Download - all about cornea
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THE CORNEA
By
MUHAMMED FASAL . ABsc OPTOMETRY
AL SALAMA EYE RESERCH FOUNDATIONPERINTHALMANNA
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THE CORNEATHE CORNEA
GROSS ANATOMY GROSS ANATOMY
Anterior 1Anterior 1/6 of outer coat /6 of outer coat Curved & Domshaped
Fibrous, Transparent & No BVsFibrous, Transparent & No BVs
Diameter : Horizontal 12mmDiameter : Horizontal 12mm Vertical 11mm Vertical 11mm Thickness: Central 0.5 - 0.6mm Thickness: Central 0.5 - 0.6mm Peripheral 0.8 – 1.0mmPeripheral 0.8 – 1.0mm Radius of Curvature : Anterior 8 mm Radius of Curvature : Anterior 8 mm Posterior 7 mmPosterior 7 mm Refractive Index : 1.37 ?Refractive Index : 1.37 ? Refractive Power : 42 D ( what is Diopeter?)Refractive Power : 42 D ( what is Diopeter?)
( What is The LIMBUS ?)( What is The LIMBUS ?)
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5 LAYERS5 LAYERS
(1) Epithelium St. Squamous Nonkeratinised (5-6 St. Squamous Nonkeratinised (5-6
layers)layers) Surface Surface Flat Flat cells (2-3 layers)cells (2-3 layers)
Intermed. Intermed. Polyhedral Polyhedral cells (2-3 cells (2-3 layers)layers)
Basal Basal ColumnarColumnar cells (one layer) cells (one layer)
(2) (2) Bowman’s layer Structure less (Acellular) Structure less (Acellular)
condensationcondensation Never regenerateNever regenerate
Ends as a round borderEnds as a round border
MINUTE MINUTE ANATOMYANATOMY
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(3) THE STROMA (Substantia (3) THE STROMA (Substantia Propria)Propria)
- 90% of corneal thickness- 90% of corneal thickness - C T Bundles ( Regular arrangement )- C T Bundles ( Regular arrangement ) - Bundles of each layer \\ to each other- Bundles of each layer \\ to each other perpendicular to next perpendicular to next
layerlayer - Cells ( present in Lacunae )- Cells ( present in Lacunae ) Corneal corpuscles ( Keratoblasts )Corneal corpuscles ( Keratoblasts ) Corneal metabolism & Corneal metabolism &
HealingHealing LeucocytesLeucocytes Inflammation
(4) DESCEMET’S MEMBRANE(4) DESCEMET’S MEMBRANE Homogenous, Structureless & Highly Homogenous, Structureless & Highly
ElasticElastic Resistant & Easily RegenerateResistant & Easily Regenerate
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CORNEAL ENDOTHELIUMCORNEAL ENDOTHELIUM
One Layer of Polyhedral cellsOne Layer of Polyhedral cellsPartial dehydration of the corneaPartial dehydration of the corneaContinuous with the Endothelium of Continuous with the Endothelium of T MT M
NERVE SUPPLY OF THE CORNEANERVE SUPPLY OF THE CORNEA55THTH C.N C.N
OPHTH. division NASOCILIARY N 2 LongOPHTH. division NASOCILIARY N 2 Long CILIARY NCILIARY N
PAIN & COLD & SUPERFICIAL TOUCHPAIN & COLD & SUPERFICIAL TOUCH
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CORNEAL PHYSIOLOGY CORNEAL PHYSIOLOGY NUTRITIONNUTRITION ( ( cornea is avascular cornea is avascular ))By diffusion By diffusion Tear Film Aqueous humour Limbal capillariesTear Film Aqueous humour Limbal capillaries
CORNEAL TRANSPARENCYCORNEAL TRANSPARENCY ( ( WHY WHY ?? ))Anatomical Factors : Anatomical Factors : Cornea is avascularCornea is avascular Epithelium is nonkeratinizedEpithelium is nonkeratinized Stromal lamellae are regularStromal lamellae are regular Nerves are nonmyelinatedNerves are nonmyelinated Precorneal tear filmPrecorneal tear film
Physiological Factors :Physiological Factors : Corneal dehydrationCorneal dehydration Uniform refractive indices of corneal tissueUniform refractive indices of corneal tissue
FUNCTIONS OF THE CORNEAFUNCTIONS OF THE CORNEARefractive 42 DRefractive 42 DProtective ( corneal reflex )Protective ( corneal reflex )
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THE LIMBUS ( The Corneo-Scleral THE LIMBUS ( The Corneo-Scleral Junction )Junction )
Corneal epithelium Conjuctival Corneal epithelium Conjuctival epitheliumepithelium
Bowman’s membrane ends as a rounded borderBowman’s membrane ends as a rounded border
Substantia propria Sclera (irregular Substantia propria Sclera (irregular lamellae)lamellae)
Descemet’s membrane Trabecular Descemet’s membrane Trabecular meshworkmeshwork
Endothelium Endothelium of the Endothelium Endothelium of the angle of ACangle of AC
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KERATITISKERATITIS KERATOSKERATOS CORNEACORNEA iTiS INFLAMMATIONiTiS INFLAMMATION
SUPERFICIAL KERATITISSUPERFICIAL KERATITIS Suppurative (Corneal Ulcer) Suppurative (Corneal Ulcer) NonSuppurative (Pannus)NonSuppurative (Pannus)
INTERSTITIAL KERATITISINTERSTITIAL KERATITIS Suppurative (Central Suppurative (Central Abscess)Abscess)
NonSuppurative (Diffuse or NonSuppurative (Diffuse or Local)Local)
DEEP KERATITISDEEP KERATITIS Suppurative (Post Abscess or Suppurative (Post Abscess or Ulcer)Ulcer)
NonSuppurative (Keratitis Profunda)NonSuppurative (Keratitis Profunda)
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SUPPURATIVE SUPERFICIALSUPPURATIVE SUPERFICIAL KERATITSKERATITS
(CORNEAL ULCERS) (CORNEAL ULCERS)DEFINITIONDEFINITION Localized Necrosis of Sup. Localized Necrosis of Sup.
StromaStroma with destruction of overlying with destruction of overlying
Epith.Epith.
ETIOLOGYETIOLOGY Predisposing FactorsPredisposing Factors Precipitating FactorsPrecipitating Factors Causative OrganismsCausative Organisms
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Predisposing Predisposing FactorsFactors
LocalLocal a) Traumaa) Trauma - Abrasion - Abrasion ( ( Gono & Diph can invade normal epithelium )
-- FB , Rubbing lashes , PTDs , CLFB , Rubbing lashes , PTDs , CL b) Loss of corneal sensationsb) Loss of corneal sensations c) Ocular causes c) Ocular causes ( ( xerosis, A deficiency, Lagoph.).)
d) Prolonged use of Steroidsd) Prolonged use of Steroids
GeneralGeneral malnutrition Pregnancymalnutrition Pregnancy Diabetes Liver & Renal FailureDiabetes Liver & Renal Failure
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PRECIPITATING FACTORSPRECIPITATING FACTORS
Infection of nearby structuresInfection of nearby structures
CAUSATIVE ORGANISMSCAUSATIVE ORGANISMS
a) Bacterial e.g. Gono, Diphth., Pneumo, a) Bacterial e.g. Gono, Diphth., Pneumo, Staph, Staph, StreptStrept….….
b) Fungal ( not common )b) Fungal ( not common )
c) Viral e.g. Herpes Simplex and Zosterc) Viral e.g. Herpes Simplex and Zoster
d) Acanthamoeba (C.L.)d) Acanthamoeba (C.L.)
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PATHOLOGY OF CORNEAL PATHOLOGY OF CORNEAL ULCERSULCERS
Stage of InfiltrationStage of Infiltration Inflammatory reaction PNLs Grey disc shaped area - Oedema - Ciliary injectionGrey disc shaped area - Oedema - Ciliary injection
Stage of ulceration A) Progressive unclean Stage Necrotic area
ulcer with irregular Edge Necrotic Floor Surrounded by Dense reaction
B) Regressive Clean Stage Large ulcer with regular Edge Deep, Clear, Transparent Floor Less infiltration
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Stage of HealingStage of Healing A) Vascularization Limbal cap. Sup. Vasc. AB & Fibroblasts
B) Fibrous tissue formation
NB :NB :
Epith. Mitosis & Migration
B.M. Never regenerate Permanent scar
Stroma Irregular F.T. Nebula or Leucoma
D.M. Regenerates as an elastic membrane
Endothelium Enlargement and Widening of cells
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CLINICAL PICTURECLINICAL PICTURESymptomsSymptoms Pain Severe ( FB or pricking sensation )Pain Severe ( FB or pricking sensation ) Irritation of nerve endingsIrritation of nerve endings PhotophobiaPhotophobia LacrimationLacrimation BlepharospasmBlepharospasm Diminution of visionDiminution of visionSignsSigns Lids: OedemaLids: Oedema Conj.: Ciliary injectionConj.: Ciliary injection Cornea: Loss of luster, Grey infilt., Cornea: Loss of luster, Grey infilt.,
Oedema & +ve FTOedema & +ve FT Iris: Tender CB, Const. pupil & Iris: Tender CB, Const. pupil &
Aqueous flareAqueous flare
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COMPLICATIONS OF CORNEAL COMPLICATIONS OF CORNEAL ULCERSULCERS
A) Non Perforated corneal ulcer Early Complications (1) (1) 2ry Iridocyclitis : ( Toxins )2ry Iridocyclitis : ( Toxins ) (2) 2ry Glaucoma(2) 2ry Glaucoma : Open angle glaucoma : Open angle glaucoma (3) Descematocele : Small translucent bleb Not seen in children or T hypopyon
ulcer
Late Complications (Healing abnormalities) (1) Corneal opacity ( Nebula, Macula or Leucoma non adherent
) (2) Corneal Facet : rapid healing of the epith.
(3) Keratectasia : ( weak corneal scar & IOP )
(4) Pseudoptregium
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B) COMP. OF PERFORATED CORNEAL B) COMP. OF PERFORATED CORNEAL ULCERSULCERS
Early Complications
(1) Iris Prolapse ( Big Para central or periph. Perforation )
(2) Anterior synechia ( Small periph. Perforation)
(3) Corneal Fistula ( Small central perforation ) Lost AC IOP River Green Sign
(4) Malposition of the Lens Sublaxation Ant. Dislocation Extrusion
(5) Intra-ocular Hge Hyphema Vit., Ret. And choroidal hges
(6) Macular and Optic Disc Oedema
(7) Endo or Panophthalmitis
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Late complications
(1) Ant.Polar Cataract (Toxins )
(2) Leucoma Adherent ( Large Peripheral Perforation )
- AC irregular - Pupil pear shaped - IOP may be high - may be pigmented
(3) Ant. Staphyloma ( partial or total )(4) 2ry Glaucoma (closed angle by PAS )(5) Atrophia bulbi ( atrophy of the cil. processes )
B) COMP. OF PERFORATED CORNEAL ULCERS B) COMP. OF PERFORATED CORNEAL ULCERS (cont.)(cont.)
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MANAGEMENT OF CORNEAL MANAGEMENT OF CORNEAL ULCERSULCERS
INVESTIGATIONS + TREATMENT
A) Corneal Scrapping ( Culture & Sensitivity ) Gram Stain for Bacteria Geimsa Stain for Trachoma & Acanthamoeba Silver Stain for Fungi
B) Local ttt (1) Atropine sulphate 1% (3) Bandage or Dark Glasses (4) Counter irritant (2) Dressings ( Antibiotic dps & oint )
C) Systemic ttt Antibiotics Analgesics Vitamins A & C
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D) Treatment of Complications
(1) 2ry Glaucoma Usual ttt Antiglaucoma ttt
paracentesis
(2) Descematocele Bilateral Bandage or C L Avoid Straining Antiglaucoma ttt Hood Flap PKP
(3) Perforation Small CyanoacrylateTissue
Adhesive Large Hood Flap or PKP
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E) Treatment of Corneal Opacity
Central Nebula Glasses or CL Eximer Laser Lamellar KP Leucoma PKP In blind eye CCL Tattoo
Treatment of Resistant CU
Scrapping for Culture & Sensitivity Debridement Cautery Chemical Physical S.C. injection of AB Conjunctivoplasty Therapeutic KP (Lamellar or Penetrating)
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CORNEAL ULCERSCORNEAL ULCERSPrimary Corneal Ulcers - Infected Corneal ulcer Hypopyon Ulcers
(Bacterial) Herpetic Ulcers (Viral) Mycotic Ulcers (Fungal) Acanthamoeba K
(Protozoa)
- Non-Infected Corneal ulcer Mooren’s Ulcer Keratomalacia Atheromatous Ulcer Ulcer with Lagophthalmos Neuroparalytic Ulcer Traumatic Ulcer
Secondary Corneal Ulcers
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HYPOPYON ULCERHYPOPYON ULCER Predisposing Factors Causative Agents:
Pneumococci ( 80% ) Typical HU Morax Axenfield Bacillus (10%) Streptococci, Staphylococci, Pseudomonas and Fungi
Clinical Picture
Symptoms Pain Photophobia
Lacrimation
Blepharospasm Poor vision
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Signs ( Acute Serpiginous ulcer ) - Haziness of the cornea ( loss of luster ) - Ciliary injection - Ulcer Near the centre Central advancing Edge
Crescentic, undermined, preceded by dense infiltration
Peripheral Healing Edge Flat, Epithelialized, Vascularized
- Posterior Abscess : Dense infiltration in front of D M
- Flourescein Test is +ve - Hypopyon in the Anterior Chamber
( Steril Pus ) PNL +Fibrin +Iris Pigment
NB Perforation is common…why? Desematocele is Rare
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Treatment of Hypopyon Treatment of Hypopyon UlcerUlcer
Treatment of the cause ( Dacryocystectomy)
Usual ttt of corneal ulcer ABCD Subconjunctival Injection of AB Cephazoline ( 100mg in 0.5 ml ) Tobramycin or Amikacine ( 20mg in o.5 ml )
Fortified Eye Drops Gentamycine or Tobramycine 15mg/ml.
Treatment of 2ry Glaucoma Cautery in Resistant Cases ( Pure
Carbolic A )
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Atypical Hypopyon Ulcer
Pyogenic organisms other than Pneumococci (20%)
Common in children with increased resistance
The Ulcer : Anywhere in the cornea Not Serpiginous, spreads in
all directions Perforation is less common Desematocele may occur
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Fungal UlcerFungal Ulcer
Predisposing Factors Trauma with green plant Use of Steroids Contact Lenses
Causative Agent Fusarium ( Filamentary fungi ) Candida ( Yeast forming fungi ) Aspergillus
Clinical Picture Little or no ciliary Injection Raised, dry, grey white lesion with feathery margins Satellite lesions Stromal deep infiltrate Endothelial plaques Hypopyon
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Treatment Treatment
Usual ttt Topical Antifungal ttt Natamycine 5% Miconazole 1% Amphotericin B o.3% Systemic Antifungal ttt Ketoconazole 400mg/day Fluconazole 400mg/day ( In cases of deep Keratitis or failure of
topical ttt ) Surgical ttt (PKP)
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Acanthamoeba keratitisAcanthamoeba keratitis Aetiology Protozoa ( Tap water and Swimming pools ) 70% of cases are C L wearers Clinical Picture Punctate or Dendritic K Superficial Stromal K Partial or Complete ring of Infiltration Limbitis and Scleritis Treatment Debridment Topical ttt Diamidines (Propamidine) Biguanides (Chlorohexidine 0.02%) Aminoglycosides (Neomycin) Antifungal (Miconazole and Ketoconazole)
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Dendritic Corneal UlcerDendritic Corneal Ulcer
Herpes Simplex Virus ( Epitheliotropic ) 1ry infection in early childhood Dormant in 5th Ganglion Recurrence with body resistance
Predisposing factors Fevers (Influenza, Common cold and
Pneumonia) Menstruation Drugs ( Immunosuppressive drugs or Steroids)
Clinical Picture 1ry Ocular infection Dermato-blepharitis Follicular Conjunctivitis Epithelia Keratitis
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Recurrent Ocular Infection (C/P of H. Keratitis)
(A) Blepharoconjunctivitis (as 1ry infection)(B) Epithelial Keratitis Symptoms : as those of corneal ulcer Signs : A) SPK B) (Characters of Dendretic Herpetic Corneal Ulcer) Dendritic appearance
Long course with tendency to Recurrence Superficial ( never perforate except in … ) Never Vascularised Hypothesia Double Stain Test
C) Amoeboid Ulcer due to immunity or local Steroids
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C) C) Stromal Keratitis (cell mediated immune reaction)
Interstitial Keratitis (unifocal or multifocal) Disciform Keratitis (stromal inf. and epithelial odema
+kps) Necrotizing Keratitis Severe and rapidly progressive Overlying ulceration eccentric to
infiltration -ve double stain Vascularisations
D) Herpetic Iridocyclitis
Complications Toxic punctate epithelial erosions (Antiviral
drugs) Keratitis Metaherpetica Neurotrophic Keratitis
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Treatment of Herpetic Epithelial Treatment of Herpetic Epithelial KeratitisKeratitis
Local Antiviral Drugs Acyclovir ( Zovirax ) 3% eye ointment 5 times/day TFT ( Tri-Fluro-Thimidine ) eye drops Ara-A ( Vidarabine ) eye ointment IDU ( Iodo-deoxy-uridine ) eye dropsNB Corticosteroids are contraindicated
Treatment of Stromal H Keratitis Topical Corticosteroids Prophylactic Antiviral drugs
Treatment of resistant cases Debridement ( to remove infected cells ) Cautery by Tinct. Iodine 7% in alcohol (kill the
virus) Therapeutic L K
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Herpes Zoster OphthalmicusHerpes Zoster Ophthalmicus
Varicella-Zoster Virus Neurotropic Virus Old age - ImmunityClinical Picture : Lids : Dermatoblepharitis ( pain and rash )
Keratitis : ( Hutchinson’s rule ) Epithelial Keratitis ( Punctate or dendritic ) Interstitial Keratitis
Scleritis
Iris : 2ry iridocyclitis
IOP : 2ry glaucoma
Choroid : Focal choroiditis
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Clinical Picture of H Z Ophthalmicus Retina : retinal vasculitis,detachment and necrosisOptic Nerve: Papillitis or Retrobulbar neuritis
Orbit : Orbital oedema and Proptosis
EOM : Paralytic Squint (3rd N. palsy)
Treatment: Acyclovir tab. 800mg 5 times/
day for 7 days Steroids + Antibiotic skin oint. Steroids + Antibiotic eye drops Analgesics
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Ulcer with LagophthalmosUlcer with Lagophthalmos
A primary ulcer in the lower 1/3 of the cornea Bell’s phenomena Symptoms as usual corneal ulcer ( of vision is not
marked..why?)
Signs Incomplete lid closure Ciliary injection & +ve flurorescein Ulcer in lower 1/3 with straight upper border
Treatment Usual ttt Methyl cellulose drops 0.5% several
times/day ttt of the cause
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KeratomalaciaKeratomalacia Non infective ulceration and melting of the cornea Vitamin A (malnourished infants or malabsorption in adults)
Clinical Picture Loss of corneal luster Appearance of yellow dots (deg. Epithelium) Melting of the cornea No inflammatory reaction (quite eye) Corneal hypothesia Conjunctiva: dry with Bitot’s spots 2ry infection Endophthalmitis
Treatment Vit. A injection (200,000 IU/day) ttt of hypoproteinemia ( fresh plasma) Topical vit. A in early cases Surgical ttt in late cases : Conj. Flap Therapeutic CL PK
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Neurotrophic (Neuroparalytic) Neurotrophic (Neuroparalytic) KeratitisKeratitis
Corneal Sensation
Aetiology Herpes Zoster Radical ttt of 5th Neuralgia ( Alcohol inj.) Damage of Orbital Ns (SOF & OA syndromes)
Clinical Picture Symptoms No pain vision (central ulcer) Signs Epithelial exfoliation starts at the
center Large deep ulcer perforation
Treatment Usual ttt of corneal ulcer Long term Bandage Tarsorraphy ( median )
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Traumatic Corneal ulcerTraumatic Corneal ulcer
Trauma + 2ry Infection
Trauma External: wounds, chemicals, burn & FB
Local: Lash, PTD & PTC
Treatment Usual ttt + ttt of the cause
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Mooren’s Ulcer ( chronic Mooren’s Ulcer ( chronic serpeginous ulcer )serpeginous ulcer )1ry non infective corneal ulcerRareCommon in old age
Aetiology ( unknown ) Limbal vasculitis Proteolytic enzymes necrosis of sup. layers Autoimmune diseaseSymptoms 12345
Signs Marginal grey infiltration Crescentic Ulcer Advanced edge ( undermined and creeps toward the center ) Healed edge ( Peripheral and vascularised ) Thin cornea Extension is slow and perforation is rare
Treatment Usual ttt + Topical Steroids Topical Cyclosporine Conj. Excision // to the ulcer Lamellar keratoplasty Systemic Steroids & Immunosuppressive drugs
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Atheromatous Corneal UlcerAtheromatous Corneal Ulcer
Occurs on top of an old Leucoma
Hyaline degeneration with desquamation and 2ry infection
Resistant with bad healingCommonly perforates due to 2ry infectionTreatment Usual ttt Conjunctival flap Keratoplasty
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Secondary Corneal Ulcers Secondary Corneal Ulcers Ulcers 2ry to MPC Marginal, Crescentic and Superficial ( Rare )
Rapid healing
Ulcers 2ry to Gonococcal Conjunctivitis Marginal ulcer : Most common Ring ulcer : Multiple
marginal ulcers Central and paracentral ulcers : usually perforate
Trachomatous Ulcers A) Typical Shape Horizontal
Site In front of pannus Superficial Secondary infection is common Scarred by facet ( Healing )
B) Marginal, Central and Paracentral: not related to Pannus
C) Mechanical: PTDs or Rubbing lashes
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2ry Corneal Ulcers2ry Corneal Ulcers
Phlyctenular Ulcers
A) Limbal ulcer: ( ulcer of limbal phlycten ) Deep, when perforate peripheral
Leucoma Adherent
B) Ring ulcer: multiple phylectens
C) Fascicular ulcer: Superficial
Starts near the limbus Creeps to the center followed by leash
of B.V.
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INTERSTITIAL KERATITISINTERSTITIAL KERATITIS
Non Suppurative iflammation of the Stroma + Uveitis
Aetiology Delayed hypersensitivity to infectious
organism - Syphilis, T.B., Leprosy
- Herpes Simplex and Zoster, Measles and
EBV (infectious M.) Types (1) Diffuse I.K.
(2) Dsciform Keratitis
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Syphilitic Interstitial Keratitis
Congenital Syphilis ( 95% ) 5 – 15 Years Bilateral Hutchinson’s triad ( I.K., Hutchinson’s teeth and
Deafness ) Acquired Syphilis ( 5% ) 10 years after 1ry infection
Unilateral Uveitis and Retinitis
Symptoms Pain, photophobia, lacrimation, redness and vision
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Signs of Syphilitic I.K.Signs of Syphilitic I.K.
( 1 ) Progressive Stage ( 2 weeks ) Severe infiltration ( haze ) + Vascularization Salmon patches ( reddish pink ) Ciliary injection ( 2 ) Florid stage ( 2 months ) Marked symptoms and signs vision up to HM ( 3 ) Regressive stage ( 2 years ) Residual interstitial corneal opacity Obliterated BV fine opaque lines Uveitis
Investigations +ve Wassermann reaction
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Treatment of Syphilitic I.K.Treatment of Syphilitic I.K.- Antisyphilitic ttt ( Penicillin )- Atropine - Steroids- Keratoplasty for residual opacity
DISCIFORM KERATITIS Antigen antibody reaction ( viral antigen ) H.S. & H.Z. Grey disc-shaped dense opacity Loss of corneal sensation Drop of vision Treatment Corticosteroids + Antiviral drugs Tarsorraphy
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Keratitis profunda
Localised non suppurative deep KeratitisAetiology Allergic reaction to chronic infections e.g.
TB Herpes Simplex or Zoster Trauma Idiopathic
Clinical Picture Diffuse deep Keratitis Iridocyclitis
Posterior Abscess and Ulcer Diffuse suppurative deep Keratitis Congenital, HU, Trauma, IK and endogenous
with TB and S.
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Degenerative ConditionsDegenerative Conditions
ARCUS SENELIS Bilateral peripheral Fatty degeneration
Common in old age
Symptoms non
Signs Arc shaped opacity in the upper ½ of cornea then lower ½
Clear zone between the opacity and Limbus (Lucid interval of vogt)
Outer border is sharp and well defined Inner border is diffuse and illdefined
NB ARCUS JUVENILIS may occur in hyperlipidemia or juv. DM
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Band Shaped keratopathy Band Shaped keratopathy
Horizonal opacity ( in the interpalpebral area ) Old degenerated eyes Hyaline degeneration + Ca deposition
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KERATOCONUSKERATOCONUS Definition Progressive conical protrusion of the cornea Starts at Puberty Weakness of central part Incidence Females _ Atopy Bilateral +ve family history Symptoms Gradual of vision - Myopia ( Curvature & Axial ) - irregular Astigmatism
- Opacity at the apex of the cone
Sudden of vision (Acute Hydrops i.e. acute edema due to rupture of DM)
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Signs of Keratoconus
A) Early Retinoscopy ( RR is spinning or scissoring ) placido disc: ring distortion Keratometer
B) Late - Cone shaped central cornea seen by Profile view Notching of the L.L. on looking down Manson’ Slit Lamp Thin apex and deep A.C. - Deep opacity at the apex of the cone Rupture of BM Folds of DM - Fleisher ring: brown ring the cone base ( hemosidren deposition )
DD Ant. Staph. - Keratectasia - Keratoglobus
Treatment - Early casrs : Glasses or hard CL Corneal Collagen Cross linking with Riboflavin - Late cases : PKP
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KERATOGLOBUSKERATOGLOBUS
Congenital enlargement of the Anterior Segment
Signs Cornea: Large in diameter and curvature AC : Deep Iris : Tremulous Lens : SublaxationRefraction: Stationary myopia
DD : Buphthalmos
Treatment: Glasses
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KERATOPLASTYKERATOPLASTY Aim: Replacing the opaque part by a clear
cadaveric cornea Types: - Lamellar ( Superficial ) - Deep ( Penetrating ) NB: Both of them may be partial or total - Tectonic : Has a specific shape according to site
and indication Indications: - Optical a) Central corneal opacities b) Keratoconus - Therapeutic a) Resistant corneal ulcer b) Corneal fistula
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