chapter 8 an introduction to metabolism. overview: the energy of life the living cell is a miniature...
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Chapter 8
An Introduction to Metabolism
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Overview: The Energy of Life
• The living cell is a miniature chemical factory where thousands of reactions occur
• The cell extracts energy and applies energy to perform work
• Some organisms even convert energy to light, as in bioluminescence
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings
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Metabolism
• Metabolism is the entire collection of an organism’s chemical reactions
• A metabolic pathway begins with a specific molecule and ends with a product
• Each step is catalyzed by a specific enzyme
Enzyme 1 Enzyme 2 Enzyme 3
DCBAReaction 1 Reaction 3Reaction 2
Startingmolecule
Product
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Two Types of Metabolism
• Catabolic pathways release energy by breaking down complex molecules into simpler compounds
GLUCOSE CO2 + H2O + ATP
• Anabolic pathways consume energy to build complex molecules from simpler ones
Amino acids Proteins
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Energy
• Energy is the capacity to cause change• Types of energy
– Kinetic energy is energy associated with motion
– Potential energy is energy that matter possesses because of its location or structure
• Energy can be converted from one form to another
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Fig. 8-2
Climbing up converts the kineticenergy of muscle movementto potential energy.
A diver has less potentialenergy in the waterthan on the platform.
Diving convertspotential energy tokinetic energy.
A diver has more potentialenergy on the platformthan in the water.
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The Laws of Energy Transformation
• Thermodynamics is the study of energy transformations
• First law of thermodynamics
– Energy can be transferred and transformed, but it cannot be created or destroyed
• Second law of thermodynamics
– During every energy transfer or transformation, some energy is unusable, and is often lost as heat (entropy)
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Free Energy• Free Energy (∆G) - measures a system’s energy
that is available to perform work.
∆G = ∆H – T∆S
• Spontaneous
– a process that can occur without the input of energy; ∆G must be a negative value
• Nonspontaneous
– a process that requires the input of energy; ∆G will be a positive value or zero
As Biologists, we want to know which rxns of life are spontaneous. These rxns canbe harnessed to do work (to drive the nonspontaneous rxns.
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When we apply the free energy concept to processes of life and with respect to metabolism, we describe rxns as exergonic or endergonic.
• An exergonic reaction proceeds with a net release of free energy and is spontaneous
Glucose + O2 CO2 + H2O ∆G = -686 kcal/mol
• An endergonic reaction absorbs free energy from its surroundings and is nonspontaneous
CO2 + H2O Glucose + O2 ∆G = +686 kcal/mol
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3 Main Types of Cellular Work
• Mechanical
• Transport
• Chemical
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Fig. 8-8
Phosphate groupsRibose
Adenine
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Fig. 8-9
Inorganic phosphate
Energy
Adenosine triphosphate (ATP)
Adenosine diphosphate (ADP)
P P
P P P
P ++
H2O
i
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Fig. 8-11
(b) Mechanical work: ATP binds noncovalently to motor proteins, then is hydrolyzed
Membrane protein
Pi
ADP+
P
Solute Solute transported
Pi
Vesicle Cytoskeletal track
Motor protein Protein moved
(a) Transport work: ATP phosphorylates transport proteins
ATP
ATP
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Fig. 8-12
P iADP +
Energy fromcatabolism (exergonic,energy-releasingprocesses)
Energy for cellularwork (endergonic,energy-consumingprocesses)
ATP + H2O
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Fig. 8-14
Progress of the reaction
Products
Reactants
∆G < O
Transition state
Fre
e en
erg
y EA
DC
BA
D
D
C
C
B
B
A
A
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Enzyme Inhibitors