chemical safety plan - utsa...
TRANSCRIPT
Revision 05/17/2011 1 of 1
University of Texas at San Antonio
Office of Environmental Health, Safety and Risk Management
Chemical Safety Plan
(serves as The UTSA - Chemical Hygiene & Hazard Communication Safety Plan)
Revision 05/17/2011 2 of 2
i. Review & Signature Page
This original version of this procedure manual has been reviewed for regulatory compliance and best management practices by the undersigned individuals and is hereby adopted for use and compliance by all employees at all University of Texas at San Antonio owned or operated facilities.
Printed Name Signature Title Date
J. Brian Moroney Signature on file Director, EHSRM 05/17/2011
Wendy McCoy Signature on file Laboratory Safety Manager 05/17/2011
This plan was reviewed/revised on 05/17/2011 and replaces the 07/01/2009 version. Changes to this plan have been highlighted in “gray” and are summarized below: Throughout the plan Laboratory Safety Officer has been updated to Laboratory Safety Manager. (not highlighted) Throughout the plan spelling and grammatical corrections have been made and examples updated. (highlighted) iiiA1: Updated response procedure. iiiB2d: Approved eyewash statement added. IVB5: Reference to Appendix XI and order approval added. VA6: Clarification on glove removal and hand washing added. VA9: Clarification on removing or securing jewelry, loose clothing and long hair. VI: Update of training descriptions. VIIB2C: HF guidelines updated. VIIC9: Update on need for secondary containment for chemical storage. IXB4: Update on not wearing gloves outside the laboratory. Appendix VII: Updated policy. Appendix X: Updated procedures. Appendix XI: Policy added to the plan.
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ii. Table of Contents
iii. Emergency Procedures and Contact Information.................................................... 5
I. Overview and Purpose ............................................................................................ 7
II. Scope ...................................................................................................................... 7
III. Periodic Review....................................................................................................... 7
IV. Responsibilities........................................................................................................ 7
V. General Laboratory Safety Guidelines .................................................................... 9
VI. Training Requirements .......................................................................................... 10
VII. Chemical Laboratory Safety .................................................................................. 11
VIII. Hazard Communication and the Texas Hazard Communication Act .................... 19
IX. Personal protective equipment (PPE) ................................................................... 21
X. Laboratory equipment............................................................................................ 23
XI. Chemical Waste Management .............................................................................. 26
XII. Laboratory Deactivation and Equipment Disposal................................................. 26
XIII. References ............................................................................................................ 27
XIV. Appendices............................................................................................................ 27
Appendix I: Notice to Employees ................................................................................... 29
Appendix II – Laboratory Specific Chemical Hygiene Plan ............................................ 31
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Appendix III: Chemical carcinogens regulated by OSHA.............................................. 41
Appendix IV: Peroxide Forming Chemicals................................................................... 42
Appendix V: Extremely Hazardous Substance (Texas Tier II) List ............................... 44
Appendix VI: Memorandum of Understanding - DPS & THECB .................................... 65
Appendix VII: UTSA Policy on Controlled Substance Use in Research....................... 71
Appendix VIII. Drug Scheduling .................................................................................... 84
Appendix IX: Liquid Nitrogen Storage and Use............................................................. 93 Appendix X: Laboratory Clean out / Clearance Procedure ............................................ 97 Appendix XI: Hazardous Materials Requiring Institutional Approval…………………….99
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iii. Emergency Procedures and Contact Information
Due to the multiple hazards associated with laboratories, incidents are inevitable. Preparedness for emergencies is essential. A timely and efficient response can help minimize or avoid injury and damage to property. For a comprehensive discussion of UTSA emergency procedures, including internal (fire, bomb threat) and external (tornado, flooding) emergencies, see UTSA’s Community Emergency Response Guide.
A. Chemical Spills
Response to chemical spills must be thorough and prompt to prevent further injury or contamination.
Each laboratory should design its own response plan based on its unique hazards and the location of the laboratory, in conjunction with the following general guidelines:
1. Notify the people in the immediate area and, if necessary, evacuate the laboratory. The decision to evacuate is a judgment call based on the properties and hazards of the spilled chemical. If toxic or noxious gases or vapors result from the spill, evacuation should follow. If the vapors have escaped the laboratory, contact Facilities Operations immediately and tell them to shut off air handlers to prevent the spread of toxic vapors. If vapors are contained within the laboratory, exhaust should be allowed to remove the vapors. If flammable gases or vapors result from the spill, turn off all sources of ignition in the laboratory, if it is safe to do so. Operations can be reached at X5277 or 458-5277.
2. Always attend to injured people before attending to the spill. Skin areas splashed by chemicals should be rinsed with water for at least 15 minutes in a sink, emergency shower or eyewash as appropriate. After thorough rinsing, seek medical help. Be sure to have the identity and other information—preferably the MSDS—about the chemical available for the medical help.
3. Try to contain the spill to keep it from spreading. Contact EHSRM at x5250 to advise or assist in the containment, neutralization, and cleanup of the spilled chemical. Do not attempt to clean the spill without proper spill-control supplies or equipment.
4. If the spill or release is likely to affect other facilities within the building or campus or emergency medical treatment is warranted, contact the UTSA Police Department. UTSAPD can be reached in an emergency at x4911 on a campus phone and 458-4911 on an outside phone, such as a cell phone. For the fastest response possible, UTSAPD must be contacted.
B. Emergency equipment
Laboratory emergency equipment includes emergency showers, eyewashes and fire extinguishers. Staff in laboratories that do not have their own emergency shower, eyewash station, or fire extinguisher should know where the closest one is located.
1. Showers
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An emergency shower can be used to suppress a fire or, more commonly, to decontaminate someone who has been exposed to chemicals.
a. Remove clothing, jewelry and shoes while standing under the shower. These items trap chemicals against the skin and will increase the damage if not removed.
b. Remain under the shower for at least 15 minutes to ensure adequate flushing of exposed areas.
c. Seek medical attention.
d. If the shower does not have a drain, promptly clean up the water to prevent slip hazards.
e. Always keep the area under an emergency shower unobstructed.
2. Eyewashes
a. If chemicals are splashed into your eyes, hold your top and bottom eyelids open and flush with water continuously for at least 15 minutes. Move the eye up and down and sideways to wash thoroughly behind the eyeball where chemicals could be trapped.
b. Seek medical attention.
c. Always flush your eyes immediately if chemicals are splashed into them. Even a delay of a few seconds could cause permanent damage.
d. Continuous-flow eyewashes are preferred over the portable, squeeze-bottle type, whose disadvantages include an insufficient supply of water (not 15 minutes’ worth) and easy contamination with microorganisms. Squeeze-bottle eyewashes also require the use of your hands to operate, preventing you from holding your eyelids open. For these reasons, only continuous-flow eyewashes are approved for use at UTSA.
e. To ensure a clean supply of water in the eyewash, operate it weekly to flush out any impurities.
3. Contact Information:
Emergencies (Medical or Chemical): Contact Police Dispatch - call 911 or x4911 from campus phone. If using a cell phone call 458-4911.
Minor Chemical Spills / Assistance: Contact EHSRM – call x5250 or 458-5250. To Report Occupational Injuries: Contact EHSRM – call x5250 or 458-5250. Before or After Operational Hours: Contact Police Dispatch - call 911 or x4911 from
campus phone. If using a cell phone call 458-4911 (Operation Hours = Mon – Fri: 8 AM – 5 PM)
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I. Overview and Purpose Research and education in science laboratories involve a variety of hazards. It is the University of Texas at San Antonio’s (UTSA) policy to protect and promote the health and safety of students and employees and the environment. These policies are outlined in the University’s Handbook of Operating Procedures (HOP) www.utsa.edu/hop/chapter9/: most specifically in HOP 9.5 - Occupational Safety and Health and HOP 9.6 - Compliance with the Texas Hazard Communication Act. Faculty, staff and students who may be exposed to chemical hazards in the laboratory should be informed of the nature of these hazards and how to protect themselves and others who may also be exposed. Further information on general chemical safety or specific items can be obtained through the Environmental Health Safety and Risk Management (EHSRM) office. The EHSRM main office phone number is (210) 458-5250. This Chemical Hygiene & Hazard Communication Safety Plan outlines basic good laboratory practice and safety procedures, special procedures for this institution, and will give reference to other sources of information to include federal and state guidelines that deal with work in laboratories that use and store chemical agents. This plan was prepared by EHSRM personnel after review of pertinent federal and state regulatory requirements from the Occupational Safety and Health Administration (OSHA), the Drug Enforcement Administration (DEA), the Texas Department of State Health Services (TDSHS), and the Texas Commission on Environmental Quality (TCEQ).
II. Scope This plan applies to all UTSA operated (leased or owned) facilities and equipment (including vehicles). It also applies to any UTSA employee, volunteer or student worker who works directly with chemicals, or is in close proximity to anyone conducting research using chemicals which falls under federal and state regulations or guidelines who should be familiar with all portions pertinent to their work. This plan discusses safe practices and procedures for research and educational laboratories. It is not intended to be a fully comprehensive reference but rather a starting reference. There may be chemicals, procedures and other circumstances in each laboratory that present unique or unusual hazards not addressed here; these hazards are best addressed by the principle investigator or supervisor of the respective laboratory with specific operating procedures developed in consultation EHSRM if necessary. Questions can be addressed to the Laboratory Safety Manager who also serves are the Chemical Hygiene Officer through EHSRM at 458-5250.
III. Periodic Review This plan will reviewed at least every 3 years for needed or required updates. This plan’s online version should be reviewed periodically for updates.
IV. Responsibilities
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A. The Office of Environmental Health Safety and Risk Management (EHSRM) will:
1. Have its Director serve as the Institutional / Campus Safety Officer as per HOP 9.6.
2. Hire a qualified staff member to serve as the institution’s designated Chemical Hygiene Officer and provide consulting services to the UTSA community for work with chemical agents. The Laboratory Safety Manager serves as the designated Chemical Hygiene Officer.
3. Establish the general procedures, policies and standards for the use of chemicals and hazards they may present at UTSA in conjunction with the Laboratory Safety Committee.
4. Develop and maintain safety plans and training programs relevant to the safe use, storage and disposal of chemicals agents.
5. Review applications and protocols for work with chemical agents and provide recommendations for the safe use, storage and disposal of chemicals per established procedures. Approve the purchase and use of hazardous chemicals and toxins that may require institutional approval.
6. Maintain a chemical waste disposal program.
7. Supervise decontamination and clean up activities following chemical spills.
8. Investigate chemical spill and / or potential exposure incidents. Provide chemical monitoring to determine potential exposure levels where appropriate.
9. Evaluate laboratories periodically to ensure compliance with institutional, state and federal guidelines and regulations.
B. Principal Investigators (PI), Laboratory or Technical Supervisors will:
1. Enforce all UTSA standard operating procedures (SOP’s) and policies regarding chemicals.
2. Develop specific safety procedures or protocols for the safe use, storage and disposal of chemicals in their laboratory. Reference Appendix II – Laboratory Specific Chemical Hygiene Plan
3. Determine who within their laboratory need chemical hygiene and hazard communication training and ensure laboratory personnel to include staff, students, volunteers and visiting researchers have been properly trained to work safely within their laboratory or work area.
4. Ensure that new staff attends mandatory Hazard Communication and Laboratory Safety Training and/or Hazardous Waste Generator’s Courses as appropriate to their work and offered by EHSRM prior to direct contact with hazardous chemicals or toxins.
5. Advise the Office of EHSRM of any significant protocol changes and also prior to bringing new hazardous chemical(s) onto campus. Some chemicals, biologicals and equipment require approval prior to ordering. See Appendix XI Hazardous Materials Requiring Institutional Approval.
6. Immediately report any exposures, spills, thefts or other incidents involving chemicals to EHSRM for investigation or assistance.
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7. Provide the Office of EHSRM with an updated and verified chemical inventory of each laboratory or work area with chemicals at least annually.
8. Maintain a clean and sanitary workplace.
9. Report any plans to remodel or alter UTSA facilities (Refer to HOP 8.3 - Remodeling and/or Alterations to University Facilities) to Facilities and EHSRM and gain permission before proceeding.
C. Laboratory Staff or Worker will:
1. Observe the established guidelines, departmental SOP’s and UTSA policies and procedures for chemical safety to include accessing and reviewing MSDS’s as appropriate to determine hazard characteristics and handling procedures.
2. Attend all necessary or required training – refer to Section VI – Training Requirements. Only use hazardous chemicals for which they’ve been properly trained to handle and use.
3. Properly dispose of all laboratory wastes in accordance with laboratory standard operating procedures and UTSA waste management policy
4. Report all spills or incidents to their supervisor and EHSRM if necessary.
5. Report to the PI, lab supervisor or EHSRM any unsafe practices or conditions in the laboratory.
D. The Laboratory Safety Committee will:
1. Assist in reviewing new safety issues involving laboratories at UTSA facilities and compliance with established regulatory and institutional policy.
2. Review facility and maintenance safety issues involving laboratories.
3. Review continuing safety issues involving laboratories and recommend corrective action.
4. Have as its chairperson an Assistant VP or higher level representative from the Provost’s Office, VP for Research, or VP for Business Affairs and contain a minimum of one Assistant VP or higher level person to represent each of these offices.
5. Have as serving members the Director of EHSRM, the Director of Facilities Operations & Maintenance and the Laboratory Safety Manager. Additional members / attendees may be approved by the chairperson.
6. Meet at least once per quarter.
V. General Laboratory Safety Guidelines Everyone in the laboratory is responsible for his or her own safety and the safety of others. Before starting any work in the laboratory, become familiar with the procedures, equipment and chemicals that will be used and learn how to protect yourself from any associated hazards. If you don’t understand something, ask! Each laboratory should have a chemical hygiene plan
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in place. The generic chemical hygiene plan for UTSA can be found in Appendix II. Below are guidelines for working safely in a laboratory.
A. Guidelines
1. Students should never work alone or unsupervised in the laboratory.
2. If you must work alone, tell someone where you’ll be and have him or her check on you periodically.
3. Report dangerous activities or situations to your laboratory supervisors; if they do not respond promptly or appropriately, contact EHSRM.
4. Always incorporate safety into your experiments and anticipate and account for things that could go wrong. Never compromise safety in the interest of time.
5. Remove gloves before handling items such as the telephone, doorknobs and computer keyboards.
6. Always remove gloves and wash hands thoroughly before leaving the laboratory.
7. Designate specific break areas outside the laboratory for eating and drinking. Remember, smoking is not allowed in UTSA buildings.
8. Store food and drinks in refrigerators designated for that use only, away from areas containing chemical, biological or radiological hazards.
9. Be aware of dangling jewelry, loose clothing or long hair that might get caught in equipment. Secure or remove these items in order to work safely.
10. Do not wear shorts, sandals or open-toed shoes in the laboratory. Shoes which completely cover the foot and shed liquids provide the most protection and should be worn in the laboratory.
11. Always wear appropriate personal protective equipment.
12. Keep aisles and walkways clear and drawers and cabinet doors closed while you’re working.
13. Do not store hazardous chemicals on the floor in high-traffic or open areas.
14. Never pipette by mouth.
15. Do not allow minors (anyone under 18 years of age) into the laboratory without prior approval. Additional parental consent forms may also be required.
VI. Training Requirements
A. Hazard Communication and Laboratory Safety Training
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Hazard Communication (HazCom) training is mandated by both the federal and state governments (Texas Health & Safety Code, Title 6, Chapter 502 – Hazard Communication Act, section 502.009). If you will be exposed to hazardous chemicals within your work area, you must attend the HazCom training course. Hazardous chemicals are defined as chemicals which have a physical or health effect. An irritation is a health affect. This training must be completed before the employee works with, or in an area containing, any hazardous chemical.
B. Hazardous Waste Generator Training
Hazardous Waste Generator training covers chemical and biological waste disposal procedures in accordance with federal, state and local regulations. Generators must understand the requirements for proper bulking, packaging, labeling and disposal of hazardous waste.
C. Laboratory / Work Area Specific Training
Each PI, Laboratory or Technical Supervisor of a laboratory or work area must provide training in the specific standard operating procedures of that work area relative to chemical use, storage and disposal. This training supplements the general training provided by the EHSRM courses. This training should be documented with the subject matter covered, date(s) of training and attendees. Refer to Appendix II – Laboratory Specific Chemical Hygiene Plan.
VII. Chemical Laboratory Safety You need to be familiar with the hazardous chemical substances you are working with in the laboratory. Being able to recognize the physical and health hazards of a chemical before you handle it is very important. Once the potential hazards of a chemical have been determined, you can take the appropriate steps in the handling and storage of that chemical to protect yourself and others.
A. Classification of chemical hazards
The hazard a chemical presents depends on its physical and toxicological properties. Chemicals are considered a physical hazard if they are flammable or reactive (i.e., unstable—including explosives, organic peroxides, monomers, pyrophorics, and water reactives), or if they are combustible liquids, oxidizers or compressed gases. Chemicals that present a physical hazard are classified according to their hazardous properties. Chemicals that can cause reversible or irreversible damage to the human body are considered health hazards and are classified as toxics. This classification includes systemic poisons, irritants, carcinogens, asphyxiants, teratogens, mutagens, anesthetics and corrosives. Be aware that many chemicals exhibit multiple hazards, in which case, the more prevalent hazard must be considered. Contact EHSRM for help in identifying chemical hazards if you are unsure or need further guidance on proper handling.
1. Flammables
A flammable is any solid, liquid, vapor or gas that ignites easily and burns rapidly.
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A flammable solid is a solid, other than an explosive, that ignites readily and burns vigorously. Examples: magnesium, sulfur, decaborane, and anhydrous sodium sulfide.
A flammable liquid is a liquid that gives off vapors readily ignitable at room temperature. The Department of Transportation (DOT) defines it as a liquid with a flash point at or below 141°F, and NFPA and OSHA define it as a liquid with a flash point below 100°F. (The flash point of a liquid is the temperature at which sufficient vapors are given off by the liquid to form an ignitable mixture with air.) Many common organic solvents have flash points well below room temperature, including acetone, ethyl ether, hexane and benzene.
A flammable gas is a gas that at normal atmospheric pressure forms a flammable mixture with air. Examples: hydrogen, acetylene and propane.
2. Combustible liquids
The DOT defines a combustible liquid as a liquid with a flash point above 141°F and below 200°F. NFPA and OSHA define it as a liquid with a flash point at or above 100°F but below 200°F. These liquids, even though not classified as flammable liquids, still present a significant fire hazard. Examples: kerosene, glacial acetic acid and phenol.
3. Reactives
A chemical is reactive, or unstable, if it has a tendency to undergo chemical reaction either by itself or with other materials with the release of energy. Undesirable effects such as pressure build-up, temperature increase or the formation of noxious, toxic or corrosive byproducts may occur because of the chemical’s reactivity to heating, shock, direct contact with other materials or other conditions in use or in storage. Reactives can be divided into the following hazards:
a. Explosives. A material that produces a sudden, almost instantaneous release of pressure, gas and heat when subjected to abrupt shock, pressure or high temperature. Examples: “dry” picric acid (2, 4, 6-trinitrophenol), 2, 4, 6-trinitrotoluene (TNT) and nitroglycerine.
b. Organic peroxides. An organic compound containing the bivalent -O-O- structure. These chemicals are very unstable and may be explosive. A common organic peroxide is benzoyl peroxide.
c. Monomers. Under appropriate conditions, monomers undergo polymerization, in which the monomers combine with each other to form repeating structural units, or a polymer. If not controlled, polymerization can occur at a rate that releases large amounts of energy that can cause fires, explosions or burst containers. Examples: formaldehyde and styrene.
d. Pyrophoric. A material that ignites spontaneously in air. Pyrophoric chemicals are also known as air-sensitive compounds or as spontaneously combustible. Examples: the Alkali metals (sodium, potassium), hydrides (lithium aluminum hydride) and white phosphorus.
e. Water reactive. A material that by contact with water becomes spontaneously flammable or gives off a flammable or toxic gas. Examples: the Alkali and Alkaline Earth metals, hydrides (sodium borohydride) and strong acids (sulfuric acid).
4. Oxidizers
An oxidizer is a material that yields oxygen readily to cause or enhance the combustion (oxidation) of organic matter. Materials that do not contain oxygen can also be oxidizers because
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of their ability to accept electrons. Examples: nitrates, permanganates, dichromates, peroxides, nitric acid, perchloric acid and chlorine.
5. Compressed gas
A compressed gas is any material which at room temperature and atmospheric pressure is a gas, but is contained under pressure as a compressed, liquefied or dissolved gas. Compressed gases present a physical hazard due to the storage pressure, but can also exhibit overt hazards such as, flammability, corrosivity, or toxicity. Examples: hydrogen (compressed gas), acetylene (gas dissolved in a solvent) and chlorine (liquefied gas).
6. Cryogenic Materials
A cryogenic material is one which is a gas at room temperature that has been cooled to a temperature where it condenses to a liquid. Cryogenic materials present a physical hazard due to their extremely cold temperatures (less than -150o C). Examples: liquid nitrogen (LN2), liquid oxygen and liquid helium.
7. Toxics
A toxic is any chemical that, when ingested, inhaled or absorbed, or when applied to, injected into, or developed within the body in relatively small amounts, by its chemical action may cause damage to biological structure and/or disturbance of biological function.
Damage can be local (direct) or systemic (indirect). Local toxicity is the effect of a substance on the body area that has been exposed to the substance. Systemic toxicity is the effect of a substance on body tissue after absorption into the bloodstream.
Damage can also be acute (immediate) or chronic (delayed). Acute toxicity is the effect manifested on short exposure or single contact. Chronic toxicity is the effect observed when a toxic substance acts on the body over time. This can be due to multiple or continuous exposure.
Toxicity is affected by the following parameters: routes of entry (skin, nose, mouth, eye, lungs or stomach), dose, exposure duration, physical condition and sensitivity of exposed individual, synergistic effects with other chemicals, and other parameters such as age, sex and race. Remember that all chemicals are potentially toxic—the dose makes the poison!
Toxics can be divided into the following hazards:
a. Systemic toxics. Materials which, after entering the bloodstream, adversely affect a particular body organ or system (target organ). Systemic toxics can be classified as
1) Hematotoxins. Chemicals that affect blood-forming tissues. Examples: cyanides and benzene.
2) Neurotoxins. Chemicals that affect the nervous system. Examples: carbon disulfide and mercury.
3) Nephrotoxins. Chemicals that damage the kidneys. Examples: chloroform and carbon tetrachloride.
4) Hepatotoxins. Chemicals that damage the liver. Examples: ethanol and carbon tetrachloride.
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b. Irritants. Materials that cause a reversible inflammatory effect on living tissue. Examples: nickel, dilute solution of ammonia and acetone.
c. Carcinogens. Materials that cause cancer in humans or, because they cause cancer in animals, are considered capable of causing cancer in humans. Examples: carbon tetrachloride, formaldehyde, chloroform and benzene. See Appendix III for a list of carcinogens regulated by OSHA.
d. Asphyxiants. Vapors or gases that can cause unconsciousness or death by suffocation. Asphyxiants can be classified as simple or chemical.
1) Simple asphyxiants. Materials that displace available oxygen in the air. Examples: nitrogen and carbon dioxide.
2) Chemical asphyxiants. Materials that reduce the blood’s ability to carry oxygen or interfere in the body’s utilization of oxygen. Examples: carbon monoxide and hydrogen cyanide.
e. Anesthetics. Materials that depress the central nervous system, producing loss of sensation or feeling. Examples: chloroform and ether.
f. Teratogens. Materials that cause physical defects in a developing embryo. Example: lead.
g. Mutagens. Materials that induce genetic mutations in DNA, usually by chronic exposure. Examples: ethidium bromide and formaldehyde.
h. Corrosives. Materials that by direct action are damaging to body tissue or corrosive to metal. Damage can range from minor skin irritation to actual physical disruption of body tissue. Note that corrosives are also physical hazards. Examples: ammonia and chlorine (gases), acids, bases, and bromine (liquids), and phenol (solids).
B. Chemical safety guidelines
Chemical hazards in the laboratory are varied and numerous. You should develop a healthy respect for all chemicals, even those that are designated “safe” or “benign,” because evidence may develop indicating that continued exposure may cause unexpected or cumulative adverse effects. Never take chemical safety for granted.
Follow these general and chemical-specific guidelines for the safe handling and use of chemicals in the laboratory.
1. General guidelines
a. Be familiar with the chemicals you work with. Review the container labels and MSDS's for information on the associated hazards and how to protect yourself. The more you know about the chemicals you work with, the better you can protect yourself.
b. Always return chemicals to their proper storage location after use.
c. Perform all work with volatile and toxic chemicals in the fume hood.
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d. Do not leave chemical containers open any longer than it takes to remove what you need. This will help minimize exposure to the chemicals and potential contamination of the chemicals.
e. Be sure that all chemical containers are properly labeled in your laboratory. Do not use a chemical from an unlabeled container if you are not sure of the contents.
f. Exercise great care when transporting chemicals within or between laboratories. When transporting chemicals between floors, use the freight elevator, if one is available. Polyethylene or rubber acid/solvent bottle carriers and utility carts for transportation provide effective protection and containment in the event of an accident.
g. Use flammables only in an area free of ignition sources.
h. Use absorbent paper on work surfaces to help contain spills for those chemicals which are not reactive with paper.
2. Chemical-specific guidelines
The following chemicals deserve special attention because of their extremely hazardous nature. These are by no means the only extremely hazardous chemicals which may be in use on campus; therefore, it is important to review the hazards of each chemical prior to working with it. A more thorough list of extremely hazardous chemicals can be found in Appendix V.
a. Ethers
Ethers such as ethyl ether, isopropyl ether, p-dioxane and tetrahydrofuran deserve special attention because of their tendency to react with oxygen from the air to form explosive peroxides. These peroxides may detonate with extreme violence when they become concentrated by evaporation or distillation or when they are exposed to unusual heat, shock or friction. These are examples, not an extensive list of peroxide formers. A more extensive list can be found in Appendix IV.
Peroxides may form in “unstablized” ethers in as little as three days. Exposure to light and air, as in opened and partially emptied containers, accelerates the formation of peroxides in ethers. It is important to keep ether containers tightly closed when they are not in use and to store them in a dark place. “Stabilized” ethers, which contain peroxide inhibitors, are available and should be used whenever possible.
The presence of peroxides can be determined with potassium iodide test strips, which turn black in the presence of peroxides. Once the presence of peroxides is confirmed, they can be reduced with a 30% aqueous ferrous sulfate solution (40 grams for each liter of ether). Removal of the peroxides can be confirmed by the potassium iodide test strips. Peroxide decontamination should only be carried out by experienced faculty.
Follow these guidelines for the proper use of peroxide-forming ethers in the laboratory:
1) Clearly mark each container of ether with the date of receipt and the date it was first opened to ensure disposal at the appropriate time.
2) Unopened bottles of ether should be discarded after one year. Opened bottles of ethyl ether, p-dioxane and tetrahydrofuran should be discarded after six months, and isopropyl ether should be discarded after three months.
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3) Test for peroxides frequently, especially when evaporating or distilling. Never distill ether to dryness. Note the date and result of each test on the bottle.
4) If crystals are observed around the cap of a container of ether, do not open it. The friction of opening the container can be sufficient to detonate the peroxides.
5) Since ethers have a limited shelf life, they should be bought in the smallest containers possible (appropriate to the rate of usage in the laboratory). The cost and hazards of disposal far outweigh any of the benefits of buying in bulk.
b. Perchloric acid
Perchloric acid can be dangerously reactive. Aqueous perchloric acid at concentrations less than 70% at room temperatures is a strong acid. At elevated temperatures or concentrations greater than 70% it is a strong oxidizing agent and can cause violent explosions if misused. Anhydrous perchloric acid (greater than 85%) is unstable even at room temperatures and ultimately decomposes spontaneously with a violent explosion. Contact with oxidizable material can cause an immediate explosion.
Follow these guidelines for the proper use of perchloric acid in the laboratory:
1) Perchloric acid in concentrations greater than 70% is not recommended.
2) Any procedure involving heating of perchloric acid must be conducted in a properly functioning perchloric acid fume hood with the sash down.
3) Do not allow perchloric acid to come into contact with organic material or dehydrating agents.
4) Anhydrous perchloric acid should only be made as required and should never be stored. Only experienced faculty should handle anhydrous perchloric acid. EHSRM should be contacted prior to any work with anhydrous perchloric acid.
5) Do not allow contact with metals to prevent the formation of metal perchlorates which are very unstable and can explode.
6) Do not allow contact with wood or paper as fires can result from such contact.
c. Hydrofluoric acid
Hydrofluoric acid (HF) is an extremely corrosive material. All forms, including vapors and solutions, can cause severe, slow-healing burns to human tissue, including the lungs and eyes. At concentrations greater than 50% the burning is noticeable in a matter of minutes or less, while at concentrations below 50% the burns may not be felt until several hours after exposure. Burns from concentrated acid involving as little as 2.5% of body surface have resulted in death. Because it has a low boiling point and a high vapor pressure, HF must be kept in a non-glass pressure container. HF dissolves glass; therefore, it should never be stored in a glass container.
Follow these guidelines for the proper use of hydrofluoric acid in the laboratory: 1) Have calcium gluconate available prior to acquiring or working with HF.
2) Never work alone with HF.
3) Always use HF in a properly functioning fume hood. Heating of HF, or its solutions, requires an acid digestion fume hood.
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4) In work involving HF, be sure to use materials that are compatible with HF. HF attacks a variety of materials, including glass, concrete, cast iron, wood, leather and rubber. Lead, wax, polyethylene, polypropylene and Teflon will resist its corrosive action.
5) In HF exposures, time is crucial. Immediately wash the affected area(s) with copious amounts of water to minimize the extent and the depth of the burn. Never let a HF burn go untreated, as extensive damage could result. Any area that is exposed to HF must be treated immediately with calcium gluconate or another appropriate material to stop its reaction with human tissue. Medical attention should be sought as quickly as possible. Ensure medical personnel are aware that HF is involved. Mistakes in treatment can occur if a miscommunication results in treatment for a hydrochloric acid burn instead of a hydrofluoric acid burn.
d. Mercury
Mercury and its compounds are very common in laboratories. Because of its widespread use, mercury’s hazardous nature may be overlooked or ignored. Elemental mercury is volatile, and its vapors are extremely toxic. Because of the vapors’ high toxicity, it is very important to clean up mercury spills promptly and thoroughly. If this is not done, mercury can accumulate and vaporize over time. Inorganic and organic mercury compounds are also highly toxic.
Follow these guidelines for the proper use of mercury in the laboratory:
1) All work with elemental mercury should be performed over trays to capture and contain any spillage.
2) All work involving mercury should be done in a properly functioning chemical fume hood.
3) Clean up all mercury spills immediately. If you do not have the appropriate spill-control equipment, do not clean the spill yourself, as you can make the situation worse by creating small droplets that can end up in inaccessible locations such as cracks and crevices. For assistance, contact EHSRM.
4) Be careful not to heat any surfaces that may contain mercury residue, as increased temperature greatly increases the vapor pressure of mercury.
5) Red spirit thermometers are a nontoxic alternative to mercury thermometers and should be used whenever possible.
e. Chemical carcinogens
Several common laboratory chemicals, such as benzene, chloroform and formaldehyde, are suspected or known carcinogens. It is prudent to treat suspected carcinogens as if they are confirmed carcinogens. These chemicals may also have other physical or health hazards that should not be overlooked.
Follow these guidelines for the safe use of carcinogens in the laboratory:
1) Minimize the use of carcinogens in the laboratory by using nontoxic or less toxic alternatives whenever possible.
2) All work with chemical carcinogens should be done in a properly functioning fume hood.
3) All carcinogens in the laboratory should be labeled clearly and secured when not in use.
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4) Personal protective equipment and hygiene are very important when working with chemical carcinogens. While the fume hood should provide respiratory protection, you must also protect your hands to avoid skin absorption. Particularly for solvents, be sure to use protective gloves that are resistant to the chemical you are using. Wash your hands promptly after removing gloves or when a carcinogen (or any chemical) has contacted your skin.
C. Chemical storage
Proper chemical storage within the laboratory is an essential part of an effective laboratory safety program. Follow these general guidelines for the safe storage of chemicals in the laboratory:
1. Do not indiscriminately store chemicals in alphabetical order. This can lead to incompatible chemicals being stored next to each other. Instead, store chemicals according to their hazards—for example, flammables, corrosives, toxics, reactives, etc. For chemicals that have multiple hazards, segregate according to the most prominent hazard.
2. Flammable liquids should be stored in a flammable storage cabinet. Amounts of Class IA flammable liquids (flash point less than 73°F and boiling point less than 100°F) in the laboratory should be kept to a minimum.
3. Corrosives should be stored in a corrosive storage cabinet. However, acids and bases should be stored separately to prevent their mixing and reacting violently in the event of an accident.
4. Strong oxidizing agents should be stored away from organic materials and strong reducing agents to prevent the risk of fire and/or violent reactions in the event of an accident.
5. Cyanides and sulfides should be stored well away from acids to prevent the generation of the respective toxic gases in the event of an accident.
6. Label all new material with the date in which it was received and the date in which it was opened. This will help prevent the accumulation of outdated chemicals and ensure that older chemicals are used first.
7. Promptly discard outdated chemicals or chemicals no longer needed by the laboratory. Contact EHSRM for disposal.
8. Do not store chemicals on the floor especially not ones in glass containers in high-traffic areas. Large metal containers can be stored on the floor in an isolated location.
9. All chemicals must be stored inside secondary containment, even inside flammable or corrosive cabinets. This is a requirement of the Edwards Aquifer Authority.
10. Do not store chemicals near heat sources or in direct sunlight.
11. Label all chemical containers clearly and accurately. Remember, this is required under the Texas Hazard Communication Act.
12. Periodically inspect storage locations for signs of corrosion or leakage and misplaced chemicals.
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13. To avoid contact with the eyes in the event of a spill, do not store liquids above eye level.
D. Memorandum of Understanding (MOU) for controlled substances and chemical precursors
1. To comply with a statutory requirement, a Memorandum of Understanding (MOU) between the Texas Higher Education Coordinating Board and the Texas Department of Public Safety has been executed. The MOU establishes the responsibilities of institutions of higher education in implementing and maintaining a program for reporting information concerning controlled substances, controlled substance analogs, chemical precursors and certain glassware and chemical laboratory apparatuses used in educational or research activities.
2. Personnel using controlled substances under the Federal Controlled Substances Act for research, instruction and to conduct analysis are reminded that they must register annually with the Federal Drug Enforcement Administration (DEA). Accordingly, no precursor chemical listed may be sold or otherwise transferred to anyone who does not have the proper permit or the specific authority to accept the controlled items. Currently, glassware and other laboratory apparatus are not regulated by the DEA, but we must track the regulated laboratory apparatuses consistent with MOU procedures.
3. Precursor chemicals and listed laboratory apparatus must be properly secured within the laboratory to prevent unauthorized persons from accessing them. Any loss must be reported to the UTSA police department immediately. EHSRM will participate in monitoring activities involving controlled substances. Periodic internal and external audit inspections should also be anticipated. The precursor chemicals and listed laboratory apparatus specified in the MOU can be found in the MOU found in Appendix VI.
4. Controlled Substances
The official list of controlled substances can be found in Section 1308 of the most recent issue of Title 2 Code of Federal Regulations, Part 1300 to end. EHSRM has a copy of the latest Drug Enforcement Administration “List of Scheduling Actions and Controlled Substances.” The UTSA Policy on Controlled Substance Use in Research can be found in Appendix VII. The policy includes information on obtaining the proper licenses and permits and purchasing. Always check the latest policy revision at the EHSRM website to ensure proper compliance. The schedules of controlled substances from DEA can be found in Appendix VIII.
VIII. Hazard Communication and the Texas Hazard Communication Act In Texas, the Occupational Safety and Health Administration (OSHA) Hazard Communication Standard applies to private-sector businesses only. To protect public-sector employees, the Texas legislature passed the Texas Hazard Communication Act in 1985. The law, which was revised in 1993, is also known as the Public Employer Community Right-to-Know Act and can be found in the Texas Administrative Code 25 TAC § 295 or the Texas Health & Safety Code Title 6, Chapter 502 – Hazard Communication Act. It requires public employers to provide their employees with information on hazardous chemicals to which they may be exposed in the workplace. Requirements under the act include compiling and maintaining workplace chemicals lists, maintaining material safety data sheets (MSDS) and informing employees of the hazards associated with the chemicals they use. The law is similar to OSHA’s Hazard Communication Standard but is enforced by the Texas Department of State Health Services, Division of Regulatory Services, Enforcement Unit.
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The Texas Hazard Communication Act applies to public schools, colleges and universities in Texas. Chemicals in a laboratory under the direct supervision or guidance of a technically qualified individual may be exempt if: • labels on incoming containers of chemicals are not removed or defaced • the laboratory supervisor complies with MSDS and training requirements • the laboratory is not used primarily to produce hazardous chemicals in bulk
for commercial purposes. Otherwise, all requirements of the act apply. Consult with the Laboratory Safety Manager to see if any exemptions may apply to a specific laboratory. See Appendix I, Notice to Employees, for a brief summary of the act.
A. Requirements
1. Container labels
Hazardous chemical containers must have a label that identifies the hazardous chemical and lists the appropriate hazard warnings.
i. Primary or Original Containers: A label on an existing container may not be removed or defaced unless it is illegible or inaccurate or does not conform to labeling requirements.
ii. Secondary Containers: When transfers are made from the primary chemical container (stock bottle) to other containers, the secondary containers should be labeled with:
1. the name of the chemical (as it appears on the MSDS) and
2. the appropriate hazard warnings unless it is used immediately by the individual who made the transfer.
2. Material Safety Data Sheets (MSDS)
The material safety data sheets (MSDS) are an extensive compilation of chemical hazard and safe-handling information. Each sheet provides most of the information an employee needs to work with a chemical safely. Chemical manufacturers or distributors must develop an MSDS for each hazardous chemical they produce or distribute and are required to provide an MSDS with each initial shipment and with the first shipment after an MSDS is updated.
There is no required format for an MSDS, but it must include:
i. the specific chemical identity and common names of the hazardous chemical(s) involved;
ii. physical and chemical characteristics of the hazardous chemical;
iii. known acute and chronic health effects and related health information; exposure limits; whether the chemical is considered a carcinogen by the National Toxicology Program (NTP), the International Agency for Research on Cancer (IARC) or OSHA;
iv. precautionary measures;
v. emergency and first-aid procedures; and
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vi. the identification (including name, address and telephone number) of the organization responsible for preparing the MSDS.
When chemicals are purchased by UTSA faculty and staff, the MSDS is usually sent to EHSRM where a master MSDS file is maintained. If an MSDS is received with a chemical shipment, please forward a copy to the Laboratory Safety Officer in EHSRM. Employees may request copies by contacting the Laboratory Safety Officer; be sure to include the full chemical name as it appears on the label and the manufacturer.
MSDS’s must be available within the workplace. Laboratories can keep paper copies of MSDS’s for all chemicals used or can have MSDS database links on at least one computer in the laboratory. Database links are available from EHSRM’s website http://utsa.edu/safety/. A shortcut to the MSDS database must be maintained on the computer’s desktop.
3. Training
All laboratory personnel who use or handle hazardous chemicals must receive training on the hazards of those chemicals and measures they can take to protect themselves – available courses are listed in Section VI – Training Requirements. Training must include information on interpreting container labels and MSDS’s; the location, acute and chronic effects, and safe handling of hazardous chemicals to which personnel may be exposed; the proper use of protective equipment and first-aid treatment; and general safety instructions on the handling and clean-up procedures and disposal of hazardous chemicals. Training must be provided before the employee works with, or in a laboratory containing, any hazardous chemical. Retraining is required when the potential for exposure to hazardous chemicals in the laboratory increases significantly or when the principal investigator receives new and significant information concerning the hazards of a chemical.
The principal investigator / laboratory supervisor is responsible for providing continued training as necessary. All training must be documented, including the date, employee names and signatures, and the subjects covered in the session. Once laboratory specific training is completed, principle investigators must forward a copy of the training record to EHSRM.
B. Responsibilities under the Act – refer to this plan’s Section IV – Responsibilities.
IX. Personal protective equipment (PPE) Personal protective equipment (PPE) is a device or clothing worn to help protect you from direct exposure to hazardous materials. Examples include safety glasses or goggles, laboratory coats or aprons, gloves, face shields and respirators. Remember, PPE only protects you if you use it. Consult MSDS’s or other references for information on the PPE required for working with a particular chemical.
A. Eye and face protection
Eye protection must meet standards for impact resistance and provide splash protection. Safety glasses with side shields usually provide adequate impact resistance with limited splash protection and; therefore, should not be worn when working with liquid chemicals or solutions. Chemical splash goggles (with no direct perforations around the goggles) provide adequate impact resistance and splash protection and limited vapor protection and therefore provide the best all-around eye protection. Vapor resistant goggles are available if needed.
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In addition to protective eyewear, face shields or freestanding shields should be used in situations where implosion or explosion may occur. Follow these guidelines for effective eye and face protection.
1. Wear protective eyewear at all times in the laboratory.
2. Wear chemical splash goggles for maximum protection, especially if you wear corrective lenses (glasses or contacts).
B. Hand protection
Gloves protect your skin from the chemicals you work with. Not all gloves, however, are effective in providing protection against chemicals. Disposable latex gloves protect against water, dirt and microorganisms, but they do not protect against many solvents. There are several varieties of gloves (i.e., butyl, Neoprene, fluorocarbon (Viton), nitrile), each of which protect against different chemicals. There are also insulated gloves appropriate for work with cryogenic materials or hot glassware. Follow these guidelines for effective hand protection.
1. Wear gloves that provide the greatest protection from the chemical(s) with which you are working. Information on chemical-resistant gloves is available from various manufacturers, online or from EHSRM.
2. Wash your hands promptly after removing protective gloves to avoid exposure due to microscopic holes, tears, solvent penetration or accidental contact with the outside of the gloves when removing them.
3. Remove gloves when handling laboratory common items (telephones, doorknobs, etc.) to prevent their contamination.
4. Do not wear gloves outside the laboratory.
C. Body protection
The most common form of body protection in the laboratory is the laboratory coat. Laboratory coats protect your skin and clothes in the event of a spill or a splash. Chemical-resistant aprons provide extra frontal protection when there is a greater potential for spills or splashes, as when you are transferring chemicals from one container to another. Follow these guidelines for effective body protection.
1. Protective clothing should be easily removable and free from rips or tears.
2. Wear your laboratory coat or apron only in the laboratory to prevent the potential spread of contamination.
3. Always wash laboratory clothes separately from personal laundry.
4. The following are not to be worn in laboratories: high-heeled or open-toed shoes, sandals or woven shoes, shorts or miniskirts, or excessive jewelry.
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D. Respiratory protection
Respiratory protection in the laboratory is normally provided by engineering controls such as the ventilation system and chemical fume hood(s). When a higher level of respiratory protection is required, a half- or full-face respirator can be used. Contact EHSRM for assistance in selecting the correct respirator and cartridges. Medical assessment, fit testing and training on proper use and storage are necessary prior to using a respirator. Follow these guidelines for effective respiratory protection:
1. To note chemical odors, use a wafting motion of the hand to dilute the fumes before they reach your nose. Never inhale chemical fumes directly.
2. Do not use a respirator unless you have been trained to do so and have undergone a medical evaluation as well as had the respirator fit-tested.
3. If you are wearing a respirator, be sure the appropriate cartridges are used.
4. Properly store a respirator to prevent continued contamination and exhaustion of the cartridges.
X. Laboratory equipment A general understanding of laboratory equipment and how it works is essential to work safely in the laboratory.
A. Chemical fume hood
The laboratory chemical fume hood is a ventilated enclosure designed to capture, contain and exhaust fumes, gases, vapors, mists and particulate matter generated within the hood interior. The fume hood is one of the most common and important safety devices in a laboratory, so it is important to ensure that fume hoods are achieving maximum containment to provide maximum protection. Several factors decrease fume hood containment: excessive storage of equipment and chemicals inside the hood; high traffic, fans, air-conditioning vents and doors to hallways being propped open; blockage of baffle slots (exhaust openings in the back of the hood); and a high sash position (open hood face). These factors result in the generation of turbulence inside the hood, cross-drafts that disrupt hood air-flow patterns and decreased face velocity. The optimum flow rate on a fume hood is 100 feet per minute plus or minus 20 percent.
Follow these guidelines for proper hood use:
1. If large equipment must be used or stored inside the fume hood, place the equipment on blocks at least two inches off the work surface so the baffle slots are not blocked. This allows air to flow beneath the equipment.
2. Do not use the fume hood interior for a chemical storage cabinet. However, if some chemical storage inside the hood is necessary, place the containers on shelving against the side walls (not the back wall) of the hood so the baffle slots are minimally blocked.
3. Do not keep loose paper, towels or Kim wipes inside the hood. These materials can get caught in the exhaust fan and result in fume hood downtime.
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4. Equipment and other materials should be kept at least six inches behind the sash (hood opening) during experiments. This will reduce the exposure of personnel to chemical fumes that may escape into the laboratory due to small cross-drafts.
5. When the hood is not in use, keep the sash all the way down. When the hood is in use, keep the sash as low as possible to protect yourself against explosions or chemical splashes.
6. The fume hood is not a substitute for personal protective equipment. Wear your safety goggles, gloves and laboratory coat while working in a fume hood.
7. Ensure the exhaust fan is on and operating before you use a fume hood.
8. Newer models of fume hoods have audible alarms that go off when the face velocity in the hood falls below a certain level. Discontinue all work if the alarm sounds and ensure that the problem has been corrected before you continue.
9. Examinations and maintenance of all laboratory fume hoods are performed by Facilities personnel. Ensure that the system is tested at least annually and that a visual inspection sticker is placed on the system.
10. Place a visual indicator that shows air movement at the face of the hood. A strip of tissue paper works well. If the indicator is being pulled into the fume hood, the hood is functioning. If the indicator is hanging straight down stationary, the hood is not functioning. If the indicator is blowing out into the laboratory, the hood is not functioning and any contaminants in the hood are flowing into the laboratory. If the hood is not functioning, contact Facilities Work Control immediately to have the hood repaired.
B. Perchloric acid hood
Perchloric acid is a highly reactive, dangerous chemical. Its use inside a fume hood results in the deposition of perchloric acid precipitates that are potentially explosive. All work involving perchloric acid must be performed in an appropriate perchloric acid fume hood equipped with a wash-down system in the duct work to avoid precipitate buildup. Since perchloric acid reacts violently with other chemicals—such as organic materials or dehydrating agent—the perchloric acid hood must be washed down after each use and dedicated only to work involving perchloric acid. These hoods should be marked “perchloric acid hood.” Contact EHSRM for the location of the perchloric acid fume hoods on campus.
C. Radioisotope fume hood
A radioisotope hood is designed to minimize the risk of exposure by making it easier to maintain the hood in an uncontaminated condition. This hood is constructed of stainless steel and sealed to eliminate hard-to-clean areas that would allow the accumulation of radioactive materials. In situations where relatively high levels of radioactive materials are used or where the levels of radioactive fumes generated are substantial, a two stage, in-line high-efficiency particulate air (HEPA) filter may be necessary. Hoods for radioisotope use should be marked with the radioactive material symbol and “radioisotope hood.”
D. Compressed Gas Cylinders
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Compressed gas cylinders can present a dual hazard in the laboratory because the contents are under pressure and may contain hazardous materials, such as flammables, corrosives or toxics.
Follow these guidelines for proper use of compressed gas cylinders:
1. Compressed gas cylinders, empty or full, must be chained in place or otherwise secured at all times.
2. Cylinder caps must be in place except when the cylinder is in use.
3. Do not transport gas cylinders without the cylinder cap in place and an appropriate dolly with a securing strap.
4. Cylinder and delivery valves should be closed when not in use (especially true for toxic, flammable or corrosive gases).
5. Highly toxic, corrosive, and reactive gases present greater degrees of hazard. Work with these gases might require special containment, PPE, ventilation, piping systems, or alarm systems. Prior to ordering or working with these types of gases contact EHSRM for a risk assessment and determination of requirements.
6. Liquid nitrogen or any other liquefied gas can present additional hazards for handling and storage. Details on proper handling and storage can be found in Appendix IX.
E. Centrifuges
Improper centrifuge use can result in the generation and release of hazardous aerosols. Centrifuges present a contamination problem when tubes break and the contents are released.
Follow these guidelines for proper centrifuge use:
1. Make sure the lid is on and secured before operating the centrifuge and remains secured until the centrifuge has come to a complete stop.
2. Always balance the load in the centrifuge. If you are not filling the entire centrifuge rack, position the tubes opposite one another. If you have an odd number of samples, use an empty tube with enough water to equal the weight.
3. If vibration occurs, stop the centrifuge and check the load balances. Never operate an unbalanced centrifuge; this could result in breaking the centrifuge tube(s) and generating hazardous aerosols. Also, unbalanced rotors have the potential to become projectiles.
4. Keep the rotors and buckets clean, and promptly clean breakages or spills.
5. Ensure that the proper rotor is used for the centrifuge or the conditions of centrifugation.
F. Refrigerators
Follow these guidelines for proper laboratory refrigerator use:
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1. Flammable liquids must be stored in flammable or explosion-proof refrigerators.
2. Refrigerators must be labeled prominently to indicate whether they are suitable for storage of flammable liquids.
3. Never place food or beverages in a refrigerator where chemicals are stored.
4. Refrigerators containing chemicals must be labeled “No Food or Drink.”
G. Glassware
Follow these guidelines for proper laboratory glassware use:
1. Inspect all glassware before use. Discard broken, cracked or chipped glassware.
2. Fire-polish all cut-glass tubing and rods before use.
3. When inserting glass tubes or rods into stoppers, be sure the diameter of the tube is compatible with the diameter of the stopper; lubricate the glass with water or glycerol; wear heavy gloves and insert the glass tube carefully with a twisting motion.
4. Dispose of broken glassware in an appropriate “broken glass” container, not the ordinary trash.
XI. Chemical Waste Management Chemical and toxic waste generated at UTSA is managed in accordance with the HOP 9.25 - Hazardous Waste Management Program. This program is managed by EHSRM personnel in the Environmental Protection & Construction Safety Division. Individual lab chemical waste pick-ups may be arranged by completing an online request form available on the EHSRM website. For more information on chemical waste disposal, refer to Part B - Chemical Waste Management Safety Plan, which may be accessed on the EHSRM website at http://utsa.edu/safety/.
XII. Laboratory Deactivation and Equipment Disposal A. Equipment Disposal Procedure: See Appendix X for details.
Equipment to be disposed of should be wiped down with an appropriate disinfectant solution such as a bleach solution or an ethanol solution for biological contamination or residue and the appropriate solvent followed by a detergent solution to remove any chemical contamination or residue.
Once the equipment has been cleaned, EHSRM should be contacted to check the equipment and place proper signage on it stating that it has been reviewed and is ready to be removed.
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Laboratory personnel should then contact the Surplus Department to have the equipment removed from the laboratory.
B. Laboratory Deactivation Procedure: See Appendix X for details.
EHSRM should be contacted before a laboratory deactivation begins.
Pertinent personnel from EHSRM will come by the laboratory to review what items need to be dealt with. For instance, the Laboratory Safety Manager or designee will review what areas and equipment need to be cleaned due to possible biological or chemical contamination.
The Radiation Safety Officer will review for possible radiological contamination and determine what measures must be taken to deal with it.
Chemical and biological wastes will also be reviewed by the appropriate personnel. Once areas and equipment have been properly cleaned using a disinfectant or appropriate solvent, EHSRM personnel will need to review to determine if all cleaning has been done properly. Any equipment will be labeled as ready to move, repair, or to be disposed of. The area or laboratory itself will be labeled as appropriately decontaminated and ready for Housekeeping staff to do routine cleaning to prepare for its future occupants.
XIII. References
A. Chapter 502 of the Health and Safety Code. Texas Hazard Communication Act, Revised 1993. Texas Department of State Health Services, Division of Regulatory Services, Enforcement Unit.
B. Handbook of Laboratory Safety. Chemical Rubber Company, Third Edition, 1990.
C. Working Safely with Chemicals in the Laboratory. Genium Publishing, Second Edition, 1994.
D. Hazardous Chemicals in the Laboratory: A Guide for their Safe Use and Disposal. The University of Texas Southwestern Medical Center at Dallas, Office of Environmental Health and Safety, 1994.
E. Laboratory Safety Manual. The University of Texas at Austin, Office of Environmental Health and Safety, Hazardous Materials Division, 1995.
XIV. Appendices Appendix I - Notice to Employees Appendix II - Laboratory Specific Chemical Hygiene Plan Appendix III - Chemical Carcinogens Regulated by OSHA Appendix IV - Peroxide Forming Chemicals Appendix V - Extremely Hazardous Substances (Texas Tier II List) Appendix VI - Memorandum of Understanding
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Appendix VII - Controlled Substance Policy Appendix VIII- DEA Schedules of Controlled Substances Appendix IX - Liquid Nitrogen Storage and Use Appendix X - Laboratory and Equipment Clearance Procedures Appendix XI - Hazardous Materials Requiring Institutional Approval
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Appendix I: Notice to Employees On the following page is the Notice to Employees from the Texas Department of State Health Services. A version in Spanish is available from TDSHS online or from EHSRM.
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EMPLOYERS MAY BE SUBJECT TO ADMINISTRATIVE PENALTIES AND CIVIL OR CRIMINAL FINES RANGING FROM $50 TO $100,000 FOR EACH VIOLATION OF THIS ACT
Further information may be obtained from: Texas Department of State Health Services DivisionforRegulatoryServices (512) 834-6665 Enforcement Unit Fax (512) 834-6605 1100 West 49th Street Austin, Texas 78756
Texas Department of State Health
Services Approved 5/05
The Texas Hazard Communication Act (revised 1993), codified as Chapter 502 of the Texas Health and Safety Code, requires public employers to provide employees with specific information on the hazards of chemicals to which employees may be exposed in the workplace. As required by law, your employer must provide you with certain information and training. A brief summary of the law follows.
Hazardous chemicals are any products or materials that present any physical or health hazards when used, unless they are exempted under the law. Some examples of more commonly used hazardous chemicals are fuels, cleaning products, solvents, many types of oils, compressed gases, many types of paints, pesticides, herbicides, refrigerants, laboratory chemicals, cement, welding rods, etc.
Employers must develop a list of hazardous chemicals used or stored in the workplace in excess of 55 gallons or 500 pounds. This list shall be updated by the employer as necessary, but at least annually, and be made readily available for employees and their representatives on request.
Employers shall provide training to newly assigned employees before the employees work in a work area containing a hazardous chemical. Covered employees shall receive training from the employer on the hazards of the chemicals and on measures they can take to protect themselves from those hazards. This training shall be repeated as needed, but at least whenever new hazards are introduced into the workplace or new information is received on the chemicals which are already present.
Employees who may be exposed to hazardous chemicals shall be informed of the exposure by the employer and shall have ready access to the most current material safety data sheets (MSDS’s), which detail physical and health hazards and other pertinent information on those chemicals.
Employees shall not be required to work with hazardous chemicals from unlabeled containers, except portable containers for immediate use, the contents of which are known to the user.
Employees have rights to: C access copies of MSDS’s C information on their chemical exposures C receive training on chemical hazards C receive appropriate protective equipment C file complaints, assist inspectors, or testify
against their employer Employees may not be discharged or discriminated against in any manner for the exercise of any rights provided by this Act. A waiver of employee rights is void; an employer’s request for such a waiver is a violation of the Act. Employees may file complaints with the Texas Department of State Health Services at the toll free number provided below.
MATERIAL SAFETY DATA SHEETS NOTICE TO EMPLOYEES
HAZARDOUS CHEMICALS MATERIAL SAFETY DATA SHEETS
WORKPLACE CHEMICAL LIST
LABELS
EMPLOYEE EDUCATION PROGRAM
EMPLOYEE RIGHTS
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Appendix II – Laboratory Specific Chemical Hygiene Plan CHEMICAL HYGIENE PLAN FOR ____________________________________
A. Purpose of the Chemical Hygiene Plan
This Chemical Hygiene Plan is intended to summarize policies, protocols, and procedures regarding the use of chemicals in (building/room #) ______________ at the University of Texas at San Antonio. All personnel involved in laboratory research efforts should be familiar with this document and the protocols which pertain to their work. Every employee is responsible to ensure these procedures are followed. This written program is available in ________________________ office.
B. General Principles
1. Minimize exposures
Precautions for handling all laboratory chemicals should be adopted. The Permissible Exposure Limits of the Occupational Safety and Health Administration (OSHA) and the Threshold Limit Values of the American Conference of Governmental Industrial Hygienists should not be exceeded.
2. Do not underestimate the risk
Even for substances with no known significant hazard, exposure should be minimized. Unless otherwise known, assume any mixture will be more toxic than its most toxic component and all substances of unknown toxicity are hazardous.
3. Control Exposure
If possible, substitute less toxic materials. Secondly, prevent chemical vapors and mists escaping into the laboratory atmosphere by the use of fume hoods and other ventilation devices. Where other controls do not adequately control the hazard, wear appropriate personal protective equipment to prevent exposures, e.g. gloves, eye protection, laboratory coats, or respirators. Never eat in the laboratory, store food in refrigerators designated for chemical or biological storage, or place chemicals in a container where they might be ingested.
C. Procedures
1. Hazard Evaluation and Planning
a. Plan Ahead
Identify the potential hazards. Consider all weak links and things that could go wrong. Try to prevent their failure or occurrence. If the hazard still exists, build in safe guards and backups. Define small spills that are capable of being
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cleaned by area personnel – typically less than 1 liter in volume. Also define large spills (typically > 1 liter in volume) which require UTSA’s Environmental Health Safety and Risk Management (EHSRM) office to take action or possibly contact additional resources for assistance. EHSRM can deal with spills too large for area personnel, but too small to require SAFD assistance. These spill amounts should be determined and communicated to the Laboratory Safety Officer. Spill kits, including absorbent material and personal protective equipment must be on site. Personnel should be trained and drill on how to respond to possible events.
b. Spill Response
1. Assist any injured personnel. For eye or skin contact immediately remove any contaminated clothing and flush with water for 15 minutes. Seek medical attention.
2. Promptly contain chemical spills and alert people in all parts of the facility including isolated areas or restricted areas.
3. Small spills of < __________: Clean up small spills using appropriate protective apparel and equipment. Remember to dispose of contaminated articles as hazardous waste. Contact EHSRM personnel at 458-5250 if you need assistance.
4. For large spills > __________: Clear the area and call the UTSA Police dispatcher at x4911 or 458-4911. The dispatcher will contact Environmental Health Safety and Risk Management at 458-5250 or can reach EHSRM personnel in off hours. Move to a safe location and wait for the responders to arrive at the scene – they will need your important information.
2. Prohibitions
a. Eating, Smoking, etc.: Do not smell or taste chemicals. Eating, drinking, smoking, gum chewing or application of cosmetics is prohibited in areas where laboratory chemicals are present. Wash hands before conducting these activities. Do not store or handle/consume food or beverages in laboratory areas, refrigerators, glassware or utensils which are also used for laboratory operations.
b. Horseplay: Avoid practical jokes or other behavior which might confuse, startle, or distract another worker.
c. Mouth suction: Do not use mouth suction for pipetting or starting a siphon.
d. Working alone: If the procedures being conducted are hazardous do not work alone in the laboratory.
3. Equipment and glassware
Handle and store laboratory glassware with care to avoid damage; do not use damaged glassware. Use extra care with Dewar flasks and other evacuated glass apparatus. Shield or wrap them to contain chemicals and fragments should implosion occur. Use equipment only for its designed purpose.
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4. Emergency Eyewash and showers
Safety showers and eye washes must be within 10 seconds walking distance and less than 100 feet from where they may be needed. They must be well identified, remain on without the use of the operator’s hands, and be capable of running continuously for 15 minutes. Showers should be tested at least quarterly by Facilities Maintenance personnel and eyewash stations inspected weekly by designated laboratory users, but preferably all equipment monthly by Facilities Maintenance. Documentation should be annotated on the inspection form next to the system.
D. Personal Protective Equipment
Each laboratory should include protective apparel compatible with the required degree of protection for substances being handled. This can be determined from information on the MSDS or with assistance from Environmental Health Safety and Risk Management.
1. Eye Protection
ANSI approved eye wear must be worn anytime there is the possibility for an injury to the eye. This might be a splash, mist, explosive, ultraviolet radiation or particulate hazard to the eye. Protective eye wear is required in laboratories, chemical storage rooms and designated contaminated areas where work with chemicals is being performed by any of the laboratory personnel. Appropriate protection should be made available to visitors who enter the laboratory.
2. Gloves
Gloves should be worn whenever protection is needed against chemical or physical agents. They should be worn to handle corrosive materials, to prevent accidental exposure to toxic chemicals or with very hot or cold materials. Numerous materials are available including rubber, neoprene, butyl rubber, vinyl or leather. The appropriate glove can be determined by consulting MSDS’S, the material compatibility lists available from glove manufacturers, or contacting EHSRM. Inspect the gloves before each use. Wash reusable ones before removal and replace them frequently to avoid contaminating yourself and other objects such as door handles.
Chemicals Used Gloves Required
______________ ______________
______________ ______________
______________ ______________
3. Foot Wear
Shoes must be worn at all times in buildings where chemicals are used or stored. Perforated shoes, sandals, or cloth shoes should not be worn in laboratories where chemicals are used. Only leather shoes are appropriate in that instance. Shoes which completely enclose the foot are the best. Open-toed shoes are never
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appropriate in a laboratory. Steel-toed shoes should be worn when heavy objects are being handled.
4. Clothing
Where the potential for chemical contamination exists, personal clothing that will be worn home should be covered by protective apparel. Examples include laboratory coats, aprons, shoe covers, and sleeve covers. Remove permeable protective clothing, such as laboratory coats, immediately on significant contamination. Dirty laboratory coats should not be worn outside of the work area or offices, clean corridors, rest rooms, lunchrooms, libraries, or conference rooms. Re-useable cloth lab coats should not be taken home for washing – use an appropriate commercial service or purchase disposable lab coats.
5. Respirators
Respirators to protect employees shall be provided and used in areas when air contaminant concentrations are not sufficiently reduced by engineering controls. In accordance with the Occupational Safety and Health Administration (OSHA) standard, the UTSA respirator program requires Standard Operating Procedures for respirator use, training, medical evaluation, and fit-testing anytime respirators are to be used. Departments are required to provide respiratory protection equipment when determined to be necessary and enroll affected employees in the UTSA Occupational Health Program. Approval for respirator type, medical evaluations and fit testing should be arranged with the EHSRM Occupational Safety Coordinator (458-5304).
6. Hearing Protection
Ear protection should be worn when working around dangerous noise levels. As a rule of thumb, background noise levels are dangerous when conversation requires raised voices at 3 feet. The following areas require ear protection: (list any in the work area) ________________________.
E. Engineering Controls (Check box if present in the work area)
Where a hazard can not be eliminated completely, mechanical means of controlling the hazard are the safest. They attempt to control the hazard typically at the source. Some common examples are:
1. Negative Air Flow: All work areas that use hazardous chemicals are to have single pass room exhaust (not re-circulated to other areas) that is at a negative pressure differential to the air in the adjoining room or corridor. In other words air movement should flow into the work area from the outside corridor or adjoining room and be exhausted out of the room by mechanical means. If you believe your work area to be out of air balance, contact EHSRM to verify that airflows are appropriate for your work area.
2. Chemical Fume Hoods: Chemical fume hoods are built in cabinet enclosures typically with a pull down glass sash that are connected to an external building exhaust fan. These units are maintained and tested by Facilities Operations & Maintenance personnel and should be tagged with a sticker indicating the last date
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of testing and the negative air flow rate that should typically be between 80 – 120 lfpm. Contact Work Control for assistance.
3. Fume extraction devices & snorkels: Some laboratories are equipped with these bench top devices that can be put directly at or near the fume source and draw heavier than air fumes down and away or lighter than air fumes up and away from the worker’s breathing zone. They are typically connected to the building exhaust and should be verified for negative air flow with an indicating device such as a tissue paper before use. If you suspect poor negative airflow, contact Work Control and EHSRM for assistance.
4. Biosafety Cabinets: Biological safety cabinets are typically designed to provide both worker and product protection from infectious organisms. They are equipped with high efficiency particulate air (HEPA) filters and may or may not exhaust air out of the laboratory. Therefore they may or may not be acceptable for use of volatile solvents. Prior to work with hazardous materials, these units must be tested and certified annually to ANSI/NSF-49 standards by licensed workers under contract with EHSRM. Units should be tagged with a sticker indicating status – contact EHSRM for assistance. Class and Type of BSC’s specific to your work area:
Class (I, II): ____; Type (A1, A2, B1, B2): ____; Manuf.: ___________; Serial#: ________ Class (I, II): ____; Type (A1, A2, B1, B2): ____; Manuf.: ___________; Serial#: ________ Class (I, II): ____; Type (A1, A2, B1, B2): ____; Manuf.: ___________; Serial#: ________
5. Bench Top Negative Airflow, filtered cabinet enclosures: A number of manufacturers produce units in this category for specialized use such as rodent anesthetization with isofluorane. They are typically built out of an acrylic enclosure and contain a carbon impregnated filter that must be periodically changed. Specific operating and maintenance procedures per manufacturer instructions must be developed and adhered to for safe and proper operation of these units. Manufacturer: ____________; Model #: ____________
F. Chemical Use Procedures
1. Procurement
Before a substance is received, information on proper handling, storage, and disposal should be known by those who will be using, storing, or transporting the substance. Preferably, all substances should be received through Central Receiving. All material safety data sheets (MSDS) must be maintained in the immediate area as hard copies or online through a database or accessed through the EHSRM office for chemicals being used. A chemical inventory must also be maintained by the laboratory ordering and storing or using the chemicals. This will assist with the requirements mentioned and comply with federal and state regulations.
2. Labels
a. Laboratory entryways must have labels with an indication of the potential hazards and emergency telephone numbers of laboratory workers or
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supervisors. These will normally be posted by EHSRM personnel and updated at the periodic lab evaluation.
b. No container should be accepted without an adequate identifying label. Do not remove or deface labels. Identity labels must show contents of the containers (including waste receptacles) and associated hazards.
c. Location signs should mark sites of safety showers, eyewash stations, exits, and other safety and first aid equipment and should not be obstructed.
d. It is not permissible to place chemicals in a food container.
3. Material Safety Data Sheets (MSDS)
a. MSDS’s for all hazardous chemicals to which employees or students may be exposed shall be accessible either in hard copy or via an online database. The chemical user should review the MSDS for each chemical prior to the use of that chemical. The MSDS’s are available for reference or to copy at EHSRM.
b. If MSDS’s are not available or new chemicals in use do not have an MSDS, immediately contact EHSRM. MSDS’s are available through the chemical manufacturer or EHSRM. Chemicals should not be used until the MSDS’s are accessible.
c. The laboratory supervisor will review incoming MSDS’s for new and significant health/safety information. Contact EHSRM for assistance as needed and see that any new information is passed on to the affected employees.
d. Additional toxicological information and procedural assistance is available through EHSRM.
4. Storage and Distribution
a. Stockrooms Substances should be segregated in a well identified area with local exhaust ventilation providing at least six air changes per hour. Stored chemicals should be examined periodically (at least annually) for replacement, deterioration, and container integrity. Stockrooms/storerooms should be open during normal working hours and be controlled by one person. They should not be used as preparation or repackaging areas.
b. Laboratory Storage
Amounts permitted should be as small as practical. Explosion proof storage cabinets should be used. Storage on bench tops and in hoods is inadvisable. Exposure to heat or direct sunlight should be avoided. Periodic inventories should be conducted, with unneeded items being properly disposed of or returned to the storeroom/stockroom.
c. Distribution When chemicals are hand carried, containers should be packed in a secondary
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container or bucket. Use freight elevators to transport the chemicals to different floors.
5. Compressed gas cylinders
Compressed gas cylinders are to be securely fastened during transit, storage, while in use and when designated as empty. Stationary cylinders should be chained at 2/3 their height, or placed in stable racks, with valve caps attached. Use a wheel cart to transport large cylinders. Valves should be closed on empty cylinders and marked as empty. The regulator should be removed and the valve cap replaced.
6. Environmental Monitoring
Regular instrumental monitoring of airborne concentrations is not usually justified or practical in laboratories but may be appropriate when testing ventilation devices or when a carcinogenic or highly toxic substance is stored or used regularly. Contact EHSRM for chemical monitoring assistance.
7. Waste Disposal
a. Waste containers must be labeled “Hazardous Waste” and lids must be attached and secured except when adding waste.
b. Follow disposal instructions as described in the University Part B - Chemical Waste Management Safety Plan. Do not dispose of any chemicals down the sewer system, by allowing it to evaporate, or by placing it in the garbage without confirming proper interpretation of the plan with EHSRM.
c. Prior to permanently leaving the laboratory, responsible parties must properly dispose of, return to storage or sign over to the next person all chemicals prior to their departure. Refer to UTSA’s Policy on Laboratory Deactivation.
G. Inspections and Investigations
Formal housekeeping and chemical hygiene compliance should be conducted at least quarterly by the laboratory supervisor. Laboratory evaluations will be conducted periodically, but at least once per year by EHSRM’s Laboratory Safety Division. Whenever an incident occurs in the laboratory, an internal incident investigation will be carried out. An Incident Report must be filed with EHSRM. The information will be used to prevent similar situations from occurring in the future.
H. Worker’s Compensation Insurance (WCI) Policy
1. For any work-related exposure reported to a supervisor or in which a supervisor has knowledge, an incident report should be completed and submitted to the EHSRM Occupational Health and WCI Coordinator (x5304 or x5250). Report Forms are available on the EHSRM website at http://utsa.edu/safety/. An employer should keep record of the employee’s medical surveillance to ensure WCI coverage should the exposure result in an injury or disease.
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Editor note: An exposure does not meet the definition of an injury. UT System therefore cannot, under the TWCC Act, cover expenses incurred from an exposure unless the exposure results in an actual injury. UTSA however, has established funding to cover needle sticks and similar exposures. Contact the Occupational Health & WCI Coordinator at x5304 or x5250.
2. Medical surveillance under the direction of a licensed physician must be paid at no cost to the employee for work related injuries if:
a. The employee exhibits signs or symptoms associated with exposure to a hazardous chemical used in the laboratory.
b. A spill, leak or explosion occurs resulting in the likelihood of a hazardous exposure.
c. Any employee is exposed routinely above the action level, or in the absence of an action level, above the permissible exposure limit for which there are exposure monitoring or medical surveillance requirements.
d. If the employee is a student, they can be seen by the UTSA Student Health Services. If further examination by a physician is required, the student will be referred. The first report of injury form will still be required by EHSRM as well as follow-up documentation.
3. The laboratory supervisor or his/her representative should provide the physician with the identity of the chemicals, description of exposure conditions and symptoms, if any. The physician’s opinion must be written and include any need for follow-up, results, any increased risk and a statement that the employee has been notified of the previous items.
I. Worker’s Compensation Insurance (WCI) and Reporting Injuries or Illness on the Job
1. An employee of UTSA who suffers an accidental injury or occupational disease that arises out of and in the course and scope of employment should notify his or her supervisor to complete a first report of injury or illness form http://utsa.edu/safety/ within 24 hours. If an employee’s injury is found to be compensable under the WCI Program, the employee is entitled to healthcare reasonably required by the nature of the compensable injury.
2. Injuries or chemical exposures that result in the hospitalization of 5 or more employees or the death of any one employee are to be reported to both the UTSA Police and Office of EHSRM immediately. EHSRM and Police personnel will ensure proper authorities are notified.
3. Responsibilities to the injured employee include:
a. Notify the injured employee that his or her injury may be covered under worker’s compensation insurance.
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b. Arrange for appropriate treatment in an emergency situation (keep in mind that an injured employee has a right to select his or her own healthcare provider).
J. Training
1. Environmental Health Safety and Risk Management offers a laboratory safety class several times a semester to assist in complying with the Public Employers Worker Right-to-Know Act. This course is also available online. Laboratories must adhere to requirements listed in the UTSA Chemical Hygiene & Hazard Communication Safety Plan. All of the elements specified below must be provided to the employees in this work area.
a. An overview of the requirements contained in the UTSA Chemical Hygiene & Hazard Communication Safety Plan, its location and availability.
b. Hazardous chemicals present in their work place operations.
c. Physical and health hazards of the hazardous chemicals in their work area to include the Occupational Safety and Health Administration (OSHA) permissible exposure limits and the American Conference of Governmental Industrial Hygienists (ACGER) Threshold Limit Values (TLV).
d. Methods and observation techniques used to determine the presence or release of hazardous chemicals in their work area.
e. How to lessen or prevent exposure using personal protective equipment.
f. Steps the University/EHSRM has taken to lessen or prevent exposure to these hazardous chemicals.
g. Symptoms associated with exposure to chemicals found in the area.
h. Emergency procedures to follow if they are exposed to hazardous chemicals.
i. How to read labels and review a MSDS to obtain appropriate hazard information.
j. Location of MSDS file and hazardous chemical list for their work area.
2. UTSA’s Office of Business Continuity and Emergency Management (BCEM) has developed a Comprehensive Emergency Management Plan to assist all departments in case of an emergency. Various other resources are offered on campus. Training is periodically offered through EHSRM or BCEM. DVD’s / Video tapes are also available on loan for safety, health and radiation training subjects.
K. Records
1. Accident records should be written and retained according to the UTSA record retention schedule by department supervisors. A copy should be sent to EHSRM.
2. Inventory and usage records for high-risk substances should be kept.
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3. Medical reports (correspondence and physician’s employee health evaluations) are retained by EHSRM. All documentation on employees is maintained by Human Resources on an indefinite basis.
4. Training records should be maintained for at least three years. These records should include the contents of the training, date, presenter, and name of attendees.
L. Contacts
1. Fire/Ambulance/Police: 911 or x4911 (campus phone) / 458-4911 (off campus phone)
2. University Police: x4242 (non-emergency)
3. Office of Business Continuity and Emergency Management: x6756
4. Student Health Services: x4142
5. Office of Environment Health Safety and Risk Management (EHSRM): x5250
6. EHSRM - Occupational Health & Workers’ Compensation Insurance: x5250 or x5304
7. EHSRM - Chemical Hygiene Officer/Laboratory Safety Manager/Radiation Safety Officer: x6101
8. EHSRM - Environmental Protection & Construction Safety Manager/Waste Disposal: x5808
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Appendix III: Chemical carcinogens regulated by OSHA
2-Acetylaminofluorene 4-Dimethylaminoazobenzene
Acrylonitrile Ethyleneimine
4-Aminodiphenyl Ethylene oxide
Arsenic, inorganic Formaldehyde
Asbestos Methyl chloromethyl ether
Benzene Methylene chloride
Benzidine Methylenedianiline
1,3-Butadiene a-Naphthylamine
bis-Chloromethyl ether b-Naphthylamine
Cadmium 4-Nitrobiphenyl
Coke oven emissions N-Nitrosodimethylamine
1,2-Dibromo-3-chloropropane b-Propiolactone
3,3’-Dichlorobenzidine (and its salts) Vinyl chloride
This list of carcinogens is only one of many available lists of confirmed and suspected human carcinogens. Contact EHSRM to see any of the lists of carcinogens published by the following agencies and organizations:
American Conference of Governmental Industrial Hygienists (ACGIH)
International Agency for Research on Cancer (IARC)
National Institutes of Occupational Safety and Health (NIOSH)
National Toxicology Program (NTP)
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Appendix IV: Peroxide Forming Chemicals
Materials that are susceptible to peroxide formation (i.e., auto-oxidation) are ones that typically react with air, moisture or impurities and produce a change in their chemical composition in normal storage. The peroxides that form are less volatile than the solvent itself and thus tend to concentrate. This is particularly dangerous if peroxides are present during a distillation, where the applied heat to the concentrated solution may trigger a violent explosion. Equally dangerous is to allow a container of this material to evaporate to dryness, leaving the crystals of peroxide at the bottom of the container. Chemicals that are sensitive to peroxide formation can be broken into three categories (Jackson, J. Chem. Ed., 1970) as shown in the following table.
A. Peroxide hazard after prolonged storage. Form potentially explosive peroxides without concentrating.
All have been responsible for fatalities. Test for peroxide formation or discard after 3 months. isopropyl ether divinyl acetylene potassium metal potassium amide sodium amide vinylidene chloride
B. Chemicals which become a peroxide hazard if concentrated, such as through distillation or evaporation. Test for peroxide formation or discard after 1 year.
dioxane diethyl ether
tetrahydrofuran acetal
cumene cyclohexane
cyclopentene diacetylene
dicyclopentadiene ethylene glycol dimethyl ether
furan methyl acetylene
methyl cyclopentane methyl-isobutyl ketone
tetrahydronaphthalene vinyl ethers
C. Chemicals which are a hazard due to peroxide initiation of polymerization.
The peroxide forming potential increases for liquids of this group. Test for peroxide formation or discard after 1 year.
butadiene chlorobutadiene vinyl pyridine
chlorotrifluoroethylene styrene acrylonitrile
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tetrafluoroethylene vinyl acetate
vinyl acetylene vinyl chloride
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Appendix V: Extremely Hazardous Substance (Texas Tier II) List EXTREMELY HAZARDOUS SUBSTANCES (EHS) AND THEIR THRESHOLD PLANNING QUANTITIES (TPQ) LIST
All RQ (Reportable Quantities) and TPQ quantities are in pounds. Facilities that file the Texas Tier Two Report with the Texas Department of State Health Services, Tier Two Registration Section are also required to submit photocopies of this Report to the local fire department having jurisdiction over the reporting facility and to the Local Emergency Planning Committee (LEPC) for the county or area in which the reporting facility is located. Although a filing fee is not required with these submissions, please consider providing a donation to your LEPC along with the photocopy of your report. Contact the Tier Two Registration Section at 1-800-452-2791 for a free copy of the LEPC Brochure, which contains information on the services provided by LEPC's and suggestions on how you can help support these volunteer organizations.
CAS # NAME TPQ Pounds RQ Pounds
75-86-5 Acetone cyanohydrin 1,000 10
1752-30-3 Acetone thiosemicarbazide 1,000/10,000 1,000
107-02-8 Acrolein 500 1
79-06-1 Acrylamide 1,000/10,000 5,000
107-13-1 Acrylonitrile 10,000 100
814-68-6 Acrylyl chloride 100 100
111-69-3 Adiponitrile 1,000 1,000
116-06-3 Aldicarb 100/10,000 1
309-00-2 Aldrin 500/10,000 1
107-18-6 Allyl alcohol 1,000 100
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CAS # NAME TPQ Pounds RQ Pounds
107-11-9 Allylamine 500 500
20859-73-8 Aluminum phosphide 500 100
54-62-6 Aminopterin 500/10,000 500
78-53-5 Amiton 500 500
3734-97-2 Amiton oxalate 100/10,000 100
7664-41-7 Ammonia (Anhydrous) 500 100
300-62-9 Amphetamine 1,000 1,000
62-53-3 Aniline 1,000 5,000
88-05-1 Aniline, 2,4,6-trimethyl- 500 500
7783-70-2 Antimony pentafluoride 500 500
1397-94-0 Antimycin A 1,000/10,000 1,000
86-88-4 ANTU 500/10,000 100
1303-28-2 Arsenic pentoxide 100/10,000 1
1327-53-3 Arsenous oxide 100/10,000 1
7784-34-1 Arsenous trichloride 500 1
7784-42-1 Arsine 100 100
2642-71-9 Azinphos-ethyl 100/10,000 100
86-50-0 Azinphos-methyl 10/10,000 1
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CAS # NAME TPQ Pounds RQ Pounds
98-87-3 Benzal chloride 500 5,000
98-16-8 Benzenamine, 3-(trifluoromethyl)- 500 500
100-14-1 Benzene, 1-(chloromethyl)-4-nitro- 500/10,000 500
98-05-5 Benzenearsonic acid 10/10,000 10
3615-21-2 Benzimidazole, 4,5-dichloro-2-(trifluoromethyl)- 500/10,000 500
98-07-7 Benzotrichloride 100 10
100-44-7 Benzyl chloride 500 100
140-29-4 Benzyl cyanide 500 500
15271-41-7 Bicyclo[2.2.1]heptane-2- 500/10,000 500
carbonitrile, 5-chloro-6-((((methylamino)carbonyl)oxy)imino)-,(1-alpha,2-beta,4-alpha,5-alpha,6E))-
534-07-6 Bis(chloromethyl) ketone 10/10,000 10
4044-65-9 Bitoscanate 500/10,000 500
10294-34-5 Boron trichloride 500 500
7637-07-2 Boron trifluoride 500 500
353-42-4 Boron trifluoride compound with methyl ether (1:1) 1,000 1,000
28772-56-7 Bromadiolone 100/10,000 100
7726-95-6 Bromine 500 500
1306-19-0 Cadmium oxide 100/10,000 100
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CAS # NAME TPQ Pounds RQ Pounds
2223-93-0 Cadmium stearate 1,000/10,000 1,000
7778-44-1 Calcium arsenate 500/10,000 1
8001-35-2 Camphechlor 500/10,000 1
56-25-7 Cantharidin 100/10,000 100
51-83-2 Carbachol chloride 500/10,000 500
26419-73-8 Carbamic acid, methyl-, O- 100/10,000 1
(((2,4-dimethyl-1,3-dithiolan-2-yl)methylene)amino)-
1563-66-2 Carbofuran 10/10,000 10
75-15-0 Carbon disulfide 10,000 100
786-19-6 Carbophenothion 500 500
57-74-9 Chlordane 1,000 1
470-90-6 Chlorfenvinfos 500 500
7782-50-5 Chlorine (Gas) 100 10
24934-91-6 Chlormephos 500 500
999-81-5 Chlormequat chloride 100/10,000 100
79-11-8 Chloroacetic acid 100/10,000 100
107-07-3 Chloroethanol 500 500
627-11-2 Chloroethyl chloroformate 1,000 1,000
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CAS # NAME TPQ Pounds RQ Pounds
67-66-3 Chloroform 10,000 10
542-88-1 Chloromethyl ether 100 10
107-30-2 Chloromethyl methyl ether 100 10
3691-35-8 Chlorophacinone 100/10,000 100
1982-47-4 Chloroxuron 500/10,000 500
21923-23-9 Chlorthiophos 500 500
10025-73-7 Chromic chloride 1/10,000 1
10210-68-1 Cobalt carbonyl 10/10,000 10
62207-76-5 Cobalt, ((2,2’-(1,2- 100/10,000 100
ethanediylbis(nitrilomethylidyne))bis(6-fluorophenylato))(2-)-N,N’,O,O’)-
64-86-8 Colchicine 10/10,000 10
56-72-4 Coumaphos 100/10,000 10
5836-29-3 Coumatetralyl 500/10,000 500
95-48-7 Cresol (o-) (Cresylic Acid) 1,000/10,000 100
535-89-7 Crimidine 100/10,000 100
4170-30-3 Crotonaldehyde 1,000 100
123-73-9 Crotonaldehyde, (E)- 1,000 100
506-68-3 Cyanogen bromide 500/10,000 1,000
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CAS # NAME TPQ Pounds RQ Pounds
506-78-5 Cyanogen iodide 1,000/10,000 1,000
2636-26-2 Cyanophos 1,000 1,000
675-14-9 Cyanuric fluoride 100 100
66-81-9 Cycloheximide 100/10,000 100
108-91-8 Cyclohexylamine 10,000 10,000
17702-41-9 Decaborane(14) 500/10,000 500
8065-48-3 Demeton 500 500
919-86-8 Demeton-S-methyl 500 500
10311-84-9 Dialifor 100/10,000 100
19287-45-7 Diborane 100 100
111-44-4 Dichloroethyl ether 10,000 10
149-74-6 Dichloromethylphenylsilane 1,000 1,000
62-73-7 Dichlorvos 1,000 10
141-66-2 Dicrotophos 100 100
1464-53-5 Diepoxybutane 500 10
814-49-3 Diethyl chlorophosphate 500 500
71-63-6 Digitoxin 100/10,000 100
2238075 Diglycidyl ether 1,000 1,000
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CAS # NAME TPQ Pounds RQ Pounds
20830-75-5 Digoxin 10/10,000 10
115-26-4 Dimefox 500 500
60-51-5 Dimethoate 500/10,000 10
2524-03-0 Dimethyl phosphorochloridothioate 500 500
77-78-1 Dimethyl sulfate 500 100
75-78-5 Dimethyldichlorosilane 500 500
57-14-7 Dimethylhydrazine 1,000 10
99-98-9 Dimethyl-p-phenylenediamine 10/10,000 10
644-64-4 Dimetilan 500/10,000 1
534-52-1 Dinitrocresol 10/10,000 10
88-85-7 Dinoseb 100/10,000 1,000
1420-07-1 Dinoterb 500/10,000 500
78-34-2 Dioxathion 500 500
82-66-6 Diphacinone 10/10,000 10
152-16-9 Diphosphoramide, octamethyl- 100 100
298-04-4 Disulfoton 500 1
514-73-8 Dithiazanine iodide 500/10,000 500
541-53-7 Dithiobiuret 100/10,000 100
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CAS # NAME TPQ Pounds RQ Pounds
316-42-7 Emetine, dihydrochloride 1/10,000 1
115-29-7 Endosulfan 10/10,000 1
2778-04-3 Endothion 500/10,000 500
72-20-8 Endrin 500/10,000 1
106-89-8 Epichlorohydrin 1,000 100
2104-64-5 EPN 100/10,000 100
50-14-6 Ergocalciferol 1,000/10,000 1,000
379-79-3 Ergotamine tartrate 500/10,000 500
1622-32-8 Ethanesulfonyl chloride,2-chloro- 500 500
10140-87-1 Ethanol, 1,2-dichloro-, acetate 1,000 1,000
563-12-2 Ethion 1,000 10
13194-48-4 Ethoprophos 1,000 1,000
538-07-8 Ethylbis(2-chloroethyl)amine 500 500
371-62-0 Ethylene fluorohydrin 10 10
75-21-8 Ethylene oxide 1,000 10
107-15-3 Ethylenediamine 10,000 5,000
151-56-4 Ethyleneimine 500 1
542-90-5 Ethylthiocyanate 10,000 10,000
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CAS # NAME TPQ Pounds RQ Pounds
22224-92-6 Fenamiphos 10/10,000 10
115-90-2 Fensulfothion 500 500
4301-50-2 Fluenetil 100/10,000 100
7782-41-4 Fluorine 500 10
640-19-7 Fluoroacetamide 100/10,000 100
144-49-0 Fluoroacetic acid 10/10,000 10
359-06-8 Fluoroacetyl chloride 10 10
51-21-8 Fluorouracil 500/10,000 500
944-22-9 Fonofos 500 500
50-00-0 Formaldehyde 500 100
107-16-4 Formaldehyde cyanohydrin 1,000 1,000
23422-53-9 Formetanate hydrochloride 500/10,000 1
2540-82-1 Formothion 100 100
17702-57-7 Formparanate 100/10,000 1
21548-32-3 Fosthietan 500 500
3878-19-1 Fuberidazole 100/10,000 100
110-00-9 Furan 500 100
13450-90-3 Gallium trichloride 500/10,000 500
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CAS # NAME TPQ Pounds RQ Pounds
77-47-4 Hexachlorocyclopentadiene 100 10
4835-11-4 Hexamethylenediamine, N,N’-dibutyl- 500 500
302-01-2 Hydrazine 1,000 1
74-90-8 Hydrocyanic acid 100 10
7647-01-0 Hydrogen chloride (gas only) 500 5,000
7664-39-3 Hydrogen fluoride 100 100
7722-84-1 Hydrogen peroxide (Conc.>52%) 1,000 1,000
7783-07-5 Hydrogen selenide 10 10
7783-06-4 Hydrogen sulfide 500 100
123-31-9 Hydroquinone 500/10,000 100
13463-40-6 Iron, pentacarbonyl- 100 100
297-78-9 Isobenzan 100/10,000 100
78-82-0 Isobutyronitrile 1,000 1,000
102-36-3 Isocyanic acid, 3,4-dichlorophenyl ester 500/10,000 500
465-73-6 Isodrin 100/10,000 1
55-91-4 Isofluorphate 100 100
4098-71-9 Isophorone diisocyanate 100 100
108-23-6 Isopropyl chloroformate 1,000 1,000
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CAS # NAME TPQ Pounds RQ Pounds
119-38-0 Isopropylmethylpyrazolyl dimethylcarbamate 500 1
78-97-7 Lactonitrile 1,000 1,000
21609-90-5 Leptophos 500/10,000 500
541-25-3 Lewisite 10 10
58-89-9 Lindane 1,000/10,000 1
7580-67-8 Lithium hydride 100 100
109-77-3 Malononitrile 500/10,000 1,000
12108-13-3 Manganese, tricarbonyl methylcyclopentadienyl 100 100
51-75-2 Mechlorethamine 10 10
950-10-7 Mephosfolan 500 500
1600-27-7 Mercuric acetate 500/10,000 500
7487-94-7 Mercuric chloride 500/10,000 500
21908-53-2 Mercuric oxide 500/10,000 500
10476-95-6 Methacrolein diacetate 1,000 1,000
760-93-0 Methacrylic anhydride 500 500
126-98-7 Methacrylonitrile 500 1,000
920-46-7 Methacryloyl chloride 100 100
30674-80-7 Methacryloyloxyethyl isocyanate 100 100
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CAS # NAME TPQ Pounds RQ Pounds
10265-92-6 Methamidophos 100/10,000 100
558-25-8 Methanesulfonyl fluoride 1,000 1,000
950-37-8 Methidathion 500/10,000 500
2032-65-7 Methiocarb 500/10,000 10
16752-77-5 Methomyl 500/10,000 100
151-38-2 Methoxyethylmercuric acetate 500/10,000 500
80-63-7 Methyl 2-chloroacrylate 500 500
74-83-9 Methyl bromide 1,000 1,000
79-22-1 Methyl chloroformate 500 1,000
60-34-4 Methyl hydrazine 500 10
624-83-9 Methyl isocyanate 500 10
556-61-6 Methyl isothiocyanate 500 500
74-93-1 Methyl mercaptan 500 100
3735-23-7 Methyl phenkapton 500 500
676-97-1 Methyl phosphonic dichloride 100 100
556-64-9 Methyl thiocyanate 10,000 10,000
78-94-4 Methyl vinyl ketone 10 10
502-39-6 Methylmercuric dicyanamide 500/10,000 500
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CAS # NAME TPQ Pounds RQ Pounds
75-79-6 Methyltrichlorosilane 500 500
1129-41-5 Metolcarb 100/10,000 1
7786-34-7 Mevinphos 500 10
315-18-4 Mexacarbate 500/10,000 1,000
50-07-7 Mitomycin C 500/10,000 10
6923-22-4 Monocrotophos 10/10,000 10
2763-96-4 Muscimol 500/10,000 1,000
505-60-2 Mustard gas 500 500
13463-39-3 Nickel carbonyl 1 10
54-11-5 Nicotine 100 100
65-30-5 Nicotine sulfate 100/10,000 100
7697-37-2 Nitric acid 1,000 1,000
10102-43-9 Nitric Oxide 10 100
98-95-3 Nitrobenzene 10,000 1,000
1122-60-7 Nitrocyclohexane 500 500
10102-44-0 Nitrogen dioxide 100 10
62-75-9 Nitrosodimethylamine 1,000 10
991-42-4 Norbormide 100/10,000 100
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CAS # NAME TPQ Pounds RQ Pounds
NONE Organorhodium Complex (PMN-82-147) 10/10,000 10
630-60-4 Ouabain 100/10,000 100
23135-22-0 Oxamyl 100/10,000 1
78-71-7 Oxetane, 3,3-bis(chloromethyl)- 500 500
2497-07-6 Oxydisulfoton 500 500
10028-15-6 Ozone 100 100
1910-42-5 Paraquat dichloride 10/10,000 10
2074-50-2 Paraquat methosulfate 10/10,000 10
56-38-2 Parathion 100 10
298-00-0 Parathion-methyl 100/10,000 100
12002-03-8 Paris green 500/10,000 1
19624-22-7 Pentaborane 500 500
2570-26-5 Pentadecylamine 100/10,000 100
79-21-0 Peracetic acid 500 500
594-42-3 Perchloromethyl mercaptan 500 100
108-95-2 Phenol 500/10,000 1,000
4418-66-0 Phenol, 2,2’-thiobis[4-chloro-6-methyl-] 100/10,000 100
64-00-6 Phenol, 3-(1-methylethyl)-, methylcarbamate 500/10,000 1
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CAS # NAME TPQ Pounds RQ Pounds
58-36-6 Phenoxarsine, 10,10’-oxydi- 500/10,000 500
696-28-6 Phenyl dichloroarsine 500 1
59-88-1 Phenylhydrazine hydrochloride 1,000/10,000 1,000
62-38-4 Phenylmercury acetate 500/10,000 100
2097-19-0 Phenylsilatrane 100/10,000 100
103-85-5 Phenylthiourea 100/10,000 100
298-02-2 Phorate 10 10
4104-14-7 Phosacetim 100/10,000 100
947-02-4 Phosfolan 100/10,000 100
75-44-5 Phosgene 10 10
732-11-6 Phosmet 10/10,000 10
13171-21-6 Phosphamidon 100 100
7803-51-2 Phosphine 500 100
2665-30-7 Phosphonothioic acid, methyl-, O-(4-nitrophenyl) O-phenyl ester 500 500
2703-13-1 Phosphonothioic acid, methyl-, 500 500
O-ethyl O-(4-(methylthio)phenyl) ester
50782-69-9 Phosphonothioic acid, methyl-, 100 100
S-(2-(bis(1-methylethyl)Amino)ethyl) O-ethyl ester
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CAS # NAME TPQ Pounds RQ Pounds
3254-63-5 Phosphoric acid, dimethyl 4-(methylthio) phenyl ester 500 500
2587-90-8 Phosphorothioic acid, O,O- 500 500
dimethyl-s-(2-(methylthio)ethyl)ester
7723-14-0 Phosphorus 100 1
10025-87-3 Phosphorus oxychloride 500 1,000
10026-13-8 Phosphorus pentachloride 500 500
7719-12-2 Phosphorus trichloride 1,000 1,000
57-47-6 Physostigmine 100/10,000 1
57-64-7 Physostigmine, salicylate (1:1) 100/10,000 1
124-87-8 Picrotoxin 500/10,000 500
110-89-4 Piperidine 1,000 1,000
23505-41-1 Pirimifos-ethyl 1,000 1,000
10124-50-2 Potassium arsenite 500/10,000 1
151-50-8 Potassium cyanide 100 10
506-61-6 Potassium silver cyanide 500 1
2631-37-0 Promecarb 500/10,000 1
106-96-7 Propargyl bromide 10 10
57-57-8 Propiolactone (beta-) 500 10
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CAS # NAME TPQ Pounds RQ Pounds
107-12-0 Propionitrile 500 10
542-76-7 Propionitrile, 3-chloro- 1,000 1,000
70-69-9 Propiophenone, 4’-amino 100/10,000 100
109-61-5 Propyl chloroformate 500 500
75-56-9 Propylene oxide 10,000 100
75-55-8 Propyleneimine 10,000 1
2275-18-5 Prothoate 100/10,000 100
129-00-0 Pyrene 1,000/10,000 5,000
140-76-1 Pyridine, 2-methyl-5-vinyl- 500 500
504-24-5 Pyridine, 4-amino- 500/10,000 1,000
1124-33-0 Pyridine, 4-nitro-, 1-oxide 500/10,000 500
53558-25-1 Pyriminil 100/10,000 100
14167-18-1 Salcomine 500/10,000 500
107-44-8 Sarin 10 10
7783-00-8 Selenious acid 1,000/10,000 10
7791-23-3 Selenium oxychloride 500 500
563-41-7 Semicarbazide hydrochloride 1,000/10,000 1,000
3037-72-7 Silane, (4-aminobutyl)diethoxymethyl- 1,000 1,000
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CAS # NAME TPQ Pounds RQ Pounds
7631-89-2 Sodium arsenate 1,000/10,000 1
7784-46-5 Sodium arsenite 500/10,000 1
26628-22-8 Sodium azide (Na(N3)) 500 1,000
124-65-2 Sodium cacodylate 100/10,000 100
143-33-9 Sodium cyanide (Na(CN)) 100 10
62-74-8 Sodium fluoroacetate 10/10,000 10
13410-01-0 Sodium selenate 100/10,000 100
10102-18-8 Sodium selenite 100/10,000 100
10102-20-2 Sodium tellurite 500/10,000 500
900-95-8 Stannane, acetoxytriphenyl- 500/10,000 500
57-24-9 Strychnine 100/10,000 10
60-41-3 Strychnine, sulfate 100/10,000 10
3689-24-5 Sulfotep 500 100
3569-57-1 Sulfoxide, 3-chloropropyl octyl 500 500
7446-09-5 Sulfur dioxide 500 500
7783-60-0 Sulfur tetrafluoride 100 100
7446-11-9 Sulfur trioxide 100 100
7664-93-9 Sulfuric acid 1,000 1,000
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CAS # NAME TPQ Pounds RQ Pounds
77-81-6 Tabun 10 10
7783-80-4 Tellurium hexafluoride 100 100
107-49-3 TEPP 100 10
13071-79-9 Terbufos 100 100
78-00-2 Tetraethyl lead 100 10
597-64-8 Tetraethyl tin 100 100
75-74-1 Tetramethyl lead 100 100
509-14-8 Tetranitromethane 500 10
10031-59-1 Thallium sulfate 100/10,000 100
6533-73-9 Thallous carbonate 100/10,000 100
7791-12-0 Thallous chloride 100/10,000 100
2757-18-8 Thallous malonate 100/10,000 100
7446-18-6 Thallous sulfate 100/10,000 100
2231-57-4 Thiocarbazide 1,000/10,000 1,000
39196-18-4 Thiofanox 100/10,000 100
297-97-2 Thionazin 500 100
108-98-5 Thiophenol 500 100
79-19-6 Thiosemicarbazide 100/10,000 100
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CAS # NAME TPQ Pounds RQ Pounds
5344-82-1 Thiourea, (2-chlorophenyl)- 100/10,000 100
614-78-8 Thiourea, (2-methylphenyl)- 500/10,000 500
7550-45-0 Titanium tetrachloride 100 1,000
584-84-9 Toluene-2,4-diisocyanate 500 100
91-08-7 Toluene-2,6-diisocyanate 100 100
110-57-6 trans-1,4-Dichlorobutene 500 500
1031-47-6 Triamiphos 500/10,000 500
24017-47-8 Triazofos 500 500
1558-25-4 Trichloro(chloromethyl)silane 100 100
27137-85-5 Trichloro(dichlorophenyl)silane 500 500
76-02-8 Trichloroacetyl chloride 500 500
115-21-9 Trichloroethylsilane 500 500
327-98-0 Trichloronate 500 500
98-13-5 Trichlorophenylsilane 500 500
998-30-1 Triethoxysilane 500 500
75-77-4 Trimethylchlorosilane 1,000 1,000
824-11-3 Trimethylolpropane phosphite 100/10,000 100
1066-45-1 Trimethyltin chloride 500/10,000 500
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CAS # NAME TPQ Pounds RQ Pounds
639-58-7 Triphenyltin chloride 500/10,000 500
555-77-1 Tris(2-chloroethyl)amine 100 100
2001-95-8 Valinomycin 1,000/10,000 1,000
1314-62-1 Vanadium pentoxide 100/10,000 1,000
108-05-4 Vinyl acetate monomer 1,000 5,000
81-81-2 Warfarin 500/10,000 100
129-06-6 Warfarin sodium 100/10,000 100
28347-13-9 Xylylene dichloride 100/10,000 100
1314-84-7 Zinc phosphide 500 100
58270-08-9 Zinc, dichloro(4,4-dimethyl-
5((((methylamino)carbonyl)oxy)imino)pentanenitrile)-, (T-4)-
100/10,000 100
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Appendix VI: Memorandum of Understanding - DPS & THECB Memorandum of Understanding between the Texas Department of Public safety and the Texas Higher Education Coordinating Board Pursuant to Texas Health and Safety Code, Section 481.0621 (b), the Texas Department of Public Safety (DPS) and the Texas Higher Education Coordinating Board (THECB) enter into this memorandum of understanding in order to establish the responsibilities of the DPS, the THECB, and the public or private institutions of higher education for implementing and maintaining a program for reporting information concerning controlled substances, controlled substance analogues, chemical precursors, and chemical laboratory apparatus used in education or research activities of institutions of higher education.
A. Definitions
1) Agent – any peace officer or other person who is authorized by law to enforce or administer state or federal drug laws.
2) Central Location – location within an institution of higher education where records are maintained.
3) 21 CFR, Part 1301 – 21 Code of Federal Regulations, Part 1301 to End, providing for the Registration of Manufacturers, Distributors, and Dispensers of Controlled Substances and any amendments to these regulations hereafter adopted.
4) Client – any person or entity to which DPS has issued a permit authorizing the purchase, sale, transfer or furnishing of a controlled item.
5) Controlled Glassware – condensers; distilling apparatus; vacuum dryers; single, two-and three-necked flasks; distilling flasks; Florence flasks; filter funnels; Buchner funnels; separatory funnels; Erlenmeyer flasks; round-bottom flasks; thermometer flasks; filtering flasks; Soxhlet extractors; and adapter tubes made of glass.
6) Controlled Item – precursor chemicals and laboratory apparatus listed in Texas Health and Safety Code Section 481.002 (51) and 481.002 (53) and as named by rule by the Director of the Department of Public Safety pursuant to the Texas Health and Safety Code Section 481.077(b) and 481.080(c).
The table below lists the controlled items as of September 1, 2005.
Precursor Chemicals
Laboratory Apparatus
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1. Methylamine A. Condensers
2. Ethylamine B. Distilling apparatus
3. D-lysergic acid C. Vacuum dryers
4. Ergotamine tartrate D. Three-necked flasks
5. Diethyl malonate E. Distilling flasks
6. Malonic acid F. Tableting machines
7. Ethyl malonate G. Encapsulating machines
8. Barbituric acid H. Filter funnels, Buchner funnels, and separatory funnels.
9. Piperidine I. Erlenmeyer flasks, two-necked flasks, single neck flasks, round- bottom flasks, Florence flasks, thermometer flasks, and filtering flasks
10. N-acetylanthranilic acid J. Soxhlet extractors
11. Pyrrolidine K. Transformers
12. Phenylacetic acid L. Flask heaters
13. Anthranilic acid M. Heating mantles
14. Hypophosphorus acid N. Adapter tubes
15. Ephedrine
16. Pseudoephedrine
17. Norpseudoephedrine
18. Phenylpropanolamine
19. Red phosphorus
7) (g) Controlled Substance – a substance, including a drug, an adulterant and a dilutant as defined by the Health and Safety Code, Chapter 481, the Texas Controlled Substances Act.
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8) (h) Controlled Substance Analogue – (1) a substance with a chemical structure substantially similar to the chemical structure of a controlled substance in Schedule I or II or Penalty Group 1, 1-A, or 2 of the Texas Health and Safety Code, Chapter 481, Texas Controlled Substances Act; and (2) a substance specifically designed to produce an effect substantially similar to, or greater than, the effect of a controlled substance in Schedule I or II or Penalty Group 1, 1-A, or 2 of the Texas Health and Safety Code, Chapter 481, Texas Controlled Substances Act.
9) DPS – Department of Public Safety Narcotics Service Regulatory Program that is charged with the regulation of controlled substances and items listed in this MOU.
10) Institution of Higher Education or Institution – this term includes an institution of higher education, as defined in Texas Education Code, Section 61.003(8), a private or independent institution of higher education, as defined in Texas Education Code, Section 61.003(15), and a private postsecondary educational institution, as defined in Texas Education Code, Section 61.302(2).
11) MOU – memorandum of understanding as required by the Texas Health and Safety Code, Section 481.0621(b).
12) Nar-22 – form prepared and issued by DPS Narcotics Service to clients to report sale, transfer, or furnishing of a controlled substance or item.
13) Site – a specific location at an institution where controlled items are utilized and/or stored.
14) THECB – Texas Higher Education Coordinating Board.
15) Unacceptable Discrepancy – any difference in the amount on hand and the amount documented that cannot reasonably be explained by accidental or normal loss.
B. PROCEDURES Institutions of higher education in Texas shall adopt procedures in compliance with this MOU. When requested, the DPS shall provide technical advice to the institution or site, and educational materials or presentations if funds and personnel are available.
C. RECORDS AND REPORTS
1. The site shall maintain all purchase order records, in accordance with the minimum retention requirements established by the Texas State Library and Archives Commission, of the incoming controlled substances, controlled substance analogues, precursor chemicals and laboratory apparatus (including controlled glassware) covered in this MOU that have been purchased or received by the site or central location.
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2. An institution or site that discovers a readily unacceptable discrepancy, loss, pilferage or theft of a controlled substance, controlled substance analogue, precursor chemical or laboratory apparatus (including controlled glassware) shall submit a written report of the incident to the appropriate law enforcement agency no later than 5 business days after the date of discovery of the discrepancy, loss, pilferage or theft. The institution shall forward the report to DPS within 5 additional business days after the report is submitted to the appropriate law enforcement agency.
3. Upon request, the DPS shall assist the law enforcement agency conducting an investigation regarding the pilferage or theft of the controlled substance, precursor chemical, or laboratory apparatus named in this MOU.
4. The DPS may request that an institution or site provide a duplicate of any record(s) covered by this MOU and the institution or site shall provide such record(s) within 10 business days of the request. The record(s) may be provided in electronic or hard copy form.
D. SALE, TRANSFER OR FURNISHING OF CONTROLLED ITEMS
1. The institution or site shall prohibit the sale, furnishings, or transfer of controlled items, including glassware, covered by this MOU to any person or entity not holding a DPS permit, unless the recipient is specifically exempted by law or rule.
2. The institution shall report to the DPS on a Nar-22 form or any form mutually agreed upon by all parties, every sale, furnishing or transfer of a controlled item leaving the institution. The site shall submit these reports to the DPS within 30 days of the furnishing or transfer of the controlled items. This report shall include the name, address, telephone number, permit number (if applicable), driver license number, and date of birth of the client receiving the controlled items.
E. CONTROLLED SUBSTANCES AND CONTROLLED SUBSTANCE ANALOGUES
1. The institution or site is responsible for complying with the established procedures as required in 21 CFR, Part 1301 to End and as required by any amendments to 21 CFR Part 1301.
2. Upon request, the DPS shall provide technical advice to the institution or site regarding the inventories required in 21 CFR, Part 1301 to End.
3. Upon request, the DPS shall assist the law enforcement agency conducting any investigation regarding any significant loss, pilferage or theft of the controlled substances or controlled items contained in this MOU.
F. AUDITS AND INSPECTIONS
The institution or site shall permit any DPS agent to conduct audits and inspections of all records made in accordance with the MOU at any reasonable time and shall not interfere with the discharge of the agent’s duties.
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G. SECURITY AND STORAGE
The institution or site shall ensure the security of the controlled items by cost-effective means that afford a reasonable sense of safety and accountability, such as electronic records keeping and physical security. In addition, the institution or site shall require that the controlled substances and precursor chemicals are stored in accordance with recommendations of the manufacturer, the Texas Commission on Environmental Quality and the Federal Environmental Protection Agency.
H. CONTACT PERSON(S)
Each institution or site shall appoint one or more individuals, as needed, to be responsible for implementing the security measures established by the institution or site. The institution shall annually provide a list of these individuals to the DPS and shall ensure that these individuals serve as the contact between the institution and the DPS. The initial list of contact persons shall be provided within ninety (90) days after the effective date of this Memorandum of Understanding.
The general provisions of this Memorandum of Understanding shall be effective on the date of signature by representatives of both parties. This agreement, upon review of both parties, may be amended by written agreement whenever such action is necessary.
I. Suggestions for Implementing MOU Procedures
1. Notify all personnel involved with environmental and safety issues about the MOU.
2. Notify all science and health laboratory personnel about the MOU.
3. Provide information to appropriate personnel regarding the potential problem of diversion of laboratory chemicals and apparatus to illegal drug operations.
4. Notify the Department of Public Safety (DPS) of the person designated to act as the liaison between the institution and the DPS.
5. Notify all personnel involved in the sale or transfer of surplus equipment that none of the precursor chemicals or laboratory apparatus, including glassware, listed as controlled items in the MOU should be sold or otherwise transferred to anyone who does not have the proper permit or the specific authority to purchase or accept the
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controlled items. Personnel involved in the transfer or sale of these items should be provided with copies of the Nar-22 form, which should be used to report the sale, transfer, or furnishing of the listed precursor chemicals or laboratory apparatus. Any party involved in an auction of surplus equipment should be informed of the MOU.
6. Establish procedures to assure an appropriate level of security for controlled items in educational and research laboratories and storerooms. Designate an individual to be responsible for establishing security measures.
7. Encourage all personnel to be alert and attentive to the disappearance of any of the controlled items and to report losses to the institution’s contact person for controlled substances.
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Appendix VII: UTSA Policy on Controlled Substance Use in Research
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Review and Signature Page
This policy has been reviewed for regulatory compliance and best management practices by the undersigned individuals and is hereby adopted for use and compliance by all employees at the University of Texas at San Antonio. Printed Name Signature Title Date James Weaver Signature on file Director, Institutional
Compliance and Risk 1/30/09
J. Brian Moroney Signature on file Director, EHSRM 1/30/09
Wendy McCoy Signature on file Laboratory Safety Manger
1/30/09
Review Date
Signature of Director of EHSRM May 20, 2011
Signature on file
This plan was reviewed/revised on 5/20/2011 and replaces the 5/28/2008 version. Changes to this plan have been highlighted in “gray” and are summarized below: Throughout: Laboratory Safety Officer (LSO) has been updated to Laboratory Safety
Manager (LSM). (not highlighted) VIII: Intra-facility Tranfers has been revised. IX: More information on the Form 41 has been provided. XI: The website has been updated. Appendix B: The inventory form has been updated. Appendix C: A new question has been added to the checklist.
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Table of Contents I. Purpose and Scope 4
II. Application and Licensing 4 III. Committee Approval 5 IV. Ordering Controlled Substances 5 V. Delivery and Receiving 6 VI. Storage and Security 6 VII. Appointing a Designee 7 VIII. Intra-facility Transfers 7 IX. Disposal 8 X. Abandoned Controlled Substances 8 XI. Schedules of Controlled Substances 8 Appendix A Designee Letter 9 Appendix B Inventory Form 11 Appendix C Inspection Checklist 13
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I. Purpose and Scope Through a Memorandum of Understanding (MOU) between the Texas Higher Education Coordinating Board and the Texas Department of Public Safety (TDPS), UTSA researchers are allowed to use controlled substances in their research on campus under the conditions listed in this policy. A controlled substance is defined in 21 U.S.C. 802, section 102 as, “a drug or other substance, or immediate precursor, included in Schedules I, II, III, IV, or V of part B of this subchapter. The term does not include distilled spirits, wine, malt beverages, or tobacco, as those terms are defined or used in subtitle E of the Internal Revenue Code of 1986.” The regulations for controlled substances may be found in Title 21 of the Code of Federal Regulations – Food and Drug Administration, Chapter 2 – Drug Enforcement Administration (DEA), Department of Justice, Parts 1300-1316 (21 CFR §1300-1316). No Principle Investigator (PI or Licensee) may use controlled substances on campus for research purposes until they have obtained licenses from the DEA and TDPS and these licenses have been registered with the UTSA Office of Environmental Health, Safety and Risk Management (EHSRM) and the Laboratory Safety Manger (LSM). II. Application and Licensing The PI must first obtain federal licensure from the DEA. The application can be obtained from the DEA website. Prior to applying, certain documentation is needed for an interview with DEA. This documentation may need to be submitted to the local DEA office and should be on hand prior to an interview. Information packets on this documentation and the application process are available in EHSRM from the LSM. First time applications and reapplication after a period of non-licensure will most likely require a phone interview by the local DEA office and possibly an inspection. Licenses must be renewed on a yearly basis. DEA will send out renewal documentation/notices a few months prior to the expiration of the license. If no changes are necessary, including controlled substance listings, then the renewal can be done online. A copy of the completed online renewal form should be printed out and kept with the PI’s controlled substance records. A copy of this renewal form must be sent to EHSRM immediately. Initial and paper renewal applications for the DEA license must be routed through the office of the Vice President for Business Affairs (VPBA) via the Senior Administrative Assistant. The application will be sent to the UTSA Police Department (UTSA-PD) and to EHSRM for their approval. After approval and signature by the VPBA or AVPBA as the certifying official, the application is returned to the PI to be forwarded to DEA. Once the DEA license is obtained, the PI must apply to the Texas Department of Public Safety (TDPS) for state licensure. This application will then be routed for processing and approval in the same manner as the DEA application. TDPS sends out renewal forms a few months prior to the renewal deadline. As with the DEA license, the TDPS
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license must be renewed on a yearly basis. Once the application is approved by the TDPS and both licenses are in place in the laboratory and a readable copy of each has been provided to EHSRM, the PI may order controlled substances as allowed by the licenses. Licenses are issued for specific schedules of controlled substances and only the specified items on the specific schedules may be ordered. If an item not specified on the license is needed, the PI must contact the local DEA office to add this item to the license and get approval before an order can be placed. Compliance with all federal regulations is solely the responsibility of the licensee. Failure to comply can result fines of up to $10,000 per item. Failure to comply can also result in loss of license or imprisonment. III. Committee Approval All research involving controlled substances must be approved by the appropriate committee prior to the start of any project. The PI must obtain appropriate committee approval prior to the start of any project.
• The Institutional Animal Use and Care Committee (IACUC) must approve research projects involving animals and controlled substances.
• The Institutional Review Board (IRB) must approve research projects involving humans and controlled substances.
According to the scope of these projects, approval of the Institutional Biosafety Committee (IBC) and/or the Chemical Safety Committee (CSC) may be required as well. The institutional Laboratory Safety Committee (LSC) has oversight for compliance with federal, state, local and UTSA regulations and policies pertaining to laboratories including work with controlled substances. IV. Ordering Controlled Substances Prior to placing a first order for controlled substances, the licensee should contact EHSRM to set up an appointment with the LSM to review UTSA procedures and some of the federal regulations pertinent to inventory and storage. The LSM strives to stay updated on pertinent federal regulations, but in no way should be the only source of information utilized by a licensee. The licensee has the sole responsibility for compliance with federal regulations and is subject to penalties and fines if not in compliance. All purchase orders (PBOs, PB4s) for controlled substances must utilize the commodity code 190-36. Use of this commodity code will route the order to EHSRM for approval. Failure to use this code may result in disciplinary action. The individual placing the order will require the vendor to label the package directly to the PI and to ensure the packing slip is secured to the outside of the package. A Form 222 must be sent to the vendor when placing orders for Schedule I or II controlled substances. Form 222 must be obtained from DEA in advance. EHSRM will verify that the PI has a current license, and provide to the PI and any other appropriate University offices any additional direction regarding the order that may be required. The requestor must be the person who holds the licenses for use of controlled
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substances. A designee is not allowed to place controlled substance orders for approval. Proper labeling on the box will indicate that only the addressee (licensed PI) should open the box. No purchases of controlled substances may be made using a Procard or personal credit card. Such use can result in revocation of Procard privileges or other actions. V. Delivery and Receiving All controlled substance orders will be delivered to Central Receiving Warehouse (CRW). EHSRM will inform CRW personnel when the order is placed as well as anticipated delivery date and any information necessary to identify the package, including PO number, PI, and vendor. Proper labeling on the box will indicate that only the addressee should open the box. CRW personnel will lock the package in a secure location and contact the PI. The PI or approved designee must go to CRW in person to pick up the package and be prepared to present a valid UTSA ID or Texas driver’s license picture identification card. A designee as described in section VII may pick up the package if proper documentation has been provided to CRW and EHSRM in advance of ordering. A designee must be approved in advance by EHSRM. Upon receipt of the package the addressee must provide the necessary receipt documentation to the CRW personnel including a signature. The PI or designee will open the package and confirm the amount received in the presence of CRW personnel. CRW personnel will serve as a witness and will document and verify shipment content by providing a signature on the packing slip. The PI or designee must also sign the packing slip. Any discrepancy must be annotated on the packing slip. VI. Storage and Security Once the controlled substance is released to the PI or designee, it must be taken directly to the laboratory and secured in accordance with DEA regulations. Exact inventories with annotations of amounts received and amounts used along with the dates used must be kept in the laboratory. Biennial Inventories must be done at least every two years. It is strongly recommended that these “biennial” inventories be done more frequently such as quarterly. Audits of the inventories will be conducted periodically by the university Compliance Office, IACUC, and/or EHSRM. The use of the UTSA Controlled Substance Inventory form is mandatory (Appendix B). The controlled substance must be secured at all times when not in use in the laboratory. The University Compliance Office, IACUC and/or EHSRM personnel will review the storage location and security precautions during their periodic audits – any suspected security issues noted will be reported to UTSA-PD for advice and consultation with the license holder as well as the Laboratory Safety Committee. The laboratory itself must be secured at all times when unoccupied. Only the licensed PI, or designee as appointed in section VII, should have access to the storage area. No extra keys or lock combinations can be given out other than to the designee. Any known or suspected theft should be reported immediately to the UTSA-PD. The LSM should also be contacted immediately. At no time should students be given unsupervised access to controlled substances.
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VII. Appointing a Designee At their discretion, the licensee can designate one other person to have access to the storage area and carry out other functions except ordering of controlled substances. This person must be a staff member. To designate this individual, the licensee must fill out a “Power of Attorney” letter. An example letter is given in Appendix A of this document. This letter must be stored with the controlled substances and provided to DEA at their request. Copies must be provided to the LSM, Central Receiving Warehouse (CRW), and UTSA-PD. If a person is being removed as a designee, for whatever reason, the LSM, CRW, and UTSA-PD must be notified immediately (within 24 hours) by email or phone. VIII. Intra-facility Transfers The DEA has recommended against intra-facility transfers. The Laboratory Safety Manager (LSM) can provide alternatives according to the situation. Prior to undertaking any transfer, please contact the LSM. IX. Disposal UTSA has been granted permission by DEA to dispose of controlled substances through a registered chemical waste stream. The approved procedure involves the PI, the local DEA office, UTSA-PD and EHSRM. Appropriate notice must be given to the LSM whenever disposal using this procedure is needed. The LSM will coordinate the arrangements for disposal and acquire the necessary DEA documentation. EHSRM will submit a form 41 request for disposal to the DEA on behalf of the PI. In order to submit this form, EHSRM will need the name of the drug, number of containers, concentration and amount of each drug requested for disposal. Upon pick up for disposal, the PI will sign the form 41. After disposal has occurred, the person carrying out the disposal and the witnessing police officer will sign the form 41. Copies of the signed form will be provided to DEA, the PI, UTSA-PD and to EHSRM. A copy of each form 41 shall be added to a PI’s controlled substance inventory logbook as proof of such disposal. The other approved option for disposal is utilizing a reverse distributor. In no case may controlled substances be disposed of by any other methods. X. Abandoned Controlled Substances A PI cannot abandon a controlled substance. Such abandonment is subject to DEA fines and penalties. Any controlled substances found abandoned in research laboratories will be turned over to UTSA-PD for storage. The licensed PI will be contacted to arrange proper disposal. If UTSA is unable to contact the PI or if the PI does not arrange for proper disposal within seven (7) days of being contacted by UTSA, UTSA will contact the DEA. The DEA may take criminal and other action against the licensee.
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XI. Schedules of Controlled Substances Schedules I-V for controlled substances (The term “listed chemical” means any list I chemical or any list II chemical) may be obtained at the following link: http://www.deadiversion.usdoj.gov/schedules/#list
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Appendix A
Designee Letter
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Controlled Substance Designee Letter As a controlled substance licensee, I designate _______________________________ to carry out all needed actions in regard to the use of controlled substances in my laboratory with the exception of ordering. This person is allowed to have access to the storage location, provide dilutions to other lab personnel for immediate use in their work, properly administer the substances to animals, update inventory records, pick-‐up orders of controlled substances from Central Receiving Warehouse and any other actions as needed except as noted above. DEA License #_______________________ TDPS License#___________________________ Licensee’s Name (Print) __________________________________________ Licensee’s Signature _____________________________________________ Date_______________________________ As a designee, I understand the federal, state, local and UTSA regulations, policies, and procedures in regards to the use of controlled substances in research on campus. I am aware that failure to comply with these regulations, policies, and procedures could result in disciplinary actions up to and including termination, fines, criminal penalties and other actions. I understand that I cannot order controlled substances. Designee’s Job Title _________________________________ Designee’s Name (Print) _______________________________ Designee’s Signature _________________________________ Date _____________________________________ This designation of authority ends with separation of the designee from UTSA or upon leaving employment with the licensee. Original must be stored with controlled substance inventory. Copies must be provided to LSM, Designee, UTSA Police Department, and Warehouse Manager.
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Appendix B
Inventory Form
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Appendix C: Inspection Checklist Items
1. Is access to Lab area secured? 2. Are the controlled substance(s) properly
secured?
Security & Access
3. Is access to controlled substance(s) limited to the licensee and designee (if applicable)?
4. Are DEA and TDPS licenses current? 5. Is storage limited to the controlled substance(s),
their records, and inventories? 6. Is documentation of orders available, including
Form 222 if pertinent?
License & Inventory
7. Is an initial inventory available? 8. Is a biennial inventory available? 9. When was the biennial inventory conducted?
10. Is the biennial inventory properly annotated? 11. Is the inventory updated on a daily basis or as
the controlled substance is used? 12. Does the physical inventory match the written
inventory?
13. Is a designee letter available? 14. Has there been a loss or theft of a controlled
substance on site? 15. If a theft or loss has occurred is the appropriate
documentation available?
Theft & Disposal
16. Is a Form 41 available for disposal of controlled substances?
Transfer 17. Have any intra-facility transfers occurred? 18. Is the appropriate documentation available for
any transfers? Other 19. Any additional concerns or observations?
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Appendix VIII. Drug Scheduling This document is a general reference and not a comprehensive list. This list describes the basic or parent chemical and does not describe the salts, isomers and salts of isomers, esters, ethers and derivatives which may also be controlled substances.
Schedule I
Substance DEA Number
Non Narcotic Other Names
1-(1-Phenylcyclohexyl)pyrrolidine 7458 N PCPy, PHP, rolicyclidine 1-(2-Phenylethyl)-4-phenyl-4acetoxypiperidine
9663 PEPAP, synthetic heroin
1-[1-(2-Thienyl)cyclohexyl]piperidine 7470 N TCP, tenocyclidine 1-[1-(2-Thienyl)cyclohexyl]pyrrolidine 7473 N TCPy 1-Methyl-4-phenyl-4-propionoxypiperidine
9661 MPPP, synthetic heroin
2,5-Dimethoxy-4-ethylamphetamine 7399 N DOET 2,5-Dimethoxyamphetamine 7396 N DMA, 2,5-DMA 3,4,5-Trimethoxyamphetamine 7390 N TMA 3,4-Methylenedioxyamphetamine 7400 N MDA, Love Drug 3,4-Methylenedioxymethamphetamine 7405 N MDMA, Ecstasy, XTC 3,4-Methylenedioxy-N-ethylamphetamine
7404 N N-ethyl MDA, MDE, MDEA
3-Methylfentanyl 9813 China White, fentanyl 3-Methylthiofentanyl 9833 Chine White, fentanyl 4-Bromo-2,5-dimethoxyamphetamine 7391 N DOB, 4-bromo-DMA 4-Bromo-2,5-dimethoxyphenethylamine
7392 N Nexus, 2-CB, has been sold as Ecstasy, i.e. MDMA
4-Methoxyamphetamine 7411 N PMA 4-Methyl-2,5-dimethoxyamphetamine 7395 N DOM, STP 4-Methylaminorex (cis isomer) 1590 N U4Euh, McN-422 5-Methoxy-3,4methylenedioxyamphetamine
7401 N MMDA
Acetorphine 9319 Acetyl-alpha-methylfentanyl 9815 Acetyldihydrocodeine 9051 Acetylcodone Acetylmethadol 9601 Methadyl acetate Allylprodine 9602 Alphacetylmethadol except levoalphacetylmethadol
9603
Alpha-Ethyltryptamine 7249 N ET, Trip Alphameprodine 9604 Alphamethadol 9605 Alpha-Methylfentanyl 9814 China White, fentanyl Alpha-Methylthiofentanyl 9832 China White, fentanyl Aminorex 1585 N has been sold as methamphetamine Benzethidine 9606
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Benzylmorphine 9052 Betacetylmethadol 9607 Beta-Hydroxy-3-methylfentanyl 9831 China White, fentanyl Beta-Hydroxyfentanyl 9830 China White, fentanyl Betameprodine 9608 Betamethadol 9609 Betaprodine 9611 Bufotenine 7433 N Mappine, N,N-dimethylserotonin Cathinone 1235 N Constituent of “Khat” plant Clonitazene 9612 Codeine methylbromide 9070 Codeine-N-oxide 9053 Cyprenorphine 9054 Desomorphine 9055 Dextromoramide 9613 Palfium, Jetrium, Narcolo Diampromide 9615 Diethylthiambutene 9616 Diethyltryptamine 7434 N DET Difenoxin 9168 Lyspafen Dihydromorphine 9145 Dimenoxadol 9617 Dimepheptanol 9618 Dimethylthiambutene 9619 Dimethyltryptamine 7435 N DMT Dioxaphetyl butyrate 9621 Dipipanone 9622 Dipipan, phenylpiperone HCl, Diconal, Wellconal
Drotebanol 9335 Metebanyl, oxymethebanol Ethylmethylthiambutene 9623 Etonitazene 9624 Etorphine (except HCl) 9056 Etoxeridine 9625 Fenethylline 1503 N Captagon,amfetyline,ethyltheophylline amphetamine
Furethidine 9626 Gama Hydroxybutyric Acid (GHB) 2010 N GHB, gama hydroxybutyrate, sodium oxybate
Heroin 9200 Diacetylmorphine, diamorphine Hydromorphinol 9301 Hydroxypethidine 9627 Ibogaine 7260 N Constituent of “Tabernanthe iboga” plant Ketobemidone 9628 Cliradon Levomoramide 9629 Levophenacylmorphan 9631 Lysergic acid diethylamide 7315 N LSD, lysergide Marijuana 7360 N Cannabis, marijuana
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Mecloqualone 2572 N Nubarene Mescaline 7381 N Constituent of “Peyote” cacti Methaqualone 2565 N Quaalude, Parest, Somnafac, Opitimil, Mandrax
Methcathinone 1237 N N-Methylcathinone, “cat” Methyldesorphine 9302 Methyldihydromorphine 9304 Morpheridine 9632 Morphine methylbromide 9305 Morphine methylsulfonate 9306 Morphine-N-oxide 9307 Myrophine 9308 N,N-Dimethylamphetamine 1480 N N-Ethyl-1-phenylcyclohexylamine 7455 N PCE N-Ethyl-3-piperidyl benzilate 7482 N JB 323 N-Ethylamphetamine 1475 N NEA N-Hydroxy-3,4methylenedioxyamphetamine
7402 N N-hydroxy MDA
Nicocodeine 9309 Nicomorphine 9312 Vilan N-Methyl-3-piperidyl benzilate 7484 N JB 336 Noracymethadol 9633 Norlevorphanol 9634 Normethadone 9635 Phenyldimazone Normorphine 9313 Norpipanone 9636 Para-Fluorofentanyl 9812 China White, fentanyl Parahexyl 7374 N Synhexyl, Peyote 7415 N Cactus which contains mescaline Phenadoxone 9637 Phenampromide 9638 Phenomorphan 9647 Phenoperidine 9641 Operidine, Lealgin Pholcodine 9314 Copholco, Adaphol, Codisol, Lantuss, Pholcolin
Piritramide 9642 Piridolan Proheptazine 9643 Properidine 9644 Propiram 9649 Algeril Psilocybin 7437 N Constituent of “Magic mushrooms” Psilocyn 7438 N Psilocin, constituent of “Magic mushrooms” Racemoramide 9645 Tetrahydrocannabinols 7370 N THC, Delta-8 THC, Delta-9 THC and others
Thebacon 9315 Acetylhydrocodone, Acedicon, Thebacetyl Thiofentanyl 9835 Chine white, fentanyl
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Tilidine 9750 Tilidate, Valoron, Kitadol, Lak, Tilsa Trimeperidine 9646 Promedolum
Schedule II 1-Phenylcyclohexylamine 7460 N Precusor of PCP 1-Piperidinocyclohexanecarbonitrile 8603 N PCC, precusor of PCP Alfentanil 9737 Alfenta Alphaprodine 9010 Nisentil Amobarbital 2125 N Amytal, Tuinal Amphetamine 1100 N Dexedrine, Biphetamine Anileridine 9020 Leritine Benzoylecgonine 9180 Cocaine metabolite Bezitramide 9800 Burgodin Carfentanil 9743 Wildnil Coca Leaves 9040 Cocaine 9041 Methyl benzoylecgonine, Crack Codeine 9050 Morphine methyl ester, methyl morphine Dextropropoxyphene, bulk (non-dosage forms)
9273 Propoxyphene
Dihydrocodeine 9120 Didrate, Parzone Diphenoxylate 9170 Diprenorphine 9058 M50-50 Ecgonine 9180 Cocaine precursor, in Coca leaves Ethylmorphine 9190 Dionin Etorphine HCl 9059 M 99 Fentanyl 9801 Innovar, Sublimaze, Duragesic
Glutethimide 2550 N Doriden, Dorimide Hydrocodone 9193 dihydrocodeinone Hydromorphone 9150 Dilaudid, dihydromorphinone Isomethadone 9226 Isoamidone Levo-alphacetylmethadol 9648 LAAM, long acting methadone, levomethadyl acetate
Levomethorphan 9210 Levorphanol 9220 Levo-Dromoran Meperidine 9230 Demerol, Mepergan, pethidine Meperidine intermediate-A 9232 Meperidine precursor Meperidine intermediate-B 9233 Meperidine precursor Meperidine intermediate-C 9234 Meperidine precursor Metazocine 9240 Methadone 9250 Dolophine, Methadose, Amidone Methadone intermediate 9254 Methadone precursor Methamphetamine 1105 N Desoxyn, D-desoxyephedrine, ICE, Crank, Speed
Methylphenidate 1724 N Ritalin Metopon 9260 Moramide-intermediate 9802
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Morphine 9300 MS Contin, Roxanol, Duramorph, RMS, MSIR
Nabilone 7379 N Cesamet Opium extracts 9610 Opium fluid extract 9620 Opium poppy 9650 Papaver somniferum Opium tincture 9630 Laudanum Opium, granulated 9640 Granulated opium Opium, powdered 9639 Powdered Opium Opium, raw 9600 Raw opium, gum opium Oxycodone 9143 OxyContin, Percocet, Tylox, Roxicodone, Roxicet,
Oxymorphone 9652 Numorphan Pentobarbital 2270 N Nembutal Phenazocine 9715 Narphen, Prinadol Phencyclidine 7471 N PCP, Sernylan Phenmetrazine 1631 N Preludin Phenylacetone 8501 N P2P, phenyl-2-propanone, benzyl methyl ketone
Piminodine 9730 Poppy Straw 9650 Opium poppy capsules, poppy heads Poppy Straw Concentrate 9670 Concentrate of Poppy Straw, CPS Racemethorphan 9732 Racemorphan 9733 Dromoran Remifentanil 9739 Ultiva Secobarbital 2315 N Seconal, Tuinal Sufentanil 9740 Sufenta Thebaine 9333 Precursor of many narcotics
Schedule III Amobarbital & noncontrolled active ingred.
2126 N Amobarbital/ephedrine capsules
Amobarbital suppository dosage form 2126 N Anabolic steroids 4000 N “Body Building” drugs Aprobarbital 2100 N Alurate Barbituric acid derivative 2100 N Barbiturates not specifically listed Benzphetamine 1228 N Didrex, Inapetyl Boldenone 4000 N Equipoise, Parenabol, Vebonol, dehydrotestosterone
Buprenorphine 9064 Buprenex, Temgesic Butabarbital 2100 N Butisol, Butibel Butalbital 2100 N Fiorinal, Butalbital with aspirin Chlorhexadol 2510 N Mechloral, Mecoral, Medodorm, Chloralodol
Chlorotestosterone (same as clostebol) 4000 N if 4-chlorotestosterone then clostebol Chlorphentermine 1645 N Pre-Sate, Lucofen, Apsedon, Desopimon Clortermine 1647 N Voranil
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Clostebol 4000 N Alfa-Trofodermin, Clostene, 4chlorotestosterone
Codeine & isoquinoline alkaloid 90 mg/du
9803 Codeine with papaverine or noscapine
Codeine combination product 90 mg/du 9804 Empirin, Fiorinal, Tylenol, ASA or APAP w/codeine
Dehydrochlormethyltestosterone 4000 N Oral-Turinabol Dihydrocodeine combination product 90 mg/du
9807 Synalgos-DC, Compal
Dihydrotestosterone (same as stanolone)
4000 N see stanolone
Dronabinol in sesame oil in soft gelatin capsule
7369 N Marinol, synthetic THC in sesame oil/soft gelatin
Drostanolone 4000 N Drolban, Masterid, Permastril Ethylestrenol 4000 N Maxibolin, Orabolin, Durabolin-O, Duraboral
Ethylmorphine combination product 15 mg/du
9808
Fluoxymesterone 4000 N Anadroid-F, Halotestin, Ora-Testryl Formebolone (incorrect spelling in law) 4000 N Esiclene, Hubernol Hydrocodone & isoquinoline alkaloid 15 mg/du
9805 Dihydrocodeinone+papaverine or noscapine
Hydrocodone combination product 15 mg/du
9806 Tussionex, Tussend, Lortab, Vicodin, Hycodan, Anexsia ++
Ketamine 7285 N Ketaset, Ketalar, Special K, K Lysergic acid 7300 N LSD precursor Lysergic acid amide 7310 N LSD precursor Mesterolone 4000 N Proviron Methandienone (see Methandrostenolone)
4000 N
Methandranone 4000 N ?incorrect spelling of methandienone? Methandriol 4000 N Sinesex, Stenediol, Troformone Methandrostenolone 4000 N Dianabol, Metabolina, Nerobol, Perbolin Methenolone 4000 N Primobolan, Primobolan Depot, Primobolan S
Methyltestosterone 4000 N Android, Oreton, Testred, Virilon Methyprylon 2575 N Noludar Mibolerone 4000 N Cheque Morphine combination product/50 mg/100 ml or gm
9810
Nalorphine 9400 Nalline Nandrolone 4000 N Deca-Durabolin, Durabolin, Durabolin-50 Norethandrolone 4000 N Nilevar, Solevar Opium combination product 25 mg/du 9809 Paregoric, other combination products Oxandrolone 4000 N Anavar, Lonavar, Provitar, Vasorome Oxymesterone 4000 N Anamidol, Balnimax, Oranabol, Oranabol 10
Oxymetholone 4000 N Anadrol-50, Adroyd, Anapolon, Anasteron, Pardroyd
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Pentobarbital & noncontrolled active ingred.
2271 N FP-3
Pentobarbital suppository dosage form 2271 N WANS Phendimetrazine 1615 N Plegine, Prelu-2, Bontril, Melfiat, Statobex Secobarbital & noncontrolled active ingred
2316 N various
Secobarbital suppository dosage form 2316 N various Stanolone 4000 N Anabolex, Andractim, Pesomax, dihydrotestosterone
Stanozolol 4000 N Winstrol, Winstrol-V Stimulant compounds previously excepted
1405 N Mediatric
Sulfondiethylmethane 2600 N Sulfonethylmethane 2605 N Sulfonmethane 2610 N Talbutal 2100 N Lotusate Testolactone 4000 N Teslac Testosterone 4000 N Android-T, Androlan, Depotest, Delatestryl Thiamylal 2100 N Surital Thiopental 2100 N Pentothal Tiletamine & Zolazepam Combination Product
7295 N Telazol
Trenbolone 4000 N Finaplix-S, Finajet, Parabolan Vinbarbital 2100 N Delvinal, vinbarbitone Schedule IV Alprazolam 2882 N Xanax Barbital 2145 N Veronal, Plexonal, barbitone Bromazepam 2748 N Lexotan, Lexatin, Lexotanil Butorphanol 9720 N Stadol, Stadol NS, Torbugesic, Torbutrol Camazepam 2749 N Albego, Limpidon, Paxor Cathine 1230 N Constituent of “Khat” plant Chloral betaine 2460 N Beta Chlor Chloral hydrate 2465 N Noctec Chlordiazepoxide 2744 N Librium, Libritabs, Limbitrol, SK-Lygen Clobazam 2751 N Urbadan, Urbanyl Clonazepam 2737 N Klonopin, Clonopin Clorazepate 2768 N Tranxene Clotiazepam 2752 N Trecalmo, Rize Cloxazolam 2753 N Enadel, Sepazon, Tolestan Delorazepam 2754 N Dexfenfluramine 1670 N Redux Dextropropoxyphene dosage forms 9278 Darvon, propoxyphene, Darvocet, Dolene, Propacet
Diazepam 2765 N Valium, Valrelease Dichloralphenazone 2467 N Midrin, dichloralantipyrine Diethylpropion 1610 N Tenuate, Tepanil Difenoxin 1 mg/25 ug AtSO4/du 9167 Motofen Estazolam 2756 N ProSom, Domnamid, Eurodin, Nuctalon
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Ethchlorvynol 2540 N Placidyl Ethinamate 2545 N Valmid, Valamin Ethyl loflazepate 2758 N Fencamfamin 1760 N Reactivan Fenfluramine 1670 N Pondimin, Ponderal Fenproporex 1575 N Gacilin, Solvolip Fludiazepam 2759 N Flunitrazepam 2763 N Rohypnol, Narcozep, Darkene, Roipnol Flurazepam 2767 N Dalmane Halazepam 2762 N Paxipam Haloxazolam 2771 N Ketazolam 2772 N Anxon, Loftran, Solatran, Contamex Loprazolam 2773 N Lorazepam 2885 N Ativan Lormetazepam 2774 N Noctamid Mazindol 1605 N Sanorex, Mazanor Mebutamate 2800 N Capla Medazepam 2836 N Nobrium Mefenorex 1580 N Anorexic, Amexate, Doracil, Pondinil Meprobamate 2820 N Miltown, Equanil, Deprol, Equagesic, Meprospan
Methohexital 2264 N Brevital Methylphenobarbital (mephobarbital) 2250 N Mebaral, mephobarbital Midazolam 2884 N Versed Modafinil 1680 N Provigil Nimetazepam 2837 N Erimin Nitrazepam 2834 N Mogadon Nordiazepam 2838 N Nordazepam, Demadar, Madar Oxazepam 2835 N Serax, Serenid-D Oxazolam 2839 N Serenal, Convertal Paraldehyde 2585 N Paral Pemoline 1530 N Cylert Pentazocine 9709 N Talwin, Talwin NX, Talacen, Talwin Compound
Petrichloral 2591 N Pentaerythritol chloral, Periclor Phenobarbital 2285 N Luminal, Donnatal, Bellergal-S Phentermine 1640 N Ionamin, Fastin, Adipex-P, Obe-Nix, Zantryl
Pinazepam 2883 N Domar Pipradrol 1750 N Detaril, Stimolag Fortis Prazepam 2764 N Centrax Quazepam 2881 N Doral, Dormalin Sibutramine 1675 N Meridia SPA 1635 N 1-dimethylamino-1,2-diphenylethane, Lefetamine
Temazepam 2925 N Restoril Tetrazepam 2886 N
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Triazolam 2887 N Halcion Zaleplon 2781 N Sonata Zolpidem 2783 N Ambien, Stilnoct,Ivadal
Schedule V Codeine preparations - 200 mg/100 ml or 100 gm
Cosanyl,Robitussin AC,Cheracol,Cerose,Pediacof
Difenoxin preparations - 0.5 mg/25 ug AtSO4/du
Motofen
Dihydrocodeine preparations 10 mg/100 ml or 100 gm
Cophene-S, various others
Diphenoxylate preparations 2.5 mg/25 ug AtSO4
Lomotil, Logen
Ethylmorphine preparations 100 mg/100 ml or 100 gm
Opium preparations - 100 mg/100 ml or gm
Parepectolin, Kapectolin PG, Kaolin Pectin P.G.
Pyrovalerone 1485 N Centroton, Thymergix
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Appendix IX: Liquid Nitrogen Storage and Use
I. Liquid Nitrogen (LN2) A A. Description
Liquid nitrogen, often abbreviated as LN2, is an inert, odorless, stable cryogenic chemical. Nitrogen makes up almost 80% of the atmosphere however, it is not life supporting
B. Physical Properties
1. Molecular weight: 28.01
2. Boiling pint @ 1 amt.: -320.5ºF, -195.8ºC, 77K
3. Expansion ratio: 1 to 696.5
4. Liquid Density: 50.7 lb/ft³
5. Specific Gravity: 0.967
6. Color: None
C. Uses
Liquid nitrogen is mainly used to cryogenically store laboratory materials, including but not limited to cell, substrates and biological agents.
II. Handling and Storage
A. PPE required 2. Full face shield and goggles
3. Thermal insulated or leather gloves that should be loose fitting so they are able to
removed quickly if necessary.
4. Long sleeved clothing and pants
5. Closed-toe shoes
B. Standard Operating Procedure for Removing Items form Liquid Nitrogen 2. Always wear appropriate PPE when using liquid nitrogen or cryogenic containers.
3. Work in an open, well-ventilated location and NEVER directly over an open vat of
liquid nitrogen
4. Boiling and splashing can occur when inserting objects into cryogenic liquids such as nitrogen. Perform these tasks slowly to minimize splashing.
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. 5. Use tongs to withdraw objects immersed in liquid nitrogen.
6. Do not touch anything that has been immersed in liquid nitrogen until it has reached room temperature.
C. Standard Operating Procedure for transferring Liquid Nitrogen
1. Use a special separator or special filling funnel to prevent splashing and spilling when transferring liquid nitrogen into or from a dewar. The top of the funnel should be partly covered to reduce splashing
2. Use only small, easily handled dewars for pouring liquid.
3. Use only fitted transfer tubes designed for use with dewar containers. Cracked or damaged insulation on transfer tubes should be replaced.
4. Do not pour liquid while holding secondary container. The container should be on a stable stand or hung so that the transfer tube rests securely on the neck of the secondary container.
D. Storage
1. Do not store in a confined space.
2. Never allow any unprotected part of the body to come into contact with uninsulated pipes or equipment that contains liquid nitrogen.
3. Do not drop, tip or roll containers on their sides.
4. Do not remove or interchange connections.
5. Do not use adapters.
E. Containers
Liquid nitrogen containers are insulated, vacuum-jacketed pressure vessels. They are equipped with relief valves and rupture discs to protect against pressure build up. NEVER CLOSE RELIEF VALVES. The containers operate at pressures up to 250 psig. They can hold from 80 to 450 liters of liquid. Cryogenic containers and dewars should not be filled to more than 80% of capacity.
III. Standard Operating Procedure for Ventilation, Transport, & Disposal
A. Ventilation/Engineering Controls
1. Local exhaust should be used to prevent oxygen deficiency.
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2. Mechanical or general exhaust ventilation may be used if it can maintain an adequate supply of air.
B. Transportation
1. Cryogenic containers should be transported in a secure position.
2. Shipment of cryogenic containers that have been filled without the owner’s consent is a violation of federal law [49 CFR 173.301(b)].
C. Waste/Disposal
1. Do not attempt to dispose of residual or unused quantities.
2. Return containers to supplier
IV. Health Effects of Liquid Nitrogen A. Possible risks
1. Simple asphyxiant – displaces the level of oxygen in the air required to support life
2. Inhalation in excessive amounts can cause dizziness, nausea, vomiting, loss of consciousness and death
3. Neither liquid nitrogen nor liquid air should be used to cool a flammable mixture in the presence of air which can lead to an explosion hazard when oxygen condenses from the air.
4. Direct contact with cold gas or liquid can cause severe frostbite.
B. Symptoms of exposure
1. Dizziness
2. Nausea
3. Vomiting
4. Frostbite
5. Loss of consciousness; possible death
C. Spill/Contamination
1. Evacuate all personnel from spill/contaminated area.
2. Shut off flow if you can do so without risk.
3. Avoid contact with spilled liquid and allow to evaporate
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4. CONTACT EHSRM IMMEDIATELY!
V. Regulatory Information & Emergency Contact A. Agencies
1. EPA
a. CERCLA (40 CFR Parts 117 and 302)
b. SARA Sections 302/304 (40 CFR Part 55), Sections 311-312, Section 313 (40 CFR Part 372), 40 CFR 68, TSCA
2. OSHA 29 CFR 1910.119
B. Responsible Parties
1. Principle Investigator
2. Supplier
3. The University of Texas at San Antonio
C. Emergency Contact
1. EHSRM – (210) 458-5250
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Appendix X: Laboratory and Equipment Clearance Procedures LABORATORY CLEAN OUT / CLEARANCE PROCEDURE When laboratories have been vacated, the previous occupants need to ensure they have cleaned their areas of all hazardous biological, chemical (including controlled substances) and radioactive materials in preparation for renovation or reoccupation. Environmental Health Safety and Risk Management (EHSRM) must certify a laboratory to be cleared of hazards prior to Facilities Services personnel entering for final housekeeping clean out and potential renovation work. When leaving a laboratory, the occupants must clean out any remaining hazardous materials. Cabinets, countertops, and all equipment, including chemical fume hoods, must be cleaned / decontaminated to remove any hazardous materials or residue including chemicals and potentially infectious biological agents (ABSL/BSL-2 or above). o For biological agents: An appropriate tuberculocidal grade disinfectant such as 1-10% dilution of household bleach (5.25-6% sodium hypochlorite solution) applied for a contact time of 10-20 minutes should be used. Alternately, a commercially available detergent-disinfectant solution such as Dispatch®, Clorox Clean-up®, Lysol IC®, etc. may be used following manufacturer’s instructions. Caution – most disinfectants are also corrosive – proper PPE should be worn (gloves & faceshield or goggles) and metal surfaces especially should be rinsed with water and wiped down after application. o For chemicals: An appropriate solvent for the chemical residues which may be present should be used, followed by a detergent cleaning. o For radioactive material areas: Wipe tests shall be completed prior to an appropriate detergent solution wipe down. If wipe tests confirm areas of contamination, then all decontamination materials must be kept for radioactive waste disposal. If applicable, final wipe tests shall be conducted to verify proper decontamination. All wipe tests and survey locations must be documented. EHSRM must be contacted to remove any remaining waste biological agents or hazardous chemicals for disposal. Environmental Safety Division is the contact for this service. If radioactive materials were used in the laboratory then Radiation Safety Personnel (RSP)must be contacted to clear the area. Once complete, RSP will complete and sign the radiation portion of the laboratory clearance form or equipment tag for items remaining and / or going to surplus. For biological or chemical clearance of lab surfaces or equipment, either the Environmental or Laboratory Safety Division can be contacted to do the final walkthrough of the area and fill out the clearance form or equipment tag. Once the clearance form or equipment tag has been signed and posted by pertinent EHSRM personnel, Facilities Services is cleared to enter the area and remove surplus equipment or any household type trash, and begin any general cleaning or necessary renovations. CONTACTS: Environmental Safety Division X6698, X5808 Laboratory Safety Division X6697, X5807, X6101 Radiation Safety Personnel X6697, X6101 See http://utsa.edu/safety/ for more contact information.
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EQUIPMENT CLEAN OUT / CLEARANCE PROCEDURE When equipment that is used with hazardous materials, requires repair or disposal laboratory personnel need to ensure the equipment is cleaned of all hazardous biological, chemical and radioactive materials. Environmental Health Safety and Risk Management (EHSRM) must certify equipment to be cleared of hazards prior to repair, shipping for repair, sending to surplus or disposing of equipment. All equipment, including chemical fume hoods, must be cleaned / decontaminated to remove any hazardous materials or residue including chemicals, potentially infectious biological agents, and radioactive materials. o For biological agents: An appropriate tuberculocidal grade disinfectant such as 1-10% dilution of household bleach (5.25-6% sodium hypochlorite solution) applied for a contact time of 10-20 minutes should be used. Alternately, a commercially available detergent-disinfectant solution such as Dispatch®, Clorox Clean-up®, Lysol IC®, etc. may be used following manufacturer’s instructions. Caution – most disinfectants are also corrosive – proper PPE should be worn (gloves & faceshield or goggles) and metal surfaces especially should be rinsed with water and wiped down after application. o For chemicals: An appropriate solvent for the chemical residues which may be present should be used, followed by a detergent cleaning. o For radioactive material areas: Wipe tests shall be completed prior to an appropriate detergent solution wipe down. If wipe tests confirm areas of contamination, then all decontamination materials must be kept for radioactive waste disposal. If applicable, final wipe tests shall be conducted to verify proper decontamination. All wipe tests and survey locations must be documented.. Some equipment will need specialized cleaning/decontamination. For example, biological safety cabinets will need to be decontaminated with formaldehyde, vaporized hydrogen peroxide or other materials. Currently this type of decontamination is not done in-house. Contact the Laboratory Safety Division for more information. EHSRM must be contacted to remove any remaining waste biological agents or hazardous chemicals for disposal. Environmental Safety Division is the contact for this service. If radioactive materials were used in the equipment then Radiation Safety Personnel (RSP) must be contacted to clear the area. Once complete, RSP will complete and sign the radiation portion of the equipment clearance tag. For biological or chemical clearance of equipment, either the Environmental or Laboratory Safety Division can be contacted to do the review and fill out the equipment clearance tag. Once the equipment clearance tag has been signed and posted by pertinent EHSRM personnel, the equipment can be repaired or removed from the lab for service, surplus or disposal. CONTACTS: Environmental Safety Division X6698, X5808 Laboratory Safety Division X6697, X5807, X6101 Radiation Safety Personnel X6697, X6101 See http://utsa.edu/safety/ for more contact information.
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Appendix XI: Hazardous Materials Requiring Institutional Approval
Hazardous Materials Requiring Institutional Approval Office of Environmental Health, Safety & Risk Management
INSTRUCTION: Based on the health effects, regulatory status, or potential handling requirements, several classes of hazardous materials or devices require specific institutional approval prior to purchase. If a substance or device is listed below or specifically in the attached appendices contact the institutional contact prior to placing an order for the hazardous material.
List of Hazardous Materials Biological “Select Agent or Toxin” Radioactive Materials: Radiation Producing Machine Military/ Other Chemical Agents of Concern Toxic/Extremely Hazardous Chemicals Controlled Substances Laser (class 3b or 4) Chemicals/Items prohibited by Fire code P-Listed Wastes Institutional Contact: Laboratory Safety Division Contact Phone: 210-458-6697/5807 Definitions HHS Select Agent or Toxin: A biological agent (bacterium, virus, fungus, etc.), or its toxin, conforming to the most current list published in 42 CFR § 73.3 or an overlap select agent or toxin as listed in 42 CFR § 73.4. See Appendix A. USDA Select Agents or Toxins: A biological agent (bacterium, virus, fungus, etc.), or its toxin, conforming to the most current list published in 9 CFR § 121.3 or an overlap select agent or toxin as listed in 9 CFR § 121.4. See Appendix A. USDA Plant Protection and Quarantine (PPQ) Select Agent or Toxin: A biological agent or its toxin determined to pose a severe threat to plant health or plant products and as listed in 7 CFR § 331.3 (a). See Appendix A. Radioactive Materials: Any material (solid, liquid, or gas) that spontaneously emits radiation as defined in 25 TAC § 289.201(b)(80). Radiation Producing Machine Any device capable of producing ionizing radiation and not an exempt machine (contact Laboratory Safety Division to confirm exempt status) as defined in 25 TAC § 289.201(b)(78). Military / Other Chemical Agents of Concern: Any chemical agent that has been developed or may potentially be used as a weapon of mass casualty / destruction, explosive, or is otherwise of concern. See Appendix B.
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Toxic/Extremely Hazardous Chemicals: Any substance with a threshold planning quantity (TPQ) of 10 pounds or less, as listed in the Extremely Hazardous Substance list as defined in 49 CFR § 302-304, 311, or 312 and cross-listed in the Texas Community Right-to-Know Act Chapter 505-507 of the Texas Health & Safety Code. See Appendix C. Controlled Substances: Any substance regulated or specifically listed in 21 CFR Part 1300-1399. The Drug Enforcement Agency’s Diversion Control Program regulates these substances. See Appendix D. Class 3b or 4 laser: Any laser that permits human access during operation to levels of visible laser radiation in excess of limits listed in 25 TAC §289.301(d)(9) for Class 3a lasers, or access to levels of invisible laser radiation in excess of limits in 25 TAC §289.301(d)(7) for Class 1 lasers but less than limits contained in §289.301(d)(11) for Class 4 lasers is considered Class 3b. Any laser that permits human access during operation to levels of laser radiation in excess of limits contained in §289.301(d)(10) is considered Class 4 Commercially manufactured lasers are required by law to be sold with a laser class designation. Any modified or “home-built” laser must have its laser class determined by the UTSA Radiation Safety Officer before being put into use. See Appendix E.
Chemicals/Items prohibited by Fire code: The NFPA Fire Code prohibits certain materials from being used or stored in buildings categorized as business occupancies. All buildings housing laboratories at UTSA are categorized as business occupancies. See Appendix F P-Listed Wastes: These chemicals are listed by EPA for purposes of waste disposal and are classified acute hazardous waste. See Appendix G
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Appendix A List of HHS/USDA Select Agents and Toxins under 42 CFR 73; 9 CFR 121; & 7 CFR
331
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HHS Select Agents and Toxins Abrin Botulinum neurotoxins Botulinum neurotoxin producing species of Clostridum Cercopithecine herpesvirus 1 (Herpes B virus) Clostridium perfringens episilon toxin Coccidioides posadasii/Coccidioides immitis Conotoxins Coxiella burnetii Crimean-Congo heamorrhagic fever virus Diacetoxyscirpenol Eastern Equine Encephalitis virus Ebola virus Francisella tularensis Lassa fever virus Marburg virus Monkeypox virus Reconstructed replication competent forms of the 1918 pandemic influenza virus containing any portion of the coding regions of all eight gene segments (Reconstructed 1918 Influenza virus) Ricin Rickettsia prowazekii Rickettsia rickettsii Saxitoxin Shiga-like ribosome inactivating proteins Shigatoxin South American Haemorrhagic Fever viruses Flexal Guanarito Junin Machupo Sabia Staphylococcal enterotoxins T-2 toxin Tetrodotoxin Tick-borne encephalitis complex (flavi) viruses Central European Tick-borne encephalitis Far Eastern Tick-borne encephalitis Kyasanur Forest disease Omsk Hemorrhagic Fever Russian Spring and Summer encephalitis Variola major virus (Smallpox virus) Variola minor virus (Alastrim) Yersinia pestis
Overlap Select Agents and Toxins Bacillus anthracis Brucella abortus Brucella melitensis Brucella suis Burkholderia mallei (formerly Pseudomonas mallei) Burkholderia pseudomallei (formerly Pseudomonas Pseudomallei) Hendra virus Nipah virus Rift Valley fever virus Venezuelan Equine Encephalitis virus USDA Select Agents and Toxins African horse sickness virus African swine fever virus Akabane virus Avian influenza virus (highly pathogenic) Bluetongue virus (exotic) Bovine spongiform encephalopathy agent Camel pox virus Classical swine fever virus Ehrlichia ruminantium (Heartwater) Foot-and-mouth disease virus Goat pox virus Japanese encephalitis virus Lumpy skin disease virus Malignant catarrhal fever virus (Alcelphine herpesvirus type 1) Menangle virus Mycoplasma capricolum subspecies capripneumoniae (contagious caprine pleuropneumonia) Mycoplasma mycoides subspecies mycoides small colony (MmmSC) (contagious bovine pleuropneumonia) Peste des petits ruminants virus Rinderpest virus Sheep pox virus Swine vesicular disease virus Vesicular stomatitis virus (exotic): Indiana subtypes VSV-IN2, VSV-IN3 Virulent Newcastle disease virus USDA Plant Protection and Quarantine (PPQ) Select Agents and Toxins Peronosclerospora philippinensis (Peronosclerospora sacchari) Phoma glycinicola (formerly Pyrenochaeta glycines)
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Ralsonia solanacearum race 3, biovar 2 Rathayibacter toxicus Sclerophthora rayssiae var zeae Synchytrium endobioticum Xanthanomonas oryzae Xylella fastidiosa (citrus variegated chlorosis strain
The above list was current as of the date of this document listed at the bottom of the page. The latest listing of select agents and toxins, restrictions, definitions and exemptions is available online at: http://www.selectagents.gov/Select%20Agents%20and%20Toxins%20List.html.
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Appendix B List of Military / Other Chemical Agents of Concern
Military / Other chemical agents of concern (excluding biological select agents) that can be used as a potential weapon of mass casualty / destruction or is potentially explosive or is toxic or highly flammable: Type Common Name Technical Name Formula CAS Number
Blister Agents Mustard Gas (H) Bis (2-chlorethyl) sulfide (CLCH2CH2)2S 505602 Mustard Gas (HO) Bis (2-chlorethyl) sulfide C4H8Cl2S Phosgene Oxime (CX) Dichloroformoxime CHCl2NO 1794-86-1 Lewisite (L) Dichloro-(2-chlorovinyl)arsine ClCHCHAsCL2 541253
Asphyxiants Hydrogen Cyanide (AC) Hydrogen Cyanide HCN 74-90-8 Cyanogen Chloride (CK) Chlorocyan CNCl 506-77-4
Choking Agents Phosgene Gas (CG) Carbonyl Chloride COCl2 754445 Chlorine Gas (Cl2) Chlorine Cl2 7782505 Anhydrous Ammonia Anhydrous Ammonia NH3 7664417
Nerve Agents Sarin (GB) Isopropyl Methyphosphono- C4H10FO2P 107448 fluoridate Soman (GD) Pinacolyl Methylphosphono- (CH3)(C6H13)POF 96-64-0 fluoridate Tabun (GA) O-ethyl N-dimethylphosphor- C5H11N2O2P 77816 amidocyanidate VX O-ethyl S-(2-diisopropylamino) C11H26NO2PS 50782-69-9 Ethyl methylphosphonothiolate Explosives/Reactives
Picric Acid 2,4,6-trinitrophenol (NO2)3C6H2OH 88-89-1 Perchloric Acid hydronium perchlorate HClO4 7601-90-3 TNT Trinitrotoluene C6H2(NO2)3CH3 118-96-7
Explosives or explosive percursors not otherwise listed Other Chemicals of Concern
Fluorine Fluorine F 7782-41-4 Hydrofluoric Acid Hydrogen fluoride HF 7664-39-3 Silane Silane SiH4 7803-62-5 Any pyrophoric chemical not otherwise listed Any hazardous gases with a 3 or 4 in one of the hazard categories not otherwise listed (including
mixtures) Examples include: hydrogen sulfide and hydrogen.
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This list was developed using Bevelacqua and Stilp’s Terrorism Handbook for Responders (2002).
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Appendix C List of Toxic/Extremely Hazardous Chemicals
The following list was developed using the Extremely Hazardous Substance list (Texas DSHS) Tier II Chemical Reporting Program with any chemical agent having a Threshold Planning Quantity of 10 lbs or less: Common Name Threshold Planning Quantity Reportable Quantity CAS Number (lbs) (lbs) Azinphos-methyl 10/10,000 1 86500 Benzenearsonic acid 10/10,000 10 98055 Bis(chloromethyl) ketone 10/10,000 10 534076 Carbofuran 10/10,000 10 1563662 Chromic chloride 1/10,000 1 10025737 Cobalt carbonyl 10/10,000 10 10310681 Colchicine 10/10,000 10 64868 Digoxin 10/10,000 10 20830755 Dimethyl-p-phenylenediamine 10/10,000 10 99989 Dinitrocresol 10/10,000 10 534521 Diphacinone 10/10,000 10 82666 Emetine, dihydrochloride 1/10,000 1 316427 Endosulfan 10/10,000 1 115297 Ethylene fluorohydrin 10 10 371620 Fenamiphos 10/10,000 10 22224926 Fluoroacetic acid 10/10,000 10 144490 Fluroacetyl chloride 10 10 359068 Hydrogen selenide 10 10 7783075 Lewisite 10 10 541253 Mechlorethamine 10 10 51752 Methyl vinyl ketone 10 10 78944 Monocrotophos 10/10,000 10 6923224 Nickel carbonyl 1 10 13463393 Nitric Oxide 10 100 10102439 Organorhodium Complex (PMN2147)10/10,000 10 None Paraquat dichloride 10/10,000 10 1910425 Paraquat methosulfate 10/10,000 10 2074502 Phorate 10 10 298022 Phosgene 10 10 75445 Phosmet 10/10,000 10 732116 Propargyl bromide 10 10 106967 Sarin 10 10 107448 Sodium fluoroacetate 10/10,000 10 62748 Tabun 10 10 77816
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Appendix D List of Controlled Substances
Schedule I – See 21 CFR Section 1308.11 Schedule II – See 21 CFR Section 1308.12 Schedule III – See 21 CFR Section 1308.13 Schedule IV – See 21 CFR Section 1308.14 Schedule V – See 21 CFR Section 1308.15 Title 21 of the Congressional Federal Register (CFR) may be accessed on-line at the following URL: http://www.gpoaccess.gov/cfr/index.html Listings of Schedule I-V Controlled Substances can also viewed at the Drug Enforcement Administration (DEA) website at the following URL: http://www.deadiversion.usdoj.gov/schedules/index.html Refer to the UTSA policy on Controlled Substances for information on obtaining licenses from the Texas Department of Public Safety and the DEA prior to ordering Controlled Substances.
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Appendix E Specifications for Class 3b and Class 4 lasers
AMERICAN NATIONAL STANDARD Z136.1 - 2000
The following laser definitions are excerpted with permission from the ANSI Z136.1 – 2000 American National Standard for Safe Use of Lasers.
3.3.1 Class 1 Lasers and Laser Systems
3.3.1.1 Any laser, or laser system containing a laser, that cannot emit accessible laser radiation levels in excess of the applicable Class 1 AEL for any emission duration within the maximum duration inherent in the design or intended use of the laser or laser system is a Class 1 laser or laser system during operation and is exempt from all control measures or other forms of surveillance with the exception of applicable requirements for embedded lasers (see Section 4.3.1.1). The maximum exposure duration is assumed to be no more than 30,000 s, except for infrared systems not intended to be viewed (> 0.7 µm), 100 s shall be used. The exemption strictly applies to emitted laser radiation hazards and not to other potential hazards (see Section 7, Non-Beam Hazards).
3.3.1.2 Lasers or laser systems intended for a specific use may be designated Class 1 by the LSO on the basis of that use for a limiting exposure duration of Tmax less than 100 s, provided that the accessible laser radiation does not exceed the corresponding Class 1 AEL for any emission duration within the maximum duration inherent in that specific use.
3.3.2 Class 2 Visible Lasers and Laser Systems. Class 2 lasers and laser systems are visible (0.4 to 0.7 µm) CW
and repetitive-pulse lasers and laser systems which can emit accessible radiant energy exceeding the appropriate Class 1 AEL for the maximum duration inherent in the design or intended use of the laser or laser system, but not exceeding the Class 1 AEL for any applicable pulse (emission) duration < 0.25 s and not exceeding an average radiant power of 1 mW.
3.3.3 Class 3 Lasers and Laser systems.
3.3.3.1 Class 3a lasers and laser systems include lasers and laser systems which have an accessible output between 1 and 5 times the Class 1 AEL for wavelengths shorter than 0.4 µm or longer than 0.7 µm, or less than 5 times the Class 2 AEL for wavelengths between 0.4 and 0.7 µm.
3.3.3.2 Class 3b lasers and laser systems include:
(1) Ultraviolet (0.18 to 0.4 µm) and infrared (1.4 µm to 1 mm) lasers and laser systems which can emit accessible radiant power in excess of the Class 3a AEL during any emission duration within the maximum duration inherent in the design of the laser or laser system, but which (a) cannot emit an average radiant power in excess of 0.5 W for 0.25 s or (b) cannot produce a radiant energy greater than 0.125 J within an exposure time < 0.25 s.
(2) Visible (0.4 to 0.7 µm) or near-infrared (0.7 to 1.4 µm) lasers or laser systems which emit in excess of the AEL of Class 3a but which (a) cannot emit an average radiant power in excess of 0.5 W for 0.25 s and (b) cannot produce a radiant energy greater than 0.03 J per pulse.
3.3.4 Class 4 Lasers and Laser, Systems. Class 4 lasers and laser systems are those that emit radiation that exceed the Class 3b AEL.
From ANSI Z136.1 (2000) American National Standard for Safe Use of Lasers. Copyright 2000, Laser Institute of America. All rights reserved.
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Appendix F
Chemicals/Items Prohibited by Fire Code
(Contact EHSRM prior to ordering or bringing on campus any chemicals/items listed below to
discuss options for use and storage if these chemicals or items are necessary for research.)
• Consumer fireworks (1.4G) • Class 4 oxidizers (examples)
o Ammonium perchlorate (particle size > 15 microns) o Ammonium permanganate o Guanidine nitrate o Hydrogen peroxide solutions >91% o Tetranitromethane
• Unclassifiable/detonable organic peroxides • Class I and II organic peroxides
Class I and II organic peroxides definitions and typical formulations: “Class I" describes those formulations which are capable of deflagration, but not detonation. Fire hazard characteristics: Class I formulations present a deflagration hazard through easily initiated, rapid explosive decomposition. Class I includes some formulations that are relatively safe only under closely controlled temperatures. Either excessively high or low temperatures may increase the potential for severe explosive decomposition. “Class II" describes those formulations that burn very rapidly and that present a severe reactivity hazard. Fire hazard characteristics: Class II formulations present an NFPA fire hazard similar to Class I flammable liquids such as acetone or toluene. The decomposition is not as rapid, violent, or complete as that produced by Class I formulations. As with Class I formulations, this class includes some formulations that are relatively safe when used under controlled temperatures or when diluted.
Typical Class I Formulations Organic Peroxide Concentration Diluent t-Butyl hydroperoxide 90 Water and t-BuOH t-Butyl monoperoxymaleate 98 ----- t-Butyl peroxyacetate 75 Odorless mineral spirits t-Butyl peroxyacetate 60 Odorless mineral spirits t-Butyl isopropyl carbonate 92 Odorless mineral spirits Dibenzoyl peroxide 98 ----- 2,2-Di(t-butylperoxy) butane 50 Toluene Diisopropyl peroxydicarbonate 99 ----- Di-n-propyl peroxydicarbonate 98 ----- Di-n-propyl peroxydicarbonate 85 Odorless mineral spirits
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Typical Class II Formulations Organic Peroxide Concentration Diluent t-Amyl peroxybenzoate 96 ----- n-Butyl-4,4-di(t-butylperoxy) 98 ----- valerate t-Butyl hydroperoxide 70 DTBP and t-BuOH t-Butyl peroxybenzoate 98 ----- t-Butyl peroxy-2-ethyl hexanoate 97 ----- t-Butyl peroxyisobutyrate 75 Odorless mineral spirits t-Butylperoxy isopropyl carbonate 75 Odorless mineral spirits t-Butyl peroxypivalate 75 Odorless mineral spirits Diacetyl peroxide 25 DMP Dibenzoyl peroxide 78 Water 1,1-Di(t-butylperoxy) cyclohexane 80 Odorless mineral spirits or BBP Di-sec-butyl peroxydicarbonate 98 ----- Di-sec-butyl peroxydicarbonate 75 Odorless mineral spirits 1,1-Di(t-butylperoxy)-3,3,5-trimethyl 75-95 ----- cylcohexane Di(2-ethylhexyl) peroxydicarbonate 97 ----- 2,5-Dimethyl-2,5-di(benzoylperoxy) 95 ----- hexane 2,5-Dimethyl-2,5-dihydroperoxy hexane 70 Water Peroxyacetic acid, Type E, stabilized 43 Water, Acetic acid, and H2O2 Abbreviations used above: DTBP—Di-tertiary-butyl peroxide DMP---Dimethyl phthalate BBP---Butyl benzyl phthalate
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Appendix G P-Listed Wastes
P-listed Wastes are of concern for ordering purposes due to the potential for changing UTSA’s waste generator status once the chemicals need to be disposed of as waste. The list of these chemicals can be found at the EPA’s website at the following link: http://www.epa.gov/osw/hazard/wastetypes/listed.htm.