chap7 the b complex vitamins
TRANSCRIPT
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The B Complex Vitamins
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Vitamin Defined• An organic substance that occurs in foods in small
amounts and is necessary for normal metabolic functioning of the body
• May be water soluble or fat soluble• Do not contribute directly to the structure of the body,
nor do they supply energy• They regulate metabolism by releasing energy from
fats and carbohydrates• They are involved in amino acid metabolism and also
assist in forming blood, bones and tissues
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Division of Vitamin B • Those vitamins that primarily release energy
from carbohydrates and fats namely thiamin, niacin, riboflavin, pantothenic acid and biotin
• Those that catalyze formation of red blood cells namely folic acid and vitamin B12
• The vitamin that is important in protein and amino acid metabolism like Vitamin B6
• The vitaminlike compounds
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Thiamine (Vit. B1)
• A member of the B-complex family
• Water Soluble
• Relatively unstable– Destroyed with heat– Destroyed in alkaline environment– Active as thiamine pyrophosphate (TPP)– Or as thiamine tri-phosphate (TT
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Absorption and Metabolism
• Easily absorbed from the small intestine
• It is combine with phosphate within mucosal cells of the intestine and transported via the portal vein into the general circulation
• Maybe found in liver, heart, brain and muscle tissue
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Function • Important coenzyme in energy
metabolism
• It acts as coenzyme in the production of ribose
• Needed for the metabolism of carbohydrates, proteins and fats
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Deficiency• Beri-Beri – affects principally the
cardiovascular, muscular, and nervous system– Wet– Dry– Infantile
• Wernicke’s Syndrome
• Increased sensitivity of the oral mucosa, burning tongue, and loss or diminution of taste
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Wet Beriberi
• Edema (accumulation of fluid in tissues spaces) of the legs, cardiac disturbances such as enlarged heart, systolic murmurs and dyspnea (difficulty of breathing) may develop
• The pulse is rapid and irregular, and the neck veins are distented
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Dry Beriberi• Edema does not occur
• A condition consisting of paresthesia (prickling or burning) and numbness of the feet and cramps in the legs is present
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Infantile Beriberi• Caused by inadequate thiamin in the
breast milk
• Characterized by dyspnea, cyanosis and cardiac failure
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Wernicke’s Syndrome
• Severe deficiency of thiamin in the alcoholic individual
• Characterized by confusion, paralysis of eye muscles, and loss of memory
• Peculiar gait and foot and wrist drop are seen in advanced cases
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Food Sources
• Cereals, meats, and legumes
• The richest sources are brewer’s yeast, lean pork, liver, beef, dried peas and beans, nuts and whole wheat and enriched cereals and breads
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Riboflavin (Vit. B2)
• One of the B-complex vitamins
• Water Soluble
• Relatively stable
• Functions as coenzyme
• Active as flavin mononucleotide (FMN)
• Or flavin adenine dinucleotide (FAD)
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Absorption and Metabolism
• It must be phosphorylated (combined with phosphate) in the intestinal tract before it can be absorbed
• Excess riboflavin is excreted in the urine
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Function
• Acts as hydrogen carriers
• Assist in the metabolism carbohydrates, protein and fats
• Oxidation of most drugs (called the drug vitamin)
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Deficiency • Gastrointestinal disease that causes
vomiting and hypermotility of the gastrointestinal tract
• Angular stomatis
• Glossitis
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Sources • Milk, liver, heart, and kidney
• Lean meat
• Cheese
• Eggs
• Leafy green vegetables
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Niacin (Vit. B3)
• One of the B-complex nutrients• Water Soluble• Very Stable• Active as nicotinamide adenine
dinucleotide (NAD)• And NAD-phosphate (NADP)• A peculiar vitamin since it can be
synthesized in body (via tryptophane)
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Absorption and Metabolism
• Absorbed in the upper part of the small intestine
• It is stored only sparingly in the kidney, heart, brain, and liver and is exreted in the urine
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Function• Forms the active portion of the
coenzymes that play an essential role in supplying organ tissues, making its presence necessary for the health of cells
• Acts as catalyst in accepting and releasing hydrogen in cellular respiration, carbohydrate metabolism and fat synthesis
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Deficiency• Pellagra – characterized as the disease
causing 4D’s– Dermatitis– Diarrhea– Depression– Death
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Symptoms• Weakness
• Persistent fatigability
• Irritability
• Headache
• Depression
• Soreness and inflammation of the tongue (glossitis) and mouth (stomatitis)
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Sources • Found in appreciable amounts in liver,
yeast, meat, legumes, peanuts and whole cereals
• Foods that are good sources of tryptophan, such as animal protein and vegetable protein
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Pantothenic Acid (Vit. B5)
• Sometimes, erroneously called – Vitamin B5
• So plentiful in grains and vegetables, a deficiency unlikely – except in complete starvation
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Function
• Involved in the release of energy from the catabolism of carbohydrates, proteins, and fats
• It initiates the Krebs cycle and releases ATP
• It is the starting substance for the biosynthesis of cholesterol and other sterols, a component of hemoglobin
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Deficiency • Fatigue• Sleep disturbances• Headaches• Malaise• Nausea• Abdominal stress• Burning, prickling sensations (paresthesia) of
the hands and feet, cramping of the leg muscles and impaired coordination
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Sources • Widely distributed, occuring abundantly
in yeast and in animal tissue such as liver and eggs, whole-grain cereals and legumes
• Other fair sources are milk, fruits, and vegetables such as brocolli,cauliflower, and potatoes
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Pyridoxine (Vit. B6)• Water-soluble
• White crystalline compound that is stable to heat and strong acids
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Function • Helps make red blood cells
• Helps in amino acid and fatty bacid metabolism
• Aids in normal functioning of nervous tissue
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Deficiency • Early deficiency signs
– Weakness– Irritability– Nervousness– Insomnia
• Later deficiency signs– Convulsions– Anemia– Lesions around lips and eyes (red, crusty)
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Sources • Liver
• Muscle meats
• Yeast
• Legumes
• Whole grain cereals
• Wheat germ
• Wheat bran
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Biotin (Vit. B7)
• Very uneventful.
• Unlikely to have deficiency
• Is blocked by raw egg whites
• Active biological substance
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Function• Stimulates the growth of yeast and
bacteria
• Functions as a coenzyme for reactions involving the addition of carbon dioxide in the formation of purines
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Deficiency • Dermatitis• Glossitis• Loss of appetite and sleep• Nausea• Muscular pains• Hyperesthesia (increased skin sensitivity• Paresthesia (burning and prickling sensation)• Alopecia
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Sources
• The richest sources are liver, kidney, milk, egg yolk and yeast
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Folic Acid (Vit. B9)
• Yellow crystalline substance
• Sparingly soluble in water
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Function • Essential for the manufacture and
maturation of blood cells
• Necessary for the normal functioning of the hematopoietic system
• Prevent anemia, some birth defects and heart disease
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Deficiency
• Disorders of malabsorption associated with infectious disease (tropical diseases) or certain metabolic and endocrine disorders
• Megaloblastic anemia of pregnancy
• Paresthesia
• Angular cheilosis and gingivitis
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Sources • Liver• Kidney• Yeast• Dark green leafy vegetables• Asparagus• Brocolli• Soybeans and nuts• Orange juice
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Cyanocobalamin (Vit. B12)
• Consist of a cyanide ion and a cobalt ion
• Not a single substance but consist of several closely related compounds having similar activity
• By product of streptomycin
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Function
• Plays a biomechanical role in the maintenance of myelin
• Involved in the synthesis of nucleoproteins
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Deficiency • Pernicious anemia
– Usual complaints are weakness, numbness and tingling in the extremities
– Patients may have difficulty in walking and coordination of movements
– Vibratory sense may be absent– Patient may have a lemon-yellow complexion
as a result of jaundice caused by red cell destruction, early graying of hair, fast heartbeat, ankle swelling and peripheral neuritis
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Sources • Occurs primarily in animal foods, and
liver is the richest source
• Meat
• Eggs
• Milk
• Cheese
• Fish