Download - Drug-Induced Liver Injury
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DRUG-INDUCED LIVER INJURYAndi As’ad Mubarak
10542016710
Pembimbing : dr. Zakaria Mustari, Sp.PD
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Introduce
Drug-induced liver toxicity is a common cause of liver injury
It accounts for approximately one-half of the cases of acute liver failure and mimics all forms of acute and chronic liver disease.
An estimated 1000 drugs have been implicated in causing liver disease
Drug-induced liver injury subsides after cessation of treatment with the drug
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Clasification of DILI
Hepatotoxicity can be classified as
Predictable
Unpredictable
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This form is dose related. has a high incidence. and occurs with a short latency (within a few days).
The classical example of predictable drug toxicity is paracetamol.
Predictable
Clasification of DILI
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Clasification of DILI
Unpredictable occur with variable latency (1 week to 1
year or more), with low incidence, may or may not be dose related.
The classical example of unpredictable drug toxicity is fenitoin and isoniazid
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Other Clasification
1)immune mediated (allergic) 2) non-immune mediated (non- allergic)
* This immunemediated, drug-induced hepatitis is usually characterized by fever, eosinophilia, or other allergic reactions taht distinguish it from non-immune mediated drug-induced hepatitis
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Pathogenesis
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Clinical and Pathological Symptoms
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Risk Factor
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Assessment
Drug-induced liver diseases mimic all forms of acute and chronic hepatobiliary diseases
Most instances of drug-induced liver disease are unpredictable, and symptoms occur either with intermediate or long periods of latency before onset.
Alanine aminotransferase (ALT) dan Alkali Fosfatase, routine monitoring of ALT levels
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Conclusion
Drug-induced liver disorders occur frequently, can be life threatening, and mimic all forms of liver disease. However, except in rare cases of drug-induced chronic hepatitis and vanishing bile duct disease, the liver injury subsides and the adverse event disappears after the cessation of treatment with the drug.
The liver is a particular target for drug toxicity because of its role in clearing and metabolizing chemicals.
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Thank You