autonomic nervous system. homeostasis integration receptors effectors feed-back
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Somatic vs Autonomic Nervous systems
Somatic NSReceptors Integration Effectors5 senses Cortex (& assoc.) Skeletal
muscles
Autonomic NSReceptors Integration EffectorsChemo-baro hypothalamus cardiac,Osmo- medulla oblongata smoothReceptors muscles
glands
Autonomic Nervous system
• Two aspects
-1 to promote survival - the other to promote
in crisis state survival in stable state
Sympathetic Parasympathetic
Fight or flight Rest and digest
Functions:Sympathetic Parasympathetic
• Promote survival in crisis state:- Increase heart rate- Increase breathing rate- Increase blood pressure- Vasoconstriction of peripheral/non-
essential blood vessels and- Vasodilation in heart, brain, muscles - Bronchodilation- Iris dilation- Increase blood glucose
• Decrease digestion- Decrease digestive juice secretion- Decrease digestive tube motility- Promote sphincter closing
• Opposite of Sympathetic- Promotes digestion- Promotes rest
Sympathetic NS
• 2 motor neurons• Motor neuron 1 in lateral
horn of spinal cord between T1 to L3
• Motor neuron 2 in the paravertebral ganglia (forming the sympathetic trunk)
• Acetylcholine (nicotinic receptor) in ganglionic synapse, norepinephrine at the organ synapse
• Nerve pathways mixed with somatic sensory and motor pathways
Motor Sympathetic NS
• Two exceptions:
- Adrenal gland: Motor neuron 2 has evolved into a “secretory” neuron which releases mostly epinephrine
- The collateral ganglia: ganglia located between spinal cord and effectors -- ex: celiac ganglia innervating the digestive system
Sympathetic trunk: all the linked paravertebral ganglia will react as a unit to a stimulation of the sympathetic NS heart rate increases, vasodilation of bronchi ….
Collateral ganglia: they will not automatically react as a unit with the motor neurons from the sympathetic trunk
The adrenal medulla
• The gland is formed by the second motor neuron
• Secretes epinephrine
• Sympathetic effect sustained
Parasympathetic NS
• 2 motor neurons• Motor neuron 1 in medulla
oblongata or sacral spine• Motor neuron 2 in a
ganglion near the organ• Acetylcholine (nicotinic
receptor) in ganglionic synapse
• Acetylcholine (muscarinic receptor) in effector synapse
• Nerve pathways mixed with sensory and motor pathways, except for Vagus nerve (75% ANS)
Receptors in the ANS
• Cholinergic receptors: Inhibitory or excitatory - Nicotinic: fast - Muscarinic: slow
Adrenergic receptors: slow, excitatory or inhibitory - α 1 and 2 - β 1 and 2 (and 3)
Figure 11.8a
Adrenergic receptors
- α 1 and 2: affinity NE > E generally excitatory
- β 1 and 3 affinity NE = E excitatory
- β 2 affinity E > NE inhibitory
Effects of various drugs on the ANS
• Drugs acting on the cholinergic receptors:
- agonist: simulate parasympathetic effect
- antagonist: blocks parasympathetic effect (mimics sympathetic agonist)
• Drugs acting on the sympathetic NS
- agonist: simulate sympathetic effect
- antagonist: blocks sympathetic effect (mimics parasympathetic agonist)
• Epinephrine and ephedrine are given in aerosol in people suffering from an asthma attack.
- Knowing that these drugs are adrenergic agonists, which effect do you expect on the bronchi?
- Which side effects are you likely to see?
Refer to Table 11-2 from the book to answer these question
• Propanolol is a beta-blocker.
- What is this drug effect on the heart?
- Which side effects are you likely to see?
Refer to Table 11-2 from the book to answer these question
• Atropine is a muscarinic cholinergic antagonist.
- What is this drug effect on the pupils?
- What is this drug effect on the heart?
- Which side effects are you likely to see?
- Will skeletal muscles be affected by this drug?
Refer to Table 11-2 from the book to answer these
question