defective colour-vision

1
1417 mother is usually an anxious mother and that part of his job is to allay this anxiety. Illness itself causes behaviour disorders in children; guiding the mother in her handling of these problems all adds up to good doctoring. ACCIDENT PREVENTION The student comes into homes that are often over- crowded and poor. The unguarded fire, the faulty plug, the drug cupboard within too easy reach of exploring fingers, the pot on the stove with a protruding handle-the student must almost subconsciously become aware of these risks and learn to warn mothers of their dangers when he goes into practice. SOCIAL MEDICINE The hospital social worker is an integral member of the home-care team, and from her the student learns from the beginning how to assess the patient’s needs and where to find the appropriate help. He visits the local school for handicapped children, training-centres, day-nurseries, and welfare centres. A realisation of how the under- privileged live should make the doctor agitate for better housing. " I never realised human beings could live in such squalor "-a remark from a potential social reformer of the future. Home care is one way of introducing the medical undergraduate to family doctors and good family doctor- ing. He sees that there is no basic difference between the good " hospital " doctor and the good " home doctor ", and that good medicine can be practised at home, the hospital being reserved for special problems. CONCLUSION A paediatric home-care unit offers many advantages in teaching the medical student how to deal with the common illnesses of childhood. He learns that much illness can be as satisfactorily dealt with in the home as in hospital. This sort of tuition prepares him for his future work in practice. I should like to thank Dr. T. E. Oppe, director of the Pasdiatric Unit, St. Mary’s Hospital, and the Sembal Trust for their grant to home care. Occasional Book DEFECTIVE COLOUR-VISION AN ambitious and successful book,! intended mainly for geneticists and those engaged in anthropometric studies, aims to define more clearly the problems of defective colour-vision and its relation to normal colour-vision. In the pathology of colour-vision defects, Dr. Kalmus believes that in protanopes the red-responding cones are missing, while in deuteranopes probably both red-responding and green-responding cones contain only the red-absorbing pigment. In tritanopes the blue-responding cones also are missing. As would be expected from a geneticist of Dr. Kalmus’s standing, he deals admirably with the complexities of the genetics of defective red-green colour-vision. There is evidence that there are separate loci for the protan and deutan series, with two or three alleles besides the normal dominant gene for each locus. But Dr. Kalmus seems still to favour the single-locus theory, although the facts are very hard to fit into it. Of especial interest is Dr. Kalmus’s proposal to use the anomaloscope to measure the matching range (whose importance was emphasised by Franceschetti and by Willis and Farns- worth) as well as the matching point. In the first days of the anomaloscope it was assumed that the essential measurement was the proportion of red to green light needed by the observer to match the standard yellow, and it was understood that the yellow had to be varied in brightness, at least for some subjects. But if we want an observer to match a standard yellow in hue, saturation, and brightness with a mixture of red and green, then there are three dimensions of variability. For every subject we must measurer) the average proportions of red to green which match the yellow for him, (b) the limits of change in these proportions before he notices a difference in hue and/or saturation, and (c) the variations in brightness of either the red-green mixture or the yellow standard between these limits and, indeed, throughout the available range of variations. The yellow may have to be desaturated in step with the other changes, but in practice this proves to be less impor- tant, and is seldom required. Few anomaloscopes provide for desaturation of the yellow. A psychophysical technique in which the observer is asked to change the controls for yellow brightness and red-green mixture freely until he arrives at a match, even taking the average of several such readings, may work reasonably well with subjects who are practised at such adjustments and have 1. Diagnosis and Genetics of Defective Colour Vision. By H. KALMUS, M.D., SC.D. London: Pergamon Press. 1965. Pp. 114. 50s. good colour discrimination; but the poorer the subject’s hue discrimination the less satisfactory the result. This technique is acceptable if the state of the subject’s colour discrimination is known. An anomalous subject who has poor or very poor colour discrimination but is not dichromatic may make five or six settings, all different but equally good for him; but how are we to know that his matching range has been properly measured when a random technique is used ? We cannot even be sure that he is not a dichromat. Dr. Kalmus has proposed to adapt the original technique by setting the red-green mixture first at the fully red position and then asking the subject to adjust the brightness of the yellow to match it. (Dichromats can do this, and so can certain extreme protanomalous subjects whose matching range extends to the red end but not to the green end of the scale.) Then the subject is given various brightnesses of yellow and asked to match them with the red-green mixture, in order to find out whether he is a dichromat or anomalous. This kind of technique should be replaced by a systematic measurement of the subject’s matching range. The adjust- ments should be made by the tester, who must ask the subject at each step whether there is a colour difference and what it is, no claim of an apparent colour difference being accepted until the halves of the test field are satisfactorily equated in brightness for the subject. The subject’s mid-point will be the middle of his matching range, and its deviation from the normal average mid-point can be established, while his matching range and brightness variation can be compared with those of other subjects. Function fluctuation-manifested in the considerable variability of results on repeated testing-is also important in certain anomalous subjects. For dichromats, of course, the matching range always extends from one end of the red-green scale to the other (with appropriate brightness adjustments), and for them the mid-matching point is arbitrarily in the middle of the scale and is not comparable with that for other subjects. The same fundamental principle of aiming the test technique primarily at measurement of matching range and its position can be used to identify dichromats; to distinguish protans from deutans; to determine the matching range and the deviation, if any, of the mid-matching point for anomalous subjects; and to determine the same variations found on a much smaller scale among minor defectives (the deviants and colour-weak), who do not, however, inherit a sex-linked abnormality. The same technique, using other spectral colours or other colour filters, according to the kind of anomaloscope employed, can be used to measure variations of mid-matching point, matching range, and brightness level in other colour dimensions, such as blue-to-green or yellow-to-blue.

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1417

mother is usually an anxious mother and that part of hisjob is to allay this anxiety. Illness itself causes behaviourdisorders in children; guiding the mother in her handlingof these problems all adds up to good doctoring.

ACCIDENT PREVENTION

The student comes into homes that are often over-crowded and poor. The unguarded fire, the faulty plug,the drug cupboard within too easy reach of exploringfingers, the pot on the stove with a protruding handle-thestudent must almost subconsciously become aware ofthese risks and learn to warn mothers of their dangerswhen he goes into practice.

SOCIAL MEDICINE

The hospital social worker is an integral member of thehome-care team, and from her the student learns from thebeginning how to assess the patient’s needs and where tofind the appropriate help. He visits the local school forhandicapped children, training-centres, day-nurseries,and welfare centres. A realisation of how the under-

privileged live should make the doctor agitate for betterhousing. " I never realised human beings could live insuch squalor "-a remark from a potential social reformerof the future.Home care is one way of introducing the medical

undergraduate to family doctors and good family doctor-ing. He sees that there is no basic difference between thegood " hospital " doctor and the good " home doctor ",and that good medicine can be practised at home, thehospital being reserved for special problems.

CONCLUSION

A paediatric home-care unit offers many advantages inteaching the medical student how to deal with the commonillnesses of childhood. He learns that much illness canbe as satisfactorily dealt with in the home as in hospital.This sort of tuition prepares him for his future work in

practice.I should like to thank Dr. T. E. Oppe, director of the Pasdiatric

Unit, St. Mary’s Hospital, and the Sembal Trust for their grant tohome care.

Occasional Book

DEFECTIVE COLOUR-VISIONAN ambitious and successful book,! intended mainly for

geneticists and those engaged in anthropometric studies, aimsto define more clearly the problems of defective colour-visionand its relation to normal colour-vision. In the pathology ofcolour-vision defects, Dr. Kalmus believes that in protanopesthe red-responding cones are missing, while in deuteranopesprobably both red-responding and green-responding conescontain only the red-absorbing pigment. In tritanopes theblue-responding cones also are missing. As would be expectedfrom a geneticist of Dr. Kalmus’s standing, he deals admirablywith the complexities of the genetics of defective red-greencolour-vision. There is evidence that there are separate locifor the protan and deutan series, with two or three allelesbesides the normal dominant gene for each locus. But Dr.Kalmus seems still to favour the single-locus theory, althoughthe facts are very hard to fit into it.Of especial interest is Dr. Kalmus’s proposal to use the

anomaloscope to measure the matching range (whose importancewas emphasised by Franceschetti and by Willis and Farns-worth) as well as the matching point. In the first days of theanomaloscope it was assumed that the essential measurementwas the proportion of red to green light needed by theobserver to match the standard yellow, and it was understoodthat the yellow had to be varied in brightness, at least for somesubjects. But if we want an observer to match a standard

yellow in hue, saturation, and brightness with a mixture of redand green, then there are three dimensions of variability. Forevery subject we must measurer) the average proportions ofred to green which match the yellow for him, (b) the limits ofchange in these proportions before he notices a difference inhue and/or saturation, and (c) the variations in brightness ofeither the red-green mixture or the yellow standard betweenthese limits and, indeed, throughout the available range ofvariations. The yellow may have to be desaturated in step withthe other changes, but in practice this proves to be less impor-tant, and is seldom required. Few anomaloscopes provide fordesaturation of the yellow.A psychophysical technique in which the observer is asked

to change the controls for yellow brightness and red-greenmixture freely until he arrives at a match, even taking theaverage of several such readings, may work reasonably wellwith subjects who are practised at such adjustments and have1. Diagnosis and Genetics of Defective Colour Vision. By H. KALMUS,

M.D., SC.D. London: Pergamon Press. 1965. Pp. 114. 50s.

good colour discrimination; but the poorer the subject’s huediscrimination the less satisfactory the result. This techniqueis acceptable if the state of the subject’s colour discrimination isknown. An anomalous subject who has poor or very poorcolour discrimination but is not dichromatic may make five orsix settings, all different but equally good for him; but how arewe to know that his matching range has been properly measuredwhen a random technique is used ? We cannot even be surethat he is not a dichromat.

Dr. Kalmus has proposed to adapt the original technique bysetting the red-green mixture first at the fully red position andthen asking the subject to adjust the brightness of the yellow tomatch it. (Dichromats can do this, and so can certain extremeprotanomalous subjects whose matching range extends to thered end but not to the green end of the scale.) Then the subjectis given various brightnesses of yellow and asked to match themwith the red-green mixture, in order to find out whether he is adichromat or anomalous.

This kind of technique should be replaced by a systematicmeasurement of the subject’s matching range. The adjust-ments should be made by the tester, who must ask the subjectat each step whether there is a colour difference and what it is,no claim of an apparent colour difference being accepted untilthe halves of the test field are satisfactorily equated in brightnessfor the subject. The subject’s mid-point will be the middle ofhis matching range, and its deviation from the normal averagemid-point can be established, while his matching range andbrightness variation can be compared with those of othersubjects. Function fluctuation-manifested in the considerablevariability of results on repeated testing-is also important incertain anomalous subjects. For dichromats, of course, thematching range always extends from one end of the red-greenscale to the other (with appropriate brightness adjustments),and for them the mid-matching point is arbitrarily in the middleof the scale and is not comparable with that for other subjects.The same fundamental principle of aiming the test technique

primarily at measurement of matching range and its positioncan be used to identify dichromats; to distinguish protans fromdeutans; to determine the matching range and the deviation, ifany, of the mid-matching point for anomalous subjects; and todetermine the same variations found on a much smaller scale

among minor defectives (the deviants and colour-weak), whodo not, however, inherit a sex-linked abnormality. The sametechnique, using other spectral colours or other colour filters,according to the kind of anomaloscope employed, can be usedto measure variations of mid-matching point, matching range,and brightness level in other colour dimensions, such as

blue-to-green or yellow-to-blue.