connie tsao non-invasive conference april 7, 2010
TRANSCRIPT
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Connie Tsao
Non-invasive Conference
April 7, 2010
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Outline Non-tumors
Normal VariantsCathetersThrombotic diseaseInfective endocarditis
Cardiac tumorsEpidemiologyClinical ManifestationsPrimary Cardiac Tumors
○ Benign○ Malignant
Metastatic Tumors
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Non-tumors
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Normal Variants
Structural variantsFalse tendon: fibrous/fibromuscularEustachian valveChiari network
Prosthetic materialCathetersPacing wiresCardiac assist devices
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Arrhythmogenic potential? Series of 15 patients
with idiopathic LV tachycardia vs. controls referred for echo
All ILVT had false tendon from IL wall-septum 2/3 of these >2 mm
34/671 (5%) of controls had false tendon• Oriented across LV• <2 mm
Thakur RK, Circ 1996
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Epidemiology In FHS Original and Offspring cohort:
101 participants with LV false tendons (2% of population)
Kenchaiah S et al, JASE 2009
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Associated with:Lower BMIInnocent murmurECG-LVH
Not associated with ventricular ectopy, or other ECG abnormalities
No excess mortality in 7.7±1.6 yrs follow-up
Kenchaiah S et al, JASE 2009
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Eustachian valve
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Persistent Eustachian valve Case reports of association
between Eustachian valve and PFO
In 306 pts referred for TEE (211 for cryptogenic CVA): 143/211 (68%) of cryptogenic
stroke group had EV 31/95 (33%) of controls had
EV 70% of pts with EV had PFO
? Effect of flow on increasing patency of PFO
Strotmann JM, Heart 2001Schuchlenz HW, JASE 2004
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Chiari Network Hans Chiari, 1897:
11 pts, fibrous network in RA
Remnant of right valve of sinus venosusDirected IVC flow
through fossa ovalis to LA
Incomplete resorption
1-4% in autopsy studies
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Chiari network and PFO 1436 pts consecutive pts referred for TEE Prevalence 29/1436 (2%) Chiari network present in:
24/522 (4.6%) referred for paradoxical embolus 5/913 (0.5%) controls
PFO present in: 24/29 (83%) with Chiari44/160 (28%) controls
Significant R-L shunt by agitated saline in 1/3 with Chiari
Schneider B, et al, JACC 1995
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Prosthetic Material
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Impella
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Intracardiac Thrombi Accounts for 15-20% strokes
Major source: LA thrombi (>45% cases)○ LA thrombi detected by TEE:
Acute AF: 14%Chronic AF: 27%AF with clinical thromboembolism: 43%
Other: Aorta, valve prostheses, inter-atrial septum aneurysm
LV thrombiPost-MISignificant LV dysfunction
Stoddard MF et al, JACC 1995; Manning WJ et al, Ann Int Med 1995
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LAA masses
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LV Thrombus
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Same patient, LGE
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LV Thrombus: Value of LGE-CMR 784 consecutive pts with LVEF <50% Thrombus detection:
37 (4.7%) by cine-CMR 55 (7%) by LGE-CMR
Pathologic correlation in 8 pts, LV thrombus in 5All 5 detected by LGE-CMR2 detected by cine-CMR
Cine CMR missed small intracavity and mural thrombi
Weinsaft JW et al, JACC 2008
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Weinsaft JW et al, JACC 2008
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LV Thrombus: Contrast Echo vs CMR
121 pts post MI or clinical heart failure TTE, contrast-TTE, LGE-CMR
LV thrombus in 24 pts by LGE-CMRLarger infarcts, aneurysm, lower LVEF
TTE sensitivity 33%, Contrast TTE: 61%Low LVEF predictor of thrombus detection by CMR
Thrombi detected by DE-CMR vs contrast echo: mural, small apical
Close agreement with contrast echo (k=0.79)
Weinsaft JW et al, JACC Imaging 2009
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Asymptomatic 50 year old man
SSFP First pass perfusion
Hoey ED et al, Clin Radiol 2009
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Cardiac Tumors
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Majority (>75%) are benign Rare; incidence of <0.001-0.03% in
autopsy studies
Primary cardiac tumors
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Primary Benign Tumors
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Braunwald’s Heart Disease, 7th Ed.
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Classic Triad of Symptoms Intracardiac obstruction:
Dyspnea, orthopnea, pulmonary edemaPresyncope/syncopeAngina, claudication
Systemic embolization: CVA, retinal artery emboliEmboli to extremities
Constitutional symptoms: fever, fatigue, weight loss, arthalgia
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Myxoma
Mean age 50 years at diagnosis F>M (60-70%) 80% in left atrium, 15% in right atrium
Can occur in ventricles
90% solitary, 7% Carney complex Average size 5-6 cm Attachment to fossa ovalis
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Pedunculated, gelatinous
Friable/villous surface (1/3) emboli
Histology:Mesenchymal cells in
mucopolysaccharide stroma
Production of VEGF angiogenesis
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Clinical manifestations Factors: size, anatomic location Pulmonary venous or mitral valve
obstruction Stroke/neurologic deficits Systemic embolization Constitutional symptoms: fever, weight
lossAnemia, elevated ESR, leukocytosis↑IL-6, inflammatory factors
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Imaging Echo
Prolapsing mass across MV/TVIdentification of point of attachment
CMR Heterogeneous appearance on T1W, T2W
imagesPatchy LGE
CTLow attenuation mass, no enhancement Calcification in 10-15%
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T1W post gadolinium
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T2W
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58 year old man with dyspnea
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Treatment
ResectionIncluding surrounding septum at attachment
Surgical mortality <5% Risk for atrial arrhythmias Recurrence in 2-5% Recurrence in Carney complex 12-22%
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Papillary Fibroelastoma Incidence 0.002-0.33% in
autopsies Mean age 60 years Mean size 9 mm (2-70 mm) 80-90% on valvular
endocardium, AV 36%> MV 29%> TV 11% > PV 7% Downstream side
Histology: fibromyxoid core, rim of elastic fibers covered by endothelial cells Distinction from Lambl’s
excrescence
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Clinical manifestations
Embolization: tumor or thrombusCVA/TIAPEPeripheral embolization
MI, angina Sudden cardiac death Syncope 1/3 of patients asymptomatic
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Imaging
TTE can miss due to size CMR not ideal due to high mobility
Well-circumscribed nodule on T1W, T2WLGE reported
Distinction from vegetationNo significant valvular regurgitationLocation away from valvular free edge
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29 year old woman with incidentally discovered mass…
Parthenakis F et al, Cardiovasc Ultrasound 2009
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Treatment
Observation: small, nonmobile tumors Surgical resection:
Any embolic events Highly mobile>1 cm
No recurrences known
Sun JP et al, Circ 2001
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Lipoma Slow-growing Mature adipose tissue Sub-endocardial (50%)
Broad based attachmentGrowth into adjacent chambers
Myocardial (25%) Sub-epicardial (25%)
Narrow attachment pointGrowth into pericardial space
Valvular attachment rare Lipomatous hypertrophy of IAS
Older, obeseAssociated with CAD (Chaowalit N et al, Chest 2007)
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Clinical manifestations/Treatment Most asymptomatic
Invasion into tissue arrhythmias, conduction block
↑size obstruction
Resection recommended (continued growth)Lipomatous hypertrophy of IAS: no resection
unless significant clinical sxs
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Imaging Echo: variable appearance
Spares fossa ovalis CMR + CT: corresponds to fat signal CMR
Bright on T1W + T2W imagesUniform suppression by fat satNo soft tissue component/ LGE
CTHomogenous fat attenuation
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Lipoma
Leu HB et al, Eur Heart J 2004
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35 yo woman with AF, mass on TTE
T2W BB T1W BB
Lack of LGE T2W fat sat
Hoey ED et al, Clin Radiol 2009
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Rhabdomyoma
Most common primary cardiac tumor in childrenMost <1 year of age
80-90% association with tuberous sclerosis Most regress spontaneously
ArrhythmiasHeart block, VT
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Fibroma
2nd most common pediatric cardiac tumor
Fibroblasts interwoven with collagen Arise in myocardial free wall/septum LV:RV 5:1 Heart failure: obstruction, valvular
dysfunction
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Fibroma- Imaging
CMR: Low signal on T1W, T2WHypovascular on 1st pass perfusionHomogeneous on LGE
CTMildly enhancing Up to 50% calcification
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32 yo F with recurrent syncope, VT
Hoey ED et al, Clin Radiol 2009
T1W BBT2W BB
SSFP LGE
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Primary Malignant Tumors
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Braunwald’s Heart Disease, 7th Ed.
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Overview Overall 15% of primary cardiac tumors Sarcomas most common
AngiosarcomaSarcomas with myo- or fibroblastic differentiationRhabdomyosarcoma
Suggestive imaging findings:Right-sidedBroad-based attachmentIll-defined marginsTissue inhomogeneity/ heterogeneous contrast
enhancementSize >5 cmPericardial effusion
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Angiosarcoma
Highly aggressive, anaplastic epithelial cells, vascular channels
M>F, peak incidence in 40s RA involved in 75% RV, pericardium Clinical symptoms
Right heart failureTamponade
Metastases in 66-89% lungs/brain/bone/liver
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Imaging
CMRT1 isointense, T2 hyperintenseFlow voids = vascular channelsProminent LGE “sunray appearance”
CTLow attenuation/ irregularHeterogenous enhancement
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25 year old woman with dyspnea
T1W BB T2W, fat suppression
Hoey ED et al, Clin Radiol 2009
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O’Donnell DH et al, Am J Roentol 2009
T1W BB LGE
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63 year old man with chest pain
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Treatment
Resection + chemotherapy↑ survival with complete resection
TransplantationSarcoma in 15/21 malignanciesMean survival 12 months7 patients with mean survival 27 mos
Gowdamarajan A et al, Curr Opin Cardiol 2000;
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Autotransplantation8 sarcomas resected
○ 7 atrial, 1 ventricularMedian survival 18.5
mos
Reardon MJ et al, Ann Thorac Surg 1999, 2006
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Lymphoma
Majority aggressive B-cell lymphomasCommonly in immunocompromised
Disseminated non-Hodgkin’s lymphoma more common
Firm, nodular aggregates of lymphoid tissue
Mean age 38 years Treatment: anthracyclines, monoclonal
anti-CD20 antibody
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Imaging
Echo characteristic features: RA, pericardial effusion
CMRIsointense on T1W, or hyperintense on T2WHeterogeneous enhancement on LGE
CTIsointense relative to myocardium
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T1W LGET1W
T2W LGE
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54 yo F with CP, DOE, palpitations
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Metastatic Tumors
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Overview Up to 12% of oncology pts at autopsy
Most clinically silent Most common: lung cancer, melanoma Pericardial effusion common Multiple masses suggestive Imaging characteristics
Hypointense on T1W (except melanoma: paramagnetic effect of melanin)
Hyperintense on T2WEnhancement after gadolinium administrationSoft tissue attenuation on CT
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Primary Malignancy Cardiac Effect
Lung Direct extension, effusion
Breast Hematogenous/lymphatic spread, effusion
Lymphoma Lymphatic spread, variable effects
GI Variable
Melanoma Intracardiac and myocardial Involvement
Renal Cell Carcinoma IVC-RA-RV extension, can look like thrombus
Carcinoid Tricuspid and pulmonic valve abnormalities
Braunwald’s Heart Disease, 7th Ed.
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Melanoma
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Direct Extension Tumors
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Lung cancer
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Hepatocellular carcinoma
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Renal Cell Carcinoma
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Braunwald’s Heart Disease, 7th Ed.
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Summary Many conditions mimic cardiac masses Primary cardiac tumors are rare and
usually benign Clinical presentation varies by location
and size of mass TTE and CMR with gadolinium helpful to
narrow differential diagnoses Treatment: surgical resection for bulky
tumors/ chemotherapy