Download - 抗真菌药物研究进展 与临床合理用药 张 沂
-
, > : , 2070: , , : : : ,
-
1
Tab.1 ------------------------------------------------------------- 4050 60 70 80 90 2001 ------------------------------------------------------------- 47 56 52 30 26 6 217 42 28 6 3 1 0 80 5 28 46 27 25 6 137-------------------------------------------------------------
-
2
, .
2001-2005, 6
-
Tab.2 2001-2005
------------------------------------------------------------------------- ------------------------------------------------------------------------(telithromycin ) ()(biapenem) ()(ertapenem) ()(datomycin) (A-2197c)(caspofungin) (Pneumocandin in B0micafungin (Pneumocandin in A0)-----------------------------------------------------------------------------
-
()
12270
-
19811220011120149 104657513AIDS
-
(15.78%) (13.15%) (11.84%) (46.03%) (23.68%) 14.29%
-
20066-20076,187,3.0%126 ,67.37%, 39,21.05%,22,11.58%., 73.16%, 15%,3.2%
-
: : : 40%55%- 70% :85% :50% __
-
1
2 /
-
4
5
6 HIV/AIDS AIDS8590%
7
-
3 4 d ICU4 d >48 APACHE* II >10 TPN *APACHE = Acute Physiology and Chronic Health Evaluation.
-
2 (>105/ml)
-
__1,3-______ATP
-
; B, ;
-
B, .: ,.
-
,,,,,.B,,,,.
-
B(AMBL) , 50mg/ //EDTA-2Na/2 B(ABLC) B(ABCD), .
-
,,,,,,
-
: ___; () ___ : __; ;
-
1() , ,
2, ,
-
3
-
1
3
-
5-
-
2
-
P450, , 14-,___ AAAA
-
C1414CyP450-14 ____
-
CyP450-14DM,14 ___
-
CyP450-14DM
-
1 902 60803 4 80
-
Css56t1/2 t1/230h6.25~7.5d1
3.32t1/24.15dCss90 45d3.25~4t1/2
t1/2=30h Dmax=2.35D0Dmin= 1.35D0
-
S ED),.
-
2001611586(ARTEMIS)
(907/916; 99%)
(n=235) ( 218/235; 93%)(198/198; 100%)(150/150; 100%)(43/43; 100%)(24/24; 100%)Vori
-
Vori 10%CYP450(CYP3A4, CYP2C9, CYP2C19)
-
Itraconazole (35) 10mg/ml55 ,
-
2001FDA1 (CHF)
-
FDA24, 1124
CHF581345%
Am J Health Syst Pharm. 2001 Jun 15;58(12):1076.
-
: CYP4503A4,:CYP4503A4, CYP4502C9, CYP4502C19:CYP4503A4
-
__-1,3-D-
-
-1,3-D-,,, -1,3-D- -1,3-D-,,,,
-
-1,3-D-,,
-
,, ,,,-1,3-D-
-
(Caspofungin)
FDAB_______1 t1/29-11__2 t1/227,
-
__
-
97%,3041%,34%
-
__,,,,,,
CsA +CaspoCaspo AUC35%+CaspoC1226%,
-
(Micafungin) , 99.8% T1/2 1315h , 1% AUC A
-
Thank You !