Положение о Центре менеджмента качества

Federal state budgetary educational establishment of higher education

“Kursk state medical university”

of Ministry of Public Health of the Russian Federation

(FSBEE HE KSMU of the Ministry of Public Health of Russia)

CONFIRMED

at the sitting of the department

of clinical pharmacology

Protocol № of « » .

Head of Department of clinical pharmacology

Professor _________________ Povetkin S.V.

CONFIRMED

at the sitting of the methodical council

of the international faculty

Protocol № of « » .

Chairman of the methodical council

of the international faculty

Professor _________Yu. D. Lyashev

SYLLABUS in clinical pharmacology

Faculty International Faculty

Specialty 31.05.01 General medicine

Year 5,6 Term 10,11

Workload (credits) 3

Total hours 108

Form of Intermediate Attestation Credit-test

Case History

Creators of the Syllabus

head of department of clinical pharmacology, MD, professor Povetkin S.V., associate professor of the

department of clinical pharmacology, Ph.D., docent Luneva Yu.V., associate professor of the department

of clinical pharmacology, Ph.D., docent Levashova O.V., associate professor of the department of clin-

ical pharmacology, Ph.D. Kornilov A.A.

Kursk – 2020

The syllabus of the discipline clinical pharmacology has been developed in accord-

ance with the Federal state educational standard of higher education (FSES HE) for the spe-

cialty 31.05.01 General medicine with the account of the guidelines of the sample basic

educational program of higher education of the specialty 31.05.01 General medicine

1. Objective and goals of the discipline

The objective of teaching the discipline.

The main objective of teaching clinical pharmacology is to teach the future doctor:

1. individualization of the pharmacotherapy choice on the basis of knowledge of

pharmacodynamics, pharmacokinetics, interactions and side effects of drugs, on the one

hand, and features of the disease, changes in drugs metabolism in the patient's body, on

the other hand;

2. methods for monitoring the efficacy and safety of drugs.

Аttention is paid to the ethical aspects of the doctor-patient relationship in pharma-

cotherapy, the culture of the doctor’s behavior in the treatment process, and the legal and

ethical issues of new drugs testing.

Goals of teaching the discipline.

The main goals are the formation of knowledge, skills and abilities of pharmaco-

logical support for the treatment of diseases, based on the study of the following sections

of clinical pharmacology:

1. Pharmacokinetics of main groups of drugs.

2. Pharmacodynamics of main groups of drugs.

3. Features of local and systemic use of drugs.

4. Features of pharmacotherapy in renal dysfunction.

5. Features of pharmacotherapy in liver dysfunction.

6. Basics of combined pharmacotherapy.

7. Side effects of drugs and their prevention.

8. Algorithms of pharmacotherapeutic strategies for the correction of diseases.

2. Position of the discipline in the structure of the educational program and re-

quirements to the planned outcomes of teaching the discipline

The discipline clinical pharmacology is referred to the basic part of the educational

program.

The process of studying the discipline provides gaining the planned outcomes of

mastering the educational program and is aimed at forming the following competencies:

Competency Logical connection with disciplines on

the curriculum Code Definition

GPC-4 Able and ready to implement

ethical and deontological

principles in professional ac-

tivities

Nursing; bioethics; propedeutics of internal

diseases; general surgery; dermatovenere-

ology; neurology; faculty therapy; faculty

surgery; urology; obstetrics and gynecol-

ogy; otorhinolaryngology; ophthalmology;

endocrinology; phthisiology; psychiatry,

medical psychology; hospital therapy. oc-

cupational disease; polyclinic therapy,

physiotherapy; traumatology, orthopedics;

hospital surgery; neurosurgery; infectious

diseases; anesthesiology, resuscitation, in-

tensive care; dentistry; oncology, radiation

therapy; pediatric surgery; childhood infec-

tious diseases; clinical immunology; surgi-

cal diseases; tropical diseases; obstetric

and gynecological care.

GPC-5 Is able and ready to analyze

the results of one’s own ac-

tivity to avoid professional

mistakes

Propedeutics of internal diseases; general

surgery; dermatovenereology; neurology;

faculty therapy; faculty surgery; urology;

obstetrics and gynecology; otorhinolaryn-

gology; ophthalmology; endocrinology;

phthisiology; psychiatry, medical psychol-

ogy; hospital therapy. occupational dis-

ease; polyclinic therapy, physiotherapy;

traumatology, orthopedics; hospital sur-

gery; neurosurgery; infectious diseases; an-

esthesiology, resuscitation, intensive care;

forensic Medicine; oncology, radiation

therapy; clinical pathology; pediatric sur-

gery; childhood infectious diseases; clini-

cal immunology; surgical diseases; tropical

diseases; obstetric and gynecological care.

GPC-6 Is ready to maintain medical

documentation

Nursing; propedeutics of internal diseases;

general surgery; public health and

healthcare; dermatovenereology; neurol-

ogy; faculty therapy; faculty surgery; urol-

ogy; obstetrics and gynecology; otorhino-

laryngology; ophthalmology; endocrinol-

ogy; phthisiology; psychiatry, medical psy-

chology; hospital therapy. occupational

disease; polyclinic therapy, physiotherapy;




dentistry; forensic Medicine; oncology, ra-

diation therapy; clinical pathology; pediat-

ric surgery; childhood infectious diseases;

genetics, medical ecology; clinical immu-

nology; surgical diseases.

GPC-8 Is ready to apply pharma-

ceuticals and other sub-

stances and their combina-

tions in medical practice for

solving the professional

tasks

Pharmacology; pharmacology in cardiol-

ogy.

PC-8 Capable of determining

the tactics of managing pa-

tients with various nosologi-

cal forms

Propedeutics of internal diseases; general

surgery; dermatovenereology; neurology;

faculty therapy; faculty surgery; urology;

obstetrics and gynecology; otorhinolaryn-

gology; ophthalmology; endocrinology;

phthisiology; psychiatry, medical psychol-

ogy; hospital therapy. occupational dis-

ease; polyclinic therapy, physiotherapy;




dentistry; oncology, radiation therapy; pe-

diatric surgery; clinical immunology; sur-

gical diseases; gerontology and geriatrics

in internology, topical issues of geriatric

endocrinology; pharmacology in cardiol-

ogy; sexually transmitted infections; inno-

vative technologies in aesthetic dermatol-

ogy; formation of professional compe-

tences of a general practitioner / family

doctor; palliative care for patients.

PC-20 Ready for analysis and pub-

lic presentation of medical

information based on evi-

dence-based medicine

Faculty Therapy; faculty surgery; obstet-

rics; gynecology; hospital therapy. occupa-

tional disease; polyclinic therapy, physio-

therapy; hospital surgery; fundamentals of

scientific work in medicine; Russian lan-

guage as a means of professional commu-

nication of a doctor; methodological prob-

lems of scientific research in medicine;

training communicative competence of the

doctor.

PC-21 Able to participate in scien-

tific research

Philosophy; medical informatics; public

health and healthcare, health economics;

fundamentals of scientific work in medi-

cine; methodological problems of scientific

research in medicine

Contents of competencies (stages of competency formation)

Code of

the com-

petency

Definition of

the compe-

tency

Stages of formation and indicators of attaining the

competency

Knows Is able to Is proficient in (Has

practical experience in)

GPC-4 Able and

ready to im-

plement ethi-

cal and deon-

tological

principles in

professional

activities

- moral, ethi-

cal and deon-

tological

norms, rules

and principles

of profes-

sional and

medical be-

havior

- the main

ethical docu-

ments of in-

ternational or-

ganizations,

domestic and

international

professional

medical asso-

ciations

- rights and

obligations of

patients and

health care

workers

- put into

practice ethi-

cal and de-

ontological

principles of

professional

activity

- apply the

main ethical

documents

of interna-

tional organ-

izations, do-

mestic and

international

professional

medical as-

sociations

- skills in the implementa-

tion of medical deontology

and medical ethics

- skills to implement and

protect one’s own rights

and the rights of patients

- ways to

communicate

and interact

with different

age categories

of patients,

parents, col-

leagues

GPC-5 Is able and

ready to ana-

lyze the re-

sults of one’s

own activity

to avoid pro-

fessional mis-

takes

- the basis for

analyzing the

results of

one’s own ac-

tivity to avoid

professional

mistakes

- normative

documenta-

tion concern-

ing the re-

sponsibility

of medical in-

stitutions and

medical per-

sonnel for im-

proper treat-

ment, profes-

sional and of-

ficial miscon-

ducts

- theoretical

questions of

gathering,

storing, seek-

ing, pro-

cessing, and

spreading

medical infor-

mation

- potential

mistakes in

medical prac-

tice of various

profile

- the basis of

evidence-

- to analyze

the results of

one’s own

activity to

avoid medi-

cal mistakes

- to analyze

diagnostic

and curative

measures ac-

cording to

medical doc-

umentation

(case his-

tory) taking

into consid-

eration the

current pro-

cedures for

medical as-

sistance,

clinical rec-

ommenda-

tions (treat-

ment proto-

cols) for

medical as-

sistance con-

sidering

medical as-

sistance

standards

- to solve

professional

tasks inde-

pendently

with the use

- the skills of analyzing the

results of one’s medical

activity and making con-

clusions

- the skills of applying the

methods of evidence-

based medicine in as-

sessing the state of health

of adult population, the ac-

tivity of medical institu-

tions and in scientific re-

searches

- has the experience in an-

alyzing the data from med-

ical documents to verify

the diagnosis

based medi-

cine

of all availa-

ble informa-

tive re-

sources and

to assess the

results of

one’s profes-

sional activ-

ity

- to assess

possible ef-

fects of pro-

fessional

mistakes

GPC-6 Is ready to

maintain

medical doc-

umentation

- principle

types of med-

ical documen-

tation, used in

medical insti-

tutions, in-

cluding while

managing pa-

tients

- rules of

drawing up

medical docu-

mentation

- to fill in

medical doc-

umentation,

including

computer

version

- to work

with per-

sonal data of

patients and

information

which is

considered

the medical

confidential-

ity

- to draw up

working

plans and re-

ports on

work per-

formed

- the skills of drawing up

medical documentation in-

cluding computer version

- the skills of drawing up

working plans and reports

on work performed

GPC-8 Is ready to

apply phar-

maceuticals

and other

substances

and their

combina-

tions in med-

ical practice

- classifica-

tion and basic

characteris-

tics of phar-

maceuticals,

pharm dy-

namics and

pharm kinet-

ics taking into

- to adminis-

ter proper

therapeutic

treatment ac-

cording to

the syn-

dromes de-

tected and

- the skills of administer-

ing, applying, and as-

sessing the effects of me-

dicinal preparations in

management, rehabilita-

tion and prevention of dif-

ferent diseases and patho-

logical conditions

for solving

the profes-

sional tasks

consideration

age-related

features

- indications

and contrain-

dications for

using phar-

maceuticals,

their side-ef-

fects

- general prin-

ciples of pre-

scription for-

malization

and composi-

tion of official

medicinal

formulae

diagnosis

made

- to give rea-

sons for

pharmaceu-

tical therapy

in the patient

with basic

pathologic

syndromes

and urgent

conditions

-to write out

prescriptions

for pharma-

ceuticals for

definite dis-

eases and

pathological

processes

- the skills of writing out

prescriptions for medicinal

preparations

- the skills of rational

pharm therapy

PC-8 Capable of

determining

the tactics of

managing

patients with

various noso-

logical forms

- tactics of

managing pa-

tients with

various noso-

logical forms

- modern

methods of

drugs admin-

istration,

medical de-

vices and

medical nutri-

tion in case of

diseases and

patients’ con-

ditions in ac-

cordance with

current medi-

cal care pro-

cedures, clini-

cal guidelines

(treatment

protocols) on

medical care

issues, taking

- determine

the tactics of

patients’

management

with various

nosological

forms

- draw up a

treatment

plan for the

disease and a

patient's

condition,

taking into

account the

diagnosis,

the patient's

age, the clin-

ical picture

of the dis-

ease in ac-

cordance

with the ex-

isting medi-

- skills of determining the

tactics of maintaining and

developing a treatment

plan for a disease or condi-

tion, taking into account

the diagnosis, age and clin-

ical picture in accordance

with the existing medical

care procedures, clinical

guidelines (treatment pro-

tocols) on the issues of

medical care, taking into

account the standards of

medical care

into account

medical care

standards

- mechanism

of drugs,

medical de-

vices and

medical nutri-

tion action,

medical indi-

cations and

contraindica-

tions to their

use; compli-

cations

caused by

their use

- modern

methods of

non-pharma-

cological

treatment of

diseases and

conditions in

accordance

with the cur-

rent medical

care proce-

dures, clinical

guidelines

(treatment

protocols) on

the issues of

medical care,

taking into ac-

count the

standards of

medical care

- mechanism

of action of

non-drug

treatment;

medical indi-

cations and

cal care pro-

cedures,

clinical rec-

ommenda-

tions (treat-

ment proto-

cols) on the

issues of

medical

care, taking

into account

the standards

of medical

care

contraindica-

tions to its

appointment;

side effects,

complications

caused by its

use

PC-20 Ready for

analysis and

public

presentation

of medical in-

formation

based on

demonstra-

tive medicine

- the basis of

the analysis of

scientific and

medical infor-

mation, tak-

ing into ac-

count demon-

strative medi-

cine, modern

theoretical

and experi-

mental meth-

ods of scien-

tific research

in medicine

- basic re-

quirements

for the public

presentation

of medical in-

formation

- to work in-

dependently

with the

sources of

scientific

and medical

information

- to make re-

ports (report

sections), lit-

erature re-

views, re-

ports on the

topic or its

section (task

stage)

- to use sci-

entific and

medical in-

formation,

domestic

and foreign

experience,

to put into

practice

knowledge

and skills in

the presenta-

tion of medi-

cal infor-

mation

based on

demonstra-

tive medi-

cine

- presentation skills of an

independent point of view,

public speech, moral and

ethical argumentation, dis-

cussion and round table

meetings

- skills of public presenta-

tion of medical infor-

mation based on demon-

strative medicine

PC-21 Able to par-

ticipate in

- the methods

of organizing

- to partici-

pate in the

performance

- skills of participation in

the solution of individual

scientific re-

search

scientific re-

search and as-

sessing the re-

liability of the

obtained re-

sults

- modern the-

oretical and

empirical

methods of

scientific re-

search

- the funda-

mentals of

statistical

methods ap-

plication in

biomedical

research

- the role of

various mod-

eling methods

in the study-

ing of patho-

logical pro-

cesses, their

capabilities,

limitations

and perspec-

tives

- safety regu-

lations when

conducting

scientific re-

search

of scientific

research, to

solve the

tasks set in

it, and evalu-

ate the relia-

bility of the

obtained

data

- to formu-

late a scien-

tific hypoth-

esis, to de-

termine the

goals and

objectives of

scientific ac-

tivity

- to apply

modern the-

oretical and

empirical re-

search meth-

ods, make

calculations

on the re-

sults of their

usage, carry

out statisti-

cal pro-

cessing of

the data

- to plan and

participate in

carrying out

(in compli-

ance with

the relevant

rules) scien-

tific experi-

ments, pro-

cess and an-

alyze the re-

sults of ex-

periments

research and applied re-

search tasks

- methods of statistical

processing of research re-

sults

- principles of the main la-

boratory equipment opera-

tion

- the basics of using

demonstrative medicine

when conducting research

- to use

basic labora-

tory equip-

ment, to plan

laboratory

research

3. Topics of the discipline and competencies formed during their study

Name of the topic of the

discipline Contents of the topic Code of the competency

Evidence-based medi-

cine. Formulary treat-

ment of diseases.

Pharmacoeconomics.

Pharmacoepidemiology.

Evidence-based medicine.

Definition. Formulary drug

supply system, its goals. For-

mulary Therapeutic Commit-

tee. The concept of pharmaco-

economics and pharmacoepi-

demiology. Methods of phar-

macoeconomic analysis.

Principles of clinical research

planning.

GPC- 4, GPC-5, GPC-6

GPC-8, PC-8, PC-20,

PC-21.

Basics of clinical phar-

macology. Principles of

rational use of drugs.

Clinical pharmacology. Defi-

nition. Subject and goals.

Pharmacokinetics of drugs.

Basic laws, parameters. The

concept of pharmacodynam-

ics. Methods of assessing drug

PK and PD.

GPC- 4, GPC-5, GPC-6

GPC-8, PC-8, PC-20,

PC-21.

Age aspects of clinical

pharmacology. Drug In-

teractions. Problems of

combined pharma-

cotherapy.

Pharmacogenetics.

Features of pharmacotherapy

in children age, with diseases

of the liver and kidneys.

Basics of combined

pharmacotherapy. The

concept of pharmacogenetics.

GPC-8, PC-8, PC-20,

PC-21.

Adverse drug reactions

(side effects of drugs).

Principles of rational

use of drugs in lactating

and pregnant.

Classification of undesirable

effects of drugs. Definitions of

main side effects (drug over-

dose, immediate negative

pharmacological action, sec-

ondary side effects, idiosyn-

crasy, drug allergy, teratog-

enous action). Mechanisms of

development, pathogenesis

GPC- 4, GPC-5, GPC-6,

GPC-8, PC-8, PC-20,

PC-21.

and clinical picture of side ef-

fects. Prevention and treat-

ment of side effects manifesta-

tions. Features of pharma-

cotherapy during pregnancy

and lactation. Drug safety cat-

egories on the FDA system.

Clinical pharmacology

of agents affecting the

digestive organs. The

principles of modern

pharmacotherapy.

Pharmacodynamics and the

pharmacokinetics, side ef-

fects, indications and contra-

indications to drugs affecting

the secretory function of gas-

trointestinal tract; antimicrobi-

als; antacids; alginates; tissue

regeneration stimulants; gas-

tro-and hepatoprotectors;

choleretics; antispasmodics,

prokinetics; enzymes; antie-

metics; laxatives; drugs used

in diarrhea. The choice of the

above medicines for gastroin-

testinal diseases treatment.


GPC-8, PC-8, PC-20.


of antianginal drugs, li-

pid-lowering drugs and

antithrombotic agents.

The principles of

modern

pharmacotherapy of

coronary heart disease.

Pharmacokinetics and phar-

macodynamics, side effects,

approaches to the use, indica-

tions and contraindications to

drugs used in ischemic heart

disease: nitrates and syd-

nonimine; beta blockers; cal-

cium channel blockers; inhibi-

tors of If-channels; potassium

channel activators; myocardial

cytoprotectors. Pharmacody-

namics and the pharmacoki-

netics, side effects, indications

and contraindications to poli-

pidemcs, antithrombotic

drugs. Rational combination

therapy.


GPC-8, PC-8, PC-20.


of drugs used to treat

heart failure. Clinical

pharmacology of anti-

arrhythmic drugs.

Principles of modern





drugs used in CHF: ACE in-


GPC-8, PC-8, PC-20.

pharmacotherapy of

circulatory failure and

arrhythmias.

hibitors, diuretics, cardiac gly-

cosides, beta-blockers, sar-

tans. Rational combination

therapy. Algorithm for treat-

ment of patients with CHF.

Pharmacodynamics and phar-

macokinetics, side effects, in-

dications and contraindica-

tions to antiarrhythmic drugs,

beta-blockers, antiadrenergic

drugs, calcium channel block-

ers. Algorithms of arrhythmias

treatment.


of antihypertensive

drugs. Principles of

modern pharmacother-

apy of arterial hyperten-

sion.





antihypertensive drugs: beta-

blockers, diuretics, calcium

channel blockers, angiotensin

converting enzyme inhibitors,

angiotensin receptor antago-

nists, agonists of central imid-

azolin receptors, alpha adre-

noblockers,direct renin inhib-

itors. Rational combination of

antihypertensives. Treatment

of hypertensive crisis.


GPC-8, PC-8, PC-20.


of drugs used in pulmo-

nology . Principles of


apy of bronchial asthma

and COPD.



indications and contraindica-

tions to bronchodilators (beta-

adrenergic agonists,

methylxanthines, inhibitors of

bronchoconstriction atropino-

voy group) and drugs for anti

farmakoter and FDI (stabi-

lizers of mast cell membranes

antileukotriene drugs, gluco-

corticoids ) . For patients with

bronchial asthma , COPD .


GPC-8, PC-8, PC-20.


of anti-inflammatory

drugs, cytostatics and

immunostimulants.





GPC-8, PC-8, PC-20.


pharmacotherapy of

rheumatic diseases.

tions to glucocorticoid hor-

mones, salicylic acid deriva-

tives, pyrazolone derivatives,

indole derivatives, phenyla-

cetic acid derivatives; alka-

noic acid derivatives, amino-

quinoline derivatives, coxibs,

oxycams; other COX inhibi-

tors. Pharmacotherapy algo-

rithm for rheumatic diseases .


of antibacterial drugs.


pharmacotherapy of the

infectious process.




tions to natural penicillins,

streptomycin, chlorampheni-

col, tetracycline, semisyn-

thetic penicillins, cephalo-

sporins carbapenems , mac-

rolides, aminoglycosides, gly-

copeptides , quinolones , sul-

fonamides, metronidazole, ni-

trofurans , antigungal drugs,

antiviral drugs. Rules of com-

bined antibiotic therapy. Al-

gorithms of antibacterial

treatment in the infectious

process.


GPC-8, PC-8, PC-20.

4. Plan of studying topics of the discipline (in academic hours)

Name of topic of the

discipline

Contact work

Individual

work (self-

instruction)

Total

hours

Applied

teaching

technolo-

gies, means

and meth-

ods of teach-

ing

Forms of

current ac-

ademic

achieve-

ment as-

sessment

and inter-

mediate at-

testation

To-

tal

including

lec-

tures

prac-

tical

clas-

ses

Tradi-

tional

In-

ter-

ac-

tive

Evidence-based medi-

cine. Formulary treat-

ment of diseases.

Pharmacoeconomics.

Pharmacoepidemiology.

6 2 4 2 8 PC,

CD,

CH,

SSRW,

SRW

PL T, I, ACC

Basics of clinical phar-

macology. Principles of

rational use of drugs.

7 2 5 2 9 PC,

CD,

CH,

SSRW,

SRW,

PL T, I, ACC

Age aspects of clinical

pharmacology. Drug In-

teractions. Problems of

combined pharma-

cotherapy.

Pharmacogenetics.

5 1 4 2 7 PC,

CD,

CH,

SSRW,

SRW,

PL T, I, ACC

Adverse drug reactions

(side effects of drugs).

Principles of rational

use of drugs in lactating

and pregnant.

6 1 5 2 8 PC,

CD,

CH,

SSRW,

SRW,

PL T, I, ACC


of agents affecting the

digestive organs. The

principles of modern

pharmacotherapy.

8 8 1 9 PC,

CD,

CH,

SSRW,

SRW,

ST

PL T, I, ACC,

Pr.


of antianginal drugs, li-

pid-lowering drugs and

antithrombotic agents.

The principles of

modern

pharmacotherapy of

coronary heart disease.

7 1 6 5 12 PC,

CD,

CH,

SSRW,

SRW,

ST

PL T, I, ACC,

Pr.


of drugs used to treat

heart failure. Clinical

pharmacology of anti-

arrhythmic drugs.


pharmacotherapy of

circulatory failure and

arrhythmias.

7 1 6 5 12 PC,

CD,

CH,

SSRW,

SRW,

ST

PL T, I, ACC,

Pr.


of antihypertensive

drugs. Principles of


apy of arterial hyperten-

sion.

6 6 5 11 PC,

CD,

CH,

SSRW,

SRW,

ST

PL T, I, ACC,

Pr.


of drugs used in pulmo-

nology . Principles of


apy of bronchial asthma

and COPD.

7 1 6 5 12 PC,

CD,

CH,

SSRW,

SRW,

ST

PL T, I, ACC,

Pr.


of anti-inflammatory

drugs, cytostatics and

immunostimulants.


pharmacotherapy of

rheumatic diseases.

6 6 3 9 PC,

CD,

CH,

SSRW,

SRW,

ST

PL T, I, ACC,

Pr.


of antibacterial drugs.


pharmacotherapy of the

infectious process.

5 1 4 4 9 PC,

CD,

CH,

SSRW,

SRW,

ST

PL T, I, ACC,

Pr., DCH

Credit-test 2 2 2 Т, Pr., С

Total: 72 10 62 36 108

4.1. Applied teaching technologies, means and methods of teaching

PL* problem

lecture

CD** case discussion

PC** practical

class

CH** Filling in a case history

ST** Solving

situa-

tional

tasks

SSRW** students'scientific research work (compilation of an in-

formational review of literature on the proposed

topics)

SRW** student research work

4.2. Forms of current academic achievement assessment and intermediate attestation

ACC analysis of clinical cases (clin-

ical analysis)

I assessment based on interview re-

sults (oral survey)

Т testing DCH defense of case history

Pr. assessment of the develop-

ment of practical skills (skills,

possessions)

5. Educational, methodical and informational support of the discipline

5.1. Main literature:

1. Wirfs MJ. The APRN’s Complete Guide to Prescribing Drug Therapy 2018. New

York, NY: Springer Publishing Company; 2017. – URL: http://search.ebsco-

host.com/login.aspx?di-

rect=true&db=e600tww&AN=1521652&lang=ru&site=ehost-live

2. Methodical textbook of clinical pharmacology for self-traning of the students of

pharmaceutical faculty [Текст] / N. G. Philippenko. - Kursk : KSMU, 2002. - 37 p.

3. Methodical textbook of clinical pharmacology for self-training of 5-th year medical

students [Текст] / G. S. Mal. - Kursk : KSMU, 2002. - 20 p.

4. Клиническая фармакология [Электронный ресурс] : учебник / под ред. В. Г.

Кукеса, Д. А. Сычева. - 5-е изд., испр. и доп. - М. : ГЭОТАР-Медиа, 2017. –

1024с. - – URL: http://www.studentlibrary.ru/book/ISBN9785970441961.html

5. Клиническая фармакология и фармакотерапия в таблицах, схемах и алгорит-

мах (разделы: доказательная медицина, формулярная система лечения забо-

леваний, основы клинической фармакологии, кардиология): учеб. пособие

для врачей, клин. интернов, ординаторов, аспирантов, студентов мед. и фар-

мацевт. вузов / Н. Г. Филиппенко [и др.] ; Курск. гос. мед. ун-т. - 2-е изд. -

Курск : Изд-во КГМУ, 2009. - 164 с. : ил. (электронная версия в библиотеке

КГМУ). – URL: \\10.0.0.151\fulltext\Издания КГМУ\Филиппенко Н.Г\Клин.

фармакология .pdf

http://search.ebscohost.com/login.aspx?direct=true&db=e600tww&AN=1521652&lang=ru&site=ehost-live



http://www.studentlibrary.ru/book/ISBN9785970441961.html

file://10.0.0.151/fulltext/Издания%20КГМУ/Филиппенко%20Н.Г/Клин.%20фармакология%20.pdf

file://10.0.0.151/fulltext/Издания%20КГМУ/Филиппенко%20Н.Г/Клин.%20фармакология%20.pdf

5.2. Additional literature:

1. Aaronson E, Venkatesh A, Antonsen E, Walls RM, Adler J. Emergency Medicine

Evidence : The Practice-Changing Studies. Philadelphia, Pa: Wolters Kluwer

Health; 2015. – URL: http://search.ebscohost.com/login.aspx?di-


2. Arnett DK, Shah S. Cardiovascular Genetics and Genomics in Clinical Practice.

New York: Demos Medical; 2015. – URL: http://search.ebsco-



3. Amyes SGB. Antibacterial Chemotherapy : Theory, Problems, and Practice. Ox-

ford: OUP Oxford; 2010. – URL: http://search.ebscohost.com/login.aspx?di-


4. Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. [Place of

publication not identified]: Wolters Kluwer Health; 2016. – URL: http://search.eb-

scohost.com/login.aspx?di-


5. Murrell KE. Urinary Tract Infections : Epidemiology, Pathogenesis and Preven-

tion. New York: Nova Science Publishers, Inc; 2014. – URL: http://search.ebsco-



6. Rao R, Suster S, Moran C. Pulmonary Pathology. New York: Demos Medical;

2014. – URL: http://search.ebscohost.com/login.aspx?di-


7. Riddell RH, Jain D, Bernstein CN, Guha S, Lewin K. Lewin, Weinstein and Rid-

dell’s Gastrointestinal Pathology and Its Clinical Implications. Vol Second edition.

Philadelphia, PA: Wolters Kluwer Health; 2014. – URL: http://search.ebsco-





















8. Steinberg BA, Cannon CP. Evidence-Based Cardiology. Vol 4th ed. Philadelphia:

Wolters Kluwer Health; 2015. – URL: http://search.ebscohost.com/login.aspx?di-


9. Бронхообструктивный синдром - индивидуальный выбор лекарственной те-

рапии в соответствии с протоколами ведения больных. Принципы фармако-

терапии аллергических заболеваний [Электронный ресурс] : учеб.-метод. по-

собие / Н. Г. Филиппенко, С. В. Поветкин, С. И. Корнеева ; Курск. гос. мед.

ун-т. - Электрон. текстовые дан. - Курск : КГМУ, 2015. - 1 эл. опт. диск (CD-

ROM) (электронная версия в библиотеке КГМУ). – URL::

ftp://fulltext.kursksmu.net/fulltext/Electron_publications_KSMU/2015/17674.7z

10. Выбор противоинфекционной фармакотерапии в клинике внутренних болез-

ней. Протоколы ведения больных [Электронный ресурс] : учеб.-метод. посо-

бие / Н. Г. Филиппенко, С. В. Поветкин, О. В. Левашова ; Курск. гос. мед. ун-

т. - Электрон. текстовые дан. - Курск : КГМУ, 2015. - 1 эл. опт. диск (CD-

ROM) (электронная версия в библиотеке КГМУ). – URL:


11. Клиническая фармакология и фармакотерапия в таблицах, схемах и алгорит-

мах (разделы: пульмонология, аллергология): учеб. пособие для врачей,

клин. интернов, ординаторов, аспирантов, студентов мед. и фармацевт. вузов

/ Н. Г. Филиппенко, С. В. Поветкин ; Курск. гос. мед. ун-т. - Курск : Изд-во

КГМУ, 2009. - 90 с. : ил. (электронная версия в библиотеке КГМУ). – URL::

ftp://fulltext.kursksmu.net/fulltext/arhiv_rio/2009/FilippenkoNG/Filippen-

koNG_Klin_farmakol_2009.pdf

12. Рациональная фармакотерапия заболеваний мочевыводящих путей у бере-

менных и кормящих женщин: научное издание / Н. Г. Филиппенко, С. В. По-

веткин, А. А. Корнилов [и др.]; под ред. Н. Г. Филиппенко ; Курск. гос. мед.

ун-т; Ком. здравоохранения Курской обл. - Курск : Изд-во КГМУ, 2012. - 52

с. - (Конспект практическому врачу). - Библиогр.: с. 51-52(20 назв.). (элек-

тронная версия в библиотеке КГМУ). – URL:

ftp://fulltext.kursksmu.net/fulltext/arhiv_rio/2012/463/463.pdf





ftp://fulltext.kursksmu.net/fulltext/arhiv_rio/2009/FilippenkoNG/FilippenkoNG_Klin_farmakol_2009.pdf

ftp://fulltext.kursksmu.net/fulltext/arhiv_rio/2009/FilippenkoNG/FilippenkoNG_Klin_farmakol_2009.pdf

ftp://fulltext.kursksmu.net/fulltext/arhiv_rio/2012/463/463.pdf

13. Современные алгоритмы фармакотерапии аритмий [Электронный ресурс] :

мультимедийное учеб. пособие / С. В. Поветкин [и др.] ; Курск. гос. мед. ун-

т, каф. клин. фармакологии. - Электрон. текстовые дан. - Курск : КГМУ, 2017.

- 1 эл. опт. диск. (электронная версия в библиотеке КГМУ). – URL:

ftp://fulltext.kursksmu.net/fulltext/Electron_publica-

tions_KSMU/2017/0321702430.7z

5.3. Periodicals:

1. Клиническая фармакология и терапия.

2. Рациональная фармакотерапия в кардиологии.

3. Кардиоваскулярная терапия и профилактика.

4. Российский кардиологический журнал.

5. Пульмонология.

5.4. Electronic information support and professional databases:

1. Guidelines of the European Society of Cardiology in English. Electronic re-

source: https://www.escardio.org/Guidelines

2. Guidelines of the European Respiratory Society in English. Electronic re-

source: www.ers-education.org/guidelines.aspx

3. Guidelines of the World Society of Gastroenterology in English. Electronic re-

source: http://www.worldgastroenterology.org/guidelines/global-guidelines

4. Guidelines of the European Antirheumatic League in English. Electronic re-

source: https://www.ncbi.nlm.nih.gov/pubmed/?term=guidelines%20EULAR

5. Cochrane Collaboration. Electronic resource: http://www.cochrane.org

6. Cochrane Library. Electronic resource: http://www.thecochraneli-

brary.com/view/0/index.html

7. Consultant Plus https://kurskmed.com/department/library/page/Consult-

ant_Plus



https://www.escardio.org/Guidelines

http://www.ers-education.org/guidelines.aspx

http://www.worldgastroenterology.org/guidelines/global-guidelines

https://www.ncbi.nlm.nih.gov/pubmed/?term=guidelines%20EULAR

http://www.cochrane.org/

http://www.thecochranelibrary.com/view/0/index.html

http://www.thecochranelibrary.com/view/0/index.html

https://kurskmed.com/department/library/page/Consultant_Plus

https://kurskmed.com/department/library/page/Consultant_Plus

8. Database of international scientific citation index "WEB OF SCIENCE".

Electronic resource: http://www.webofscience.com

9. Full-text database "Medline Complete". Electronic resource: http://search.eb-

scohost.com/

10. World Health Organization. Electronic resource: http://www.who.int/

http://www.webofscience.com/

http://search.ebscohost.com/

http://search.ebscohost.com/

http://www.who.int/

6.Material-technical support of the discipline

No. Names of special rooms and

rooms for individual work

Equipment of special rooms and rooms for in-

dividual work

List of licensed program support. Requisites of

confirming document

1. Russian Federation, 305004,

Kursk, Semyenovskaya str.76, 2nd

entrance, 4th floor, conference

room

Classroom for lecture-type classes (210 m): spe-

cialized furniture (sections of chairs, lecturers' trib-

une); technical training tools that serve to present

information to a large audience ( multimedia pro-

jector, laptop).


Kursk, Semyenovskaya str.76, 1st

entrance, 2nd floor, study room №1

Learning room for seminar classes, group and

individual consultations, current control and in-

termediate attestation: specialized furniture (edu-

cational furniture, cabinets); technical training

equipment and demonstration equipment (personal

computer, multifunctional printer); visual aids,

providing thematic illustrations.



entrance, 3rd floor, study room №2





equipment and demonstration equipment (laptop,

MFP); visual aids, providing thematic illustrations.









MFP); providing thematic illustrations.



entrance, 5th floor, study room №4















TV); visual aids, providing thematic illustrations.












entrance, 4th floor, display class

Rooms for independent work of students,

equipped with computer equipment and the

ability to connect to the Internet and provide ac-

cess to the organization’s electronic information

and educational environment: specialized furni-

ture, technical equipment (personal computers).

1. The program for creating tests - Adit Testdesk ,

contract number 444 from 06/22/2010

2. The program for the organization of distance

learning - ISpring Suite 7.1, contract number 652

from 09/21/2015

3. Office software package - Microsoft Win Office

Pro Plus 2010 RUS OLP NL , contract No. 548

dated August 16, 2010

4. Operating system - Microsoft Win Pro 7, contract

No. 904 of 12/24/2010

5. Antivirus - Kaspersky Endpoint Security, con-

tract number 832 of 10/15/2018

6. Office software package - MyOffice Education,

contract number 733 of 09/17/2018

7. Office software package - MyOffice Standard,

contract No. 733 dated 09/17/2018

8. Library Automation System IRBIS 64, Contract

No. 865 dated 10.22.2018

9. Web service for video conferencing - Imind ,

contract number 632 from 08.27.2018


Kursk, Semyenovskaya str.76, ad-

mission department

Premises provided for the provision of medical

care to patients, including those associated with

medical interventions, equipped with specialized

equipment and (or) medical products: tonome-

ter, stethoscope, stetofonendoskop, medical ther-

mometers, stadiometer medical, antishock kit, set

for emergency preventive and therapeutic measures

.


Kursk, Semyenovskaya str.76, car-

diology department




equipment and (or) medical products: 6-channel

ECG Cardiovit AT-2, 3-channel ECG Cardimax

FX -7102, Holter ECG Valenta , stethoscope, ex-

press - measuring instrument of blood glucose con-

centration portable PCG "Satellite Express Z834",

pulse oximeter, medical thermometer, wheel chair,

rubber band, antishock set, tonometer , ne-

gatoscope.


Kursk, Semyenovskaya str.76, de-

partment of functional and ultra-

sound diagnostics




equipment and (or) medical products: ECG 6-

channel Cardiovit AT-2, ECG 3-channel Cardimax

FX- 7102, Holter ECG Valenta, SMBP MNSDP,

VEM Valenta, Reograf Valenta, ultrasound scanner

VIVID 7, ultrasound scanner SonoScape

7. Assessment tools

Questions for the oral part of the credit-test

1. Pharmacotherapy. Subject and tasks. The basic principles of modern drug therapy.

2. The concept of drugs bioavailability. The main directions of increasing the bioavaila-

bility of drugs.

3. The absorption of drugs. General patterns. Factors affecting absorption and ways to

optimize it.

4. Transport, distribution of medicinal substances in the human body and the influence

of various factors on them.

5. General patterns of biotransformation of medicinal substances in the human body and

their determining factors.

6. General patterns of excretion of medicinal substances in the human body and their

determining factors.

7. General rules for taking medication depending on the diet.

8. Features of pharmacokinetics of drugs in childhood.

9. Features of pharmacokinetics of drugs in the elderly and senile age.

10. The concept of physical and chemical incompatibility of drugs.

11. Formulary system for providing medicinal products.

12. General patterns of combined pharmacotherapy.

13. Evidence-based medicine.

14. Side effects of drugs.

15. Adverse drug reactions. Allergic reactions. Reasons, ways of prevention and treat-

ment.

16. Adverse drug reactions caused by the direct pharmacological action of drugs.

17. Pharmacoepidemiology and pharmacoeconomics.

18. The general concept of clinical pharmacology. Pharmacokinetics and pharmacody-

namics of drugs.

19. Pharmacogenetics.

20. Characteristics of beta-blockers.

21. Modern principles of medicinal treatment of pyelonephritis, cystitis.

22. Characteristics of angiotensin-converting enzyme inhibitors.

23. Modern principles of drug treatment of osteoarthritis deformans.

24. Characterization of antagonists of angiotensin receptors.

25. Modern principles of drug treatment of rheumatoid arthritis.

26. Characteristics of diuretics.

27. Modern principles of drug treatment of gastritis.

28. Characteristics of calcium channel blockers.

29. Modern principles of drug treatment of gastric ulcer and duodenal ulcer.

30. Characteristics of nitrovasodilators.

31. Modern principles of medicinal treatment of bronchial asthma.

32. Characteristics of antiarrhythmic drugs.

33. Modern principles of drug treatment of pneumonia.

34. Characteristics of bronchodilating agents. Adrenomimetics.

35. Modern principles of drug treatment of circulatory failure.

36. Characteristics of bronchodilating agents. M-cholinolytics.

37. Modern principles of drug treatment of arterial hypertension.

38. Characteristics of antisecretory anti-ulcer agents. Blockers of H2-histamine recep-

tors.

39. Modern principles of drug treatment of COPD.

40. Characteristics of antisecretory anti-ulcer agents. Proton pump inhibitors.

41. Modern principles of medicinal treatment of ischemic heart disease.

42. Characteristics of aminoglycosides, tetracyclines.

43. Modern principles of pharmacotherapy of supraventricular and ventricular tachycar-

dias.

44. Characteristics of penicillins.

45. Modern principles of pharmacotherapy of acute myocardial infarction.

46. Characteristics of cephalosporins, carbapenems.

47. Modern principles of pharmacotherapy of chronic cholecystitis.

48. Characteristics of macrolides, glycopeptides.

49. Modern principles of pharmacotherapy of chronic pancreatitis.

50. Characteristics of glucocorticosteroid hormones.

51. Modern principles of pharmacotherapy for GERD.

52. Ways to increase the effectiveness of pharmacotherapy in patients with impaired

elimination of drugs.

53. Characteristics of nonsteroidal anti-inflammatory drugs.

54. Modern principles of pharmacotherapy of irritable bowel syndrome.

55. Characteristics of choleretic and enzyme preparations.

56. Modern principles of pharmacotherapy of atrial fibrillation.

57. Characteristics of cytostatic agents.

58. Modern principles of pharmacotherapy extrasystole.

59. Characteristics of quinolones and monobactams.

60. Modern principles of pharmacotherapy of gout

Bank of profession-oriented situational problems for the credit-test

Problem № 1. Diagnosis: Congenital heart disease: IVS defect. CHF1 FC.

Per os Parenterally

Tab. Hydrochlorothiazidi 25mg in the morn-

ing

Tab. Losartan 50 mg in the evening

Aethylmethylhydroxypyridini succinas 1ml

+ i/v

Inosini 200mg

Questions.

1. Are indicated doses, routes of administration, time of reception correct?

2. Are drugs chemically compatible?

3. Are drugs pharmacologically compatible?

4. Whether there is a violation of bioavailability, absorption processes, transport, metabolism,

excretion of drugs?

5. Suggestions for optimization of treatment (exclude, replace).

Problem №2 Diagnosis: CHD: stable angina pectoris, FC II. CHF III FC.

Per os Parenterally

Tab. Metoprololi 100 mg 1 time per day

Tab. Acidi acetylsalicylici 150mg three times

a day

Tab. Enalaprili 10 mg 2 times a day

Furosemidi 40mg

+ i/v Nitroglycerini 1ml 1%

Questions.





excretion of drugs?


Problem №3 Diagnosis: CHD: PICS. CHF IV FC. Recurrent cardiac asthma.

Per os Parenterally

Tab. Isosorbidi mononitras 40 mg 2 times a

day

Tab. Spironolactoni 50mg in the morning

Tab. Simvastatini 40 mg 2 times a day

Furosemidi 80mg +

Sol. Nitroglycerini 1% 1ml

+

200ml isotonic solution

Questions.





excretion of drugs?


Problem №4 Diagnosis: COPD, bronchitic variant. Resp. insufficiency 3.

Per os Parenterally

Carbocisteini 2 capsules 3 times a day

Fluticasone 500 mg 2 times per day by in-

halation

Prednisoloni 60mg+

Amoksiklavi 500mg 3 times a day

+

200ml isotonic solution

Questions.





excretion of drugs?


Problem №5 Diagnosis: Bronchial asthma, mixed, severe course, without exacerbation.

Per os Parenterally

Tab. Montelukast 10mg in the morning

Tab. Bromhexin 8 mg 4 times a day

1-2 Fenoteroli 200 ug dose (inhaled) at attacks

Prednisoloni 120mg

+ i/v

Sol. Aminophyllini 2,4% 5ml

Questions.





excretion of drugs?


Problem №6 Diagnosis: Duodenal ulcer, exacerbation.

Per os Parenterally

T. Omeprazoli 20mg x 2 p \ day

T. Clarithromycini 500mg x 2p \ day

S. Cerucali 1,0

Platiphyllini hydrotartratis 1,0 - 0,2% / i/m in a

single syringe

Questions.





excretion of drugs?


Problem №7 Diagnosis: Stomach ulcer. H. pylory revealed resistance to clarithromycin.

Per os Parenterally

T. Omeprazoli 20mg x 2 p \ day

T.Metronidazoli 500mg x 3p \ g

Bismuth dicitratis 120mg x 4p \ d

S. Drotaverini 2 ml i/m in one syringe

S. Cerucali 1,0

Questions.





excretion of drugs?


Problem №8 Diagnosis:Chronic pyelonephritis, worsening. CKD 1.

Per os Parenterally

tab. Diclophenaci 50 mg 2 times a day

tab. Furosemidi 40mg in the morning

Cefazolini 1000mg

+

Kanamycin 500 mg drip 2 t / d

+

200.0 0.9% NaCl solution

Questions.





excretion of drugs?


Problem №9 Diagnosis: Acute bacterial rhinosinusitis.

Per os Parenterally

tab. Loratadine 10 mg 1 time per day

tab. Acetylcysteini 200 mg 2 times a day

(dissolved in 1 cup water)

Cefotaximi 1000mg +

Clarithromycini 1000mg

3 times per day in one set

Questions.





excretion of drugs?


Problem №10 Diagnosis: Nosocomial pneumonia is the lower lobe of the left lung, severe course.

Per os Parenterally

tab. Diclophenaci 100 mg 1 time per day

tab. Ambroxoli 30mg 3 times per day

Levofloxacini 500mg +

Ceftriaxone 1000mg / drip

+

200.0 0.9% NaCl solution

Questions.





excretion of drugs?


Problem №11 Diagnosis: CHD: Stable angina IIIFC. CHF II FC.

Per os Parenterally

Tab. Nifedipini 0,01

1tabl. 3 times a day before meals.

Tab. Isosorbidi mononitrati 0,05 in the morn-

ing every day.

Sol. Nitroglycerini 1% -1.0 ml per 200ml 0,9%

NaCl / drip (5-7 drops per minute).

Sol. Furosemidi 40 mg / i/v

Questions.





excretion of drugs?


Problem №12 Diagnosis: Essential hypertension, III degree, III stage MHLV risk 4. Hypertensive crisis. CHF IIIFC.

Per os Parenterally

Tab. Telmisartani 40mg

1tabl. 1 in the morning every day.

Tab. Bisoprololi 5mg

1tabl. 1 in the morning every day.

Sol. Enalaprilati 1,25mg

/ drip in 200.0 ml 0,9% Nacl.

Sol. Furostmidi in 40mg / jet.

Questions.





excretion of drugs?


Problem №13 Diagnosis: Gestational hypertension. Heart rate of 120-130 beats per minute at rest. Pregnancy 28

weeks.

Per os Parenterally

Tab. Enalaprili 5mg

1tabl. 2 times a day.

Tab. Bisoprololi 2,5 mg

1tabl. morning.

Sol. Cordaroni 450 mg / drip 200.0 5% glu-

cose.



Questions.





excretion of drugs?


Problem №14 Diagnosis: OA of the knee, IIIst. Secondary synovitis. Chronic gastritis with hypersecretion syndrome.

Per os Parenterally

T. Meloxicami 15 mg during meals x 1p \ d

Almagel 1d.l x 3times a day for 30 minutes

before a meal

S. Aflutopi 1 ml

S.Diclophenaci 3.0 ml in \ m.

In one syringe

Questions.





excretion of drugs?


Problem №15 Diagnosis: Essential hypertension, III degree, III stage MHLV risk 4.CHF II FC. Atherosclerosis of

the lower extremities.

Per os Parenterally

Tab. Betaxololi 20mg

½ tab. morning

Tab. Perindoprili 10 mg

1 tab. morning

Tab. Amlodipini 10mg

1 tab. in the morning every day.

Sol. Enalaprilati 1,25mg / drip in 200.0 ml

0,9% Nacl.

Sol. Furosemidi 40mg / i/v.

Questions.





excretion of drugs?


Problem №16 Diagnosis: CHD: Acute myocardial infarction anterior left ventricular wall.

CHF FC II.

Per os Parenterally

Tab. Metoprololi succinati 200mg

Table 1. 1 time per day in the morning.

Tab. Acetylsalicylici acidi 75 mg

1 tabl. evening.

Sol. Nitroglycerini 1% -1.0 ml per 200ml 0,9%

Nacl / drip (5-7 drops per minute).

Sol. Dalteparini sodiumi 10000ME subcutan.

every 12 hours.

Questions.





excretion of drugs?

5. Suggestions for optimization of treatment (exclude, replace)

.

Problem №17 Diagnosis: Essential hypertension, III degree, III stage MHLV risk 4.CHF II FC. Atherosclerosis of the

lower extremities.

Per os Parenterally

Tab. Betaxololi 10mg

½ tab. morning

Tab. Perindoprili 10 mg

Tab. Amlodipini 5 mg

1 tabl. in the morning every day.



Sol. Furosemidi 40mg i/v.

Questions.





excretion of drugs?


Problem №18 Diagnosis: Acquired pneumonia of the lower lobe of the left lung.

Per os Parenterally

Tab. Amoxicillini 500 mg

1tabl. 3 times a day.

Tab. Ambroxoli 30mg

1 pill 3 times a day.

Sol. Cefotaximi 1g 2 times a day i/m.

Sol. Gentamicini 80 mg 2 times a day i/v.

Questions.





excretion of drugs?


Problem №19 Boy P ,, 16 years.

Carried out routine vaccination.

After administration of the vaccine, appeared after 2 weeks temperature up to 39 degrees, skin rashes,

joint pain, muscle weakness, increased peripheral lymph nodes, nephritis phenomenon.

1) What type of side effect occurs?

2) What is the mechanism of this side effect?

3) Name drugs with similar side effects.

4) What is the principle of providing emergency care?

5) Suggestions for optimizing treatment.

Problem №20 Diagnosis: Chronic pyelonephritis, worsening. Pregnancy 15 weeks.

Per os Parenterally

Kanefron 2p 3 times a day

Tabl. Furagini 0,05

2 tabl. 3 times a day after meals

S. Cefotaximi 1g x 2t \ d i\ m

S. Gentamicini 1,0 ml x 2t \ d i\ m

Questions.





excretion of drugs?


Base of typical test tasks for the credit-test

(complete base of test tasks is kept at the department and in the testing center)

1. PROVIDE YOUR ANSWER

DUAL-CHAMBER MODEL OF DRUG DISTRIBUTION IS CHARACTERIZED BY:

() drug accumulation in any organ or tissue

() drug, once in the central chamber, then enters into the peripheral chamber

() uniform distribution of drug in the body


FIRST STAGE OF TRANSFORMATION OF DRUGS IN THE BODY

() breeding

() absorption

() distribution

() adsorption

() metabolism


THIRD STAGE OF TRANSFORMATION OF DRUGS IN THE BODY

() metabolism

() adsorption

() absorption

() breeding

() distribution

4. SPECIFY THE APPROPRIATE

CLASS OF RECOMMENDATIONS CHARACTERISTIC

IIA class a distinct preponderance of data

on the use and effectiveness

class I less obvious preponderance of

data on the benefits and effi-

ciency

class IIB a high level of evidence or gen-

eral agreement about the benefit,

use and effectiveness of the pro-

cedure and the method of treat-

ment

IV class diagnostic methods or treatment,

for which there is evidence

and/or general agreement about

inefficiency


LEVELS OF EVIDENCE CHARACTERISTIC

C data descriptive studies, cross-

sectional, expert agreement

A small randomized trials

B multicenter studies

6.

SELECT THE CORRECT ANSWER FROM A LIST

CHAPTER OF CLINICAL PHARMACOLOGY, STUDIED STAGE OF PASSING

THE MEDICAMENT OF THE ORGANISM CALLED ______________.


ALDOSTERONE ANTAGONISTS ARE:

() mannitol

() indapamide

() eplerenone

() hydrochlorothiazide

() torasemide


DRUGS THAT CAN BE ADDED IN CHF IN PATIENTS WITH THE

INEFFECTIVENESS OF MAXIMUM DOSES OF BETA-BLOCKERS FOR THE

NORMALIZATION OF HEART RATE IN SINUS RHYTHM:

() amlodipine

() trimetazidine

() eplerenone

() torasemide

() ivabradine


GROUP OF DRUGS DRUGS

ACEI fosinopril

angiotensin II receptor blocker betaxolol

selective beta-blocker candesartan



angiotensin II receptor blocker bisoprolol

ACEI telmisartan

selective beta-blocker zofenopril


CLASSES OF ANTIARRHYTHMIC

DRUGS

DRUGS

II propranolol

Ia lidocaine

novokainamid

propafenone


IA ANTIARRHYTHMIC DRUGS CLASS IS ...

() diltiazem

() quinidine

() etatsizin

() sotalol

() mexiletine


WHAT TYPE OF ADVERSE REACTIONS IS REFLEX NEGATIVE EFFECTS OF

DRUGS RELATED TO:

() idiosyncrasy

() toxic effect

() secondary

() direct side effects

() intolerance


WHAT TYPE OF ADVERSE REACTIONS IS DYSBIOSIS RELATED TO:

() direct side effects

() intolerance

() idiosyncrasy

() secondary

() toxic effect



cytostatics dexamethasone

glucocorticosteroids krizanol

mercaptopurine



immunostimulants T-activin

4-aminoquinoline derivatives Plaquenil


DRUG INTERACTIONS BEFORE THE INTRODUCTION OF BODY CALLED:

() pharmaceutical

() pharmacodynamic

() pharmacokinetic

() antagonism


INTERACTIONS DEFINITION

antagonism effect of the combination is less

than that of one or more compo-

nents

synergy combination effect is the action

of one of the components

indifference effect of the combination is

greater than the effect of each

component separately


GROUPS OF DRUGS DRUGS

drugs forming the protective

film

sucralfate

drugs which inhibit acid secre-

tion

carbenoxolone

almagel

omeprazole

20. SPECIFY MULTIPLE CORRECT ANSWER

PROTON PUMP INHIBITORS:

[] lansoprazole

[] omeprazole

[] famotidine

[] metoclopramide

[] de-nol


MODE OF IVABRADINE ACTION:

() increasing slow calcium current into the cell

() blockade slow calcium channels of the cell membrane

() increase in the activity of beta-receptors of the vascular wall of the coronary arteries

() If-channel blockade

() relaxation of smooth muscles in the vascular wall due to the formation of nitric oxide


NICORANDIL IS ...

() potassium channel activator

() blocker of late sodium ion current

() If-channel inhibitor

() beta-blocker

() prolonged nitrate


GROUPS OF DRUGS DRUGS

aminoglycosides gentamicin

tetracyclines amikacin

doxycycline


DISEASE THE DRUG OF CHOICE

exacerbation of COPD in pa-

tients younger than 65 years

levofloxacin

COPD exacerbation with risk

factors for infection with P. ae-

ruginosa

amoxicillin / clavulanate

COPD exacerbation in patients

older than 65 years

amoxicillin


GLUCOCORTICOSTEROIDS DURATION OF ACTION

hydrocortisone long

dexamethasone medium

prednisolone short

26. SPECIFY MULTIPLE CORRECT ANSWER

Beta-adrenergic agonist (long-acting)

[] ketotifen

[] salmeterol

[] formoterol

[] omalizumab

[] tiotropium bromide


MODE OF ACTION DRUGS

cholesterol absorption inhibition lovastatin

inhibition of HMG-CoA reduc-

tase

ezetimibe

modification utilization of free

fatty acids

nicotinic acid



fibrates pravastatin

statins colesevelam

anion exchange resins gemfibrozil


CORRECTION FOR DYSLIPIDEMIA WITH NONALCOHOLIC FATTY LIVER

DISEASE DESIGNATE:

() tiazolididions

() statins

() gepatoprotectors

() antioxidants

() vitamin complexes


CLINICAL CONDITION CHOICE OF THERAPEUTIC FORM

exacerbation of chronic pancrea-

titis pain syndrome

tablets enzyme

exocrine insufficiency encapsulated enzyme

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