complete revascularization in elderly - when it’s contraindicated
DESCRIPTION
COMPLETE REVASCULARIZATION IN ELDERLY - When it’s contraindicated. Giuseppe Biondi-Zoccai S. Giovanni Battista “Molinette” Hospital University of Turin. 3rd International Interventional Forum – Turin, 18 January 2008 (h 12.20-12.40). Learning goals. - PowerPoint PPT PresentationTRANSCRIPT
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COMPLETE REVASCULARIZATION IN COMPLETE REVASCULARIZATION IN
ELDERLY - When it’s contraindicatedELDERLY - When it’s contraindicated
Giuseppe Biondi-ZoccaiGiuseppe Biondi-Zoccai
S. Giovanni Battista “Molinette” Hospital
University of Turin
3rd International Interventional Forum – Turin, 18 January 2008 (h 12.20-12.40)
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Learning goals
• How do you define complete
revascularization (MVD)?
• What is the risk-benefit balance of culprit
vs multivessel PCI in stable MVD?
• What is the risk-benefit balance of culprit
vs multivessel PCI in acute MVD?
• When is complete revascularization
contraindicated in the elderly?
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To achieve a greater To achieve a greater
understanding, let us begin with understanding, let us begin with
an example from a related field…an example from a related field…
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Defining revascularization
I.I. Anatomically completeAnatomically complete:: PCI of every occluded or stenotic epicardial vessel
II.II.Functionally complete:Functionally complete: PCI of every occluded or stenotic epicardial vessel of adequate size and supplying a zone of viable myocardium
III.III.Incomplete (culprit only):Incomplete (culprit only): PCI of occluded or stenotic epicardial vessel identified by comprehensive clinical judgement as responsible for signs/symptoms of ischemia
IV.IV.Incomplete (truly):Incomplete (truly): everything else
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Defining revascularization
I.I. Anatomically completeAnatomically complete:: PCI of every occluded or stenotic epicardial vessel
II.II.Functionally complete:Functionally complete: PCI of every occluded or stenotic epicardial vessel of adequate size and supplying a zone of viable myocardium
III.III.Incomplete (culprit only):Incomplete (culprit only): PCI of occluded or stenotic epicardial vessel identified by comprehensive clinical judgement as responsible for signs/symptoms of ischemia
IV.IV.Incomplete (truly):Incomplete (truly): everything else
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23
39
1612 14
20
4852
2836
81
90
9
2114
18
37
47
2 40
15
30
45
60
75
90
Female Obese PriorCABG
PriorPCI
DM HTN Renalfailure
LVEF<35%
3VD ULM
<75 years >75 years
Wiemer et al, AHJ 2004
%
ALL P<0.05
Scope of the problem
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Learning goals
• What is the risk-benefit balance of culprit
vs multivessel PCI in stable MVD?
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Learning goals
• What is the risk-benefit balance of culprit
vs multivessel PCI in acute MVD?
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Early invasive management in elderly with ACS: TACTICS
Study
Brener et al, Am J Cardiol 2002
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Yet PCI based only on oculostenotic
reflex is also not justified in acute MVD
Hirsch et al, Lancet 2007
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What about complete PCI in STEMI?
Single vs multivessel treatment during primary
angioplasty: results of the multicentre
randomised HEpacoat for cuLPrit or
multivessel stenting for Acute Myocardial
Infarction (HELP AMI) Study.
Di Mario C, Sansa M, Airoldi F, Sheiban I, Manari A, Petronio A, Piccaluga E, De
Servi S, Ramondo A, Colusso S, Formosa A, Cernigliaro C, Colombo A, Monzini N,
Bonardi MA.
Int J Cardiovasc Intervent. 2004;6(3-4):128-33.
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53
69
0 3
35
1722 20
0
10
20
30
40
50
60
70
Length ofprocedure
In-hospitalMACE
12-monthrePCI
12-monthcosts
Culprit PCI group Complete PCI group
53 vs 69 minutes, p<0.05
0 vs 4%, p=NS
35% vs 17% p=NS
22,330€ vs 20,382€, p=NS
Di Mario et al, Int J Cardiovasc Intervent 2004
%
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Learning goals• When is complete revascularization
contraindicated in the elderly?
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Learning goals• When is complete revascularization
contraindicated in the elderly?
• Mainly when its expected benefits do not
overwhelm the expected risks
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COURAGE Nuclear Substudy
Shaw et al, AHA 2007
0
5
10
15
20
25
30
Ischemiareduction>5%
No ischemiareduction
Ris
k o
f d
eath
or
MI (
%)
P=0.037
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Take home messages
• Current data disCOURAGE from extensive
multivessel PCI based only on
angiographic assessment in stable MVD
• No definite benefits have been shown
from multivessel PCI in patients with acute
CAD and MVD
• According to evidence available to date,
PCI of non-culprit vessels cannot thus be
recommended routinely
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Take home messages• Thus, major contraindications to
complete revascularization in elderly are:
Lack of clear-cut signs/symptoms of ischemia Extremely diffuse disease or challenging
lesions Increased bleeding or renal failure risk Lack of compliance or poor life expectancy
• Individualized clinical decision making is pivotal to maximize benefit and minimize risks