chemical reaction engineering asynchronous video series
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Chemical Reaction Engineering Asynchronous Video Series. Chapter 7, Part 1: PSSH Enzyme Kinetics H. Scott Fogler, Ph.D. Active Intermediates/Free Radicals. Active Intermediates/Free Radicals. Active Intermediates/Free Radicals. Mechanism:. Active Intermediates/Free Radicals. Mechanism:. - PowerPoint PPT PresentationTRANSCRIPT
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Chemical Reaction Engineering
Asynchronous Video Series
Chapter 7, Part 1:
PSSH
Enzyme Kinetics
H. Scott Fogler, Ph.D.
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Active Intermediates/Free Radicals
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Active Intermediates/Free Radicals
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Active Intermediates/Free Radicals
Mechanism:
€
r1NO 3* = k1CNOCO2
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Active Intermediates/Free Radicals
Mechanism:
€
r2NO 3* = −k 2CNO 3
*
€
r1NO 3* = k1CNOCO2
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Active Intermediates/Free Radicals
Mechanism:
€
rNO2= k3CNO 3
* CNO
€
r2NO 3* = −k 2CNO 3
*
€
r1NO 3* = k1CNOCO2
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Active Intermediates/Free Radicals
Mechanism:
€
r2NO 3* = −k 2CNO 3
*
€
r1NO 3* = k1CNOCO2
€
rNO2= k3CNO 3
* CNO
€
r3NO2
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Pseudo Steady State Hypothesis (PSSH)A* is an active intermediate that is highly reactive. It disappears as fast as it is formed.
€
rA*net
=0
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Pseudo Steady State Hypothesis (PSSH)A* is an active intermediate that is highly reactive. It disappears as fast as it is formed.
€
rNO3
* =r1NO3
* +r2NO3
* +r3 NO3
*
€
rA*net
=0
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Pseudo Steady State Hypothesis (PSSH)A* is an active intermediate that is highly reactive. It disappears as fast as it is formed.
€
rNO3
* =r1NO3
* +r2NO3
* +r3 NO3
*
€
rA*net
=0
€
r1NO3
* =k1 NO( ) O 2( )
r2NO3
* = −k 2 NO 3*
( )
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Pseudo Steady State Hypothesis (PSSH)A* is an active intermediate that is highly reactive. It disappears as fast as it is formed.
€
rNO3
* =r1NO3
* +r2NO3
* +r3 NO3
*
€
rA*net
=0
€
r3NO3
* = −r3 NO2
2= −
k 3
2NO 3
*( ) NO( )
€
r3NO 3
*
−1 =r3NO 2
2
€
r1NO3
* =k1 NO( ) O 2( )
r2NO3
* = −k 2 NO 3*
( )
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Pseudo Steady State Hypothesis (PSSH)A* is an active intermediate that is highly reactive. It disappears as fast as it is formed.
€
rNO3
* =r1NO3
* +r2NO3
* +r3 NO3
*
€
rA*net
=0
€
r3NO3
* = −r3 NO2
2= −
k 3
2NO 3
*( ) NO( )
€
r3NO 3
*
−1 =r3NO 2
2
€
k1 NO[ ] O 2[ ]− k 2 NO3*
( ) −k 3
2NO 3( ) NO( ) = 0
€
r1NO3
* =k1 NO( ) O 2( )
r2NO3
* = −k 2 NO 3*
( )
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Pseudo Steady State Hypothesis (PSSH)A* is an active intermediate that is highly reactive. It disappears as fast as it is formed.
€
rNO3
* =r1NO3
* +r2NO3
* +r3 NO3
*
€
rA*net
=0
€
r3NO3
* = −r3 NO2
2= −
k 3
2NO 3
*( ) NO( )
€
r3NO 3
*
−1 =r3NO 2
2
€
k1 NO[ ] O 2[ ]− k 2 NO3*
( ) −k 3
2NO 3( ) NO( ) = 0
€
r1NO3
* =k1 NO( ) O 2( )
r2NO3
* = −k 2 NO 3*
( )
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Pseudo Steady State Hypothesis (PSSH)
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Enzymes: Michaelis-Menten Kinetics
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Enzymes: Michaelis-Menten Kinetics
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Enzymes: Michaelis-Menten Kinetics
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Urea DecompositionA given enzyme can only catalyze only one reaction. Urea is decomposed by the enzyme urease, as shown below.
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Urea DecompositionA given enzyme can only catalyze only one reaction. Urea is decomposed by the enzyme urease, as shown below.
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Urea DecompositionA given enzyme can only catalyze only one reaction. Urea is decomposed by the enzyme urease, as shown below.
Rate Laws:
€
rP = ′ k 3 E • S( ) W( ) = k 3 E • S( )
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Urea DecompositionA given enzyme can only catalyze only one reaction. Urea is decomposed by the enzyme urease, as shown below.
€
rE•S = r1E•S + r2E•S + r3E•S
Rate Laws:
€
rP = ′ k 3 E • S( ) W( ) = k 3 E • S( )
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Urea DecompositionA given enzyme can only catalyze only one reaction. Urea is decomposed by the enzyme urease, as shown below.
€
rE•S = r1E•S + r2E•S + r3E•S
Rate Laws:
€
=k1 E( ) S( ) − k 2 E • S( ) − k 3 E • S( ) W( )If
€
E • S( ) =k1 E( ) S( )
k2
+ k3
€
rE•S ≈ 0
€
rP = ′ k 3 E • S( ) W( ) = k 3 E • S( )
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Urea Decomposition
€
E T( ) = E( ) + E • S( )
€
= E( ) +k1
k 2 + k 3
⎛
⎝ ⎜ ⎞
⎠ ⎟ E( ) S( )
€
rP = ′ k 3 E • S( ) W( ) = k 3 E • S( ) =k1 k 3 E( ) S( )
k2
+ k3
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Urea Decomposition
€
E T( ) = E( ) + E • S( )
€
= E( ) +k1
k 2 + k 3
⎛
⎝ ⎜ ⎞
⎠ ⎟ E( ) S( )
€
E( ) =k 2 + k 3
k1
⎛
⎝ ⎜ ⎞
⎠ ⎟E T
k 2 + k 3
k1
⎛
⎝ ⎜
⎞
⎠ ⎟ + S
€
rP = ′ k 3 E • S( ) W( ) = k 3 E • S( ) =k1 k 3 E( ) S( )
k2
+ k3
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Urea Decomposition
€
rP =k 3 E T
k 2 + k 3
k1
⎛
⎝ ⎜
⎞
⎠ ⎟ + S
€
E T( ) = E( ) + E • S( )
€
= E( ) +k1
k 2 + k 3
⎛
⎝ ⎜ ⎞
⎠ ⎟ E( ) S( )
€
E( ) =k 2 + k 3
k1
⎛
⎝ ⎜ ⎞
⎠ ⎟E T
k 2 + k 3
k1
⎛
⎝ ⎜
⎞
⎠ ⎟ + S
€
rP = ′ k 3 E • S( ) W( ) = k 3 E • S( ) =k1 k 3 E( ) S( )
k2
+ k3
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Urea Decomposition
€
rP =k 3E TS
k 2 + k 3
k1
⎛
⎝ ⎜
⎞
⎠ ⎟ + S
€
E T( ) = E( ) + E • S( )
€
= E( ) +k1
k 2 + k 3
⎛
⎝ ⎜ ⎞
⎠ ⎟ E( ) S( )
€
E( ) =k 2 + k 3
k1
⎛
⎝ ⎜ ⎞
⎠ ⎟E T
k 2 + k 3
k1
⎛
⎝ ⎜
⎞
⎠ ⎟ + S
€
rP = ′ k 3 E • S( ) W( ) = k 3 E • S( ) =k1 k 3 E( ) S( )
k2
+ k3
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Urea Decomposition
VMAX
rP
S
€
VMAX
2
Km
€
E T( ) = E( ) + E • S( )
€
= E( ) +k1
k 2 + k 3
⎛
⎝ ⎜ ⎞
⎠ ⎟ E( ) S( )
€
E( ) =k 2 + k 3
k1
⎛
⎝ ⎜ ⎞
⎠ ⎟E T
k 2 + k 3
k1
⎛
⎝ ⎜
⎞
⎠ ⎟ + S
€
rP = ′ k 3 E • S( ) W( ) = k 3 E • S( ) =k1 k 3 E( ) S( )
k2
+ k3
€
rP =k 3E TS
k 2 + k 3
k1
⎛
⎝ ⎜
⎞
⎠ ⎟ + S
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Urea Decomposition
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Types of Enzyme Inhibition
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Types of Enzyme Inhibition
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Types of Enzyme Inhibition
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Types of Enzyme Inhibition
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Types of Enzyme Inhibition