welcome page - qineticare

12/19/2020 Apeiron

https://apeirongenomics.com/tools/report-print/1117 1/130

COMPREHENSIVE REPORTfor Poonyatorn Suthipongchai

© 2020 Apeiron

Module 1

Welcome Page

Welcome to your Genomic Report!

Apeiron Certified Coaches use a complex systems approach to optimizeperformance. It is important to understand that the human system is acomplex system, rather than a complicated system. In a complicatedsystem there are many independent pieces that can be modified withoutaffecting the other pieces; whereas, in a complex system, each piece isdependent on its relationship with the other pieces.

Let’s take flight as an example; A computer can explain and model anairplane because it is a complicated system. It cannot adequately modeland explain a bird, a complex system.

Your genetic blueprint is one of the many pieces of the complex humansystem. The genetic blueprint is made up of a combination of DNAmarkers (C, T, A, G) known as Single Nucleotide Polymorphisms, orSNPs. While studies demonstrate the SNPs in this report are impactfulon different lifestyle aspects, they are one part of the system. DNA is notdeterministic; one SNP does not correspond to one outcome. Otheraspects of the complex system affect the expressions of your geneticblueprint such as environment, mindset, and exercise.

Complex systems require complex thinking which is where an EpigeneticCertified Coach comes into the picture; a coach is capable of complexthinking. Yet coaches currently need complicated systems (computers and algorithms) to assist in bringing biometric data together. Coaches thenapply the complicated data to complex thinking; this process is “augmented” intelligence. Therefore, genetic reports are better understood with anEpigenetic Certified Coach; they can assist you to interpret your complicated data to create optimal outcomes.

If you're not working with an Apeiron Certified Epigenetic Coach and you'd like to, please visit our coach directory: https://apeironzoh.com/coaches/

As you read through the report, use the below legend:

Gray benefits the most from supportLight Red is likely to have benefit from support

https://apeironzoh.com/coaches/

12/19/2020 Apeiron


Deep red is typically desirable; support can be leveraged to enhance performanceLeft represents low and right represents highWhen gauges have no benefit or support need, results range in shades of red

Please visit the Apeiron Store for the highest quality supplements and performance devices:

https://apeiron.store

https://apeiron.store/

12/19/2020 Apeiron


Module 2

About Nutrition

Interpretations & Recommendations from your coach, Mickra Hamilton

Decreased dopamine production and breakdown; possible decreased receptors Moderate insulin resistance risk. Consider lab testing Likely Lactosesensitivity Slightly above average gluten allergy risk Increased propensity towards grain sensitivity Bitter-testing gene Great benefit from fiber andcomplex carbs Strong need for Omega-3 support Possible Plant sterol buildup; consider lab testing Despite slightly above average metabolism;strong benefit from mitochondrial boosters due to PPARGC1A CT Macronutrient breakdown Complex carbs: 45% Protein: 25% based on likely goalsSaturated Fat: <10% Polyunsaturated fat: <6% Monounsaturated fat: 20-25% Consider eating more fish and supplementing with omega-3 Use Extravirgin olive oil or avocado oil for cooking Mitochondrial boosters: High Quality Sleep, exercise, intermittent fasting, cold thermogenesis, MitoQ,berberine, D-ribose Holy Basil and Bacopa Monnieri to support BDNF Check blood sugar labs; hA1c, glucose, insulin; and consider berberine forsupport Check omega-6 to omega-3 ratio, aim for 2:1 or 1:1 ratio due to BDNF and TNF 1800-2100 daily calories (or more if exercising regularly andaiming to gain weight)

ABOUT NUTRITION

Genetics are responsible for determining physical traits such as hair andeye color, however, genetics are probability/propensity, not guaranteed.For instance, genetics may program for brown hair, yet hair color typicallychanges as an individual ages. This process is an example ofepigenetics; how the environment affects genetics. In this example, thehair color (brown or grey) is referred to as the ‘expression’. One of themost impactful ways to affect epigenetic expression is through nutrition.This report covers three areas that have a strong impact on epigeneticexpression; food sensitivities, eating behaviors, and macronutrients.

The food sensitivity genetics relate to the body's response to food suchas dairy or gluten. Eating behavior genetics consider propensity towardssnacking habits and sweet consumption. Understanding macronutrientratios (protein, carbohydrate, and fat) is the foundation for developingnutrition plans. Understanding genetic blueprint is pivotal to optimizeexpression.

Nutrition is one of the most impactful ways to affect epigenetic expression. There are two genetics-informed strategies to approach nutrition;nutrigenetics and nutrigenomics. Nutrigenetics is eating solely based on genetics; following genetic propensity regardless of goals or lifestyle.Nutrigenomics is eating and supplementing to optimize epigenetic expression; strategically consuming nutrients based on the combination ofgenetics, goals, and lifestyle. While going through this report, an epigenetic coach can assist in creating an individualized strategic nutrition plan basedon nutrigenomics.

12/19/2020 Apeiron


Module 3

Hunger & Satiety

RELEVANT SNP'S

WHAT THIS MEANS

Appetite is a combination of hunger response and satiety. Many studieshave identified DNA variations that contribute to hunger and satietysignaling. Science reveals this is a complex interaction between manysystems, including: brain neurotransmitters (responsible for carryingchemical messages to and from the brain), messages between cells, andappetite hormones.

Hunger Propensity: Hunger is the sensation to eat.

Satiety: Satiety is the sensation of fullness.

WHY THIS MATTERS

All of these systems require coordination in the central sensingmechanism of our brains to create a response. Identifying thesecomponents can provide the guidance we need to create an optimaloutcome. When signals are not expressing in an optimal manner, we caninstitute strategies to improve signaling and create a more favorableresponse.

Hunger Propensity: Sometimes individuals experience a desire for food that is not actual hunger. It could be due to sleepiness, boredom, habits etc.While hunger is affected by environmental factors, understanding genetic propensities can provide insight towards optimal strategies.

Satiety: Individuals with low sensation of satiety may not accurately perceive when they reach fullness. As a result, they may consume more food thanintended, and subsequently gain weight.

Gene Marker Your Genotype

ADIPOQ(2) rs17300539 GG

MC4R rs17782313 TT

ANKK1 rs1800497 GG

COMT rs4680 GA

Hunger Perception

Accurate

You are likely to have good sensing of hunger; abnormalexperience of hunger could relate to specific components thatmake up this report such as dopamine status, hunger hormonesfrom fatty tissue, or intestinal neuropeptides. Considerconsultation with one of our certified coaches to help identifyspecific interventions that may help.

12/19/2020 Apeiron



Potential for dopamine inadequacy. This may cause cravings for sweets and/or slightly decreased overall sense of well being, If sensing thisconsider supplementation with Mucuna Pruriens Extract 98% L Dopa 350mg, to boost dopamine production.

DRD2(1) rs6277 GG

NMB rs1051168 GG

LEPR(1) rs1137100 GG


HTR2C rs3813929 C

MTHFR 1298c rs1801131 TG

FTO(1) rs9939609 TT

GHSR(1) rs572169 CT

GHSR(2) rs490683 GC

POMC rs1042571 GG


Satiety Sensing

Accurate

You likely have a propensity to accurately sense your bodilysignals of satiety.

12/19/2020 Apeiron


Module 4

Insulin Resistance

RELEVANT SNP'S

WHAT THIS MEANS

Insulin is a hormone that regulates the amount of glucose (sugar) in theblood. Insulin resistance means a body requires greater amounts ofinsulin in order to drive down blood sugar levels. It is usually associatedwith diabetes or a pre-diabetic state. Studies demonstrate that someindividuals possess a greater predisposition towards insulin resistance,which can be more probable based on genetic variations. Individuals thatcarry greater propensity tend to have higher fasting blood sugar andinsulin levels.

WHY THIS MATTERS

Higher fasting blood sugar levels promote accelerated rates of aging andoverall lower levels of health. Individuals with a propensity towardsinsulin resistance often report greater difficulty losing weight than othersthat follow similar diets (despite aggressive adherence to the diet).


GCKR rs780094 CC

MTNR1B(2) rs10830963 CC

TCF7L2(1) rs7903146 CC

FABP2 rs11724758 GG

PPARD(2) rs2267668 GA

VDR fok rs2228570 .

IRS1 rs2943634 AC

Insulin Resistance Propensity

Average Risk

You have an average propensity towards insulin resistance. Thisdoes not mean that you are protected from developing insulinresistance. A healthy diet that keeps simple carbohydrates andsugars low is still advised. Consider working with an epigeneticscoach or physician to measure blood sugar markers such asHbA1c, fasting glucose, and fasting insulin. Consider limitingsugar intake and supplementing with Berberine.

http://apeironzoh.com/coach

https://apeiron.store/products/ampk-activator

12/19/2020 Apeiron



Speak with your physician to measure blood sugar markers such as HbA1c, fasting glucose, and fasting insulin. Consider limiting processed sugarintake, keeping fruit to one to two servings a day and supplementing with Berberine or Metformin.

CRY2 rs11605924 AC

FADS1(1) rs174550 TC

PROX1 rs340874 TC

ADCY5 rs11708067 AA

SLC30A8 rs13266634 TT

G6PC2 rs560887 CC

MADD rs7944584 AA

ADRA2 rs10885122 GG

GLIS3 rs7034200 CC

LIPC(2) rs1800588 CC

12/19/2020 Apeiron


Module 5

Dairy Digestion

RELEVANT SNP'S

WHAT THIS MEANS

This section relates to the processing of sugar and fat in dairy products.

Lactose Sensitivity: Lactose is a sugar found in milk, whereas lactasebreaks down lactose and is essential to digest milk.

Weight Gain with Dairy Fat: People with certain genetic variants have apropensity towards adverse responses to foods with saturated fat andespecially high dairy fat content.

WHY THIS MATTERS

Lactose Sensitivity: Approximately 65% of the worlds population islactose intolerant; however individuals with European ancestry have apropensity to be lactose tolerant. Consuming lactose with apredisposition towards lactose intolerance can result in gut disruption,sinus inflammation, stuffy nose, and phlegm.

Weight Gain with Dairy Fat: Certain genotypes express a greaterpropensity toward weight gain and obesity when consuming high fat dairy.

Foods with high dairy fat: heavy cream, whole milk, cream cheese, butter, and full-fat yogurt.


APOA2 rs5082 GA

MCM6(1) rs4988235 GG

MCM6(2) rs182549 CC

Lactose Intolerance

Genetic Risk Present

Your genetics correspond with a 2.6x higher potential forsensitivity to the lactose in dairy. This does not guarantee that youwill have lactose intolerance as it is only an increased geneticrisk. Keep in mind this does not assess your response to milkproteins.

12/19/2020 Apeiron



If not sensing dairy sensitivity you might consider doing a period of 4 to 6 weeks dairy elimination then reintroducing for effect.

Dairy Fat Induced Weight Gain

Low Risk

Some people have a genetic propensity for weight gain with toomuch saturated fat in the diet. Dairy is a significant source ofthis.Your genetics indicate that you are less sensitive to thiseffect.

12/19/2020 Apeiron


Module 6

Gluten

RELEVANT SNP'S


Consider decreasing and/or minimizing gluten and processed grain intake.

WHAT THIS MEANS

In order to develop a gluten allergy, three criteria must be met: geneticpredisposition, leaky gut syndrome, and exposure to gluten. The geneticsrelated to gluten are based on predisposition and are only suggestive ofsusceptibility to developing reactions to gluten in foods. This is not adiagnostic test.

WHY THIS MATTERS

Gluten can be found in wheat and some related grains as well as in manyfood preparations because it provides elasticity and chewiness to manyprepared and processed foods.

Foods containing gluten: wheat, barley, rye, triticale, sauces, and oats


HLA-DQA1 rs2187668 CT

HLA-DQA2 rs2858331 AA

HLA-DRA rs2395182 TT

HLA-DQB1 rs7775228 TC

Gluten Allergy Propensity

Average Risk

Your genetics are associated with an average potential fordevelopment of gluten allergy. Gluten allergy is still uncommonwith average risk.

12/19/2020 Apeiron


Module 7

Grain Sensitivity

RELEVANT SNP'S

WHAT THIS MEANS

Many people believe they have a gluten sensitivity; however, unless thereis a demonstrated gluten allergy or celiac diagnosis, it is likely a grainsensitivity. Grain sensitivity is often due to excess glutamate and/orinsufficient GABA. Glutamate is involved in virtually every majorexcitatory brain function, and in excess can cause anxiety, agitation, anddifficulty sleeping. Conversely, gamma aminobutyric acid (GABA)produces an inhibitory and calming effect which can mitigate feelings ofanxiety, stress, and fear. Glutamic acid decarboxylase (GAD) isresponsible for the conversion of glutamate into GABA; decreased GADfunction contributes to a grain sensitivity propensity.

WHY THIS MATTERS

Many grains, sauces, and oils are high in glutamate. When thesevariations are significant and the symptoms are expressed, it isimportant to reduce exposure to glutamate. If this is the case, we wantto ensure healthy B6 levels since it is required for glutamic acid to work optimally.

Sources of high glutamic acid foods include wheat and grains, soy, dairy, seeds, protein powder, and the flavor enhancer MSG (monosodiumglutamate).


GAD1(1) rs3749034 GG

GAD1(2) rs3828275 CT

GAD1(3) rs3791878 GT

GAD1(4) rs769407 GC

GAD1(5) rs12185692 CA

Grain Sensitivity

Increased Propensity

You are likely to demonstrate an increased sensitivity to glutamicacid. Limit exposure and find appropriate intake levels of glutamicacid foods. Magnesium and Vitamin B6 may support the system.In strong reactions, consider DHH-B supplementation.

https://apeiron.store/products/magnesium-glycinate

https://apeiron.store/products/foundation-multivitamin

https://apeiron.store/products/dhh-b

12/19/2020 Apeiron



GAD sensitivity propensity relates to the conversion of glutamate to gaba in the brain. It can present with ADHD like symptoms, mind racing,difficulties getting restful sleep, increased stress expressions and brain fog following consumption. If noticing any of these consider decreasing oreliminating foods high in glutamic acid. Processed grains and MSG preservatives as well as protein powders with glutamate are the generaloffenders. Supplementing with Magnesium and B12 vitamin is beneficial with this expression.

12/19/2020 Apeiron


Module 8

Sweets and Snacking

RELEVANT SNP'S

WHAT THIS MEANS

Sweet Perception: These genetics look at how intensely we tastesweetness. Genetic variants affects the way our brain responds when wetaste something sweet or sugary.

Sweet Addiction Propensity: Along the same lines, many perceive theinability to stop eating sweets is based on willpower; however, this isalso coded in DNA.

Snacking Drive: Many people perceive snacking behaviors are based onwillpower. While this may be true in some cases, much of the drivetoward snacking is coded in our DNA.

WHY THIS MATTERS

Sweet Perception: Those with a decreased sensing of sweetness arelikely to consume more sweets, yet, the opposite is not necessarily true -those with an increased sweet perception may not always consume lesssweets. Other factors contribute to determining overall sweet intake.

Snacking Drive: Clinical practices have shown there is an extremely high correlation between genetic variations and reported snacking behaviors.

Sweet Addiction Propensity: Research demonstrates there are genes that code for the brain's response to sweet and sugary foods. In someindividuals, sugar decreases inhibitions and encourages greater consumption regardless of willpower.


MC4R rs17782313 TT

ANKK1 rs1800497 GG

COMT rs4680 GA

DRD2(1) rs6277 GG

Sweet Perception

Less Intense Sensing

You’re likely to have decreased sweet perception which maycontribute to increased sweet intake or a lack of desire forsweets. Be aware that your taste receptors are likely wired to beless sensitive than others, which can drive eating more sugar toget the same “reward” that other people can get from less. Try touse this to your advantage and use mindful awareness whileeating sweet foods (eat slowly and consciously enjoy your food).

12/19/2020 Apeiron



Genetic predisposition to snacking and sweet addiction is low. If experiencing one or both consider that either a habit of snacking has beendeveloped or the slightly reduced dopamine production may be playing a role.

NMB rs1051168 GG


FTO(3) rs1421085 TT


FTO(1) rs9939609 TT

FGF21 rs838133 GG

SLCA2 rs5400 GG

SLC2A2 rs1499821 CC

TAS1R2 rs3935570 GG

TAS1R3 rs35744813 TC

TAS2R38 rs1726866 GG

Snacking Drive

Genetically Low

You’re unlikely to have a strong snacking drive; this is subject tochanges in epigenetic expression based on the environment. Forexample, sugar, stress, and neurotransmitter imbalances cancreate an increased desire for snacking despite this geneticpropensity.

Sweet Addiction Propensity

Low Genetic Risk

Researchers have found that people with your genetic profile tendto find certain foods more bitter, such as coffee, brussel sprouts,and grapefruit. This does not mean that you dislike these foodsjust that you tend to use salt or other seasoning to mask thebitter.

12/19/2020 Apeiron


Module 9

Carbohydrates

RELEVANT SNP'S

WHAT THIS MEANS

There are two different types of carbohydrates: simple and complex.Simple carbohydrates include foods like sugar, pasta, and bread,whereas complex carbohydrates are primarily fibrous foods such asvegetables.

Carbohydrate Intake: Carbohydrates are a very individualized componentof the diet. Using scientific literature and clinical experience, we are ableto identify the relevant impactful genes for optimal complexcarbohydrate intake.

Fiber Benefit: Research has shown some genetic variants contribute to adesirable response from increased fiber intake.

WHY THIS MATTERS

Simple carbohydrates should generally be avoided. The optimal amountof complex carbs is variable based on genetic predisposition.

Carbohydrate Intake: This is especially relevant in relation to ideal body composition as some people do better with a lower carbohydrate intake whileothers tend to burn fat in the flame of a carbohydrate.

Fiber Benefit: Some individuals show a propensity towards improved weight loss and cholesterol management with higher levels of fiber in theirnutrition plan.

Examples of fibrous complex carbohydrate foods include vegetable such as broccoli, carrots, and leafy greens. Carbohydrates such as sweet potatoand rice also provide benefit however are less impactful to desirable outcomes than fibrous vegetables.


KCDT10 rs10850219 GG

MMAB rs2241201 CC

PLIN1 rs894160 CT

Carbohydrate Intake

Higher Intake

You’re genetics are likely to respond well to a higher complexcarbohydrate intake. Research and our clinical experience hasfound that with your particular genetic variants, you shoulddemonstrate a greater benefit for abdominal fat loss withcomplex carbohydrate intake greater than 200g/day.

12/19/2020 Apeiron



You will respond well to higher complex carbohydrate intake. Maintain simple carbohydrates at minimum intake.

UCP1 rs1800592 TT

TCF7L2(1) rs7903146 CC

TCF7L2(2) rs12255372 GG

TCF7L2(3) rs290487 TT

TCF7L2(4) rs2287019 CC

CEBPA rs12691 GG

ABCG4 rs3802885 AA

VLDLR rs2242104 GG

IGF1R rs7166565 GG

LPIN2 rs607549 TT

AGER rs184003 CA

GIPR rs8050136 CC

FTO(5) rs8050136 CC

Fiber Intake

Highly Benefit

Fiber intake response based on your genetics suggests that it isstrongly beneficial.

12/19/2020 Apeiron


Module 10

Total Fats

RELEVANT SNP'S

WHAT THIS MEANS

There are three primary fats within the human diet; saturated fats (SFA),monounsaturated fats (MUFA), and polyunsaturated fats (PUFA). Thereare several opinions regarding which fats are 'good' and which fats arenot. There are two problems with this; first, fats are a macronutrient thatour bodies require for optimal health. Second, there are significantindividual differences in how each person responds to the different typesof fat.

WHY THIS MATTERS

This section provides guidelines for planning the ideal percentage ofcalories from fat in your daily diet. When using genetic variations toprovide guidance on fat intake, it is important to understand that many ofthe studies used did not differentiate the types of fat.


APOe(3) rs4420638 .

PPARG rs1801282 CC

FABP2 rs11724758 GG

APOA2 rs5082 GA

APOB rs1367117 GG


TFAP2B rs987237 AA

FTO(1) rs9939609 TT

Total Fat Intake Benefit

Higher Intake Benefit

Your genetics suggest a good response to fat overall andsuggests some flexibility here. Some experimentation with higherfat intake may be desirable. See individual fat recommendationsfor more details.

12/19/2020 Apeiron



Will benefit from high fat intake.

TNF rs1800629 GA

LIPC(1) rs2070895 GG

APOe(1) rs429358 TT

APOe(2) rs7412 CC

12/19/2020 Apeiron


Module 11

Saturated Fats

RELEVANT SNP'S

WHAT THIS MEANS

Saturated Fat Intake: Saturated fats (SFA) represent one of the mostdebated aspects of human nutrition today. Various studies discuss thebenefits and drawbacks of SFA intake. The Atkins and Paleo movementshave brought saturated fat into the forefront of discussions. Ultimately,saturated fats are necessary for healthy human function. Saturated fatmakes up 50% of the membrane fats in every cell of the body and isessential for healthy immune function. The brain is 60% fat and ispredominantly saturated fat and cholesterol. Despite this, high intakeisn't necessarily beneficial.

APOe Status: APOe status is a genetic predisposition that is highlyimpactful across many aspects of the human system.

WHY THIS MATTERS

Saturated Fat Intake: Individuals carry genetic variations that change theresponse to saturated fats from a health and wellness standpoint. Thepropensity identified below is based on leading scientific studies intogenome wide associations as well as from our extensive experience inapplying this in clinical practice. Even with moderate intakerecommendations, it is best for most individuals to keep saturated fat intake to less than 10% of total calories per day.

APOe Status: APOe status can create differences in how individuals respond to saturated fat. In certain variants, saturated fat intake can trigger anincreased propensity towards plaque buildup and cognitive decline over time. Understanding your APOe status can assist you to create bio-specificstrategies for optimal outcomes.

Sources of saturated fat include coconut oil, butter, ghee, red meat, and dairy products


APOe(3) rs4420638 .

PPARG rs1801282 CC

APOA2 rs5082 GA

Saturated Fat Response

Better Tolerance

Some individuals do not carry strong genetic predispositions toadverse responses with saturated fat. This does not mean thatexcess intake cannot be detrimental. Even with this beneficialpropensity, we have found that keeping saturated fat intake toless than 10% of total calories can contribute to healthieroutcomes.

12/19/2020 Apeiron



You have the ability to eat saturated fat at less than 10% of total calories without significant negative impact. However, if inflammation markers arenoted you will want to keep saturated fat intake to less than 5% of your daily caloric intake.

APOB rs1367117 GG

APOe(1) rs429358 TT

APOe(2) rs7412 CC

APOe Status

APOe 3/3

APOE 3/3 variant is typical

You can likely use saturated fat effectively — coconut oil and MCToil may be useful in the presence of low sugar.

12/19/2020 Apeiron


Module 12

Polyunsaturated Fats

RELEVANT SNP'S

WHAT THIS MEANS

Polyunsaturated fatty acids (PUFA) have a role in many physiologicalprocesses, including energy production, inflammation modulation, andmaintenance of cell membrane integrity. PUFAs include omega-6 (O6)and omega-3 (O3) and are essential for life; there are health benefits toconsuming both in the appropriate ratios.

Omega-6 PUFA Intake: O6 contributes to improved immune health andblood clotting and is responsible for providing beneficial inflammation inthe body.

Omega-3 Need: O3 plays an important role in the body; its primaryfunctions include maintaining the immune system, counteractinginflammation, and supporting cognitive function.

WHY THIS MATTERS

Research has focused on omega-6/omega-3 ratios and there is a clear benefit to keeping this ratio at 4:1 or less. While this is the beneficial zone, mostpeople consume these fats in a 10:1 ratio. Many in the industrialized world are reaching levels as high as 25:1

Omega-6 PUFA Intake: Individuals with certain genotypes show a propensity towards higher inflammation from Omega-6 andtherefore should consume less omega-6 to achieve an optimal ratio.

Omega-3 Need: Research demonstrates having optimal levels of fish-based omega-3 contributes to highly beneficial epigenetic changes.

Beneficial omega-6 sources include nuts and fish, however, other sources such as soybeans, vegetable oils, and sunflower oil should beavoided. Beneficial Omega-3 sources include fatty fish and fish oil.


APOA5 rs662799 AA

FADS1(2) rs174537 GT

ELOVL2 rs953413 AA

PTGS2(1) rs5275 AG

12/19/2020 Apeiron



Intake of vegetable oils and many nuts can be detrimental for inflammation. Olive oil and avocado oils will be the best predominant oil sources forcooking and salad dressing. You have a higher than average need for fish oil (Omega 3) intake. This should come primarily from eating high omega 3fish.

COX-2 rs4648310 TT

IL-1B rs16944 GG

TNF rs1800629 GA

BDNF rs6265 CT

Omega-6 PUFA Intake

Lower Intake Beneficial

Keep omega-6 intake on the lower side - many nuts, seeds,vegetable oils - most oils that are liquid at room temperature arehigh O-6 unless they specifically are high in monounsaturated fat(such as olive oil and avocado oil). Omega-6 fats are required bythe body but the amount relative to other fats is important tohealth. Omega-6 to Omega-3 ratio is best kept on the lower sidefor optimal health. See the chart of common oil compositionshere.

Omega-3 Need

Higher Need

Strong benefit from maintaining optimal omega-6 and omega-3balance. Consider blood lab testing to assess, as well as fish oilsupplementation and regular seafood consumption.

https://drive.google.com/file/d/15vDsyi32k7O6zht-miS8dT6wJxpeli5R/view?usp=sharing

https://apeiron.store/products/high-potency-epa-dha

12/19/2020 Apeiron


Module 13

Monounsaturated Fats

RELEVANT SNP'S

WHAT THIS MEANS

Monounsaturated fats (MUFA) support many bodily functions and aretypically beneficial for everyone, although some genetic variants indicatean increased benefit from higher levels of intake.

WHY THIS MATTERS?

MUFAs are suspected to be the major health benefit of theMediterranean diet where some traditionally consume as much as 40%of their total calories from extra virgin olive oil. MUFAs also have a longlist of studies supporting health benefits which include; decreasedinflammation, lower cancer rates, less chance of heart disease, andweight loss.

Beneficial MUFA sources include extra virgin olive oil, macadamia nut oil,avocado, macadamia nuts, beef, salmon, pumpkin seeds, and chicken.



APOA5 rs662799 AA

FAAH rs324420 CC

LPL rs13702 TT

IL-1B rs16944 GG


TNF rs1800629 GA

MUFA Benefit

Good Response

You’re likely to benefit from monounsaturated fat intake. ExtraVirgin Olive oil, macadamia nuts, and avocado are ideal sources.From an epigenetic standpoint, the monounsaturated fat alongwith the beneficial phytonutrients in olive oil, you cannot gowrong. Olive oil has a profoundly beneficial effect on geneexpressions and you possess a genetic pattern that has a goodresponse.

12/19/2020 Apeiron



MUFA fats will be your ideal type of fat intake. Avocados, olive oil and macadamia nuts in small quantities will be beneficial.

BDNF rs6265 CT

12/19/2020 Apeiron


Module 14

Protein

RELEVANT SNP'S

WHAT THIS MEAN

The human body requires 20 amino acids (body’s building blocks) tocreate many different proteins. Ten of these amino acids are consideredessential, meaning they are not made in the body so must be consumedin the diet. This is a complex network of gene interactions and there areways to epigenetically shift the expressions of these genes to achievedesired outcomes.

WHY THIS MATTERS

Protein is a macronutrient the body needs in relatively large amounts togrow, develop, and function properly. Some people will respond better toa diet with a higher percentage of calories from protein, while others dobetter with lower intake.


FTO(2) rs1558902 TT

LPIN1 rs4315495 GA

BDNF-AS rs4923461 AG

TFAP2B rs987237 AA

FTO(1) rs9939609 TT

Protein and Weight Loss

Lower Intake

You’re likely to have optimal weight loss effects from 15-20% ofcalories from protein

12/19/2020 Apeiron



If choosing to gain weight for increased muscle mass it will be ideal to take in 20% of daily calories in high quality protein. Fish will be thepredominant source of protein, plant and whey protein powder can be added to assist with getting high enough protein intake.

12/19/2020 Apeiron


Module 15

Plant Sterols

RELEVANT SNP'S

WHAT THIS MEANS

Plant Sterol Buildup: Plant sterols are cholesterol-like molecules foundin all plant foods, with the highest concentrations occurring in vegetableoils. Plant sterols work by blocking cholesterol absorption.

Plant Sterol Benefit: Plant sterols are typically understood to decreaseinflammation, lower cholesterol levels, and enhance cardiovascularsupport.

WHY THIS MATTERS

Plant Sterol Buildup: Under normal circumstances plant sterols areabsorbed in trace amounts, but some individuals have agenetic propensity to absorb greater amounts. Dietary plant sterol intakecan be beneficial in some cases, however, excess amounts could beundesirable and contribute to increased plaque build-up.

Plant Sterol Benefit: While many individuals are likely to benefit from plant sterols, some carry genotypes which correspond with no benefit.


ABCG8(1) rs4299376 TT

ABCG8(2) rs6544713 CC

ABCG8(3) rs4245791 TT

CETP rs5882 AA

ABCG5(1) rs11887534 GG

ABCG5(2) rs6720173 GG

Plant Sterol Buildup

Low Probability

You’re likely to have regular plant sterol absorption.

Plant Sterol Benefit

Less Likely

Plant sterols are unlikely to provide anti-inflammatory support.

12/19/2020 Apeiron


Module 16

Metabolism

RELEVANT SNP'S

WHAT THIS MEANS

Metabolism is how effectively an individual creates energy and burnscalories. Metabolism is often measured using basal metabolic rate(BMR). BMR is the number of calories burned while resting throughout aday; it's a complex combination of genetics and environmental factors.

WHY THIS MATTERS

Metabolism aids in creating precise strategies to fuel yourbody effectively. Leveraging genetic predispositions can increasethe body's energy levels and enhance overall function.


GCKR rs780094 CC

MC4R rs17782313 TT

UCP2(1) rs659366 TT

FTO(6) rs17817449 TT

PPARGC1A rs8192678 CT

UCP2(2) rs660339 AA

Metabolism

Normal

Likely to have average metabolic function; may benefit frommitochondria boosters such as high quality sleep, exercise,intermittent fasting, cold showers, berberine, D-ribose, or NMN


https://apeiron.store/products/performance-chewables

https://apeiron.store/products/nmn

12/19/2020 Apeiron


Module 17

Macronutrient Worksheet

YOUR DETAILS

Height 172 cm

Weight 68 kg

Age 36

Sex Male

Basal Metabolic Rate 1,613 calories/day


If weight gain for increased muscle mass is desired consider eating up to 2100 calories per day.

WHAT THIS MEANS

This worksheet provides basic recommendations for macronutrientsbased on genetic predispositions, epigenetic expression, and goals. Thisworksheet refers back to nutritional genetically informed macronutrientrecommendations.

WHY THIS MATTERS

BMR Calculators are estimates and should be used as directional guides. When used in combination with factors such as genetic predisposition,calories burned during exercise, and biometric data, BMR calculators canprovide a more accurate picture of an individual's needs.

45.0%45.0%45.0%

25.0%25.0%25.0%

30.0%30.0%30.0% Carbohydrates 231 g/day

Protein 129 g/day

Fats 60 g/day

Daily calorie goal 1,800 calories/day

12/19/2020 Apeiron


Module 18

About Supplementation


Key Points Some benefit from B12 supplementation due to secretor status Very low vitamin A conversion Increased selenium need May benefit frommagnesium for grain sensitivity Slightly increased choline need for liver support Strong Need for vitamin C Increased need for Vitamin D, decreasedsunlight conversion, consider testing active and inactive levels. Increased benefit from vitamin K Increased benefit from Folate; avoid folic acidIncreased risk of excess zinc; avoid high-dose supplementation except in combination with copper Possibly increased sodium sensitivity SlowCaffeine Metabolism Recommendations 1-2g/day Liposomal vitamin C 5mg Sublingual Methyl-B12 or injections Magnesium Glycinate for enhancedsleep or Threonate for enhanced cognition Eat runny egg yolks 2-3x/week for choline Vitamin D3/K2 mix Avoid zinc supplementation Avoid folic acidform of B9 Multivitamin for all others Nitric Oxide saliva test strip to check levels

ABOUT SUPPLEMENTATION

As covered in the Nutrition section, nutrigenomics is eating andsupplementation to optimize epigenetic expression; strategicallyconsuming nutrients based on the combination of genetics, goals, andlifestyle. Supplementation, obtaining micronutrients from nonfoodsources, is the second half of nutrigenomics. Many people believemicronutrients should come solely from food, however modern farmingtechniques have impacted the nutrient levels in food. The nutrients invegetables are much lower now than they were 100 years ago.

In addition, our ancestors historically lived in the same environments forgenerations and their bodies (genes) adapted accordingly. Since then,technology has increased the ability to easily travel around the world.Ease of travel has encouraged blending genetic profiles from a widevariety of environments. Today it is almost impossible to find theenvironment our genes are optimized for; instead we usesupplementation to enhance our genetic expression. This is why thegenetic blueprint is so impactful for precise recommendations.

Through nutrigenomics, strategic supplementation can prevent deficiencies and optimize performance. Several of the nutrients in this report can befound in a high quality multivitamin; such as the Apeiron Multivitamin. While going through this report, an epigenetic coach can assist in creating anindividualized strategic supplementation plan based on nutrigenomics.

12/19/2020 Apeiron


Module 19

Vitamin B12

RELEVANT SNP'S

WHAT THIS MEANS

B12 Need: Vitamin B12 plays an essential role in the production of redblood cells and DNA, as well as the proper functioning of the nervoussystem. It is absorbed through the stomach lining and is typically foundin animal-based foods.

FUT2 Status: Determines genetic propensity for an individual towardsbeing a secretor or non-secretor. A secretor is likely to have less B12production in the body and also have a healthy diverse gut bacteria. Anon-secretor is likely to produce more B12 in the body and have a lessdiverse gut biome.

WHY THIS MATTERS

B12 Need: It’s estimated that 40% of American’s don’t get enoughvitamin B12, and deficiencies can contribute to fatigue and brain fog.

FUT2 Status: Certain variants of FUT2 show good correlation with bodyB12 levels as well as propensities for certain gut conditions.

Benefits of Vitamin B12 include:

Increased energy – B12 converts carbohydrates into glucose, increases overall energy, and reduces fatigue.

Improved brain function – B12 helps make DNA and keep the nervous system healthy. It may reduce depression, lower stress levels, and reduce brainshrinkage.

Healthy digestive system – B12 promotes gut health and may prevent heart disease by curbing cholesterol levels, protecting against stroke and highblood pressure.

B12 food sources include liver, salmon, tuna, mackerel, sardines, red meat, cheese, and eggs.


12/19/2020 Apeiron



It is important to consider supplementing with B12 due to the fact that you have the FUT2 secretor status. This can result in larger amounts ofbeneficial microbiome bacteria. This type of bacteria utilizes the B12 consumed in the diet. Consider B12. The best form will be Methyl B12 either5mg sublingual or injection.

FUT2(1) rs492602 AA

FUT2(2) rs602662 GG

FUT2(3) rs601338 GG

MTR rs1805087 AA

COMT rs4680 GA

TCN1 rs526934 AA

MTRR A66G rs1801394 AA

MTHFR 677t rs1801133 GA

VDR taq rs731236 AA

B12 Need

Typical Need

You’re likely to have normal need for B12; some B12supplementation may provide increased energy levels

FUT2 Status

Secretor

You’re likely to have more desirable gut biome health, withreduced levels of B12 in the blood; increased benefit from B12supplementation.

https://apeiron.store/products/methyl-b-12-60-ct

https://apeiron.store/products/methyl-b-12-60-ct

12/19/2020 Apeiron


Module 20

Vitamin B6

RELEVANT SNP'S

WHAT THIS MEANS

Vitamin B6 is a vitamin which is significant to protein, fat, andcarbohydrate metabolism as well as the creation of red blood cells andneurotransmitters. Common symptoms of low vitamin B6 are irritability,depression, and anxiety.

WHY THIS MATTERS

Vitamin B6 is important for many processes in the body; it helps turnfood into energy, supports adrenal function, and maintains a healthynervous system. It also supports the healthy development in babies’brains during pregnancy and breastfeeding.

Benefits of Vitamin B6 include

Adrenal function – Through regulating hormones, B6 lowers stress,stabilizes mood, and contributes to a happy disposition.

Metabolism – Crucial to hundreds of metabolic processes, B6 assists the body to turn food into energy.

Healthy nervous system – B6 is often referred to as the happy vitamin because it helps make serotonin and norepinephrine, which impacts mood.

Digestive support – B6 assists the body to maintain healthy digestive processes.

B6 food sources include brewer's yeast, bananas, milk, cheese, eggs, fish, carrots, spinach, peas, legumes, and potatoes.


NBPF3 rs4654748 TT

ALPL(1) rs1256341 TC

B6 Need

Typical Need

You’re likely to have ideal B6 levels

12/19/2020 Apeiron


ALPL(2) rs1256335 AA

12/19/2020 Apeiron


Module 21

Vitamin A

RELEVANT SNP'S

WHAT THIS MEANS

Vitamin A is naturally present in many foods and has two forms; Beta-carotene and retinoic acid. Beta-carotene is found in plant based foodwhereas retinoic acid is found in animal based foods. The body alsoconverts beta-carotene into retinoic acid, and genetics can affectconversion rate. Vitamin A supplements can contain beta-carotene,retinoic acid, or a combination of the two. The gene BCMO1 convertsbeta-carotene into retinoic acid.

WHY THIS MATTERS

The body relies on vitamin A conversion for healthy maintenance of theheart, kidneys, lungs, and eyes.

Benefits of Vitamin A

Improved immune system – Vitamin A boosts the immune system andassists in fighting infections. It also helps mucus membranes stay moist,which strengthens white blood cell activity.

Healthy skin – With the ability to trap free radicals and toxins, vitamin A keeps skin supple & healthy. Free radicals are unstable atoms that candamage cells, causing illness and aging.

Increased tooth strength – Vitamin A keeps teeth strong by forming a hard material just beneath the surface of the teeth, called dentin.

Eye health – Vitamin A supports macular health and provides overall protection for the eye.

Retinoic acid sources of vitamin A include fish liver oil, beef liver, and egg yolk.


BCMO1(1) rs7501331 CC

BCMO1(2) rs12934922 AA

Vitamin A Conversion

Very Low Conversion

Very low conversion of vitamin A. You have a strong benefit froma multivitamin that includes palmitate.


12/19/2020 Apeiron



A multi vitamin with vitamin A in the form of beta carotene and palmitate will be beneficial.

BCMO1(3) rs11645428 GG

BCMO1(4) rs6420424 AA

BCMO1(5) rs8044334 TG

BCMO1(6) rs6564851 GG

12/19/2020 Apeiron


Module 22

Selenium

RELEVANT SNP'S

WHAT THIS MEANS

Selenium is a mineral found in the soil which plays a key role inmetabolism. It is an antioxidant which means it protects the body fromharmful free radicals and oxidative stress. Oxidative stress is animbalance between the production of free radicals and the ability of thebody to counteract or detoxify their harmful effects.

WHY THIS MATTERS

Selenium delays cell damage and helps protect the body from oxidizingagents caused by many diseases and pollutants. Selenium isnutritionally essential for everyone as it supports thyroid hormonemetabolism and protects against infections. The below gaugedetermines the severity of a selenium deficiency. An increased resultdoes not necessarily a need for more selenium; it indicates a strongerneed for optimal levels because deficiencies will likely have a strongimpact.

Benefits of Selenium

Thyroid support – Selenium is important for the thyroid gland; it plays a key role in the gland’s ability to produce thyroid hormone.

DNA repair – Selenium prevents serious DNA damage by neutralizing free radicals.

Metal detoxification – Studies have shown that organic selenium supports the excretion of the harmful element mercury.

Reproductive health – Selenium is vital for both male and female reproductive health. In men, it enables sperm movement. In women, low seleniumcan negatively impact fertility and fetal development.

Selenium sources include brazil nuts, fish, beef liver, pork, and mushrooms.


GPX1(1) rs1050450 GG

SEPP1 rs7579 CC

Selenium Need

Increased Need

You’re likely to have more intense symptoms with seleniumdeficiency; likely to benefit from regular supplementation such asin a multivitamin.


12/19/2020 Apeiron



Obtain this through either a multi vitamin or food sources high in selenium such as brazil nuts. Not advised to supplement separately due to potentialfor too high levels.

AGA rs1395479 CA

BHMT(1) rs567754 CT

MST1 rs3197999 GG

DMGDH rs921943 CC

12/19/2020 Apeiron


Module 23

Magnesium

RELEVANT SNP'S

WHAT THIS MEANS

Magnesium is a mineral found in the earth, sea, plants, animals, andhumans. It is an essential nutrient that the body needs in high amounts,however, about 50% of all Americans are believed to be deficient. It’srecommended to consume at least 200-400 milligrams per day.

WHY THIS MATTERS

Magnesium is vital to over 300 reactions in the body includingmetabolism, transmission of nerve impulses, and blood pressureregulation. It impacts several bodily systems and can even affect mood.

Benefits of Magnesium

Bone strength – Magnesium supports bone absorption of calcium.

Healthy metabolism – Magnesium is an essential co-factor in manymetabolic processes, especially carbohydrate processing.

Heart health – Magnesium is responsible for keeping the heart muscles healthy and strong. It assists with the transmission of electrical signalsthroughout the body. Proper magnesium levels have shown to lower artery calcification, hypertension, and atherosclerosis (fatty buildup on arterywalls).

Anxiety – Low magnesium levels have been shown to increase anxiety.

Gut – Magnesium works as a stool softener and can relieve constipation naturally.

Magnesium food sources include dark leafy greens, brazil nuts, mackerel, white beans, quinoa, avocados, yogurt, bananas, and dark chocolate.


CNNM2 rs3740393 GG

MUC1 rs4072037 TT

Magnesium Need

Typical Need

Despite normal levels; you’re likely to benefit from regularsupplementation due to global statistical deficiency. MagnesiumGlycinate benefits sleep, Magnesium Threonate benefitscognition and performance

https://apeiron.store/products/magnesium-glycinate

https://apeiron.store/products/magnesium-threonate-powder

12/19/2020 Apeiron



Consider 400mg Magnesium Glycinate for enhanced sleep or Magnesium Threonate for enhanced cognition. Both will be beneficial for the GAD grainsensitivity propensity.

DCDC5 rs3925584 TT

Shroom3 rs13146355 GA

TRPM6(1) rs2274924 TT

TRPM6(2) rs3750425 CC

12/19/2020 Apeiron


Module 24

Choline

RELEVANT SNP'S

WHAT THIS MEANS

While choline is not a vitamin or mineral, it is an important ingredient inmany bodily process and plays a major role in metabolism andneurotransmitter health. The body does produce choline, although, itdoesn’t produce sufficient quantities of this essential nutrient tomaintain optimal health.

WHY THIS MATTERS?

Less than 10 percent of adults get enough choline in their diet. Somerisks of choline deficiency include muscle damage, anxiety, and brainfog. Those at risk for choline deficiency include: pregnant women,choline depleted diets (plant based diets), and people with geneticvariations. It’s particularly important for fetuses and babies to ensurehealthy brain development.

Benefits of Choline

Cell structure – The body relies on choline to make the fats that help maintain the structural integrity of all cell membranes.

Cell messaging – Choline assists with the production of compounds that act as cell messengers.

Fat transport and metabolism – Insufficient choline levels can lead to fatty liver.

DNA synthesis – Choline, vitamin B12, and folate are three vital nutrients in DNA synthesis.

Nervous system health – Acetylcholine, a neurotransmitter involved in memory, muscle movement, and regulating heartbeat, is derived from choline.

Choline food sources include beef liver, eggs, chicken breast, cauliflower, broccoli, mushrooms, dark leafy greens, shellfish, asparagus, brussel sprouts,boy chow, and cod.


BHMT(2) rs3733890 GA

12/19/2020 Apeiron


CHDH rs9001 .

MTHFD1 rs2236225 GG

PEMT rs7946 CT

CHKA rs10791957 CA

Choline Supplementation Need

Typical Need

Your genetics are associated with normal choline needs; you’relikely to benefit from regular consumption of eggs with runnyyolks.

12/19/2020 Apeiron


Module 25

Vitamin C

RELEVANT SNP'S

WHAT THIS MEANS

Vitamin C, also known as ascorbic acid and ascorbate, is a nutrientthat plays several key roles in bodily functions. It isn’t produced by thebody naturally and is consumed in the form of fruits and vegetables.

WHY THIS MATTERS

Vitamin C is a powerful antioxidant responsible for trapping free radicalsand preventing harmful effects of toxins. Those with agenetic predisposition or those with diets lacking fruits and vegetableshave a stronger propensity for deficiency.

Benefits of Vitamin C

Collagen synthesis – Vitamin C repairs and regenerates tissues andmaintains healthy skin and connective tissue.

Protection against heart disease – Through increasing the body’s levelof glutathione, vitamin C protects the arteries.

Iron absorption – Vitamin C prevents anemia and assists iron absorption.

Cholesterol and triglyceride reduction – Vitamin C reduces the risk of heart attack and stroke.

Blunts oxidative stress – In disease states, vitamin C has shown to help reduce cellular damage by free radicals. Vitamin C food sources include bell peppers, guava, dark leafy greens (especially turnip greens), kiwi, broccoli, strawberries, tomatoes, peas, papaya,oranges, grapefruits, and lemons.


GSTT1 rs11550605 .

SLC23A1(1) rs6596471 AA

SLC23A1(2) rs10063949 TC

Vitamin C Need

Much Increased Need

Your genes are associated with lower C levels.

1-2g of liposomal vitamin C supplementation recommended eachday

https://apeiron.store/products/c-rla

12/19/2020 Apeiron



Eat foods high in vitamin C and consider 1-2g/day Liposomal vitamin C.

SLC23A2 rs6133175 GG

12/19/2020 Apeiron


Module 26

Vitamin E

RELEVANT SNP'S

WHAT THIS MEANS

Vitamin E Need: Vitamin E plays a vital role in many aspects ofhealth. Although there are eight forms of Vitamin E, Alpha-tocopherol isthe only form that is readily absorbed and used by the body.

Vitamin E Inflammation Propensity: While vitamin E is typically anti-inflammatory, some genotypes are predisposed to inflammation fromhigh dose supplementation.

WHY THIS MATTERS

Vitamin E Need: Vitamin E is a powerful antioxidant that assists in maintaining optimal levels of selenium, vitamin K, and many other essentialnutrients.

Vitamin E Inflammation Propensity: High dose vitamin E (greater than 400IU) can correspond with high levels of inflammation in individuals withgenetic predisposition.

Benefits of Vitamin E

Helps store vitamins A, K, iron, and selenium – Vitamin E helps maintain sufficient levels of many essential nutrients.

Supports the formation of red blood cells – Red blood cells rely on vitamin E to strengthen their interior lining, which is another way it toughens theimmune system.

Keeping skeletal, cardiac, and smooth muscles healthy – Vitamin E is important for the structural function and maintenance of these muscles.

Prevent eye damage – Studies suggest relatively high vitamin E intake may reduce the occurrence of macular degeneration and cataracts in elderlyindividuals.

Vitamin E food sources include almonds, swiss chard, pine nuts, broccoli, mustard greens, avocado, spinach, turnip greens, kale, plant oils, andhazelnuts.


CD36 rs1527479 TT

SCARB1 rs11057830 GG

Vitamin E Need

Increased Need

You’re likely to benefit from increased vitamin E levels throughmultivitamin or food sources.


12/19/2020 Apeiron



Do not supplement with additional vitamin E due to likelihood for increased inflammation.

ZPR1 rs964184 CC

TNF(2) rs361525 GG

GSTP1(1) rs1695 AG

IL10 rs1800896 TT

Vitamin E Inflammation Propensity

High Propensity

You’re likely to have an inflammatory reaction to high-dosevitamin E supplementation rather than an anti-inflammatoryeffect; avoid >180 IU of vitamin E supplementation. Levels foundin food and multivitamins are fine.

12/19/2020 Apeiron


Module 27

Vitamin DWHAT THIS MEANS

Vitamin D is not readily found in many foods. An estimated 70 percent ofthe population is thought to be vitamin D deficient. This is concerningbecause it is responsible for regulating over 1000 genes in the humangenome.

Sunlight Response: The skin can convert sunlight into vitamin D.

Vitamin D Testing: There is an active and inactive form of vitamin D. The active form is the form that supports the body: however, whentesting vitamin D levels most blood analysis only look at the inactiveform. The inactive form tends to correlate well with the active form. Insome rare cases, some individuals genetics correspond with higherlevels of the active form which is not reflected in typical vitamin Dtesting.

WHY THIS MATTERS

Vitamin D Supplementation Need: From a genetic standpoint, peopletend to vary in their ability to process dietary vitamin D. This means that there’s a difference in the baseline amount needed to maintain healthy vitaminD levels from person to person.

Sunlight Response: Certain genotypes demonstrate a decreased ability to convert sunlight into vitamin D.

Vitamin D Testing: When individuals have the corresponding genetics, analysis of the active form of vitamin D (1,25) in combination with the inactiveform (25-OH) may be beneficial to determining optimal levels.

Benefits of Vitamin D

Bone health – Vitamin D increases calcium and strengthens bones.

Prevention of diabetes – Vitamin D can decrease the risk of both Type 1 and Type 2 diabetes.

Heart health – Studies have shown vitamin D deficiency as a risk factor for congestive heart failure and heart attacks.

Mood regulator – Vitamin D is believed to reduce or prevent depression.

Muscle growth – Vitamin D has been shown to aid in muscle growth and retention in both adults and the elderly.

12/19/2020 Apeiron


RELEVANT SNP'S


Important to supplement with Vitamin D3/K2 combination and have vitamin D labs checked for active (25-OH D3) and inactive levels (1,25-2OH D3).

Vitamin D food sources include fatty fish, tuna, mackerel, salmon, beef liver, cheese, egg yolks, and cod liver oil.


GC rs2282679 TG

CYP2R1(1) rs12794714 AA

CYP2R1(2) rs1993116 GG

DHCR7 rs7041 AA

CYP27B1 rs4646537 TT

CYP24A1 rs2296241 AA

Klotho rs9536314 TT

VDR taq rs731236 AA

VDR apal rs7975232 CC

VDR fok rs2228570 .

VDR bsm rs1544410 CC

TYR rs1042602 CC

TYR(2) rs1393350 GG

Vitamin D Supplementation Need

Increased Need

Your genetics are associated with significantly decreased vitaminD levels and stronger need for supplementation. Consider aD3/K2 combination for more effective absorption.

Sunlight Response

Diminished

Sunlight is not likely to be converted into vitamin D effectively inyour body. Vitamin D3/K2 supplementation is stronglyrecommended.

Vitamin D Testing

Suggest Added Testing

Your genetics suggest typical vitamin D testing may be unreliable.Consider testing inactive and active vitamin D levels with aphysician or epigenetic coach to ensure optimal management.

https://apeiron.store/products/d3-5000-k2



12/19/2020 Apeiron


Module 28

Vitamin K

RELEVANT SNP'S

WHAT THIS MEANS

Vitamin K has many different forms that contribute to blood clotting,bone metabolism, and regulating blood calcium levels. Themost impactful forms of vitamin K include vitamin K1 and vitamin K2.Vitamin K1 is found in plants, such as leafy green vegetables. Vitamin K2is usually of bacterial origin and can be found in some animal-based andfermented foods, it is mostly converted by the large intestine or liverfrom vitamin K1.

WHY THIS MATTERS

Many people get an adequate amount of vitamin K through their diet. It’salso present in most multivitamin supplements. Genetics are an activeplayer in this process and can be predictive of absorptionand conversion.

Benefits of Vitamin K

Bone health – In a study in the Netherlands, vitamin K2 was three times more effective in enhancing bone metabolism than K1.

Blood clotting – Vitamin K is essential to blood clotting. In fact, in studies of severe vitamin K deficiency, clotting was almost impossible.

Supporting the efficacy of vitamin D – Vitamin K improves the impact of vitamin D when they are taken in combination.

Vitamin K1 food sources include spinach, kale, turnip greens, collards, swiss chard, mustard greens, parsley, romaine, brussel sprouts, broccoli,cauliflower, and cabbage. Vitamin K2 food sources include fermented foods, liver and natty


APOe(1) rs429358 TT

APOe(2) rs7412 CC

NQO1 rs1800566 GA

Vitamin K Need

Increased Need

Your genetics are associated with increased vitamin K2 needs forbone health, cardiovascular health, and vitamin D and calciumtransport. Vitamin D3/K2 combination enhances absorption.


12/19/2020 Apeiron



Supplement D#/K2 combo to meet the D3 and K2 needs,

12/19/2020 Apeiron


Module 29

Folate

RELEVANT SNP'S

WHAT THIS MEANS

Folate Need: Folate, or vitamin B9, is one of the B-vitamins needed tomake red and white blood cells in the bone marrow, convertcarbohydrates into energy, and produce DNA. It is available in manyfoods and typically found in multivitamin supplements.

Folic Acid Conversion: Folic acid is the synthetic, inactive form ofvitamin B9. In order to be used by the body, it needs to be converted intothe active form: folate.

WHY THIS MATTERS

Folate Need: It’s difficult to get too much folate from food; however, itis possible to consume too much folic acid in the form of supplementsor fortified foods. Folate is crucial to the body, brain and heart; thoseorgans rely on sufficient folate levels for optimal health.

Folic Acid Conversion: Some individuals have a genetic predispositiontowards decreased conversion of folic acid. When folic acid isconsumed regularly, it can lead to a buildup in the body which can contribute to undesirable outcomes.

Benefits of Folate

DNA synthesis and repair – Folate helps with the creation and maintenance of DNA.

Tissue growth – Folate’s role in DNA synthesis makes it essential to tissue and cell growth.

Cardiovascular health – Studies have shown that folate encourages normal cholesterol levels which are important to cardiovascular health.

Neurological health – Most observational studies show that higher folate levels correlate with low Alzheimer’s disease and dementia.

Folate food sources include beef liver, spinach, broccoli, bananas, strawberries, oranges, beans, avocado, tomatoes, beets, celery, asparagus, legumes,yeast, mushrooms, fish, and eggs.


DHFR(1) rs1643649 TT

12/19/2020 Apeiron



Coumpound heterozygous MTHFR which could indicate undermethylation state. Check undermethylation symptoms.

FOLR1 rs2071010 GG

DHFR(2) rs70991108 DI

SLC19A1 rs1051266 TC



Folate Need

Increased Need

Your genetics are associated with increased folate need;recommend low-dose supplementation via a multivitamin.

Folic Acid Conversion

Low

A buildup of folic acid is likely with supplementation; avoid folicacid form, and use the methylfolate form of B9 instead.


12/19/2020 Apeiron


Module 30

Thiamine

RELEVANT SNP'S

WHAT THIS MEANS

Thiamine, also known as vitamin B1, is essential to many bodilyfunctions, including nervous system integrity, muscle function, digestion,and carbohydrate metabolism.

WHY THIS MATTERS

Very little thiamine is stored in the body and depletion can occur quicklywhen not supplied through diet or supplementation. It is sometimescalled an "anti-stress" vitamin because it can strengthen the immunesystem and improve the body's ability to withstand stressful conditions.

Benefits of Thiamine

Energy production - B1 is responsible for converting sugar into energy which supports the smooth functioning of the body organs, especially the heart,brain, lungs, and kidneys.

Improves brain function - It ensures optimal cognitive performance of the brain and helps improve memory and concentration. Vitamin B1 helpsrelieve stress and also helps strengthen the nerves.

Thiamine food sources include beef, brewer's yeast, legumes (beans, lentils), milk, nuts, oats, oranges, pork, and rice.


SLC19A3 rs6713116 CC

Thiamine Need

Increased

You’re likely to benefit from increased thiamine intake from foods.For optimal levels, ensure your B complex or multivitamin hasthiamine or focus on macadamia nuts as a source.


12/19/2020 Apeiron



Multivitamin.

12/19/2020 Apeiron


Module 31

Copper

RELEVANT SNP'S

WHAT THIS MEANS

Copper is a micronutrient that is involved in many processes in the bodyand can easily become deficient due to the lack of intake (even in ahealthy diet). The body cannot produce copper on its own so it requiresdietary intake with food or supplementation.

WHY THIS MATTERS

Copper has a narrow range of safety; it is a common deficiency yet cancreate toxicity if over-supplemented. Most whole food sources are lowin copper.

Benefits of Copper

Cognitive function - Too little or too much copper can have a negativeimpact on the brain. Ideal levels promote growth and development ofbrain pathways.

Thyroid health - Copper promotes optimal thyroid levels. A healthy thyroid is important in keeping adequate absorption of copper from the diet.

Long-term health - Copper is a requirement for ongoing DNA maintenance and repair.

Bone - Copper is important in maintenance and repair of bone and cartilage. Deficiencies can lead to low bone density.

Blood - Lack of copper can lead to iron deficiency.

Skin & hair - Copper is involved in the production of melanin, a pigment responsible for skin and hair color.

Copper food sources include oysters, shellfish, whole grains, beans, nuts, potatoes, and organ meats (kidneys, liver, etc).


SELENB1 rs2769264 TT

ATP7B rs76151636 GG

Copper Levels

Typical Levels

Your genetics are associated with normal copper metabolism;however, this may not reflect actual blood levels.

12/19/2020 Apeiron


12/19/2020 Apeiron


Module 32

Zinc

RELEVANT SNP'S

WHAT THIS MEANS

Zinc is an essential mineral that is responsible for regulating the nervoussystem. It is involved in assisting at least 100 different processes inthe human body and is a common micronutrient deficiency.

WHY THIS MATTERS

Deficiencies can lead to many health issues and optimal levels areessential to thrive. Plant based sources of zinc generally providesignificantly lower bioavailability than animal based food sources.

Benefits of Zinc

Immunity - Zinc is an essential nutrient for the immune system.

Cognitive function - It is essential for optimal communication betweenneurons in the brain.

Common cold - Zinc has been shown to lessen the severity and duration of the common cold.

Wound healing - Zinc decreases inflammation and reduces bacterial growth to helping maintain skin integrity.

Taste & smell - The senses of taste and smell are reliant on zinc for proper function; it has been shown to heighten these senses.

Weight loss - Zinc deficiencies can lead to overeating.

Zinc food sources include oysters, beets, chicken, pork, seeds, nuts, lentils, and mushrooms.


CA1 rs1532423 AA

PPCDC(1) rs2120019 TC

PPCDC(2) rs4826508 T

12/19/2020 Apeiron



Avoid over supplementation of Zinc.

Zinc levels

High Levels Likely

Your genetics are associated with higher levels of zinc maintainedin the blood.

Copper/zinc/ceruloplasmin testing through a physician may bebeneficial depending on symptoms. Avoid supplementationwithout directly testing blood levels.

12/19/2020 Apeiron


Module 33

Iron

RELEVANT SNP'S

WHAT THIS MEANS

Iron Need: Iron is an essential mineral and one of the mostcommon nutritional deficiencies around the world. Individuals with thehighest likelihood of an iron deficiency include menstruatingfemales, pregnant women, children, and those consuming a plant baseddiet.

Iron Excess Propensity: Some individuals have a genetic propensitytowards increased iron levels.

WHY THIS MATTERS

Iron Need: Almost 10% of women in developed countries are irondeficient. Fatigue, insomnia, hair loss, and ice crunching are commonsigns of deficiency. Inadequate intake of vitamin C can can contribute toiron malabsorption. Plant based iron is not incorporated as well asanimal based iron.

Iron Excess Propensity: Excessive levels of iron can contribute tofatigue, weakness, loss of libido, and high blood sugar.

Benefits of Iron

Hemoglobin production - Dietary iron is a critical component for producing oxygen transport proteins within red blood cells.

Oxygen transport - Iron contributes to oxygen transport throughout muscles.

Muscle function - Iron is critical for the brain and it is important in the production of neurotransmitters. Insufficient iron in the diet is associated withlow iron levels in the brain which can lead to changes in behavior and cognitive functioning.

Iron food sources include fish, eggs, meat (especially high in red meats) legumes, lentils, green leafy vegetables, spinach, turnips, and sprouts.


TMPRSS6 rs4820268 GA

Iron Need

Typical

You’re likely to have normal iron metabolism and requirements.

12/19/2020 Apeiron


TFR2 rs7385804 AA

TF rs3811647 GA

HFE(1) rs1799945 CG

HFE(2) rs1800562 GG

HFE(3) rs1800730 AA

Iron Excess Propensity

Typical

You’re unlikely to have increased iron levels.

12/19/2020 Apeiron


Module 34

Nitric Oxide

RELEVANT SNP'S

WHAT THIS MEANS

Nitric Oxide is a molecule made by the body that allows blood, nutrients,and oxygen to travel to every part of your body effectively and efficiently.Bodies are capable of producing nitric oxide but some genetic variantscan alter that ability. Nitrates are the natural forms of nitric oxide that thebody can utilize. 80% of the nitrates in our diet come from vegetables.Interestingly, organic vegetables have less nitrates than conventionallyfarmed food due to reduced use of nitrogen based fertilizers.

WHY THIS MATTERS

High levels of nitric oxide have been shown to boost endurance andoxygen utilization.

Benefits of Nitric Oxide

Cardiovascular – Nitric oxide can lower blood pressure and dilateblood vessels.

Exercise – Nitrates have been shown to decrease oxygen requirements of muscles during exercise and lead to greater endurance.

Brain – Nitric oxide is a potent antioxidant in the brain and functions as a neurotransmitter.

Immunity – Nitric oxide is used by our immune cells to kill invading bacteria.

Nitric oxide food sources include spinach, kale, beets, carrots, legumes, celery, eggplant, ham, and bacon.


NOS3(2) rs2070744 TT

NOS1(1) rs3782218 CC

NOS1(2) rs2682826 GG

Nitric Oxide Need

Typical Need

Your genetics are associated with normal nitric oxide levels;consider using a saliva tester strip to check levels to ensureoptimal performance

https://apeiron.store/products/n-o-indicator-strips

12/19/2020 Apeiron


NOS2 rs2248814 AG

NOS3(1) rs1800779 AA

NOS3(3) rs7830 GG

12/19/2020 Apeiron


Module 35

Sodium

RELEVANT SNP'S

WHAT THIS MEANS

Sodium balance is one of the most monitored systems in the body.Because sodium is so important to the maintenance of health, it is finelytuned to a very narrow and precise level. Taking excess sodium for mostpeople will not result in health problems, assuming the body isfunctioning well.

WHY THIS MATTERS

Genetics can increase the effect the sodium on blood pressure andoverall functionality.

Types of sodium include table salt (sodium chloride and iodine),himalayan salt (slightly lower sodium plus calcium, potassium, iron oxide(pink color)), and celtic salt (slightly lower sodium and trace minerals).


ACE del rs4343 GA

AGT rs699 GG

ADD1 rs4961 GT

NEDD4L rs4149601 GG

WNK1 rs12828016 GG

Sodium Sensitivity

Increased Possibility

Your genetics suggest higher correlation between blood pressureand sodium. If you notice the effects of sodium on bloodpressure, it may be beneficial to reduce sodium intake.

12/19/2020 Apeiron



Potential for increased sodium sensitive high blood pressure. If noticing increases in blood pressure or edema decrease sodium intake.

12/19/2020 Apeiron


Module 36

Caffeine

RELEVANT SNP'S

WHAT THIS MEANS

Caffeine is a stimulant of the central nervous system. It is one of themost researched substances in the history of science and the world'smost consumed psychoactive drug. Genetic propensity can determinehow beneficial caffeine is for an individuals system.

Caffeine Metabolism: Genetics provide an insight into how quickly anindividual breaks down or metabolizes caffeine.

Caffeine Jitters: Many people experience jitters when consuminghigh amounts of caffeine, genetics can inform the predispositionto experience jitters with low or moderate consumption.

WHY THIS MATTERS

Caffeine Metabolism: While many individuals metabolize caffeine slowly,some have a genetic propensity to eliminate caffeine from their bodiesefficiently. Studies demonstrate fast metabolizers have additionalbenefits from caffeine consumption.

Caffeine Jitters: Caffeine may cause anxiety and have undesirable effects on sleep. While this is dependent on several variables such as timing andquantity, some have an increased genetic propensity.

Benefits of Caffeine

Energy – Caffeine can improve daily energy by interfering with a substance called adenosine.

Fat burning – Caffeine is one of only a handful of natural substances proven to improve fat loss.

Physical performance – Caffeine is a true performance enhancing substance.

Reduced risk of neurodegenerative diseases - Coffee itself has been linked to reduced risk of cognitive decline.


12/19/2020 Apeiron



Caffeine intake may create symptoms of anxiety and disrupt sleep. If drinking caffeine drink in the early part of the day.

ADORA2A rs5751876 TC

ADA rs73598374 CC

CYP1A2(1) rs762551 CA

CYP1A2(2) rs2472297 CC

AHR rs4410790 TC

Caffeine Metabolism

Slow Metabolizer

Your genetics are associated with slower caffeine metabolism;caffeine is likely to be less beneficial for cardiovascular health,blood pressure and athletic performance.

Limit coffee consumption to 1 cup/day or less and only consumeduring morning time.

Caffeine Jitters

Typical

You have a typical propensity towards jitters from caffeine.

12/19/2020 Apeiron


Module 37

Circadian Propensity

RELEVANT SNP'S

WHAT THIS MEANS

The circadian rhythm is a cycle that signals our bodies when to sleep,rise and eat. Humans are a diurnal species, meaning we are active duringthe day and sleep at night. Many feel more awake, alert, and capable ofour best work effort in the morning. However, there are those at theopposite end of the spectrum who prefer to stay up late and sleep wellinto the daytime hours. These individuals find themselves most alert inthe evening.

WHY THIS MATTERS

Recent research has revealed that the circadian clock is not as basic aswe once suspected. Individual circadian variations regulate the timing offunctions such as appetite, hormone release, and metabolism. Sleepgenes are some of the most important and impactful geneticsindividuals inherit. They are also unlikely to change with epigeneticexpression. While some individuals are aware with their circadian rhythms, many are living in opposition of their genetic propensities. Forcing the bodyto fit into a sleep-wake cycle that does not match our genetics, can lead to circadian desynchronization.


PER3(1) rs10462021 AA

PER3(2) rs228697 CC

AANAT rs28936679 .

GNB3 rs5443 TT

PER2(2) rs934945 CC

ARNTL rs2278749 CC

Circadian Propensity

Morning

You’re likely to perform best with early wake and sleep times. 8-10pm is typically ideal bedtime, with a 4-6am wake-time.Reinforce this with good light exposure habits and sleep hygiene.

12/19/2020 Apeiron



Key Points Likely to do best with early sleep and wake times; 8-10pm and 4-6am Good melatonin production; slow breakdown Likely ideal Sleeponset time; possible delay Benefit most from 7-8 hours of high quality sleep Likely to have about 60 minutes of micro-awakenings through the nightUnlikely to experience excessive sleep movement except as a result with grain sensitivity symptoms Sleep Recommendations Create a sleep ritual toprepare for sleep and start the onset timer early Magnesium glycinate will support sleep Aim for 8-9 hours for 7-8 hours of high-quality sleep.Consider Oura Ring, biostrap, or Garmin Watch to track over time.

12/19/2020 Apeiron


Module 38

Melatonin

RELEVANT SNP'S

WHAT THIS MEANS

Melatonin is the sleep hormone. Genetic can help to guide the need forsupplementation by looking at production, response to supplementation,and breakdown speed. Melatonin can be supplemented in conditionswhere production or response is diminished.

Melatonin Production: Light has a strong production on melatonin;melatonin production decreases when light gets brighter and increasesas lights dim. It can take up to 4 hours to produce optimal melatoninlevels for optimal sleep.

Melatonin Response: Certain individuals tend to respond to melatoninsupplementation whereas others experience minimal effects.

Melatonin Breakdown: Similar to caffeine, genetics can predispose individuals to vary in melatonin breakdown efficiency.

WHY THIS MATTERS?

Melatonin Production: Production drops off dramatically as we age and this can have significant health impacts. Genetics provide an understanding asto optimal strategies to increase melatonin production and increase sleep quality.

Melatonin Response: Those with specific genetics may experience a better response from dietary sources of melatonin rather than supplementation.

Melatonin Breakdown: Depending on melatonin breakdown efficiency, some forms of melatonin may be more beneficial than others. For example, afast metabolizer may benefit from a delayed release supplement, whereas a slow metabolizer may feel waking drowsiness from the same levels.

Functions of melatonin:

Sleep - Melatonin is intimately involved with regulation of our circadian rhythm.

Antioxidant - A powerful free radical scavenger, melatonin interacts with immune cells to help boost response to infectious organisms.

Immune function - Melatonin interacts with immune cells to help boost response to infectious organisms.

Anti-aging - Melatonin plays a role in longevity.


12/19/2020 Apeiron


MTNR1B(1) rs1387153 CC

MTNR1B(2) rs10830963 CC


TPH2(1) rs4570625 GT

AANAT rs28936679 .

ADA rs73598374 CC

CYP1A2(1) rs762551 CA

Melatonin Production

Average

You’re likely to have ideal production of melatonin in combinationwith healthy sleep habits.

Melatonin Response

Average

You’re likely to respond effectively to melatonin supplementation.

Melatonin Breakdown

Slow

You’re likely to break down melatonin slowly throughout the night;you’re likely to benefit from lower doses (0.3 to 1.5mg) ofsupplementation. Extended-release melatonin should be avoided.

https://apeiron.store/products/melatonin-sl

12/19/2020 Apeiron


Module 39

Sleep Onset

RELEVANT SNP'S

WHAT THIS MEAN

Normal sleep onset is the time from lying down to the first stages ofsleep. Onset is approximately 15-20 minutes, however, falling asleepfaster can indicate a degree of sleep deprivation.

WHY THIS MATTERS

Individual genetics play a large role in predicting longer or shorter sleeponset. Despite possessing a propensity for delayed sleeponset, identifying the genetic components that are most impactful to theprocess allows a much more directed and personalized approach tooptimal sleep interventions. Onset of sleep outside of the typical rangeusually indicates either a genetic or lifestyle component.

0-5 minutes = severe sleep deprivation 6-15 minutes = moderate sleep deprivation 15-20 minutes = normal >20 minutes = probable genetic or environmental


NPSR1 rs324981 TT

CLOCK(3) rs1801260 AA

PER3(1) rs10462021 AA

PER3(2) rs228697 CC

COMT rs4680 GA

AANAT rs28936679 .

CACNA1C(1) rs4765913 TT

Sleep Onset

Typical Onset

You’re likely to fall asleep normally; within 15-20 minutes of goingto bed or starting your sleep routine.

12/19/2020 Apeiron


CACNA1C(2) rs2239063 AA

12/19/2020 Apeiron


Module 40

Sleep Duration

RELEVANT SNP'S

WHAT THIS MEANS

When we don't get the sleep we need, we experience surges of stresshormones which disrupt our cognition and ability to regulate emotions.90% of adults require 7 - 9 hours of sleep a night.

WHY THIS MATTERS

Studies have demonstrated that just two hours of sleep deprivation (5 - 6hours of sleep) results in a vigilance level equivalent to the consumptionof two alcoholic drinks. Interestingly, while there is a detrimental declinein vigilance our perceived level of vigilance will be normal. Lost sleepreduces brain power and productivity, diminishes concentration, andimpairs memory. It lowers creativity, reduces the ability to communicate,impairs motor skills, and increases stress and anxiety. Many factorscontribute to how long we sleep. Assessing your genetic sleep variationsand establishing effective sleep strategies are essential steps in theprocess of sleep optimization.

Sleep requirements Teens - 9-10 hours Adults - 7-9 hours


NPSR1 rs324981 TT



COMT rs4680 GA

ADA rs73598374 CC

GNB3 rs5443 TT

Sleep Duration

Shorter Sleep Time

Your genetics are associated with shorter sleep cycles. (6.5-8hours of high quality sleep is desirable). Consider the impact ofthis section in combination with sleep onset and sleep disruption.

12/19/2020 Apeiron


ABCC9(1) rs1517284 TT

GRIA3(1) rs687577 C

ABCC9(2) rs11046205 GG


DEC2 rs121912617 GG

12/19/2020 Apeiron


Module 41

Sleep Disruption

RELEVANT SNP'S

WHAT THIS MEANS

Sleep is the most important thing you can do to improve performance inlife. Sleep quality is determined by a complex network ofinteracting physiological processes which are strongly influencedby lifestyle. It is influenced by the amount of deep sleep, the number ofrapid eye movement (REM) episodes, and the number and durationof waking episodes. When our lifestyle is not in sync with ourchronotype, sleep quality can be significantly impacted.

WHY THIS MATTERS

Genetic predispositions can provide a directed approach that can betaken to improve sleep quality. It's important to align with your circadianpropensity before addressing sleep quality.



PPP2R4 rs10988217 AG

COMT rs4680 GA

ADORA2A rs5751876 TC

GNB3 rs5443 TT

GRIA3(1) rs687577 C

ARNT rs2228099 CC

Sleep Disruption

Low

Overall, your genetics are indicative of natural propensity for goodsleep quality with healthy sleep habits. If your experience isdifferent, an epigenetic coach can assist in achieving your sleepgoals.


12/19/2020 Apeiron


FABP7 rs2279381 CC

TNF rs1800629 GA

BDNF rs6265 CT

12/19/2020 Apeiron


Module 42

Daytime Drowsiness

RELEVANT SNP'S

WHAT THIS MEANS

Daytime Drowsiness involves a decreased ability to regulate sleep/wakecycles.

WHY THIS MATTERS?

Certain genotypes may predispose individuals to increased daytime drowsiness propensity in combination with micronutrient deficiencies.


HLA-DRB1 rs3135388 GG

TRCA rs1154155 TT

P2RY11 rs2305795 GA

Daytime Drowsiness Propensity

Unlikely to Express

You have a low propensity towards daytime drowsiness. If you’reexperiencing sleepiness during the day, it may be the result ofsleep deprivation. An epigenetic coach can assist in enhancingyour performance.


12/19/2020 Apeiron


Module 43

Sleep Movement

RELEVANT SNP'S

WHAT THIS MEANS

Excessive sleep movement is a condition that can disrupt your sleep. Itis characterized by a need to move the legs and tends to be worse whileattempting to sleep. Spontaneous movements are triggered by rest,relaxation, or sleep. Potential causes include iron deficiency,genetic predisposition, brain neurotransmitter imbalances, and increasedbrain glutamate.

WHY THIS MATTERS

Carrying genetic predispositions does not suggest that it is present, thisis solely based on probability. Many people have the symptoms without agenetic predisposition as well. The genetic variations can provideinterventions that will have a higher probability of mitigating expression.


MEIS1 rs2300478 TT

BTBD9(1) rs9357271 CC

BTBD9(2) rs3923809 AG

MAP2K5(1) rs12593813 AA

MAP2K5(2) rs11635424 AA

PTPRD rs4626664 GA

Excessive Sleep MovementPropensity

Typical

You’re unlikely to experience excessive sleep movement fromgenetics. If you’re experiencing sleep movement, considerworking with an epigenetic coach to enhance your sleep.


12/19/2020 Apeiron


Module 44

Phase 1 Detox

RELEVANT SNP'S

WHAT THIS MEANS

Phase 1 is the first line of defense against toxins. Although 'toxins' havea negative connotation, they are necessary for bodily function. Toxinsinclude medications, supplements, and even things that are produced byan individual's physiology. Phase 1 changes toxins into a form that canbe flushed out of an individual's system.

Medication, anesthetic, acetaminophen, and NSAID metabolisms: Eachindividual has different breakdown speeds of various toxins dependingon genetic propensity and also epigenetic factors.

Estrogen Metabolism: This is a more complex breakdown compared toother toxins.There are multiple ways estrogen can break down;some more desirable than others. Genetics can predict this likelihood.

WHY THIS MATTERS

This first phase can convert toxins into benign forms but it also has thepotential of creating an even more toxic product. Therefore, it is important to pay attention to both phase 1 and phase 2 detoxification pathways.

Medication, anesthetic, acetaminophen, and NSAID metabolisms: Depending on breakdown speed, individuals can experience different formsof imbalance when theres a build-up of these toxins. Understanding one's propensity can provide insight into how the body responds to them.

Estrogen Metabolism: Understanding the propensity can indicate an area that may benefit from more precise measurement and support.


CYP1A1 rs2606345 CA

CYP2A6(2) rs5031017 CC

CYP2C9(2) rs1799853 CC

CYP1B1(1) rs1056836 GG

Medication Metabolism

Optimal

Ideal breakdown of nicotine, nitrosamines, and certainmedications. Ensure optimal glutathione function.

12/19/2020 Apeiron


CYP2C19(2) rs28399504 AA

CYP3A4 rs2740574 TT

CYP2D6 rs3892097 CC

CYP2D6(3) rs133333 AA

CYP2D6(4) rs5758550 AA

CYP2E1(1) rs6413419 GG

CYP2E1(2) rs2031920 CT

Anesthetics Metabolism

Optimal

Likely to have an ideal, fast metabolism of anesthetics.

Acetaminophen Metabolism

Slow

Likely to have very slow metabolism of acetaminophen (tylenol)and alcohol. Regular use can contribute to liver issues. Limit theirusage.

NSAIDS Metabolism

Optimal

Fast metabolism of NSAIDs.

Estrogen Metabolism

Typical

Likely to have a balance of desirable and undesirable estrogenmetabolism. Consider working with an epigenetic coach orphysician to support estrogen metabolism.


12/19/2020 Apeiron


Module 45

Methylation

RELEVANT SNP'S

WHAT THIS MEANS

As you know, epigenetics changes the expression of genes based on theenvironment. Methylation plays a crucial part in this process, andoptimal balance creates desirable outcomes. Methylation is one of themost important processes in the body and it plays a significant role indetoxification.

WHY THIS MATTERS

When methylation is out of balance, it causes systemic effects that canlead to undesirable outcomes. There are many variables toconsider such as micronutrient levels and lifestyle factors.Impactful micronutrients include B12, B6, and folate,whereas, important lifestyle factors include smoking and alcoholreduction, consistent exercise, and stress optimization.

Overmethylation symptoms include paranoia, self mutilation (tattoos,piercings), depression, artistic or music abilities, low motivation, upperbody/head/neck pain, high pain threshold, a lot of body hair, hard time shutting mind off, food/chemical sensitivities, high anxiety, sleep disorder, panictendencies, adverse reactions to antihistamine, and pacing.

Undermethylation symptoms include obsessive compulsive tendencies, history of perfectionism, history of high accomplishment, ritualistic behaviors,low tolerance for pain, addictive tendencies, self-motivated, history of competitiveness in sports, social isolation, tendency towards slenderness,phobias, seasonal allergies, frequent headaches, very strong willed, poor concentration endurance.


DHFR(1) rs1643649 TT

FOLR1 rs2071010 GG

COMT rs4680 GA

DHFR(2) rs70991108 DI

Methylation

Typical

Genes associated with relatively normal methylation ability.

12/19/2020 Apeiron


SLC19A1 rs1051266 TC



CBS rs234706 GG

12/19/2020 Apeiron


Module 46

Acetylation

RELEVANT SNP'S

WHAT THIS MEANS

As you know, epigenetics changes the expression of genes based on theenvironment. Acetylation plays a crucial part in this process, andoptimal balance rates desirable outcomes. Acetylation is one of themost important processes in the body and it plays a significant role indetoxification. It works to help detoxify histamines, tobacco smoke,exhaust fumes, and medications.

WHY THIS MATTERS

Proper acetylation contributes to optimal organ function, and providesprotection agains long term imbalances.


NAT1(1) rs1805158 CC

NAT1(2) rs4986782 GG

NAT2(1) rs1801280 TT

NAT2(2) rs1799931 GG

NAT2(3) rs1801279 GG

Acetylation

Typical

Genes associated with normal acetylation function.

12/19/2020 Apeiron


Module 47

Glutathione System

RELEVANT SNP'S

WHAT THIS MEANS

Phase 2 detoxification systems are responsible for eliminating toxinsfrom the body. Glutathione is one of the most important systems of thephase 2 detoxification process. It is the master antioxidant and isgenerally responsible for reducing inflammation. While many peoplefocus on taking antioxidants, this may not be the best option foroptimizing the body. Focusing on enhancing the glutathione system willallow the body to manage inflammation in a more efficient manner.

WHY THIS MATTERS

In addition to inflammation management, glutathione boosts immunefunction, enhances mitochondrial function, repairs DNA, and detoxifiesheavy metals, medications, environmental toxins, and pollutants.


GSTM1(2) rs366631 AG

GPX1(2) rs3448 CC

GSTT1 rs11550605 .

GPX1(3) rs3197999 GG

GSTP1(2) rs1138272 CC

GSTP1(1) rs1695 AG

GPX1(1) rs1050450 GG

Glutathione

Support Benefit

You have an increased benefit from supporting your glutathionesystems. An epigenetics coach can provide more individualizedsupport; however, you’re likely to benefit most from adequateselenium from a multivitamin, adaptogens, and NAC.

http://apeironzoh.com/coaches


https://apeiron.store/products/adrenal-adaptogens

https://apeiron.store/products/nac

12/19/2020 Apeiron


GSTM1(1) rs1056806 CC

GCLC rs553822 CT

CAT rs1049982 TC

CAT(2) rs769217 CC

TXN rs2301241 GA

12/19/2020 Apeiron


Module 48

Mitochondria

RELEVANT SNP'S

WHAT THIS MEANS

The mitochondria are classically viewed as the batteries of our cells.They produce the energy required for cell function. Many opportunitiesfor enhancements are either directly or indirectly related to mitochondria;health experts have increasingly focused on maximizing mitochondrialhealth to optimize the human system.

WHY THIS MATTERS

Because of energy production, the mitochondria produce free radicals.Free radicals are typically understood as unstable atoms that candamage cells, causing illness and aging. This is not completely accurateas some free radicals are essential and beneficial. Therefore, it isimportant to maintain balance and homeostasis in the body.


NQO1 rs1800566 GA

UCP2(1) rs659366 TT

SOD2 rs4880 AA

UCP4 rs2270450 CT

SIRT1 rs12778366 TT

SIRT5 rs10498683 CC

SOD2(2) rs2758331 CC

Mitochondria

Support Needed

Strong benefit from mitochondrial support to reduceinflammation and generate more energy. Consider mitochondrialboosters such as Fish oil, MitoQ, NMN, and D-ribose, as well ashigh quality sleep, intermittent fasting, regular exercise, and coldthermogenesis.

https://apeiron.store/products/high-potency-epa-dha

https://apeiron.store/products/mitoq


https://apeiron.store/products/performance-powder

12/19/2020 Apeiron


COX6B1 rs6510502 CC

ATP5C1(1) rs11255367 AA

ATP5C1(2) rs2802460 TT

NDUFS2 rs1136224 AG

NRF2(1) rs6721961 GG

NRF2(2) rs1962142 GG


12/19/2020 Apeiron


Module 49

Mold Sensitivity

RELEVANT SNP'S

WHAT THIS MEANS

It is estimated that nearly 25% of the population carries genetics that predispose to decreased mold detoxification. Often genetic variants correspondto decreased production of the antibodies that eliminate mold toxins. This can lead to chronic inflammation and overall diminished wellness. There aretwo factors to consider when determining need for support: level and duration of exposure and genetics of the detoxification system.

WHY THIS MATTERS

When it comes to mold, consider that according to the Environmental Protection Agency (EPA) Building Assessment Survey and Evaluation (BASE)study, 45% of U.S. buildings have current/ongoing water damage and 85% have past water damage. This is a ripe breeding ground for mold. Symptomscan include: chronic headache, fatigue, dizziness, memory problems/brain fog, muscle aches, cough, and shortness of breath.


HLA-DRA(1) rs7192 TG

HLA-DRA(2) rs3135391 GG

HLA-DRA(3) rs8084 AC

Sensitivity to Mold Toxin

More Sensitive

Genes suggest correlation with increased sensitivity and lessability to detoxify mold. Limit exposure overall; A HEPA air filtercan assist in home and work environments.

12/19/2020 Apeiron


Module 50

Lyme Intensity

RELEVANT SNP'S

WHAT THIS MEANS

Lyme is a disease transmitted by ticks. There are two different variationsof Lyme disease; acute and chronic. Acute infection is the immediatereaction after exposure to Lyme. It is well documented, and earlytreatment is important. Chronic Lyme disease is a bit more complicatedand can be difficult to diagnose.

WHY THIS MATTERS

Antibody tests are available, however, they only confirm past infection. The diagnosis of chronic Lyme disease is based primarily on symptoms.These symptoms can include:chronic fatigue, headache, muscle andjoint aches, memory loss /other cognitive impairments,numbness/tingling, and gastrointestinal symptoms. Chronic Lymedisease is becoming a significant issue and several geneticvariants predispose individuals to more significant health issues.


TLR1 rs5743618 AA

ACSL1 rs13120078 GG

GAD1(1) rs3749034 GG

GAD1(2) rs3828275 CT

GSTP1(2) rs1138272 CC

GAD1(3) rs3791878 GT

SOD2(2) rs2758331 CC

Lyme Intensity Propensity

Typical

If exposed to Lyme, you're likely to have a typical response.

12/19/2020 Apeiron


12/19/2020 Apeiron


Module 51

Envirotoxin and Pollution Sensitivity

RELEVANT SNP'S

WHAT THIS MEANS

The consequences of living in an industrialized world is the exposure to new toxins created by society. Many of these envirotoxins can significantlyalter gene expression if they aren't adequately detoxified. Genetic propensities indicate the inflammatory response after exposure to envirotoxins.

WHY THIS MATTERS

These toxins can cause chronic disruptions and can even lead to disruptions of genetic expressions in our children and subsequent generations. It isimpossible to avoid exposure to these chemicals so it is essential to make sure our defense systems are optimized to manage and process exposure.


CAT(3) rs2300181 CC

NQO1 rs1800566 GA

UGT2B15 rs1902023 AC

LOX rs1800449 CC

IL6 rs1800795 GG

Pollution and Envirotoxin Sensitivity

Increased

Likely to experience strong undesirable reactions to envirotoxinssuch as BPA, phthalates, pollution, smoke, etc. Limit exposure byusing air and water filters. Consider hypo-allergenic andfragrance-free cleaning and beauty supplies. Glutathione supportsuch as selenium from a multivitamin and NAC may be beneficial,as well as overall environmental support from Quercetin.


https://apeiron.store/products/NAC

https://apeiron.store/products/environmental-support-formula

12/19/2020 Apeiron


Module 52

Histamine Sensitivity

RELEVANT SNP'S

WHAT THIS MEANS

Histamines are a compound the body uses to signal that it is underattack, and is a natural part of our defense system. Histamines comefrom the environment and are also produced in our own gut.

WHY THIS MATTERS

Histamines are responsible for sneezing, itching, hives, rashes, stuffynose, etc. These all sound unpleasant but they have a purpose. Thissystem, like every system in the body, requires balance. This means thatit is good to have the response but we also need to be able to control itand turn it off when it is no longer needed.


AOC1(1) rs10156191 CC

AOC1(2) rs1049742 CC

AOC1(3) rs1049793 CC

AOC1(4) rs2052129 GG

HNMT rs1050891 AA

MAO-B rs10521432 G



MAO-B(2) rs1799836 T

Histamine Sensitivity

Typical

Genes associated with relatively average histamine processing.

12/19/2020 Apeiron


12/19/2020 Apeiron


Module 53

Heavy Metal Processing and Impact

RELEVANT SNP'S

WHAT THIS MEANS

Genetics predispose the likely health impact of heavy metals such as lead, arsenic, cadmium, chromium, and mercury. All heavy metalsare processed similarly, however mercury is the most encountered.

Overall Heavy Metal Processing: Heavy metal processing is how fast your body absorbs and eliminates heavy metals.

Inorganic Metal Processing: Inorganic mercury exposure comes from inhaled environmental pollutants, food, dental amalgams, vaccinations, andeven supplements. Some Ayurvedic herbs have significant heavy metal contamination. Ayurveda is the traditional Hindu system of medicine; it isbased on the idea of balance in the body and uses diet, herbal treatment, and yogic breathing.

Organic Metal Processing: Organic metal is the form found in nature; individuals are principally exposed to through fish consumption.

Heavy Metal Health Impact: Certain gene variants can predispose an individual to significant impact from even low levels of exposure. Studies havedemonstrated that this may be related to genetics; gene variants provide a picture of how heavy metal ingestion affects overall health. Heavy metaleffects impact each individual differently due to variations in the distribution, metabolism, and elimination.

WHY THIS MATTERS

Overall/Inorganic/Organic Metal Processing: Low processing can contribute to a build up of heavy metals in the system and creates non-desirablehealth impacts.

Heavy Metal Health Impact: Heavy metals can affect many body systems including the brain & nervous system, heart, and kidneys. There are impactson reproductive and endocrine function. It can induce or exacerbate autoimmune disease and neurologic risks in the perinatal and earlychildhood period can lead to cognitive and behavioral changes. Although all forms of heavy metals have adverse effects on human health at highdoses, the evidence suggests low level of exposure may potentially lead to significant outcomes.


GSTM1(2) rs366631 AG

GSTT1 rs11550605 .

GSTP1(2) rs1138272 CC

MT4 rs11643815 GG

Overall Heavy Metal Processing

Low

Low processing of heavy metals overall. Limit exposure andconsider glutathione and antioxidant support to ensure optimalprocessing of heavy metals. Selenium from a multivitamin, NAC,and Quercetin are ideal for supporting processing.




12/19/2020 Apeiron


GSTP1(1) rs1695 AG

GCLM rs41303970 GG

GPX1(1) rs1050450 GG

SEPP1 rs7579 CC

ABCC2(1) rs1885301 GG

ABCC2(2) rs717620 CC

ABCC2(3) rs2273697 GA

ATP7B(2) rs1061472 TC

BDNF rs6265 CT

COMT rs4680 GA

CPOX4 rs1131857 TG

CPOX5 rs1729995 TC

PON1 rs854561

PGR rs1042838 CC

TF rs3811647 GA

MMP2 rs243865 CC

Inorganic Metal Processing

High

You’re likely to have ideal processing of heavy metals frominorganic sources such as dental amalgams. Limit exposure andensure optimal selenium levels.

Organic Metal Processing

Very Low

Very low processing of heavy metals from organic sources suchas food. Limit exposure and consider glutathione and antioxidantsupport to ensure optimal processing of heavy metals. Seleniumfrom a multivitamin, NAC, and Quercetin are ideal for supportingprocessing.

Heavy Metal Health Impact

High

Heavy metal buildup is likely to create intense and undesirablelong-term effects. Limit your exposure and ensure optimalprocessing. Selenium from a multivitamin, NAC, and Quercetin areideal for supporting this system.







12/19/2020 Apeiron


Module 54

Mercury and Fish

Fish consumption is one of the more robustly discussed topics as itrepresents the greatest source of exposure to organic mercury. Thisinformation by itself may prompt people to avoid fish yet it is only part ofthe story. The truth is that fish is very healthy; it is full of omega-3 fats. Additionally, most fish contain a high ratio of selenium to mercury. Thisratio is much more important than the absolute mercury contentbecause selenium essentially makes mercury nonreactive. Recentevidence suggests a major contributors of mercury symptoms may bedue to selenium deficiency. Consuming fish with a higher level ofselenium than mercury is safe and healthy. Listed below are the averageratios for many common fish.

12/19/2020 Apeiron


Module 55

About Athletic Performance Genetics


Key Points Strong VO2 Max genetics; especially muscle VO2 Max Low muscle fatiguability; longer muscle endurance Slightly increased recovery timeafter intense exercise; liposomal vitamin C will enhance recovery Average strength and hypertrophy genetics Propensity towards endurance ratherthan power/sprint Above average benefit from soft tissue support over time Performance Recommendations Berberine, D-ribose and allmitochondrial boosters mentioned earlier to boost ATP recycling and mitochondrial function Ashwagandha to reduce soreness and fatigue afterintense exercise Incorporate flexibility training over time to protect soft tissue; BPC-157 is also very effective.

There is strong correlational evidence that genetics play an importantrole in athletic performance. Correlation means two things have ademonstrated tendency to show up together. For example, elite athletestend to have certain genetics, however, having genetics similar to eliteathletes does not guarantee elite performance. On the other hand, thereare elite athletes that possess genetics which are not indicators of eliteperformance. Several factors can attribute to this seemingly disparateoccurrences such as genetics, epigenetics, and environmental factors.

Athletic propensities are generally expressed through a combination ofSNPs rather than a single relevant SNP. Epigenetics provides the abilityto change the genetic expression through environment and lifestyle. Thealteration of specific genes occurs through nutrigenomics, which is the strategic use of nutrition and supplementation to change epigeneticexpression.

Keep in mind, genetics is about propensities and probabilities, not absolutes. Having ideal genes for elite performance will not make you an eliteathlete, and not having optimal performance genetics does not make it out of reach. This translation guide is not designed to provide direct toconsumer guidance; it should be used as away to open a discussion with an Apeiron Certified Epigenetic Human Performance Coach who understandsthe art and science of genetics, epigenetics, and the interactive component of using the personal genetic blueprint to guide success in alignment withyour specific goals.

12/19/2020 Apeiron


Module 56

VO2 Max Overall

RELEVANT SNP'S

WHAT THIS MEANS

VO2 max is the maximum amount of oxygen a person can use during intense exercise. There are three different categories of VO2 Max:cardiovascular, metabolic, and muscle. Most genetic analysis are correlation based studies and compare athletes with elite performance capabilitiesto non-elite athletes. VO2 max is a common measure of athletic performance and can be used to guide training programs for optimal outcomes. Eliteendurance athletes consider optimal VO2 max an essential area to optimize.

WHY THIS MATTERS

There is a strong genetic component to VO2 max; genetics can predict 25-50% of the differences between individuals. VO2 max takes into accountcardiac stroke volume, heart rate, vascular tone, muscle fiber type, and metabolic machinery of the cell. This report breaks down individual pieces ofthe system that contribute to VO2 max and the specific gene variants that contribute to the components. This helps to bio-individualize recommendations for improvement.


RGS18 rs10921078 GG

BTAF1 rs2792022 TC

TSHR rs7144481 TT

GRIN3A rs1535628 AA

KCNH8 rs4973706 TT

C9 rs12115454 GA

ZIC4 rs11715829 TT

CAMTA1 rs884736 TC

BIRC7 rs6090314 AA

Overall VO2 Max

Strong

You’re likely to have higher VO2 max trainability; see eachindividual section for more information.

12/19/2020 Apeiron


NDN rs824205 CC

TTC6 rs12896790 TT

APOe(1) rs429358 TT

APOe(2) rs7412 CC

HFE(1) rs1799945 CG

HFE(2) rs1800562 GG

PPARA rs4253778 GG

VEGFa(1) rs2010963 GG

HBB rs11036351 CT

CHRM2 rs324640 GG

EPAS1 rs1867785 AA

12/19/2020 Apeiron


Module 57

Cardiovascular VO2 Max

RELEVANT SNP'S

WHAT THIS MEANS

The first component of VO2 max is cardiovascular function. Thegenetics of cardiovascular function affects the heart rate, heart rhythm,blood flow, nervous system response, and blood capillary size.

WHY THIS MATTERS

Genetics that improve cardiovascular VO2 max enhance the function ofthe above processes. Better processes typically correspond withstronger athletic performance from training.


ADRB1 rs1801253 GC

NFIA-AS2 rs1572312 GG

EDN1 rs5370 GT

BDKRB2 rs1799722 CC

HIF1A rs1885088 GG

DBX1 rs10500872 TT

ADRB2(1) rs1042713 GA

Cardiovascular VO2 Max

Strong

You’re likely to have higher VO2 max trainability via thecardiovascular system. You can train cardiovascular VO2 maxwith HRV training, CO2 training, and HIIT training.

https://apeiron.store/products/heartmath-inner-balance-lightning

12/19/2020 Apeiron


ADRB2(2) rs1042714 GC

CREB1 rs2253206 AG

KIF5B rs211302 CC

NPY rs16139 TT

12/19/2020 Apeiron


Module 58

Metabolic and Muscular VO2 Max

RELEVANT SNP'S

WHAT THIS MEANS

Metabolic and muscular components of VO2 max are grouped together in this section because there is crossover in the genes involved with each. VO2max is the body's ability to uptake oxygen, deliver it efficiently to the cells, transport it effectively into the muscle and then rely on the muscles to use itin an optimized fashion.

Metabolic VO2 Max: How oxygen is used by mitochondria to create energy.

Muscle VO2 Max: How oxygen is used in the muscles to generate force.

WHY THIS MATTERS

Oxygen is a key component for converting macronutrients into energy. Without adequate and efficient supply of oxygen, the conversion of nutrientsinto usable energy can be compromised.

Metabolic/Muscle VO2 Max: If beneficial, they can contribute to VO2 potential trainability.


DEPTOR rs7386139 GA

MIPEP rs7324557 AG

AGTR2(2) rs1403543 A

ACSL1(2) rs6552828 AA

AMPD1 rs17602729 GG

NRF1(1) rs2402970 CC

NRF1(2) rs6949152 AG

HIF1A rs1885088 GG

Metabolic VO2 Max

Strong

Your metabolic system is likely to contribute effectively to VO2max; you can enhance your mitochondrial function and VO2 maxusing mitochondrial boosters such as D-ribose, NMN, MitoQ, andBerberine.

Muscle VO2 Max

Elite

You’re likely to have optimal use of oxygen within the muscles toenhance performance. You can train muscle VO2 max throughhigh intensity interval training (HIIT) and D-ribosesupplementation.



https://apeiron.store/products/mitoq



12/19/2020 Apeiron


CKMM rs8111989 TT

TTN rs10497520 TC

UCP3 rs1800849 GA


KIF5B rs211302 CC

GABPB1 rs7181866 AA

DAAM1 rs1956197 TT

12/19/2020 Apeiron


Module 59

Muscle Fatigability

RELEVANT SNP'S

WHAT THIS MEANS

Muscle fatiguability is the amount of inflammation generated in muscle. During intense exercise and over the course of training, a muscles abilityto generate forces decreases as the muscle becomes fatigued.

WHY THIS MATTERS

Elite muscle fatiguability allows an individual to work out longer andmore intensely than someone that has a lower fatiguability.


AGTR2(1) rs11091046 C

AGTR2(2) rs1403543 A

HNF4A rs1885088 GG

AMPD1 rs17602729 GG

COL5A1(1) rs12722 .

TTN rs10497520 TC

NAT2(4) rs1208 AA

ACE(2) rs1800764 CC

Muscle Fatigability

Low

You’re likely to experience a slightly slower rate of muscle fatigueduring exercise.

12/19/2020 Apeiron


IL15Ra(1) rs2228059 TG

12/19/2020 Apeiron


Module 60

Recovery

RELEVANT SNP'S

WHAT THIS MEANS

Recovery is the ability to eliminate inflammation from your muscles.

WHY THIS MATTERS

The body requires a certain amount of time to repair thedamage incurred by intense workouts; understanding your geneticpropensities can guide strategic planning to achieve the highest impactfrom your routine.


SOD2 rs4880 AA

COL5A1(1) rs12722 .

IL-1B(2) rs1143634 GA

IL6 rs1800795 GG

CKMM rs8111989 TT

NAT2(4) rs1208 AA

TNF rs1800629 GA

Recovery

Slower

Genes associated with longer than average recovery time afterintense exercise. Consider taking additional time between intenseexercise sessions. Antioxidant support such as Vitamin C orCurcumin can speed up recovery at the cost of exercise gains.Consider using a biometric tracker such as the Garmin Fenix 6 totrack stress and recovery more precisely.

https://apeiron.store/products/c-rla

https://apeiron.store/products/bio-optimized-curcumin

https://apeiron.store/products/fenix%C2%AE-6x

12/19/2020 Apeiron


CRP(1) rs1205 CT

CHRM2 rs324640 GG

12/19/2020 Apeiron


Module 61

Strength and Hypertrophy

RELEVANT SNP'S

WHAT THIS MEANS

Strength: Your muscles ability to generate power.

Hypertrophy: Your ability to build muscle size.

WHY THIS MATTERS

It has been estimated across multiple genomic studies that >50% ofmuscle strength and muscle size is attributable to heritablegenetics. While there is no doubt genetics provides a strong benefit, ideallevels of muscle size and strength are attainable for anyone throughproper training.

Strength/Hypertrophy: With beneficial genetics, it's easier to leverageadvantages to achieve optimal performance.


AGTR2(1) rs11091046 C

AGTR2(2) rs1403543 A

ACE del rs4343 GA

ACTN3 rs1815739 TC

DIO1(1) rs11206244 CC

IL6 rs1800795 GG

SHBG(4) rs727428 CC

Strength

Average

You have a typical ability to build strength. Holy basil can beeffective at increasing growth hormone production naturally.

Hypertrophy

Average

You’re likely to build muscle size at an average rate. Holy basiland sauna use can be effective at increasing growth hormoneproduction naturally.

https://apeiron.store/products/holy-basil

https://apeiron.store/products/holy-basil

12/19/2020 Apeiron


MSTN rs1805086 TT

RETN(1) rs1862513 CG

IGFBP3 rs3110697 AA

ACVR1B rs2854464 GG

IGF1 rs7136446 TT

CNTF rs1800169 GG

IGF2(2) rs3213221 CG

IGF2(3) rs7924316 GG

CCL2(1) rs1024611 AA

CCL2(2) rs1024610 AA

CCR2 rs1799865 TT

IL15Ra(1) rs2228059 TG

IL15Ra(2) rs1057972 TT

IL15Ra(3) rs2296135 AC

RETN(2) rs3745367 AA

IL6R rs4537545 TT

12/19/2020 Apeiron


Module 62

Endurance

RELEVANT SNP'S

WHAT THIS MEANS

Endurance genetics are an individuals's propensity to build muscles that have fatigue resistance and focus on sustained and smaller movements.

WHY THIS MATTERS

Genetics can predispose towards an advantage in endurance related athletic performance.


AGTR2(1) rs11091046 C

AGTR2(2) rs1403543 A

ACE del rs4343 GA

ACTN3 rs1815739 TC

BDKRB2 rs1799722 CC

GNB3 rs5443 TT

ADRB2(1) rs1042713 GA

ADRB2(2) rs1042714 GC

ADRB2(3) rs1800888 CC


PPARD(1) rs2016520 CT


Endurance

Strong

Your genetics are similar to those of elite endurance-basedathletes.

12/19/2020 Apeiron


ADRA2A(2) rs553668 AG

EPHX1 rs1051740 TC

LTBP4 rs1051303 AG

SCGB1A1 rs3741240 GG

UCP2(2) rs660339 AA


12/19/2020 Apeiron


Module 63

Power/Sprint

RELEVANT SNP'S

WHAT THIS MEANS

Power/sprint genetics are an individual’s propensity to produce shortbursts of explosive power.

WHY THIS MATTERS

Genetics can predispose towards an advantage in power/sprint relatedathletic performance.


AGTR2(1) rs11091046 C

AGTR2(2) rs1403543 A

ACE del rs4343 GA

ACTN3 rs1815739 TC

DMD rs939787 G

AGT rs699 GG

TTN rs10497520 TC

ACVR1B rs2854464 GG

NAT2(4) rs1208 AA

NOS3(2) rs2070744 TT

Power/Sprint

Moderate

You have some correlations with the genetics of elitepower/sprint-based athletes.

12/19/2020 Apeiron



12/19/2020 Apeiron


Module 64

Power vs Endurance

RELEVANT SNP'S

WHAT THIS MEANS

This panel looks at the balance between power/sprint and endurance based genetics to determine the likely individual preference.

WHY THIS MATTERS

Knowing your genetics can guide your training to focus on enhancing your strengths or training areas that benefit from support.


AGTR2(1) rs11091046 C

AGTR2(2) rs1403543 A

ACE del rs4343 GA

ACTN3 rs1815739 TC

BDKRB2 rs1799722 CC

DMD rs939787 G

GNB3 rs5443 TT

AGT rs699 GG

ADRB2(1) rs1042713 GA

TTN rs10497520 TC

ADRB2(2) rs1042714 GC

ACVR1B rs2854464 GG

Power Vs Endurance Propensity

Moderate Endurance

You’re likely to perform better with endurance-based activitiesrather than sprint or power-based exercises.

12/19/2020 Apeiron


NAT2(4) rs1208 AA

ADRB2(3) rs1800888 CC


NOS3(2) rs2070744 TT

PPARD(1) rs2016520 CT



ADRA2A(2) rs553668 AG

EPHX1 rs1051740 TC

LTBP4 rs1051303 AG

SCGB1A1 rs3741240 GG

UCP2(2) rs660339 AA


12/19/2020 Apeiron


Module 65

Soft Tissue

RELEVANT SNP'S

WHAT THIS MEANS

Regardless of exercise frequency, genetic propensities for soft tissuesupport are an important consideration. Soft tissue connects,supports, and surrounds organs and structures within the body.

Tendon and Ligament Support Need: Tendons attach muscles to otherstructures within the body whereas ligament connect bone to bonewhile stabilizing structures.

Cartilage Support Need: Cartilage is a type of tissue that maintainsjoint elasticity .

Lumbar Disc Support Need: The lumbar disc refers to the spinal discs inthe lower back.

Rotator Cuff Support Need: The rotator cuff is the primary muscle groupthat surrounds the shoulder joint.

WHY THIS MATTERS

Knowing your genetic predispositions can guide support strategies.

Tendon and Ligament Support Need: Genetic propensity indicates the likely strength and support need of tendons and ligaments .

Cartilage Support Need: This indicates the likely need for support in maintaining fluid motion of the joints.

Lumbar Disc Support Need: Genetic propensity indicates support benefit for lower back spinal health.

Rotator Cuff Support Need: This indicates overall support for the different rotator cuff muscles.


COL1A1 rs1800012 CC

COL3A1 rs1800255 .

COL12A1 rs240736 AA

Tendon and Ligament Support Need

Average

Typical need for tendon/ligament support over time. Ensure softtissue support such as flexibility training, lower inflammation, andgood form during exercise.

12/19/2020 Apeiron


COL5A1(1) rs12722 .

IL6 rs1800795 GG

COL5A1(2) rs3196378 CA

GDF5 rs143383 AG

MMP3(1) rs591058 TC

MMP3(2) rs679620 TC

FAM46A rs3117582 TT

CILP rs2073711 AA

COL11A1 rs1676486 AG

CRP(1) rs1205 CT

CRP(2) rs3093066 GG

ADAM12 rs1871054 CT

ESRRB1 rs17583842 TT

FGFR1 rs13317 CC

SASH1 rs12527089 CC

SAP30BP rs820218 GG

COL6A4P1 rs7639618 CC

IL1RN rs9005 GG

IL1A rs1800587 AA

CCDC111 rs12108497 CT

FGF10 rs1011814 TC

Cartilage Support Need

Average

Typical need for cartilage support over time. Ensure soft tissuesupport such as flexibility training, lower inflammation, and goodform during exercise.

Lumbar Disc Support Need

Increased

Increased need for lumbar disc support. Consider working with anEpigenetic coach and using BPC-157 to achieve optimal supportand protection.

Rotator Cuff Support Need

Average

Typical need for rotator cuff support over time. Ensure soft tissuesupport such as flexibility training, lower inflammation, and goodform during exercise.

http://apeironzoh.com/coaches

https://apeiron.store/products/bpc-157

12/19/2020 Apeiron


HIF1A(2) rs11549467 GG

KDR(1) rs1870377 TA

KDR(2) rs2071559 AG

VEGFa(2) rs1570360 .

12/19/2020 Apeiron


Module 66

Thyroid

RELEVANT SNP'S

WHAT THIS MEANS

The thyroid gland is one of the most important organs in the body. It is responsible for production of hormones that control metabolism. The gland'sinvolvement in metabolism affects a range of body functions such as body weight, cognitive functions, body temperature, menstrual cycles, muscleperformance, and cholesterol.

TSH Propensity: Thyroid stimulating hormone (TSH) is a hormone that determines how much thyroid hormone is produced

DIO1 Activity: These SNPs predict conversion of inactive thyroid hormone to the active form throughout the body (not including within the brain)

DIO2 Activity: These SNPs predict conversion of inactive thyroid hormone to the active form within the brain

WHY THIS MATTERS

The production and utilization of thyroid hormone is highly complex. Optimizing outcomes requires a deep knowledge of the interactions of lifestyle,environment, genetics, and epigenetics.

TSH Propensity: Genetic variations predict likely TSH levels for optimal production. This works well in combination with blood lab tests to createprecise strategies for optimal outcomes

DIO1 Activity: Thyroid conversion is important to maintaining optimal performance

DIO2 Activity: Reduced activity can contribute to thyroid hormone deficiency in the brain which may not be present in blood testing

Possible signs of over-active thyroid include anxiety, insomnia, shaking hands, weight loss, sweating, and hair loss.

Possible signs of under-active thyroid includes weight gain, fatigue, dry skin, hair loss, cold hands/feet, and constipation.


PDE8B(1) rs4704397 AA

PDE8B(2) rs1382879 CC

TSH Propensity

Average

Likely to have typical TSH levels associated with normal thyroidfunction.

12/19/2020 Apeiron


PDE8B(3) rs12515498 CC

DIO1(1) rs11206244 CC

PDE8B(4) rs6885099 GG

THRA rs939348 TT

DIO1(2) rs2235544 CA

DIO2(1) rs12885300 CC

DIO2(2) rs225014 CC

SLCO1B1 rs4149056 TT

SLC16A2 rs6647476 C

DIO1 Activity

High

Likely to have increased conversion from the inactive to activethyroid hormone; consider lab testing to manage levels.

DIO2 Activity

Low

Decreased conversion from the inactive to active thyroid hormonein the brain; consider lab testing to ensure optimal active thyroidhormone levels. Forskolin and Ashwagandha can promoteincreased conversion.

12/19/2020 Apeiron


Module 67

Autoimmune Thyroid

RELEVANT SNP'S

WHAT THIS MEANS

Autoimmune thyroid conditions look at the geneticpropensity for inflammation to trigger an undesirable immune response.

WHY THIS MATTERS

It can provide important insight into benefits of inflammationmanagement strategies.


FOXE1(1) rs965513 GG

FOXE1(2) rs7850258 GG

PTPN22 rs2476601 GG

DIO1(1) rs11206244 CC

IL6 rs1800795 GG

CTLA4(1) rs3087243 GA

CTLA4(2) rs231775 AA

FCRL3 rs7528684 AG

IL23R rs10889677 AA

TNF rs1800629 GA

Autoimmune Thyroid

Average

Average autoimmune response to inflammation based oncorrelations.

12/19/2020 Apeiron


12/19/2020 Apeiron


Module 68

Cortisol

RELEVANT SNP'S

WHAT THIS MEANS

Cortisol is frequently referred to as the “stress” hormone, however, it is an essential part to human optimization.

Cortisol Production: Genetics predict the likely production of cortisol in alignment with circadian propensity and in response to stress

Cortisol Receptor Response: The responsiveness of your body to cortisol

WHY THIS MATTERS

Many of these SNPs are highly vulnerable to life events that can epigenetically modify their expression. This suggests lifestyle factors may producesignificant impacts on expressions despite genetic predispositions.

Cortisol Production: Cortisol is essential to wake us up in the morning, it boosts performance during acute stress, and low to moderate levels areneeded for decision making

Cortisol Receptor Response: Sensitivity is responsible for producing a reaction to cortisol and managing stress optimally


FKBP5(1) rs1360780 CC

FKBP5(2) rs3800373 AA

FKBP5(3) rs4713916 GG

HTR2C(2) rs1414334 G

COMT rs4680 GA

GSTP1(1) rs1695 AG

Cortisol Production

Typical Production

Likely to have typical production of cortisol.

Cortisol Receptor Response

Less Responsive

Likely to have decreased response to stress. Mindfulness practiceand HRV training can support optimal response to stress.

12/19/2020 Apeiron


NR3C1 rs6190 CC

CRHR1(2) rs12938031 AA

CRHR2(1) rs2190242 CA

CRHR2(2) rs2267715 GA

NR3C2 rs5522 TT

NR3C1(2) rs10052957 GG

NR3C1(3) rs41423247 GG

12/19/2020 Apeiron


Module 69

Estrogen

RELEVANT SNP'S

WHAT THIS MEANS

Estrogen is a beneficial hormone in both males and females. It has manybenefits beyond involvement in reproduction; it is essential to bonehealth.

Estrogen Conversion from Testosterone: Testosterone is broken downinto estrogen; this is the primary way it is produced

Estrogen Receptor Response: Genetics predict the likely response toestrogen - this gauge only applies to females

Estrogen Metabolism: There are multiple ways estrogen can breakdown; some more desirable than others. Genetics canpredict this likelihood

WHY THIS MATTERS

Estrogen Conversion from Testosterone: In females, estrogen is important for maintaining the health of the sex organs, sex drive, and sexualfunction. In males, a lack of estrogen, even with normal testosterone, can contribute to diminished sex drive and erectile dysfunction

Estrogen Receptor Response: When estrogen levels and receptors are out of balance, it can contribute to symptoms such as decreased memorycognitive function or increased intensity of menstrual cycles

Estrogen Metabolism: Understanding the propensity can indicate an area that may benefit from more precise measurement and support


ESR1(1) rs9340799 AG

ESR1(2) rs2234693 TC

CYP1A1 rs2606345 CA

CYP1B1(1) rs1056836 GG

Estrogen Conversion fromTestosterone

Increased

May have higher estrogen levels due to increased conversionfrom testosterone; consider lab testing to ensure optimaltestosterone levels.

12/19/2020 Apeiron


COMT rs4680 GA

CYP3A4 rs2740574 TT

GSTP1(1) rs1695 AG

CYP19A1(1) rs7176005 CC

CYP19A1(2) rs749292 GG

Estrogen Receptor Response

Increased

Only applies to females; Increased receptor response to estrogencorresponds with higher frequency of severe PMS symptoms,although decreased intensity of menopause symptoms.

Estrogen Metabolism

Typical

Likely to have a balance of desirable and undesirable estrogenmetabolism. Consider working with an epigenetic coach orphysician to support estrogen metabolism.


12/19/2020 Apeiron


Module 70

Testosterone

RELEVANT SNP'S

WHAT THIS MEANS

Testosterone is traditionally classified as the primary sex hormone; the reality is that it is the primary sex hormone in both males and females. To fullyunderstand testosterone availability and benefits in the body, it is important to look at several factors that contribute to the outcome. These include;the amount of binding from SHBG (sex hormone binding globulin), response to LH (luteinizing hormone), and conversion to DHT (dihydrotestosterone),and conversion to estrogen.

LH Levels: Luteinizing hormone (LH) is responsible for the production of testosterone

SHBG Levels: Sex Hormone Binding Globulin (SHBG) is responsible for binding testosterone making it unavailable

DHT Levels: Testosterone breaks down into Dihydrotestosterone (DHT) which is responsible for adolescent male development

Estrogen Conversion from Testosterone: Testosterone is also broken down into estrogen

WHY THIS MATTERS

Optimal testosterone levels contribute to many benefits including improved wellbeing, improved confidence and drive, improved sex drive, improvedbone density, improved strength & muscle, decreased cognitive decline, decreased body fat, and improved mood.

LH Levels: Understanding LH levels provides insight into testosterone production propensity

SHBG Levels: In order to experience the benefits of testosterone, it must be available and useable. SHBG is one of the most important pieces todetermine testosterone availability

DHT Levels: Genetics provide insight regarding if further measurement and management is advisable

Estrogen Conversion from Testosterone: In females, estrogen is important for maintaining the health of the sex organs, sex drive, and sexualfunction. In males, a lack of estrogen, even with normal testosterone, can contribute to diminished sex drive and erectile dysfunction


JMJD1C rs10822184 TT

FAM9B rs5934505 T

LH Levels

Decreased

Likely to have decreased production of testosterone; considerblood lab testing to measure and manage.

12/19/2020 Apeiron


SHBG(1) rs6258 CC

SHBG(3) rs1799941 GG

SHBG(4) rs727428 CC

PLCH2 rs10910078 CC

REEP3 rs10822184 TT

LHCGR rs2293275 CC

CYP19A1(1) rs7176005 CC

APOe(1) rs429358 TT

CYP19A1(2) rs749292 GG

APOe(2) rs7412 CC

CYP17A1 rs1004467 AA

SRD5A1 rs518673 GA

SRD5A2 rs523349 GG

HDAC4 rs9287638 CC

HDAC9 rs2073963 GG

TARDBP rs12565727 AG

FOXA2 rs6047844 CC

MAO-A(1) rs909525 C

MAO-B(2) rs1799836 T

SHBG Levels

Average

Likely to have typical SHBG and free testosterone levels; considerblood lab testing to measure and manage.

DHT Levels

Average

Typical conversion to DHT.

Estrogen Conversion fromTestosterone

Increased

May have higher estrogen levels due to increased conversionfrom testosterone; consider lab testing to ensure optimaltestosterone levels.

12/19/2020 Apeiron


Module 71

Bone Density

RELEVANT SNP'S

WHAT THIS MEANS

Various degrees of low bone density are common in todays society. Studies show that over 50% of 50-59yo females and over 30% of 50-59yo males have low bone density. This process is usually silent andoften discovered after a major bone fracture. Therefore, regularscreening and optimization are so important.

Vitamin K Need: Vitamin K includes a family of compounds,including vitamin K1 and vitamin K2. Vitamin K1 is found in plants, suchas leafy green vegetables. Vitamin K2 is usually of bacterial origin andcan be found in some animal-based and fermented foods but is mostlyconverted by the large intestine or liver from vitamin K1

Bone Density Support Need: Genetics can provide a propensity towardsbone density advantage or need for support

WHY THIS MATTERS

Decreased bone density is becoming more common in younger population; screening shows low levels in males and females in their 20’s and lateteens.

Vitamin K Need: Many people get an adequate amount of vitamin K through their diet. It’s also present in most multivitamin supplements. Geneticscan be an active player in this process and can be predictive of absorption and conversion

Bone Density Support Need: Everyone is at risk of low bone density without consistent load-bearing exercise and optimal vitamin D levels. Geneticsprovides a more precise picture towards need for management.


CYP19A1(3) rs2470152 GA

CYP19A1(5) rs1062033 CC

Vitamin K Need

Increased Need

Your genetics are associated with increased vitamin K2 needs forbone health, cardiovascular health, and vitamin D and calciumtransport. Vitamin D3/K2 combination enhances absorption.


12/19/2020 Apeiron


CYP19A1(6) rs700518 TT

LRP5(2) rs7176005 CC

IL6 rs1800795 GG

LRP5(3) rs3736228 CC

FAM3C rs7776725 TT

ARHGEF3 rs7646054 GG

IL-1B rs16944 GG

TNF rs1800629 GA

VDR taq rs731236 AA

VDR fok rs2228570 .


APOe(1) rs429358 TT

APOe(2) rs7412 CC

Bone Density Support Need

Typical

Genes overall associated with normal bone density response.

Vitamin K2 supplementation and weight-bearing exercise isextremely helpful in maintaining healthy bone density.

welcome page - qineticare

Documents