months if not years of partia
disabilities, had lost their goals in life an
evinced a group of signs and symptomnever before seen together in this popu
lation group.
The medical team decided tha
we were facing a new syndrome of greasignicance to which laboratory test
were oblivious.
The AIDS epidemic at the sam
time had brought about signicant inter
est in viral diseases and AIDS itself andherpes became important diagnoses a
the time. At the same time, this new
kid on the block seemed to be relatedto a widespread new and apparentl
unimportant virus: Epstein Barr. One othe clinical advantages about this new
virus was the fact that we already ha
available sophisticated tests to discoveits present level of activity and to deter
mine whether we were facing a new o
old problem.
A GUIDE TOCHRONIC FATIGUE SYNDROME
by Melba Romero, MD
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The new interest in viral testingrapidly brought to light for our physicians
the fact that the new syndrome con-
sistently included an elevation of EBVtiters.
By then the term Chronic Fatigue
Syndrome had been coined and has
remained in place probably because itso accurately describes one of the most
important factors of this illness: periods
of extreme fatigue.
Chronic Fatigue Syndrome (CFS)
is the ofcial name given by the UnitedStates Centers for Disease Control and
Prevention (CDC) for a multifactorial dis-
order that in the USA was not recognizeduntil 1988.
CFS has had several names:
Epstein Barr Virus, Yuppie Flu, Chronic
Fatigue Immune Dysfunction Syndrome(CFIDS) and in many places Myalgic
Encephalomyelitis.
Its signs and symptoms can be
confused with such related conditions
as mononucleosis, thyroid dysfunction,chemical sensitivities, autoimmune dis-
eases and other viral conditions.
This dysfunction seems to be
mainly associated with several viruses.Among the more common are those
within the herpes family (EBV and HHV-
6) and less commonly the Enterovirusesand Retroviruses, but there may be other
infectious agents at work as well, includ-
ing mycoplasmas.
CLINICAL SYMPTOMS
The most important complaint ofthe CFS sufferer is energy loss, trans -
lated into a fatigue that does not improvewith rest, vacation, or entertainment.
This fatigue lingers for long periods of
time, and worsens with time.
Along with the fatigue other
symptoms -- mostly from the neuro-logical sphere-- occur: insomnia, depres-
sion, mood shifts, emotional instability
and personality changes are frequentsymptoms; unexplained sadness or guilt
or feelings of worthlessness and suicidalthoughts are not uncommon.
Other symptoms reflecting achronic, viral condition are frequently
present such as weakness, malaise, joint
pains, recurrent headaches, stomaches,sore throat, low-grade fever, swollen
glands, night sweats, cough and cold
symptoms.
These symptoms, and others,can occur in any combination and at any
intensity. For physicians the world over,
the protean span of signs and symptomsseen in apparently healthy young people
and with no apparent cause made it
frustratingly difcult to come up with asingle diagnosis.
Physicians were often faced withsuch a myriad of disturbances -- diges-
tive problems ranging from belching toatulence to diarrhea or constipation,
together with loss of appetite, and al-
lergy/sensitivity reactions which mightinvolve the skin, eyes, or other organs
and tissues -- that they could not grasp
the idea that they were dealing with asingle syndrome.
A Guide To Chronic Fatigue Syndrome
The easy way out was often asnoted to blame it all on the patients
mental state, write him a prescription
for an antidepressant or sedative, andrecommend psychological counseling.
Probably one of the best diagnos-tic clues for the physician is that CFS pa-
tients feel like they are not themselves.
They feel disoriented, do not understandwhat is going on and desperately seek
an answer.
ORIGIN
Our research suggests that CFShas multiple causes and that either new
or old reactivated viruses or mycoplas-
mas may be playing roles as catalysts
to a preexisting condition of general im-mune impairment, elements of which are
often related to prior or ongoing abuseof steroids, prior or ongoing abuse of
antibiotics (from medications or food),prior or ongoing abuse of recreational
drugs, elevated numbers of mercury
amalgam llings and/or root canals inthe mouth, continual overexposure to
industrial chemicals and/or herbicides/
pesticides, uoridated water, immuniza-tions/vaccinations, continual exposure
to low-level electromagnetic emissions
poor responses to anesthesia or in
compatible prosthetics, elements of thstandard Western diet, prior or ongoing
unresolved bacterial or viral infectionsprior or ongoing parasitical infestatio
and possible genetic predispositions.
One critically important fact ithat immune impairment can frequentl
cross-react with common viruses. Inmany cases an antibody intended to attack a foreign protein may in turn reac
against a normal component of the body
hence creating an autoimmune-like response.
For this reason autoimmun
symptoms and abnormal allergic reac
tions are frequently present. The formeexplain many of the neurological, mus
cular and degenerative symptomata
the later explain the multiple allergieseven the universal reactor syndrome
and many of the digestive problems ou
doctors encounter.
LABORATORY Early in the history of this syn
drome it was discovered that standard
laboratory tests did not provide andiagnostic evidence. This was a majo
setback that caused physicians to be
unaware of an abnormal process goinon. Due to the experience of alternative
physicians in dealing with viral, funga
and yeast infections, it became clear thaone of the major parameters observabl
in CFS was the level of Epstein Barvirus (EBV) titers that became react
vated. Epstein Barr virus is a relativel
widespread virus that is acquired early ilife and, due to the immune system, be
comes dormant for the rest of a health
individuals life.
A Guide to Chronic Fatigue Syndrome
Integrative physicians stressthat the origin of the illness iswithin the immune dysfunctionof the host, or patient -- andthat whatever relief that may
result from an attack on oppor-tunistic infections will be lostif the patients immunological
integrity is not restored.
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When the immune system un-
dergoes dysfunctional conditions, thenormally dormant Epstein Barr virus can
be reactivated, elevating the amount ofantibodies the body produces against it.
The same reactivation occurs with other
viruses such as human herpes-6 virus(HHV-6). It is unclear whether these are
actual causative agents or simply the
effects of an immune dysfunction.
Whatever, the laboratory assess-
ment of antibodies to them reects theongoing immune dysfunction, are factors
suggestive of diagnosis, and may beused to monitor progression or improve-
ment.
Another important tool that is
not only consistent with the syndrome
and for the same reason an importantdiagnostic tool, but also is probably the
most important piece of evidence that
convinced orthodox medicine that CFSis a real disease, is the Single Photon
Emission Computerized Tomography(SPECT) of the brain. This technologi-
cally advanced test conclusively dem-
onstrates dysfunctional brain activity thatimproves as treatment is provided. For
this reason it is a major monitoring test
for the CFS patient.
TREATMENT CONSIDERATIONS
Because of Internationa l BioCare Hospitals prior history in the de-
velopment of individualized, integrativemetabolic protocols, its approach to
Chronic Fatigue Syndrome was not long
in coming and it is based on the followingconcepts:
The illness probably has an im-
munological imbalance in which someof the following can play a role, in no
particular category of importance: Over-administration of antibiotics, steroids,
immunizations, mercury amalgam llings;
overconsumption of refined carbohy-drates, chemical additives; environmental
chemicals including cigarette smoke;
uoridated water; agricultural chemicals;hormonal manipulation; exposure to low
level electromagnetic frequencies; and, of
considerable importance, mental stress.
With these considerations inmind, the treatment is based on the fol-
lowing concepts:
Detoxication is a primary fea-ture of any therapy and in the case of
CFS the previous history of exposure
to chemicals, antibiotics, steroids etc.makes detoxification one of the key
factors in its successful treatment. For
the same reason avoidance of toxinsbecomes a major issue. Tobacco smoke,
alcohol, prescription and recreationaldrugs should be a major target of the
life-style manipulation elements in CFS
management.
Dietary manipulation, together
with detoxication, is the foundation of
any treatment intended to restore andbalance immune function. The proper
use of diet can never be overlooked.Food is not only the basis of energy and
building materials but is also the sourceof detoxification elements, immune
substances and balanced intestinal ora
-- all of which becomes the foundationof immune performance and equilibrium.
A healthy body and immune competent
system are unobtainable under poornutritional conditions.
A Guide To Chronic Fatigue Syndrome
Since opportunistic infections
seem to be the most apparent triggers
in many of the symptoms, the treatmentof these conditions becomes a priority:
EBV, HHV-6, mycoplamas, yeasts, and
candida are the most frequent and visibleinfectious elements in this syndrome.
Oxidative therapies are the best choice
for the treatment of these conditions.BI-OX, a powerful oxidative agent, has
become the treatment of choice for them.
BI-OX is a broad-spectrum antimicrobialoxidative agent which attacks all cell
wall-decient structures -- virtually allviruses, yeast/fungal species, various
bacteria and mycoplasma.
Ozone therapy has also been
very powerful in the treatment of theseproblems, together with the irradiationof blood with ultraviolet (UV) light. Ultra -
violet irradiation has a well-documented
antimicrobial effect.
An integrative approach uti-lizes all forms of attack against a broad
spectrum of microbes, yeasts and viral
infestations so strongly present in im-mune disturbances in general and CFS
in particular.
Integrative physicians stress tha
the origin of the illness is within the immune dysfunction of the host, or patien
-- and that whatever relief that may resufrom an attack on opportunistic infection
will be lost if the patients immunologica
integrity is not restored.
Hence, immune restoration is thmajor long-term objective for the CFSpatient. The attempt to regulate immun
function without detoxication, dietar
management and relief from pathogeninfestations will fail. Since mental stres
is increasingly and demonstrably seen tbe playing an important role in immune
regulation it must also be addressed
the patient is to have lasting results anfull recovery.
Recent research reveals thamost immunologically disturbed pa
tients are neither classically immune
depressed nor autoimmune-stimulatedrather, they are suffering the highs an
lows of dysregulation of the variouelements of what is called the immun
system.
Modern biochemical researc
also has made it clear that a vast rang
of nutriments and supplements -- vitamins, minerals, enzymes, amino acids
essential and nonessential fatty acids
phytochemicals, herbs-- are of positivbenet in either specic or nonspeci
immune regulation. Many nutritional elements classed as antioxidants or free
radical scavengers also exert a balanc
ing effect on immunity.
A Guide to Chronic Fatigue Syndrome
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Fetal cell extracts (live cell thera-
py) or their derivatives have been widely
used to balance the immune system.Beginning in the 1930s the late Paul
Niehans MD in Switzerland began usinganimal fetal tissue to produce overall
health benets in chronically ill and older
patients.
Modern cell-extraction and pres-ervation techniques have helped makelive cell treatments highly successful
in immune system augmentation. The
availability of such tissue-specic ex-tracts such as those from the thymus
gland is also of great help in the long-term management of CFS. Research
continues in these areas and under-
scores the importance of integrative andindividualized treatments -- an approach
which continues to lengthen our list of
successfully managed cases.
EXPECTED OUTCOME
A multifactorial program con-taining elements of the above --tailored
for the individual case-- can expect toachieve dramatic decreases in patho-
logical symptoms in a short period of
time. However, reduction in symptoms
is not the cure of a multifaceted syn-
drome of so many parts. Restoration ofimmune and endocrine balance is a long-
term challenge and can only be achieved
through adherence to a program ofproper diet, nutrition, supplementation
and proper lifestyle.
A Guide To Chronic Fatigue Syndrome
Our experience with CFS and re-
lated disorders is that the great majority
of patients show immediate short-termimprovement; smaller numbers improve,
relapse and improve again. CFS remainsthe most unpredictable and highly indi-
vidualized of chronic conditions.
The successful treatment of this
condition demands from the patient acommitment to intensive treatments,many hospital stays followed by an
at-home program accompanied by
discipline and a commitment to createa new lifestyle and improved health.
The do-it-yourself approach is usuallywasteful, expensive, frustrating and
unsuccessful.
At the present time, the innova-
tive, integrative, individualized program
synthesized here is securing the bestresults, and is optimistically aimed at
greater success in the future against an
awesome foe which has mostly bafedstandard medicine.
The nal determinati on of the
value of this form of treatment in any
particular case will be the interaction ofdoctor and patient and correct evalu-
ation of patient clinical and laboratory
ndings.
ULTRAVIOLET BLOODIRRADIATION PROGRAM
History, rationale and clinicaconsiderations of photoluminescence
by Victor Loustaunau MD
With over half a century as avaluable therapeutic weapon, exten-sive research reported in voluminousliterature around the world describesthe effects of ultraviolet blood irradia-tion on toxins, oxygenation and viri-cidal, bactericidal, and inammatoryconditions.
UV Blood Irradiation (UBI)was rst introduced in the 1930s tocombat the polio virus, but the adventof antibiotics and the Salk vaccineminimized its use. The new viral epi-demics and failure to treat a number
of conditions have brought back thepossibility of alternative forms oftherapy for these conditions. Chronicfatigue syndrome, hepatitis C, bacte-rial infections resistant to antibioticsand even such conditions as cancerhave shown good results with the useof UBI.
UBI is the controlled application oUV irradiation to the blood within thaccepted therapeutic UV band.
Applying ultraviolet rays directly to a patients blood was originally conceived as a method of utilizing the bactericidal properties of the
rays in the treatment of blood streaminfections. Recent developments inthe use of UV have led to a wellcontrolled procedure that produceexcellent results with virtually noside effects. Proper instrumentatioand training provide clinical resultin an inexpensive, fast and reliableprocedure.
The method of applying UVrays to the blood began in 1925 witha system that allowed circulation o
a minimum amount of blood out othe body through a device enablingthe operator precise control. Experimental work with dogs infected withdifferent highly infective bacteriaproved very effective and free of sideeffects.
The polio epidemic providea new opportunity for this methodIt developed rapidly and extensiveluntil immunizations eradicated it.
The method also ourishedin the 1930s when people dying ountreatable infections responded tothe therapy.
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Clinical effects and applications:
The effect of UV radiation onthe blood has been recognized and
well researched around the world.Probably the best known applicationsof UV irradiation are in the treatmentof infectious processes such as bac-
terial and viral infections. This is ofconsiderable signicance because ofthe presence of new bacterial groupsthat are resistant to classic antibiotictherapy. And there are viral epidem-ics that threaten younger groups ofpeople for whom alternatives are few.To mention a few: chronic fatiguesyndrome, hepatitis C, bromyalgia,encephalitis, and herpes infections,all of which respond to this therapeu-tic program.
UV irradiation has an im-portant detoxifying action that hasproven very important in chronicdegenerative diseases. Another im-portant effect is in peripheral vasodi-latation that increases blood ow inapproximately 75% of patients. Thiseffect, together with the increase of
blood oxygen by about 20%, meansthat chronic circulatory conditionscan be improved with minimal risk.Since this procedure involves nokidney damage whatsoever, diabeticchronic circulatory problems andolder people can easily be treated.Peripheral arteriosclerosis and evengangrene can be treated as well.
Criteria for entering the UV bloodirradiation program:
Patients who should benetclearly from this program are thosewith infectious processes resistantto antibiotic therapy, chronic viralconditions such as chronic fatiguesyndrome, hepatitis C, and HIVrelated conditions. We also targetthis therapy for people with chronicinammatory illnesses, chronic de-generative diseases and certainforms of cancer. Other targets arepoor circulatory conditions whereblood ow is poor and more aggres-sive techniques such as chelation oreven vascular manipulation could im-
ply a health risk to the patient. Olderpatients with vascular conditions andlower immune performance are alsogood candidates for this treatment.
Final considerations:
Ultraviolet irradiation of theblood is a valuable treatment tool thatmay prove to be an important alter-native in the treatment and manage-ment of difcult chronic infectious,inammatory processes and a num-ber of degenerative conditions wherehigher oxygenation levels and betterimmune performance are required.
Ultraviolet Blood Irradiation
HEPATITIS CTHERAPY PROGRAM
The integrative, complementary approac
by Javier Vazquez, MD
Hepatitis C is a viral illnessarising from contact with the virus,most often from blood transfusions.This infection is responsible for achronic illness that affects the liver.Infection with the Hepatitis C virus
(HCV) is a leading cause of chronicliver diseases worldwide. The mostremarkable and alarming aspect ofHCV infection is its high rate of viralpersistence and its ability to inducechronic liver disease.
Chronic Hepatitis C is diag-nosed clinically due to generalized
nonspecic symptoms such as fa-tigue, low grade fever, u-like mal-aise, abdominal fullness, digestiveproblems, indigestion, and a chronicdull pain in the liver area. Clinicaldiagnosis is often difficult at thebeginning because symptoms canmislead the physician to consider
other infectious problems or diges-tive disturbances. Conrmation ofthe diagnosis in the laboratory occurs
when there is a persistent elevation inserum transaminases in the presencof HCV antibodies. If these tests arequivocal and the disease is highly
suspected, viral load (HCV-RNA detection by PCR) may be conrmatoryIn many cases a liver biopsy may benecessary.
One of the primary goals oany therapy is stopping and ultimateleliminating the viral infection. Alongwith these therapies, a program tosupport liver function and the patients immune responsiveness wibe of great importance, particularlsince enhanced immune activity iable to arrest other forms of virahepatitis infections.
Oxidative Therapies are
the easiest procedures. This oftenimplies the use of BI-OX intravenously during a treatment period oabout 20 days. BI-OX is a moleculethat will release free oxygen into thblood when injec