Download - Embriologi Musculoskeletal (29 Mei 2012)
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EMBRIOLOGI MUSKULOSKELETAL
dr. Rohmania Setiarini
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Muskuloskeletal →otot rangka, tulang, kartilago
Mesoderm>>>, krista neural (neural crest)
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Perkembangan Mesoderm•Lapisan primitif→lapisan msoderm•Mesoderm ekstraembrionik →connecting stalk
•Mgg ke 3 → mesoderm bersegmen•Neural plate →neural groove & lipatan
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Perkembangan Mesoderm•Mesoderm paraksial membentuk somit (1 somit/90mnt)•Intraembrionik coelom terbentuk,memisahkan mesoderm somatik dan splanchnic
•Neural groove berdifusi mbentuk neural tube•Somit terus terbentuk•Krista neural (neural crest) bermigrasi ke mesoderm
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Perkembangan Somit•Mesoderm disamping notocord menebal & membentuk mesoderm paraksial
•Mesoderm paraksial mulai bersegmen & membtk somit pertama•Somitocoel akan hlg saat somit matur
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Perkembangan Somit
•Sel somit berdiferensiasi membtk sclerotome (kolumna vertebralis) & dermomyotom (kulit & otot)
•Dermomyotom membtk dermatom (dermis) & miotom (otot)
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Perkembangan Somit
•Myotom berdiferensiasi membentuk epimer dan hipomer →otot epaxial (otot ekstensor leher, panggul, otot transversa spinalis)dan hipaxial (tungkai & lengan, sebagian besar badan, diafragma)•Mgg 5
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Perkembangan Limb
•Otot hipaxial berdifusi dlm kuncup pembentukan otot mjd myotube →sel otot skelet
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Tahap Carnegie
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Stage
Days (approx)
Size (mm)
Images Events
1 1 (week 1)
0.1-0.15
fertilized oocyte, pronuclei
2 2 - 3 0.1-0.2
cell division with reduction in cytoplasmic volume, formation of inner and outer cell mass
3 4 - 5 0.1-0.2 loss of zona pellucida, free blastocyst
4 5 - 6 0.1-0.2 attaching blastocyst
5 7 - 12(week 2) 0.1-0.2 implantation
6 13 - 15 0.2extraembryonic mesoderm, primitive streak
7 15 - 17 (week 3) 0.4 gastrulation,
notochordal process
Carnegie Stage Table
Carnegie Stage Table
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8 17 - 19 1.0 - 1.5 primitive pit, notochordal canal
9 19 - 21 1.5 - 2.5Somite Number 1 - 3neural folds, cardiac primordium, head fold
10 22 - 23 (week 4) 2 - 3.5 Somite Number 4 - 12
neural fold fuses
11 23 - 26 2.5 - 4.5 Somite Number 13 - 20rostral neuropore closes
12 26 - 30 3 - 5 Somite Number 21 - 29caudal neuropore closes
13 28 - 32 (week 5) 4 - 6
Somite Number 30leg buds, lens placode, pharyngeal arches
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14 31 - 35 5 - 7 lens pit, optic cup
15 35 - 38 7 - 9 lens vesicle, nasal pit, hand plate
1637 - 42
(week 6)
8 - 11nasal pits moved ventrally, auricular hillocks, foot plate
17 42 - 44 11 - 14
finger rays
1844 - 48
(week 7)
13 - 17
ossification commences
19 48 - 51 16 - 18
straightening of trunk
2051 - 53
(week 8)
18 - 22
upper limbs longer and bent at elbow
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21 53 - 5422 - 24
hands and feet turned inward
22 54 - 56 23 - 28
eyelids, external ears
23 56 - 60 27 - 31
rounded head, body and limbs
Following this stage Fetal Development occurs until birth (approx 40 weeks)
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Otot Rangka
Mesoderm paraksial Mgg 5, myotom→ epimer (disarafi ramus
dorsalis) & hipomer (disarafi ramus ventralis)
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Tulang
lateral plate mesoderm generates the limb skeleton,
the cranial neural crest gives rise to the branchial arch and craniofacial bones and cartilage
Ada 2 osifikasi: Endokondral Intramembranosa
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Tulang
Osifikasi endokondral Tulang panjang Kartilago→ osteoblas →osteosit Osifikasi primer →diafisis (hipertrofi, kalsifikasi
matriks, kematian sel-selnya) Lahir →>>diafisis telah mengalami osifikasi,
epifisis msh berupa kartilago
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Tulang
Osifikasi intramembranosa Tulang pipih Osifikasi dlm membran mesenkim Mesenkim proliferasi →osteoblas →osteosit Osteoblas di perifer →penebalan perifer Osteoklas di tengah →penipisan
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Tengkorak : neurokranium dan viscerokranium (wajah).
Neurokranium bagian membranosa →kubah kepala bagian kartilaginosa (kondrokranium)
membentuk dasar tengkorak. Sel-sel Krista neuralis membentuk wajah,
sebagian besar batok kepala, dan bagian prekordal kondrokranium (bagian yang terletak di sebelah rostral notokord).
Mesoderm paraksial membentuk bagian tengkorak sisanya
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Kartilago
Sel mesenkim →kondensasi, proliferasi, diferensiasi →kondroblas →sekresi kolagen & matriks →kondrosit →terus mensekresi matriks →kartilago memanjang
Sel mesenkim perifer →fibroblas→ perikondrium (jar ikat kolagen)
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PrAy 23
TERIMAKASIH