February 2012

CURRICULUM VITAE

Dale Hattis, Ph.D. Research Professor

George Perkins Marsh Institute

Clark University, 950 Main Street, Worcester, Mass. 01610

(508) 751-4603; (781)-641-0305; FAX (508) 751-4600

Email: DHattis@AOL.com; DHattis@clarku.edu;

Education

1974 Ph.D. -- Genetics

Stanford University

Stanford, California

1967 B.A. -- Biochemistry

University of California

Berkeley, California

Professional Experience

9/98-Present Research Professor

George Perkins Marsh Institute, Clark University

Worcester, Massachusetts

1/90-5/98 Research Associate Professor

Center for Technology, Environment, and Development

George Perkins Marsh Institute, Clark University

Worcester, Massachusetts

7/81-9/93 Principal Research Associate

Center for Technology, Policy and Industrial Development*

Massachusetts Institute of Technology

Cambridge, Massachusetts

9/86-12/86 Visiting Senior Lecturer

Program in Social Ecology

University of California at Irvine

Irvine, California

4/75-7/81 Research Associate

Center for Policy Alternatives

Massachusetts Institute of Technology

Cambridge, Massachusetts

1/75-4/75 Consultant

Center for Policy Alternatives

Massachusetts Institute of Technology

Cambridge, Massachusetts

12/73-11/74 Senior Research Associate

Complex Systems Institute

Case Western Reserve University

Cleveland, Ohio

6/70-9/70 Summer Intern, Food and Drug Administration Project

Center for Study of Responsive Law

Washington, D.C.

Summary of Experience and Training

Research: Methodology for quantitative health risk assessment for cancer and non-

cancer health effects; Human interindividual variability in susceptibility to

toxic effects; Pharmacokinetic and Monte Carlo simulation modeling;

Implications of interindividual variability for population risk for both

carcinogens and other toxic substances; Environmental/health, economic, and

legal implications of alternative regulatory actions to control occupational

exposure to noise, perchloroethylene, ethylene oxide, butadiene, glycol ethers,

acrylamide, formaldehyde; setting priorities for control of toxic substances.

Consulting: (Pending) Member, National Toxicology Program Board of Scientific

Counselors; Past member, Clean Air Scientific Advisory Committee

(CASAC) Review Panel on Primary Standards for NOx and SOx, Member,

Food Quality Protection Act Science Review Board. Past member,

Environmental Health Committee, EPA Science Advisory Board (Ethylene

Oxide Health Risk Assessment Review Panel). Review of proposed IRIS

analysis for trichloropropane. Review of the benefits analysis for the EPA

standard for arsenic in drinking water. Review of the EPA RfD for boron.

Past memberships: Trichloroethylene Health Risk Assessment Synthesis and

Characterization Review Panel, EPA peer review committee for PCB’s, EPA

peer review committee for Hazardous Air Pollutant emissions for electric

generating plants; National Academy of Sciences/Institute of Medicine

Committee on Evaluation of the Safety of Fishery Products; National

Research Council Committee on Neurotoxicology and Models for Assessing

Risk; U. S. Food and Drug Administration (Office of Device Evaluation)--

mercury dental amalgams and polyurethane breast implants. OSHA—cancer

risk assessment policy and risks from occupational noise exposures in the

construction industry; Natural Resources Defense Council and Occupational

Safety and Health Administration, carcinogenesis by diesel exhaust; State of

California (use of PBPK modeling and uncertainty analysis in risk

assessment); International Life Sciences Institute--quantitative risk assessment

for non-cancer effects; Risks of municipal water supply and wastewater

treatment; Use of biomarkers in assessing causation of radiation-induced

cancers; Monte Carlo simulation analysis of uncertainties in carcinogenic

risks from diesel particulates in air and from different substances in drinking

water; Risks of occupational noise exposures, Dose response relationships for

acute toxicity from chlorine or ammonia.

Other: Distinguished Educator Award, Society for Risk Analysis; Lifetime

Achievement Award, American Environmental Health and Science

Foundation; Past Chair, Society for Risk Analysis Dose Response Specialty

Group; Member, Past member, National Research Council Committee on

Estimating the Health-Risk-Reduction Benefits of Proposed Air Pollution

Regulations; Fellow, Society for Risk Analysis (awarded 12/00); Councilor,

Society for Risk Analysis 12/97-12/00; Past member, Expert Panel on

Acrylamide for the National Toxicology Program’s Center for the Evaluation

of Risks to Human Reproduction, Member, Editorial Board for Risk Analysis;

Past member, National Research Council Subcommittee on Methyl Bromide,

Member, Massachusetts Department of Environmental Protection/Department

of Public Health Advisory Committee on Health Effects. Past President, New

England Chapter of the Society for Risk Analysis.

Teaching: Tools for Quantitative Policy Analysis (Clark University graduate course;

MIT Summer Session); Quantitative Risk Assessment for Ecological Risks for

Near-Shore Systems (in cooperation with the U.S. EPA’s Narragansett RI

Laboratory); Cancer, Science and Society (Clark University, undergraduate

course).

Grants and Contracts Through Clark University

U. S. Environmental Protection Agency— Use of Biomarkers and Physiologically Based Pharmacokinetic (PBPK)

Modeling in Risk Analysis for Developmental Effects of Chlorpyrifos--$677.5K—9/07-9/11

U. S. Environmental Protection Agency—Interspecies Differences and Human Inter-Individual Variability in

Tissue-Level Pharmacokinetic Parameters—68K—9/05-10/06.

U. S. Environmental Protection Agency—Age-Related Differences in Susceptibility to Carcinogenesis by Non-

Mutagenic Mechanisms—98K 6/1/05-5/31/07.

U.S. Environmental Protection Agency— PBPK Model Development and Use in Support of the IRIS Assessment

for Acrylamide—20k, 2/1/05-7/31/05.

U. S. Department of Energy—Low Dose Modeling of the Risks of Ionizing Radiation (Rob Goble, PI)—200K/year

9/1/03-8/31/05.

U.S. Environmental Protection Agency, Role of Dosimetric Scaling and Species Extrapolation in Evaluating risks

Across Life Stages—90K 11/25/02-3/31/04.

U.S. Environmental Protection Agency, Age-Related Differences in Susceptibility to Carcinogenesis—100K 6/1/02-

10/30/03.

Connecticut Department of Public Health (subcontract from an original contract from EPA), Pharmacokinetic

Parameters—Adult Child Comparisons and Interindividual Variability—15 months, 70K, beginning 4/99; extended

11/00-8/1/02 for an additional 175K; new 2 year project—case studies in adult/child pharmacokinetic differences

and implications of genetic differences in metabolism begun 8/1/02--154K.

U.S. Environmental Protection Agency, Interindividual Variability in Response to Particulates--3 year 190K project

initiated by EPA personnel started 10/98 (Principal Investigator, with Rob Goble).

U.S. Environmental Protection Agency grant, “Human Variability in Parameters Potentially Related to

Susceptibility for Noncancer Risks” 332K over 3 years, beginning 12/96.

State of California, Project on Electromagnetic Fields (Rob Goble, PI) 1 year effort beginning 12/97, 1.25 months of

support.

State of Connecticut subcontract on work for the U.S. Environmental Protection Agency “Pharmacokinetic

Modeling for Site-Acting Carcinogens” $52K, 11/15/96 - 11/14/97.

U.S. Environmental Protection Agency, via subcontract to Research Triangle Institute, “Considerations for

Hazardous Waste Identification Rules--Development of Toxicity Values for Chemicals that Do Not Have Official

RfD’s ” $10.8K, 12/96-9/97.

State of Connecticut subcontract on work for the U.S. Environmental Protection Agency “Pharmacokinetic

Modeling for Site-Acting Carcinogens” $30K, 11/15/95 - 11/14/96

Ministry of Health, Canada, (Dale Hattis, Principal Investigator) “New Estimates Of Variability In Parameters

Putatively Related To Individual Cancer Risk” $14K, 1/31 - 3/31/95

U.S. Environmental Protection Agency, Measures of Pollution Prevention (Sam Ratick, PI) 1994-95, 3 months of

support.

Office of Technology Assessment (Rob Goble, PI) “Implementation of the Occupational Lead Standard the

Secondary Lead Smelting Industry“ 20K 7/1/94 - 9/30/94.

U. S. Environmental Protection Agency, “Principles of Ecological Risk Analysis and Management as Applied to

Near-Coastal Waters” (two year project, with involvement by Halina Brown, Sam Ratick, Rob Goble, Andrea

Lemerise, and Arshad Bahl) 2nd Year FY 1992 and 1993--$230K.

U. S. Environmental Protection Agency, "Interspecies Projection of Carcinogenic Risks per Unit of Active Dose

Delivered to Target Sites" (with involvement by Rob Goble, Halina Brown, and Joanne Shatkin) 3 Years in FY

1991, 1992, 1993--$200K.

Health and Welfare Ministry, Government of Canada, "Pharmacokinetic Modeling of Lead in Primates--Parameters

of Interest for Adapting Human Models and Representing the Effects of Pregnancy," (7 Month effort with

involvement by Mary Ballew) $25K, FY 1991.

Hattis D. 2010 Intermediate effect biomarkers--alternatives to direct concentration-response data for regulatory

benefits analyses. The Open Epidemiology Journal 2011 4:70-77. Available at

http://benthamscience.com/open/toepij/openaccess2.htm [DOI: 10.2174/1874297101104011070]

5.

7.

8. Thompson CM, Johns DO, Sonawane B, Barton HA, Hattis D, Tardif R, Krishnan K. Database for

physiologically based pharmacokinetic (PBPK) modeling: physiological data for healthy and health-

impaired elderly. J Toxicol Environ Health B Crit Rev. 12(1):1-24, 2009.

9. Hattis D. “The Role of Uncertainty and Susceptible Populations in Environmental Health Decision-Making.” In

Cable Y, Coussens C, and Quinn K, Rapporteurs, Environmental Health Sciences Decision Making—Risk

Management, Evidence, and Ethics, Institute of Medicine, National Academy Press, Washington, D.C. pp.

24-27, 2009.

10. Hattis D. “High Throughput Testing—the NRC Vision, The Challenge of Modeling Dynamic Changes in

Biological Systems, and the Reality of Low Throughput Environmental Health Decision-Making.” Risk

Analysis, 29:483-484, 2009.

11. Ginsberg G, Smolenski S, Neafsey P, Hattis D, Walker K Guyton KZ, Johns DO, Sonawane B. Analysis of the

influence of genetic polymorphisms on inter-individual variability in xenobiotic metabolism for six enzyme

systems. J Toxicol Environ Health, Part B, 12(5-6): 307-333, 2009.

. J Toxicol Environ Health, Part B, 12(5-6): 334-361, 2009.

J Toxicol Environ Health, Part B, 12(5-6): 362-388, 2009.

J Toxicol

Environ Health, Part B, 12(5-6): 389-439, 2009.

J Toxicol Environ Health,

Part B, 12(5-6): 440-472, 2009.

J Toxicol Environ Health, Part B, 12(5-6): 473-507,

2009.

17. Hattis D, Chu M., Rahmioglu N., Goble R., Verma P, Hartman K, and Kozlak, M, A Preliminary Operational

Classification System for Non-Mutagenic Modes of Action for Carcinogenesis. Critical Reviews in

Toxicology, 13:1-42, 2008.

18.

19. White RH, Cote I, Zeise L, Fox M, Dominici F, Burke TA, White PD, Hattis DB, Samet JM. State-of-the-

science workshop report: Issues and approaches in low dose dose-response extrapolation for environmental

health risk assessment. Environmental Health Perspectives 117:283-287, 2009.

20. Woodruff TJ, Zeise L, Axelrad DA, Guyton KZ, Janssen S, Miller GG, Schwartz JM, Alexeef G, Anderson H,

Birnbaum L, Bois F, Cogliano VJ, Crofton K, Euling SY, Foster PMD, Germolec DR, Gray E, Hattis DB,

Kyle AD, Luebke RW, Luster MI, Portier C, Rice DC, Solomon G, Vandenberg J, Zoeller RT. Moving

upstream: Evaluating adverse upstream endpoints for improved risk assessment and decision-making.

Environmental Health Perspectives 116:1657-1675 2008.

21. Hattis, D. “Distributional Analyses for Children’s Inhalation Risk Assessments.” Journal of Toxicology and

Environmental Health, 71(3):218-226, 2008.

http://www2.clarku.edu/faculty/dhattis;

www.cityofinglewood.org

Distributions of Individual Susceptibility Among Humans for Toxic

Effects--For What Fraction of Which Kinds of Chemicals and Effects Does the Traditional 10-Fold Factor

Provide How Much Protection?”