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DISTURBANCES
OF LIPID METABOLISM
NATIONAL UNIVERSITY OF PHARMACY
DEPARTMENT OF PATHOLOGICAL PHYSIOLOGY
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PLAN OF LECTURE1. Lipids: characteristic, types, functions.
2. Types of disturbances lipid metabolism.
3. Obesity: classification, signs, implications.
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Questions of Independent
work
1. Disturbance of acid-base equilibrium. The concept of
acidosis and alkalosis: the causes, types, principles of
correction.
2. Violation of phosphorus-calcium metabolism. Disturbance
of microelement exchange.
3. The concept of basic and energy exchanges.
Infringement of power supply of a cell: the reasons,
consequences.
4. Starvation: causes, types, consequences. The concept of
curative starvation.
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Suggested Reading
Basic1. General and clinical pathophysioilogy/ Editer by Anatoliy V. Kubyshkin. – Vinnytsa : Nova
Knyha Publishers, 2016. – 656 p.
2. Lecture notebook pathological physiology. Manual for working in lectures / N.M. Kononenko, S.I. Kryzhna, V.A. Volkovoy at al.; Kh.: NPhаU, 2013. – 99 p.
3. Pathological Physiology: The textbook for the students of higher pharmaceutical educational institutions and pharmaceutical faculties og higher medical educational institutions III-IV levels of accreditation / S/I/ Kryzhna, N.M. Kononenko, I.Yu. Tishenko et al.: under edition of the professor A.I. Bereznyakova. – Kharkiv: NphaU, 2006. – 416 p.
Auxiliary
1. Professional guide to Pathophysiology / M.H. Birney, C. L. Brady, K.T. Bruchak et al. – Lippincott Williams and Wilkins. – 2002. – 696 p.
2. Crowley L.V. An introduction to human disease: pathology and pathophysiology correlations / L.V. Crowley . – London : Lones and Bartlett Publishers International Bard House. 2001. – 790 p.
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- disorders of the digestion, absorption and
excretion of fats;
- disorders of transport lipids and moving it into
the tissue;
- excessive accumulation of fat in the organs of
non-adipose tissue (fat infiltration and fatty
dystrophia);
- disorders of intermediate metabolism of
lipids;
- disorders of fat metabolism in adipose tissue.
DISORDERS OF LIPID METABOLISM
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Disorders of the digestion,
absorption and excretion of
fats
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Steatorrhea is presence of excess fat in feces
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Disorders of transport fat and
moving it into the tissue
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Disorders of transport fat and
moving it into the tissue
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Types of hyperlipemia:
• alimentary (after eating);
• transport (moving fat from depot to the liver as result
impoverishment of the liver in glycogen (starvation, diabetes
mellitus, stress);
• retentional (a consequence of delays fat in the blood)
HYPERLIPEMIA
It is increase of level of fats in the blood more than 4-8 g/l.
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Excessive accumulation of fat
in the organs of non-adipose
tissue
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Arriving in the tissue fats are oxidized or deposited.
If accumulation occurs outside the cells of adipose tissue,
we speak of fatty infiltration.
The combination of infiltration with disruption of the
structure of the protoplasm of cells is defined as fatty
dystrophia.
FATTY INFILTRATION AND FATTY
DYSTROPHIA
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The most commonly develops in the fatty dystrophia of
the liver, myocardium, kidney, and accompanied by the
following diseases and conditions:
- diabetes,
- chronic alcoholism,
- starvation,
- obesity,
- intoxication.
FATTY INFILTRATION AND FATTY
DYSTROPHIA
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Products of intermediate metabolism of higher fatty acids
are:
- acetone
- acetoacetic acid
--hydroxybutyric acid
They are formed in the liver and are oxidised to CO2 and
H2O in other organs: lungs, muscles, kidneys.
Normally amount of ketone bodies in the blood is 0.02-
0.04 g/l
ketone bodies
Disorders of intermediate
metabolism of lipids
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OBESITY
Obesity is abnormal or excessive fat
accumulation in adipose tissue.
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Classification of obesity by
mechanism of development
- alimentary;
- cerebral (trauma, brain tumors);
- endocrine (the Cushing’s syndrome,
hypothyroidism);
- hereditary.
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Classification of obesity depending
on the number of adipocytes and
their size
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Classification of obesity by
external manifestations
• symmetrical type (uniform-distribution of fat);
• upper (face, head, neck, upper body);
• medium (in the stomach in the form of an apron);
• lower (in the hips and legs).
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Obesity classification
according fat distribution
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I degree - 20-29%;
II degree - 30-49%;
III degree - 50-59%;
IV degree - 60% or more.
Obesity classification
according the percentage of
weight gain
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Body mass index = Weigh (кg) / Height (m2)
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