chapter 20. defenses against disease
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Chapter 20. Defenses Against Disease
Organs, Tissues & Cells of the Immune System
Nonspecific Defenses
Specific Defenses
Induced Immunity
Disorders of Immunity
The Immune System: protects against Diesease
• Nonspecific: defend against and/or attack any pathogen without need to develop special cells or chemicals; no immunological memory formed
• Specific: involves selection of special immune system cells that target specific pathogens; immunological memory results
The lymphatic Organs
thymus
spleen
red bone marrow
lymph nodes
• Primary Lymphatic Organs– sites of lymphocyte
formation and/or maturation
• Secondary Lymphatic Organs– sites where lymphocytes and
other immune system cells encounter and bind antigens
Primary Lymphatic Organs• Red Bone Marrow: site of all
blood cell formation including lymphocytes– B lymphocytes formed and
mature in red bone marrow
• Thymus: site of T-lymphocyte maturation– T lymphocytes formed in red
bone marrow, but mature in thymus
– T lymphocytes that leave thymus can mount an immune response, but tolerate “self”
Secondary Lymphatic Organs• Spleen
– filters blood and stores, contains lymphocytes that participate in immune responses
• Lymph Nodes– filter lymph, contains
lymphocytes that participate in immune responses
• Lymphatic Vessels– transport lymph to blood
stream, pass through lymph nodes on the way
Tissues & Cells of the Immune System
• Tonsils: aggregations of lymphatic nodules in the pharynx
• Peyer’s Patches: aggregations of lymphatic tissue in the wall of the intestine
• Appendix: concentrations of lymphatic tissue• Note: lymphatic tissue can be found in the loose
connective tissues throughout the body, especially in the walls of organs lined by mucus membranes
NonSpecific Body Defenses
• Physical Barriers• Inflammatory Reaction• Protective Body Cells• Protective Proteins
Barriers to Entry
• Skin and Mucus Membranes– secretions of these organs are toxic to bacteria (lysozymes,
acids)
– some organs have resident “beneficial” bacteria that exclude pathogens
Inflammatory Reaction
Protective Body Cells
• phagocytes: neutrophils, macrophages
• natural killer cells: lymphocytes that can attack pathogens and cancer cells without an immune response
Protective Proteins• Complement: Proteins that attack pathogens directly• Interferon: Proteins that are produced by virus infected
cells that signal nearby cells to activate antiviral infection mechanisms
Specific Defenses
B lymphocytes
produce antibodies (=antibody mediated or humoral immunity)
T lymphocytes
attack abnormal body cells, such as those infected with virus (=cell-mediated immunity)
Antibody Mediated Immunity
• clonal selection: only a B cell with the antigen receptor that can bind to the antigen is selected
• it undergoes proliferation (needs cytokines from helper T cells)
• some clonal cells become antibody producing plasma cells
• plasma cells undergo apoptosis when infection is destroyed, but other clone members remain behind as memory cells
Structure of IgG (antibody)
• Y-shaped protein
• each arm has a “heavy” (long) peptide and a “light” (short) peptide
• each peptide has a “constant and a variable region
• the variable region binds to the antigen
• there are 4 other classes of antibodies: IgM, IgA, IgD, IgE
Antibody Structure
Antibody
Cell-Mediated Immunity• Similar to Antibody mediated, but T Cells cannot
bind free antigen in body fluids, antigen must be “presented” by antigen presenting cells (APCs)
• T cell that can bind presented antigen is activated (selected)
• undergoes clonal expansion, produces cytokines and a variety of T cell types (killers, helpers, etc.)
• after immune response most T lymphocytes undergo apoptosis
• some T cells remain as memory cells
How T Cells “Kill”
Cytotoxic, I.e., “Killer” T Cells
attacking a cancer cell
Helper T Cells
• provide chemical signals, cytokines, that that regulate and enhance the function of other immune cells
• HIV virus attacks and destroys Helper T Cells, thereby destroying the immune system
Immunosuppression• HIV destroys immune system resulting in immune
deficiency• radiation, by destroying bone marrow, also
suppresses immunity• various environmental pollutants, dioxins, pesticides
suppress immunity• certain drugs, such as steroids, suppress the immune
system– immunosuppression is desirable in organ transplant
recipients, but not in most individuals
• some people are born with a part of their immune system not working
Induced Immunity
• Active immunity: acquired by infection• Artificial (induced) immunity: acquired by medical
intervention– active immunity: individual produces their own immunity
by being challenged with the “antigen”
– passive immunity: individual is given antibodies that convey immunity
Immunization (Vaccination)
University of Port Harcourt Teaching
Hospital Study, Port Harcourt,
Nigeria • 14 year old boy unconcious
with cerebral malaria in Nigeria
• 10.2 % of childhood deaths
Two year old with severe measles
• Measles infects 30 to 40 million children per year
• Measles kills over 500,000 children per year
• it costs $1 to immunize a child against measles
58%
26%
777,000 deaths worldwide
DPT = combined Diptheria, Pertussis, Tetanus vaccine
Childhood Mortality: Then & Now
Passive Immunity by Breastfeeding