AUTHOR INDEX

May 15, 1998

Aaltonen, L. A., 2087Ain. K. B., 2063Aizawa, S., 2076Albor, A., 2091Ambrosone, C. B., 2107Andersen, J„2166Arila, N., 2117Au, J. L-S., 2141

Aurelio, O. N., 2190Avizienyte, E., 2087

Barlati, S., 2234Barnas, C., 2057Bast, R. C., Jr., 2253Bastían,B. C., 2170Baylin, S. B., 2063Bekesi, J. G., 2126Bièche, I., 2081Boghaert, E. R., 2063Briffod, M., 2081Bröcker, E-B., 2170

Brown, J. M., 2098

Cajot, J-F., 2190

Campbell, I. G., 2095Cardi, G., 2078Chámpeme, M-H., 2081Chen, C-T., 2141

Chen, J. X., 2070Chen, Q., 2217Chenevix-Trench, G., 2095Copeta, A., 2234Costa, M., 2182Curici, D. T., 2134

DeClerck, Y. A„2209Delahoussaye, Y. M., 2098De Petro, G., 2234Dosemeci, M., 2176Driouch, K., 2081

Ehleiter, D., 2260Ernstoff, M. S., 2078Evans, J. W., 2098

Fan, C., 2217Fang, X., 2253Ferrane, S., 2149Fossa, S. D., 2087Freudenheim, J. L., 2107Fukayama, M., 2053Fuks, Z., 2260Furusato, M., 2076Furuya, A., 2053Fusenig, N. E., 2200

Gan, Y., 2141Gao, X., 2141Garlick, J. A., 2200Garzotto, M., 2260Giulini, S. M., 2234Gómez-Navarro, J., 2134

Graff, J. R., 2063Graham, S., 2107Gratas, C., 2057Greenberg, V. E., 2063Grim, J., 2134

Haimovitz-Friedman, A., 2260

Hainaut, P., 2057Hamm, H., 2170Hanai, N„2053Hansen, L. L., 2166Hayes, R. B., 2176Heaney, J. A., 2078Hemminki, A., 2087Herman, J. G., 2063Hiraga, S., 2117Hirose, M., 2158Hishiki, T., 2158Hitchcock, A., 2095Holland, J. F., 2126Hua, M. L-H., 2190

Ichimiya, S., 2076, 2158Ikeno, T., 2067Ishida, K., 2067Isogai, E., 2158Izumoto, S., 2117

Jang, S. H., 2141Javaherian, A., 2200Jiang. J-D., 2126

Jiang, Y., 2260Johnson, A. L., 2141Johnston, J., 2141

Kadlubar, F. F., 2107Kadono, Y., 2240Kaku, S., 2091Kamiakito, T., 2053Kanemura, Y., 2117Katsuyama, T., 2067Kawasaki, S., 2067Keck, C. L., 2196Khwaja, Z., 2190Kjnsella, T. J., 2245Knuth, A., 2149Kobayashi, Y., 2053Koike, M., 2053Kolachana, P., 2176Kolesnick, R., 2260Kondo, K., 2158Kong, A-N. T., 2102

Kruse. T. A., 2166Kuh, H-J., 2141Kulesz-Martin, M., 2091Kuo, M-L., 2245Kuriki, K., 2053

Laug, W. E., 2209Laughlin, R., 2107LeBoit, P. E., 2170Lei, W., 2102

Li, D., 2141Li, G., 2176Liao, W-C, 2260

Lidereau, R., 2081Liu, R. Y., 2217Lome, R. A., 2087Loukola, A., 2087

Mandlekar, S., 2102Marshall, J. R., 2107Martin, M. L., 2253Maruta, F., 2067Matsumura, H., 2117Mike, N., 2149Millenbaugh, N. J., 2141Miller, M. J., 2196Mills, G. B., 2253Mitchell, S., 2217Miyahara, E., 2117Momburg, F., 2149Morland, S. J„2095

Nakagawara, A., 2076, 2158Nakamura, Y., 2158Namiki, M., 2240Nelsen, L. L., 2253Nemoto, T., 2107Nimura, Y., 2076, 2158

Obata, K., 2095Ohgaki, H., 2057Ohnishi, T., 2117Ohnuma, N., 2158Okada, Y., 2240Ostrowski, M. C., 2253Overgaard, J., 2166Ozaki, T., 2158

Patton, S. E., 2253Pena, J. C, 2111Piché,A., 2134Pinkel, D., 2170Popescu, N. C., 2196Portolani, N., 2234

Rancourt, C., 2134Reed, J. C., 2134Roboz, J., 2126Roth, S., 2087Rothman, N., 2176Rudin, C. M., 2111

Saji, M., 2063Sakiyama, S., 2158Salnikow, K., 2182Salovaara, R., 2087Santoro, S. A., 2224Sato, H„2240Schned, A. R., 2078Seeger, R. C., 2209Seiki, M., 2240Seki, N., 2158

Seliger, B„2149Shields, P. G., 2107Shimada, H., 2209Shimizu, N., 2067Smith, M. T., 2176Stanbridge, E. J., 2190Stenwig, A. E., 2087Stone, A., 2107Sträuchen, J., 2126Sugiura, Y., 2209Sugiyama, A., 2067Sun, H., 2224

Takahashi, Hid., 2158Takahashi, Hir., 2076Tanabe, M., 2158Tanaka, A.. 2053Tang, M-s., 2070

Tanière, P., 2057Tatematsu, M., 2067Tavian, D., 2234Thomas, E. J., 2095Thompson, C. B., 2111Thompson, P. A., 2107Thorgeirsson, S. S., 2196Titenko-Holland, N., 2176

Tohma, Y., 2057

Vaccariello, M., 2200Vena, J. E., 2107

Wakui, S., 2076Wang, Yue., 2126Wang, Yun., 2176Wang, Z., 2149Watanabe, M., 2076Watson, R. H., 2095West, M., 2070Westra, W. H., 2063White-Jones, M., 2260

Wiemels, J., 2176Wientjes, M. G., 2141Wu, J., 2217

Xi, L., 2176

Yamasaki, M., 2053Yatani, R., 2076Yilmaz, M., 2166Yin, S., 2176Yoshida, H., 2053Yu, R., 2102Yuan, B-Z., 2196Yudoh, K., 2098

Zeiger, M. A., 2063Zhang, L., 2176Zheng, Y., 2070Zhou, D., 2182Zimmer, S. G., 2063Zimonjic, D. B., 2196Zuckerman, K. S., 2217Zutter, M. M., 2224

2268

AMERICAN ASSOCIATION FOR CANCER RESEARCHGUIDELINES FOR APPLICATION FOR ACTIVE ANDCORRESPONDING MEMBERSHIP

BENEFITS OF MEMBERSHIP

The American Association for Cancer Research (AACR), a scientificsociety of over 13,500 laboratory and clinical cancer researchers, was foundedin 1907 to facilitate communication and dissemination of knowledge amongscientists and others dedicated to the cancer problem; to foster research incancer and related biomédicalsciences; to encourage the presentation anddiscussion of new and important observations in the field; to foster publiceducation, science education, and training; and to advance the understandingof cancer etiology, prevention, diagnosis, and treatment throughout the world.

Members of the AACR enjoy the following benefits:

1. the privilege of sponsoring a proffered paper (abstract) for consideration for presentation at the AACR annual meeting;

2. subscriptions to the Association's high-quality journals Cancer Re

search, Clinical Cancer Research, Cell Growth & Differentiation, andCancer Epidemiology, Biomarkers & Prevention at reduced memberrates;

3. an advance copy of the Program and Proceedings of the AmericanAssociation for Cancer Research that contains over 4,000 abstracts ofproffered papers presented at the annual meeting:

4. reduced registration rates at annual meetings;5. priority notice of small, focussed meetings in the AACR's exciting series

of Special Conferences in Cancer Research;6. substantially reduced registration rates for Special Conferences:7. opportunities for participation in AACR meetings in North America and

abroad with other scientific societies around the world;8. receipt of AACR Newsletters and other important announcements;9. early notification of and reduced rates for participation in the AACR

Employment Register;10. an up-to-date Membership Directory of over 13,500 member researchers

in the cancer field:11. the professional benefits of the AACR's public education activities con

cerning funding for cancer research and press coverage of the latestresearch findings;

12. the opportunity to participate in three Summer Workshops that fosterknowledge in the cancer field for young investigators;

13. the facilitation of informal scientific exchange with leading researchers inthe cancer field; and

14. many more ongoing benefits.

QUALIFICATIONS FOR MEMBERSHIP

Active membershipin the AACR is open to investigatorswho live in theAmericas. Individuals who have conducted two years of research resulting inpeer-reviewed publications relevant to cancer, or who have made substantialcontributions to cancer research in an administrative or educational capacity,are eligible. If a candidate has conducted research in an area of biomédicalscience related to cancer, he or she will qualify for membership. Evidence ofpatents relevant to cancer research may be submitted as qualifications formembership in lieu of peer-reviewed publications.

Corresponding membership is open to persons who are not residentsof the Americas. The qualifications for corresponding membership are thesame as those indicated above for active membership. Visiting scientistsfrom outside the Americas who intend to return to their countries of originby the anticipated time of election should apply for corresponding membership. All other visiting scientists should apply for active membershipand transfer to corresponding status upon leaving the Americas.

Graduate and medical students, postdoctoral fellows, and physicians intraining who do not yet meet the above qualifications for active orcorresponding membership should apply for associate membership.Forms for associate membership are available from the AACR Office.

PROCEDURES FOR APPLICATION

There are three deadlines for the receipt of a membership application:January 1, May 1, and September 1 of each year. The MembershipCommittee will review all complete applications for active membershipthat have been received by these deadlines and will submit recommendations on each candidate to the Board of Directors which formally elects all

members. The same procedure is followed by the Special MembershipsCommittee which receives applications for corresponding membership.Candidates will be notified according to the following schedule:

Receipt of Applicationin AACR Office

January 1May 1September 1

Notification of CandidateMarchJulyNovember

A complete application consists of the following material:1. 6 copies of the form on the opposite side of this page, with all requested

information provided.2. 5 copies of the candidate's most current curriculum vitae and bibliog

raphy.3. 5 copies of a letter of recommendation from a nominator who is an

active, corresponding, emeritus, or honorary member of the AACR (atleast one copy must be a signed, original letter). This letter shoulddescribe the candidate's achievements in laboratory research, clinical

investigations, or epidemiological research, and it should affirm thatthis research adheres to accepted ethical scientific standards. -OR- Thenominator may supply the responses requested at the bottom of theapplication form in the section entitled "STATEMENT OF SUPPORT" (at least one copy of the form must be the signed original).

4. 5 copies of a letter of recommendation as described in Item 3 abovefrom a seconder who is an active, corresponding, emeritus, or honorarymember of the AACR (at least one copy must be a signed, originalletter). -OR- The seconder may supply the responses requested at thebottom of the application form in the section entitled "STATEMENT OFSUPPORT " (at least one copy of the form must be the signed original).

5. 5 reprints of each of two publications on which the candidate appears asauthor. As noted above, evidence of patents developed by the candidatemay be submitted in lieu of one or both of the publications. If submittingpatents, supply patent number and year awarded.

All material should be collated into five complete sets with the originalapplication form as a covering document and sent to the address givenbelow. Questions regarding procedures for membership application mayalso be directed to the following address:

Membership Services DepartmentAmerican Association for Cancer Research

Public Ledger Building, Suite 826150 S. Independence Mall WestPhiladelphia, PA 19106-3483

Phone: 215/440-9300FAX: 215/440-9412

E-mail: aacr@aacr.org

RESPONSIBILITIES OF MEMBERSHIP

Candidates should be aware of the following responsibilities of membership in the AACR. Active members must pay annual dues. In 1998annual dues for active members are $175, $100 of which is designated forAACR journal subscriptions. Newly elected members of the AACR whohave already purchased subscriptions to Cancer Research, Clinical Cancer Research, Cell Growth & Differentiation, or Cancer Epidemiology,Biomarkers & Prevention at the higher, nonmember rates will receivereimbursement of the unused portion of those subscriptions once their firstyear's membership dues are paid in full.

Corresponding members are required to pay dues ($100 in 1998) andmay, if they wish, subscribe to Cancer Research, Clinical Cancer Research, Cell Growth a Differentiation, or Cancer Epidemiology, Biomarkers & Prevention at reduced member rates.

Applicants elected in March will be responsible for payment of thatyear's dues; applicants elected in July and November will pay dues for the

following year. Applicants elected in March and July will be eligible tosponsor an abstract for the next annual meeting. Every effort will be madeto afford the same opportunity to applicants elected in November.

Margaret Foli, Ph.D.Executive Director

AMERICAN ASSOCIATION FOR CANCER RESEARCH, INC.Public Ledger Building •¿�Suite 826 •¿�150 S. Independence Mall West •¿�Philadelphia, PA 19106-3483

APPLICATION FOR ACTIVE OR CORRESPONDING MEMBERSHIP

NAME OF CANDIDATE:. DATE OF BIRTH:.LAST FIRST M.I. Month/Day/Year

PRESENT POSITION/TITLE:.

INSTITUTIONAL AFFILIATION:.

INSTITUTIONAL ADDRESS:

(City)

TELEPHONE NUMBER:.

E-MAIL ADDRESS:

(State/Province) (Country)

FAX NUMBER:.

(Postal Code)

PRIMARY FIELD OF RESEARCH (Please check only one):Biochemistry and Biophysics BiostatisticsCellular Biology and Genetics Clinical InvestigationsEpidemiology ImmunologyPreclinical Pharmacology and VirologyExperimental Therapeutics

ACADEMIC DEGREES (Including where and when granted)

_Carcinogenesis.Endocrinology_Molecular Biology and Genetics_Other:

(Please specify)

EXPERIENCE SINCE HIGHEST DEGREE WAS GRANTED (Please list most recent first)

PUBLICATIONS (Reprints of two peer-reviewed articles on which the candidate appears as an author must accompany this application. For

these two articles list the authors, title, journal, volume, inclusive pages, and year. Do not submit abstracts. If submitting patents, supply patentnumber and year awarded.)

CANDIDATE IS APPLYING FOR (Check one): D ACTIVE D CORRESPONDING MEMBERSHIP

CANDIDATENOMINATED BY*:.

CANDIDATESECONDED BY*:.

(Please print) (Please print)

STATEMENT OF SUPPORTInstead of submitting letters of recommendation, either the nominator or the seconder or both may complete the following section:

I acknowledge by signing this statement of support that this candidate adheres to accepted ethical scientific standards and has or will make along-term contribution to cancer research.

Signature of Nominator* Date Signature of Seconder*

See Guidelines for Application on the reverse side of this form for further instructions.

*Both nominator and seconder must be active, corresponding, emeritus, or honorary members of the AACR in good standing.

(This form may be reproduced.)

Date

1998

AMERICAN ASSOCIATION FOR CANCER RESEARCH

GUIDELINES FOR APPLICATION FOR ASSOCIATE MEMBERSHIP

QUALIFICATIONS FOR MEMBERSHIP

Associate membership is open to graduate students, medical students,postdoctoral fellows, and physicians in training who are following acourse of study or who are working in a research program relevant tocancer. Scientists in training who already have a substantial record ofpublications may wish to apply for active or corresponding membershipwhich confers full benefits of membership.

BENEFITS OF MEMBERSHIPThe American Association for Cancer Research (AACR), a scientific

society consisting of laboratory and clinical cancer researchers, wasfounded in 1907 to facilitate communication and dissemination of knowledge among scientists and others dedicated to the cancer problem; tofoster research in cancer and related biomédicalsciences; to encouragepresentation and discussion of new and important observations in thefield; to foster public education, science education, and training; and toadvance the understanding of cancer etiology, prevention, diagnosis, andtreatment throughout the world. Associate members of the AACR enjoythe following benefits:

1. the privilege of sponsoring a proffered paper (abstract) for consideration for presentation at the AACR annual meeting provided that (a)the associate member is the presenter of the paper and (b) an active,corresponding, emeritus, or honorary member in good standing of theAACR also signs the abstract of the paper in support of the work. (Inthis instance, the member who cosigns the abstract does not lose hisor her own sponsorship privilege.);

2. optional subscriptions to the Association's high-quality journals:

Cancer Research, Clinical Cancer Research, Cell Growth & Differentiation, and Cancer Epidemiology, Biomarkers & Prevention atreduced member rates; beginning in 1998 associate members will beable to purchase AACR journals for half the price of a regularmember subscription;

3. the privilege of registering for the annual meeting at the low associatemember rate;

4. the privilege of electing an Associate Member Council that organizesprograms benefiting associate members and that presents their concerns to the AACR Board of Directors;

5. the opportunity to stand for election to the Associate Member Council;

6. preferred access to the AACR Employment Register;7. priority notification of events in the AACR's series of special

conferences on timely subjects in the field;8. substantially reduced registration rates at special conferences;9. the receipt of AACR newsletters, meeting announcements, and an

up-to-date Membership Directory;10. the opportunity to participate in three Summer Workshops that foster

knowledge in the cancer field for young investigators; and11. the facilitation of informal scientific exchange with leading research

ers in the cancer field.

PROCEDURES FOR APPLICATIONPersons wishing to apply for associate membership must use the

official application form on the reverse side of these instructions. Eachcandidate for associate membership must be nominated by an active,corresponding, emeritus, or honorary member in good standing of the

AACR. Three completed copies of the form should be submitted; at leastone of these copies must carry the original signatures of both the candidateand the nominator. In addition, the candidate should submit one copy ofhis or her curriculum vitae. The application form may be submitted to theAssociation Office at any time.

After review of applications for associate membership, the ExecutiveDirector will notify candidates of their election or deferral within onemonth of the receipt of the application form. A check for one year's dues

payment must accompany the application. Dues for 1998 are $55 forassociate members residing in the Americas and $65 for residents of othercountries. This fee will be refunded to any candidate deemed to beineligible for associate membership. Checks should be in U.S. currency,made payable to AACR, Inc., and drawn on a U.S. bank. Send the threecopies of the application form and the appropriate dues payment to:

Membership Services DepartmentAmerican Association for Cancer Research

Public Ledger Building, Suite 826150 S. Independence Mall WestPhiladelphia, PA 19106-3483

Phone: 215/440-9300Fax: 215/440-9412

E-mail: aacr@aacr.org

RESPONSIBILITIES OF MEMBERSHIP

Associate members must pay annual dues in an amount to be determined by the AACR Board of Directors. Dues for 1998 have been set at$55 per year for residents of the Americas and $65 for residents of othercountries. If an application is submitted by August 31, the accompanyingdues payment will be credited to the current year. Candidates submittingapplications between September 1and December 31 may indicate whetherthey wish their dues payments credited to the current or forthcoming year.Candidates should be aware, however, that associate members may sponsor an abstract for the annual meeting only if their dues for the current yearare paid. For example, an associate member submitting an abstract inNovember 1998 for the forthcoming annual meeting must have paid duesfor 1998. Any newly elected associate members of the AACR who havealready purchased subscriptions to Cancer Research, Clinical CancerResearch, Cell Growth & Differentiation, or Cancer Epidemiology, Bio-markers & Prevention at the higher, nonmember rate will receive a refundfor the unused portion of that subscription upon receipt of their paymentfor a member's subscription.

Each Fall the AACR will send to current associate members an invoicefor dues for the forthcoming year. Payment of this invoice must beaccompanied by a statement signed by the associate member's currentregistrar, dean, or department head, verifying the member's current academic status. The Association's By-Laws state that dues are payable for

each year in advance by January 1 of the year to which they should beapplied. An individual may be an associate member for a maximum offive years. Each year in which an individual pays dues will count as onefull year of associate membership. Thus, an associate member who paysdues for 1998 may retain associate membership until December 31, 2002.The Board of Directors may terminate the membership of an associatemember whose dues are in arrears for two years.

Margaret Foti, Ph.D.Executive Director

AMERICAN ASSOCIATION FOR CANCER RESEARCH, INC.Public Ledger Building •¿�Suite 826 •¿�150 S. Independence Mall West •¿�Philadelphia, PA 19106-3483

APPLICATION FOR ASSOCIATE MEMBERSHIP

NAME OF CANDIDATE:. DATE OF BIRTH:_LAST FIRST M.I. Month/Day/Year

INSTITUTIONAL AFFILIATION:.

INSTITUTIONAL ADDRESS:

(City)

TELEPHONE NUMBER:

E-MAIL ADDRESS:

(State/Province) (Country)

FAX NUMBER:.

(Postal Code)

PRESENT ACADEMIC STATUS/TITLE (Please check only one):Graduate Student Medical StudentPhysician in Training Postdoctoral Fellow

PRIMARY FIELD OF RESEARCH (Please check only one):Biochemistry and Biophysics BiostatisticsCellular Biology and Genetics Clinical InvestigationsEpidemiology ImmunologyPreclinical Pharmacology and VirologyExperimental Therapeutics

Gender: D Male D Female

_Carcinogenesis.Endocrinology.Molecular Biology and Genetics.Other:

(Please specify)

ACADEMIC DEGREES (Please indicate degree(s) acquired to date along with the name of the academic institution and date of receipt. Provideinformation on degree currently being sought and the anticipated date of completion of this degree program.)

RELEVANT RESEARCH EXPERIENCE NOT RELATED TO COURSE WORK (Please list most recent first.)

PUBLICATIONS (List the authors, title, journal, volume, inclusive pages, and year of any article in a peer-reviewed journal on which the

candidate appears as an author. Do not list abstracts. Continue on a separate sheet, if necessary.)

CANDIDATE NOMINATED BY*:

(Please print!SIGNATURESI hereby apply for associate membership in the American Association for Cancer Research. I have read the instructions on the reverse side ofthis form, and I understand the privileges and responsibilities of this class of membership. I certify that the statements on this application aretrue.

Signature of Candidate:. Date:.

I recommend this candidate for associate membership in the American Association for Cancer Research. To the best of my knowledge, thecandidate is qualified for this class of membership, and the statements on this application are true.

Signature of Nominator*: Date:

Submit three copies of this form. At least one copy must contain the original signatures of the candidate and the nominator. In addition, submitone copy of your curriculum vitae. Enclose a check in U.S. funds, made payable to AACR, Inc., and drawn on a U.S. bank for one year's dues.

For 1998, dues are $55 for associate members residing in the Americas and $65 for residents of other countries.

Check one of the following boxes only if this form is being submitted between September 1 and December 31:The enclosed dues payment should be applied to the D current D forthcoming calendar year.

(NOTE: If dues are applied to the forthcoming year, membership will take effect on January 1, but the candidate will not be eligible to sponsoran abstract for presentation at the annual meeting in March or April of that year.) See Guidelines for Application on the reverse side of thisform for further instructions.

'Nominator must be active, corresponding, emeritus, or honorary member of the AACR in good standing.

(This form may be reproduced.) 1998

Guidelines for Submitting Disksto

American Association for Cancer Research Publications

The word processing packages that we prefer are as follows:

MacWriteMicrosoft Word (DOS, Windows,

and Macintosh)

WordPerfect (DOS, Windows,and Macintosh)

XyWrite (DOS and Windows)

Also acceptable:

AbilityAmiPro

AppleworksArborTEXArborTextClarisWorks WPCPT 8000CTOSDiabloDisplayWriteDuetEinsteinEnableEXPFinal WordFullWriteGemWord PlusIBM Writing AssistantInterleafLATEX

LatexLeading EdgeLotus ManuscriptLotus Write

Mass 11MS Windows WriteMS WorksMS Works WP MacMultimateMultimate AdvantageNibiaNisus (to ASCII file)NotewriterObunOfficeWriterPC WritePFS First ChoiceProfessional WriteQ&A WriteQuark XPressRagTime MS Works

(to ASCII file)Rich Text FormatRSG (to ASCII file)SignatureSLITeXSmartWhereSmartWrite II

SoloWriterSprintStxSunWriteSymphonyTEXTEX78Text ExecutiveTexturesTotal WordTroff¿¿TEXVolkswriterVuWriterWang OISWang WPSWang WriterWindow WorksWindows WriteWiziWordWordstarWordstar 2000WriteNowXerox

Software packages that we are unable to translate:

FrameMakerPageMaker

Ready, Set, GoScientific Writer

Disks produced on IBM or IBM-compatible computers are preferred, but those produced on some Apple orWang computers can also be converted. Because of the file structures and internal coding, we cannot acceptdisks created on desktop publishing systems or those created on proprietary typesetting systems. We alsocannot guarantee that all special characters can be translated. Tabular and mathematical material, such asequations, will not be captured from the disk but will be rekeyed.

To expedite work and for your own security, we do require that you submit a hard copy printout of the diskfile. The tables and equations will be keyed from this hard copy. We also need to know the name of the fileto be converted, the type of hardware (e.g., IBM PC) on which the files were created, the operating system(e.g., DOS 3.3), and the version of the software (e.g., WordPerfect 5.1) used to create the file.

PLEASE FILL OUT ALL INFORMATION ON REVERSE SIDE AND SUBMIT THIS FORM WITH YOUR DISK.DISKS WILL NOT BE PROCESSED WITHOUT THIS INFORMATION.

I

DISK SUBMISSION FORM

AACR journals are now using personal computers to copyedit manuscripts accepted for publication. Whensubmitting a revised manuscript, authors are encouraged to submit an electronic disk of the paper along withthe required four hard copy printouts. Disks will ultimately be returned to the authors.

See reverse for the word processing packages that can be accepted.

File preparation

Please be sure that the file you send is the most recent version of the manuscript and that it matches the mostrecently submitted printed copy. The file should contain all the parts of the manuscript in one file. Mathematical and tabular material, however, will be processed in the traditional manner and may be excluded fromthe disk file.

Note: AACR does not assume responsibility for errors in conversion of customized software, newly releasedsoftware, or special characters.

Please label the outside of the disk with the journal name, the first author's name, a partial title of the

manuscript, and the name of the computer file used to access the manuscript on disk. To process your diskefficiently, we need the following information. Please be sure to provide ALL the information.

Name used to access paper on disk:

Name of computer used (e.g., IBM/PS2):

Operating system and version (e.g., DOS 3.3):Word processing program and version (e.g., WordPerfect 5.0):

[See reverse for acceptable programs.]

Manuscript number:First author:

Corresponding author (if different from first author):Telephone/FAX numbers:

This form (both sides) may be reproduced.

BECAUSErou CAN'TBEEVEPTWHERE... TAKETHISMEETINGHOMEWITHrou ONAJDIOCASSETTE.

AMERICANASSOCIATIONFORCANCERRESEABCH89THANNUAL MEETING

March 28 - April 1, 1998 •¿�New Orleans, LA

AUDIO CASSETTE DISCOUNTSi - 5 cassettes $11.506 - ii cassettes 5% discount12-24 cassettes 10%discount25 - 48 cassettes 15%discount4<^i- 20% discountPROGRAMSWNSISTor i, 2 OR3 cAssimns.PRICES ARE US7T-D BEFORE PROGRAM TITUS.

OCAN 800 (2 cass., $23) Public Forum: Progress and New Hope in the FightAgainst CancerCUCAN 801 (2 cass., $23) Educational Session 1: Molecular Epidemiology: CurrentPerspectivesDCAN 802 (2 cass., $23) Educational Session 2: Cell Cycle RegulationDCAN 803 (3 cass., $34.50) Methods Workshop 2: Establishment, Maintenance,and Quality Control of BiorepositoriesDCAN 804 (3 cass., $34.50) Methods Workshop 1: Bioinformatics in CancerResearchDCAN 805 (2 cass., $23) Educational Session 3: Cancer Research and the FDADCAN 806 (1 cass., $11.50) Educational Session 4: Signaling for ApoptosisDCAN 807 (2 cass., $23) Educational Session 5: Steroid Receptors, OrphanReceptors, and Significance of Population VariationDCAN 808 (2 cass., $23) Educational Session 6: Basic Biology of Tyrosine KinasesDCAN 809 (1 cass., $11.50) Meet the Expert Sunrise Session: Cancer GenomeAnatomy Project (CGAP): Update and Potential (PaulS. Meltzer)DCAN 810 (1 cass., $11.50) Meet the Expert Sunrise Session: JAKs, STATs, andSrc Kinases: Obligate Partners in Cytokine Signaling (E. Premkumar Reddy)DCAN 811 (1 cass., $11.50) Meet the Expert Sunrise Session: Histone Acetylationand Transcriptional Regulation (Tony Kouzarides)DCAN 812 (1 cass., $11.50) Meet the Expert Sunrise Session: Molecular Geneticsof Brain Tumors (Sandra H. Bigner)DCAN 813 (1 cass., $11.50) Meet the Expert Sunrise Session: Genetic Analysis ofTumor Suppression by COX-2 Inhibitors (Makoto Mark Taketo)DCAN 814 (1 cass., $11.50) Meet the Expert Sunrise Session: Sequence-specific

Gene Regulation: Applications of Ribozymes in Preclinical Models of Cancer(ThaïeC. JarvisJDCAN 815 (1 cass., $11.50) Meet the Expert Sunrise Session: Gene Transfer toHematopoietic Progenitors (Fulvio Mavilio)DCAN 816 (1 cass., $11.50) Meet the Expert Sunrise Session: Genetic Testing forBreast Cancer Susceptibility: Psychosocial and Clinical Research Update(Caryn E. Lerman)DCAN 817 (1 cass., $11.50) Meet the Expert Sunrise Session: Nuclear HormoneReceptors in Development and Disease (Vincent Giguere)DCAN 818 (1 cass., $11.50) Presidential Address: Cancer Cell Structure:Aberrations in the Decoder of DNA (Donald S. Coffey)DCAN 819 (3 cass., $34.50) Plenary Session: New Horizons in Cancer ResearchDCAN 820 (1 cass., $11.50) Thirty-Eighth Annual G.H.A. Clowes MemorialAward Lecture: The Regulation and Function of the p53 Tumor SuppressorProtein (ArnoldJ. Levine)DCAN 821 (3 cass., $34.50) Minisymposium Radiobiology/Radiation Oncology2: Molecular Aspects of Radiation ResponsesDCAN 822 (3 cass., $34.50) Minisymposium Carcinogenesis 2: CooperativeMolecular Interactions in Tumor Promotion and ProgressionDCAN 823 (3 cass., $34.50) Minisymposium Pharmacology and ExperimentalTherapeutics 5: Biochemical Pharmacology of DNA Topoisomerase PoisonsDCAN 824 (3 cass., $34.50) Minisymposium Cell and Tumor Biology 3:Extracellular Matrix Proteases in InvasionDCAN 825 (2 cass., $23) Symposium 2: Inherited Cancer SusceptibilitySyndromes: Genetics, Genes, and FunctionDCAN 826 (2 cass., $23) Symposium 1: Telomerase and Telomeres in Normal andNeoplastic CellsDCAN 827 (2 cass., $23) Symposium 3: Cancer Gene Therapy: New Conceptsand Clinical ApplicationsDCAN 828 (2 cass., $23) Symposium 4: The Promise of Oncogene-based Drug

TargetingDCAN 829 (1 cass., $11.50) First AACR-Pezcoller International Award Lecture:

SH2 Domains and Modular Proteins Control Signal Transduction Pathways (AnthonyJ. Paulson)DCAN 830 (2 cass., $23) Minority Issues Committee Symposium: Mentorship andYou: The Key to a Successful Career m BiomédicalResearch

DCAN 831 (1 cass., $11.50) Meet the Expert Sunrise Session: MolecularPathogenesis of Non-Hodgkin's Lymphoma (Riccardo Dalla-Favcra)

DCAN 832 (1 cass., $11.50) Meet the Expert Sunrise Session: HormonalRegulation of Cell Growth and Differentiation (Lorraine]. Gudas)DCAN 833 (1 cass., $ 11.50) Meet the Expert Sunrise Session: Alterations of CellCycle Controls in Cancer (Giulio F. Draetta)DCAN 834 (1 cass., $11.50) Meet the Expert Sunrise Session: Proteases inCancer: Clinical Significance and Mechanisms in Metastasis (Henri Rochefort)DCAN 835 (1 cass., $11.50) Meet the Expert Sunrise Session: Inherited Cancersof the Kidney: Family Studies, Genes, and Biochemistry (W. Mantón Linchan)DCAN 836 (1 cass., $11.50) Meet the Expert Sunrise Session: Antimetabolites:New Insights into Cell Death/Signal Transduction Pathways as Determinants ofDrug Sensitivity (Steven Grant)DCAN 837 (1 cass., $11.50) Meet the Expert Sunrise Session: Strategies forCombining Chemotherapy and Biotherapy (Antonio C. Buzaid)DCAN 838 (1 cass., $11.50) Meet the Expert Sunrise Session: Interleukin-12:Biological and Clinical Development (Giorgio Trinchieri)DCAN 839 (1 cass., $11.50) Meet the Expert Sunrise Session: ChemopreventionTrials: Progress and Promise (Scott M. Lippman)DCAN 840 (2 cass., $23) Symposium 5: Tumor Angiogenesis and Microcirculation: An Integrated ApproachDCAN 841 (2 cass., $23) Symposium 6: Signaling by wnt-1, (1-Catenin, and the

APC Tumor Suppressor in CancerDCAN 842 (2 cass., $23) Symposium 7: Prostate Cancer: Basic Science andClinical AspectsDCAN 843 (2 cass., $23) Symposium 8: Molecular Determinants of Cellular andTumor Responses to RadiationDCAN 844 (3 cass., $34.50) Minisymposium Immunology/Preclinical andClinical 4: Dendritic Cells in ImmunotherapyDCAN 845 (3 cass., $34.50) Minisymposium Cell and Tumor Biology 8:Apoptosis III: Indictment, Judgment, Execution, and ReprieveDCAN 846 (3 cass., $34.50) Minisymposium Pharmacology and ExperimentalTherapeutics 12: Novel Agents and TargetsDCAN 847 (3 cass., $34.50) Minisymposium Pharmacology and ExperimentalTherapeutics 13: Downstream Effects of Cytotoxic Drugs and Reversal ofCheckpoint AbrogationDCAN 848 (3 cass., $34.50) Minisymposium Molecular Biology 8: Transcriptional Regulation of Cell Transformation and Tumor ProgressionDCAN 849 (1 cass., $11.50) Controversy Session 1: Environmental Estrogensand CancerDCAN 850 (1 cass., $11.50) Third Annual Joseph H. Burchenal AACR ClinicalResearch Award Lecture: The Biology and Therapy of Breast Cancer: Reflectionsfrom Several Perspectives (BernardFisher)DCAN 851 (1 cass., $11.50) Session on Survivors and Cancer ResearchDCAN 852 (3 cass., $34.50) Minisymposium Prevention 5: New Agents forCancer PreventionDCAN 853 (3 cass., $34.50) Minisymposium Clinical Research 6: Breast CancerDCAN 854 (3 cass., $34.50) Minisymposium Pharmacology and ExperimentalTherapeutics 18: Farnesyltransferase InhibitorsDCAN 855 (3 cass., $34.50) Minisymposium Cell and Tumor Biology 12:Positive and Negative Regulators of AngiogenesisDCAN 856 (3 cass., $34.50) Minisymposium Molecular Biology 13: Viral andCellular OncogenesDCAN 857 (2 cass., $23) Symposium 9: The bcl-2 Family: Death Agonists andAntagonistsDCAN 858 (2 cass., $23) Symposium 10: The Molecular Basis of ImmuneRecognition: Basic Concepts with Therapeutic ImplicationsDCAN 859 (2 cass., $23) Symposium 11: Genetic Approaches to Diagnosis: TheImpact of Molecular Medicine on Early Detection and DiagnosisDCAN 860 (2 cass., $23) Symposium 12: New Concepts in Chemotherapeuticsand Drug ResistanceDCAN 861 (1 cass., $11.50) "NCI Listens" - NCI Board of Scientific Advisors

SessionDCAN 862 (1 cass., $11.50) AACR Annual Business MeetingDCAN 863 (2 cass., $23) NCI Training Branch WorkshopDCAN 864 (1 cass., $11.50) Meet the Expert Sunrise Session: Integrin Signalingand Cell Growth Control: Consensus and Controversies (Rudolph L. Juliano)DCAN 865 (1 cass., $11.50) Meet the Expert Sunrise Session: Growth FactorSignaling: The IGF-1, IGF-2 System in Cancer (Haim Werner)

DCAN 866 (1 cass., $11.50) Meet the Expert Sunrise Session: Pathogenesis ofAcute Promyelocytic Leukemia (Pier Giuseppe Pclicci)

DCAN 867 (l cass., $11.50) Meet the Expert Sunrise Session: Radiation Sensitiza-tion: Basic and Clinical Aspects (Rufen K. Schmidt-Ullrich)

nCAN 868 (1 cass., $11.50) Meet the Expert Sunrise Session: Advances inMechanisms of Drug Resistance: Basic Science and Clinical Implications (Susan E. Bates)DCAN 869 (1 cass., $11.50) Meet the Expert Sunrise Session: Familial CancerSyndromes: Genetic Tests and Clinical Approaches (Ken Yamaguchi)nCAN 870 (1 cass., $11.50) Meet the Expert Sunrise Session: Issues and Applications in Molecular Epidemiology (Barbara S. Hulka)DCAN 871 (1 cass., $11.50) Meet the Expert Sunrise Session: Harnessing theImmune System in Tumor Therapy: Manipulating Stimulatory and Inhibitory Signalsin T-Cell Activation (James P. Allison)

DCAN 872 (1 cass., $11.50) Meet the Expert Sunrise Session: New TherapeuticDevelopments with Polyamine-directed Analogues and Inhibitors (Carl W. Porter)

DCAN 873 (2 cass., $23) Symposium 13: Cell Death Signaling Pathways: CaspaseCascades and Effectors/Initiators of ApoptosisDCAN 874 (2 cass., $23) Symposium 14: p53/p73: An Emerging Gene FamilyDCAN 875 (2 cass., $23) Symposium 15: Breast Cancer: Basic Science and ClinicalAspectsDCAN 876 (2 cass., $23) Symposium 16: Cancer Biology in Context: Stromal-Epithelial, Cell-Cell, and Cell-Extracellular Matrix Interactions in Normal Develop

ment and CancerDCAN 877 (3 cass., $34.50) Minisymposium Prevention 7: Novel Retinoids inCancer ChemopreventionDCAN 878 (2 cass., $23) Minisymposium Clinical Research 9: Human Cancer GeneTherapyDCAN 879 (3 cass., $34.50) Minisymposium Pharmacology and ExperimentalTherapeutics 24: P-Glycoprotein: Function and Modulation

DCAN 880 (3 cass., $34.50) Minisymposium Pharmacology and ExperimentalTherapeutics 25: Pharmacogenetic- and Pharmacokinetic-guided Studies of New Agents

DCAN 881 (3 cass., $34.50) Minisymposium Epidemiology 4: Molecular Basis ofCancer SusceptibilityDCAN 882 (1 cass., $11.50) Late-Breaking Research SessionDCAN 883 (1 cass., $11.50) Twenty-Second Richard and Hinda Rosenthal AwardLecture: From the Human B-Cell Surface to the Bedside (Lee M. Nodier)

DCAN 884 (1 cass., $11.50) Seventeenth Annual Cornelius P. Rhoads MemorialAward Lecture: Cancer as a Complex Developmental Disorder (Michael C Dean)DCAN 885 (3 cass., $34.50) Minisymposium Molecular Biology 21: Screening for

Gene ExpressionDCAN 886 (3 cass., $34.50) Minisymposium Carcinogenesis 10: Genetics of Cancerand Exposure SusceptibilityDCAN 887 (3 cass., $34.50) Minisymposium Pharmacology and Experimental

Therapeutics 31: MDR Gene RegulationDCAN 888 (3 cass., $34.50) Minisymposium Cell and Tumor Biology 19: Signalingthrough MAP KinasesDCAN 889 (3 cass., $34.50) Minisymposium Molecular Biology 22: MismatchRepair and Genome StabilityDCAN 890 (2 cass., $23) Symposium 17: Molecular Targets and Endpoints forChemopreventionDCAN 891 (2 cass., $23) Symposium 18: Gastrointestinal Cancer: Basic Science andClinical AspectsDCAN 892 (2 cass., $23) Symposium 19: Tumor Virology: Molecular Biology andEtiologyDCAN 893 (2 cass., $23) Symposium 20: Advances in Cancer Vaccine DevelopmentDCAN 894 (1 cass., $11.50) Seventeenth Annual Bruce F. Cain Memorial AwardLecture: Translational Research: Walking the Bridge Between Idea and Cure (Bruce A.Chabner)DCAN 896 (1 cass., $11.50) Meet the Expert Sunrise Session: ChromosomalTranslocations: Genetics, Biology, and Protein Function (James R. Downing)DCAN 897 (1 cass., $11.50) Meet the Expert Sunrise Session: Advances in theMechanisms of Invasion and Metastasis (Isaiah J. Fidler)

DCAN 898 (1 cass., $11.50) Meet the Expert Sunrise Session: From Slave toMaster: The Biological Events during Melanoma Development and Progression(Meenhard Herlyn)DCAN 899 (1 cass., $11.50) Meet the Expert Sunrise Session: FarnesyltransferaseInhibitors: From Bench to Bedside (IvanD, Horak)DCAN 8100 (1 cass., $11.50) Meet the Expert Sunrise Session: Topoisomerases:Structure and Function (James C. Wang)DCAN 8101 (1 cass., $11.50) Meet the Expert Sunrise Session: Progress inAntibody Therapy of Human Cancer (Nancy E. Hynes)DCAN 8102 (1 cass., $11.50) Meet the Expert Sunrise Session: Animal Models forChemoprevention (Michael N. Gould)DCAN 8103 (1 cass., $11.50) Meet the Expert Sunrise Session: HIV and AIDS:Factors Involved in Resistance to Infection and Disease Progression (Jay A. Levy)DCAN 8104 (1 cass., $11.50) AACR American Cancer Society Award Lecture:The Past, Present, and Future of the Prevention of Lung Cancer (Ernst L. Wynder)DCAN 8105 (2 cass., $23) Symposium 21: Combinatorial Approaches to theDetection, Treatment, and Understanding of Neoplastic ProcessesDCAN 8106 (2 cass., $23) Symposium 22: New Mechanisms of Action of Viraland Cellular OncogenesDCAN 8107 (2 cass., $23) Symposium 23: Reconstruction of Human Tumorigen-

esis and Progression: Cancer Genetics m Model OrganismsDCAN 8108 (3 cass., $34.50) Minisymposium Immunology/Preclinical andClinical 10: Tumor ImmunobiologyDCAN 8109 (3 cass., $34.50) Minisymposium Endocrinology/Preclinical andClinical 7: Steroid Hormones: Metabolism and ReceptorsDCAN 8110 (3 cass., $34.50) Minisymposium Clinical Research 14: PSA/PSMAas Targets for Diagnosis, Prognosis, and TherapyDCAN 8111 (3 cass., $34.50) Minisymposium Pharmacology and ExperimentalTherapeutics 37: Cytoreductive Gene Therapy of CancerDCAN 8112 (3 cass., $34.50) Minisymposium Molecular Biology 27: Function ofTumor Suppressor GenesDCAN 8113 (2 cass., $23) Symposium 24: Tobacco and Lung Carcinogenesis:Genetics, Biology and EpidemiologyDCAN 8114 (1 cass., $11.50) Controversy Session 2: Will Multidrug ResistanceModulators Be Effective in the Clinic?DCAN 8115 (1 cass., $11.50) DeWitt S. Goodman Lecture: Clinical CancerPrevention Research (Peter Grcenwald)DCAN 8116 (3 cass., $34.50) Minisymposium Clinical Research 17: NovelApproaches to Organ Site-specific Therapies

DCAN 8117 (3 cass., $34.50) Minisymposium Pharmacology and ExperimentalTherapeutics 42: Antisense and Biological Therapeutic ApproachesDCAN 8118 (3 cass., $34.50) Minisymposium Carcinogenesis 16: MolecularMutagenesisDCAN 8119 (3 cass., $34.50) Minisymposium Cell and Tumor Biology 27: NovelInvasion-related Genes

DCAN 8120 (3 cass., $34.50) Minisymposium Molecular Biology 31: NovelMechanisms for Cell Cycle ControlDCAN 8121 (2 cass., $23) Symposium 27: Emerging Issues for Individual CancerSusceptibility and Risk AssessmentDCAN 8122 (2 cass., $23) Symposium 26: Restoring Drug Sensitivity to Tumors:New Concepts from Tumor Biology and PhysiologyDCAN 8123 (2 cass., $23) Symposium 28: Epigenetics and CancerDCAN 8124 (2 cass., $23) Symposium 25: Transcriptional Control of theNeoplastic PhenotypeDCAN 8125 (1 cass., $11.50) NIH Grants: Changes in Review and FundingOpportunitiesDCAN 8126 (1 cass., $11.50) Associate Member Sunrise Session: Using YourNetworking Skills to Further Your Career

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TITLEORGANIZATIONADDRESS

(NO PO BOXES) CITYSTATEZIPSIGNATURE

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AACR SPECIALCONFERENCE INCANCER RESEARCH

Cellular Targets of Viral Carcinogenesis

September 24-28, 1998Marriott's Laguna Cliffs Resort

Dana Point, CaliforniaCONFERENCE CHAIRPERSONS

Thea D. Tlsty / San Francisco, CAEileen P. White / Piscataway, NJDon Ganem / San Francisco, CA

Carol Prives / New York, NY

TENTATIVE SCIENTIFIC PROGRAM

Cell CycleJean Y. J. Wang / La Jolla, CAWilliam Kaelin / Boston,MAKaren H. Vousden / Frederick,MDThomas E. Shenk / Princeton,NJ

Signal TransductionDaniel C. DiMaio / New Haven, CTElliott Kieff / Boston,MA

ApoptosisEileen P. White / Piscataway,NJAnne E. Griep / Madison,WlPhilip E. Branton / Montreal,Canada

Genomic InstabilityCarol Prives / New York, NYThea D. Tlsty / San Francisco, CAMichael R. Botchan / Berkeley, CA

Evasion of Host Cell DefensesGrant McFadden / London,CanadaMarshall S. Horwitz / Bronx,NYRobert H. Silverman / Cleveland,OH

Cell ProliferationKarl Munger / Boston,MAElizabeth Moran / Philadelphia,PADon Ganem / San Francisco,CA

Animal ModelsFrancis V. Chisari / La Jolla, CALisa M. Coussens / San Francisco,CADouglas Hanahan / San Francisco,CA

Therapeutic OpportunitiesPramod K. Srivastava / Farmington,CTDavid H. Kirn / Richmond,CA

Additional Speakers to be AnnouncedApplicants are encouraged to submitabstracts for poster presentation.Selected proffered papers will also bescheduled for oral presentations.

Application deadline: July 13, 1998

Information and Application Forms

American Association for Cancer ResearchPublic Ledger Building, Suite 826150 South Independence Mall WestPhiladelphia, PA 19106-3483215-440-9300 215-440-9313 (FAX)e-mail: aacr@aacr.orgAACR Website: http://www.aacr.org

AACR SPECIALCONFERENCE INCANCER RESEARCH

Endogenous Sources of Mutations

November 11-15, 1998Sanibel Harbour Resort and Spa

Ft. Myers, FloridaCONFERENCE CHAIRPERSONS

Lawrence J. Marnett / Nashville, INJames A. Swenberg / Chapel Hill, NC

Tomas Lindahl / London, England

TENTATIVE SCIENTIFIC PROGRAM

Mutation PatternsJeffrey H. Miller / LosAngeles, CA

Endogenous DMA DamageMirai Dizdaroglu / Gaithersburg,MDLawrence J. Marnett / Nashville,TNJames A. Swenberg / Chapel Hill,NCDavid E. G. Shuker / Leicester,EnglandNancy L. Oleinick / Cleveland, OHGerd P. Pfeifer / Duarte, CAErling Seeberg / Oslo, Norway

RepairArthur P. Grollman / Stony Brook, NYSusan S. Wallace / Burlington, VTBruce Demple / Boston, MALeona D. Samson / Boston, MATomas Lindahl / London, EnglandJoyce T. Reardon / Chapel Hill, NCMalgorzata Zdzienicka / Leiden,TheNetherlands

Susceptibility Factors inEndogenous MutationsThomas A. Kunkel / Research TrianglePark, NCChristopher W. Lawrence / Rochester,NYMark Meuth / Salt Lke City, UTPenny A. Jeggo / Palmer, England

Significance of Endogenous MutationsLawrence A. Loeb / Seattle, WAMutsuo Sekiguchi / Fukuoka, JapanSteven R. Tannenbaum / Cambridge, MA

Additional Speakers to be Announced

Applicants are encouraged to submitabstracts for poster presentation.Selected proffered papers will also bescheduled for oral presentations.

Application deadline: August 28,1998

Information and Application Forms

American Association for Cancer ResearchPublic Ledger Building, Suite 826150 South Independence Mall WestPhiladelphia, PA 19106-3483215-440-9300 215-440-9313 (FAX)e-mail: aacr@aacr.org

AACR Website: http://www.aacr.org

Visit the AACR Website!

www.aacr.org

Now Online:

1998 Annual Meeting Abstracts

Abstracts of AACR Journal Articles

Turn to our website to find:

Q AACR scientific meeting schedule

Q Tables of Contents of AACR journals

Q Instructions for Authors

Q Information about AACR Research Fellowshipsand Young Investigator Awards

Q The latest AACR newsletter, and more!

AMERICAN ASSOCIATION FOR CANCER RESEARCH

AACRSPECIALCONFERENCEINCANCERRESEARCH

GeneRegulationandCancer10thAnniversaryof theAACRSpecialConferences

October14-18,1998The HomesteadHot Springs,VA

CONFERENCE CO-CHAIRPERSONS

Phillip A. Sharp / Cambridge,MAJacqueline A. Lees / Cambridge,MASteven L. McKnight / Dallas, TX

CONFERENCE PROGRAM

KeynoteAddressLelandH.Hartwell/ Seattle,WA

Controlof Cell DivisionandGene ExpressionJacquelineA. Lees/ Cambridge,MAScottW.Lowe/ ColdSpringHarbor,NYNikolaP.Pavletich/ NewYork,NY

Mechanismsof TranscriptionalRegulationJerryL.Workman/ UniversityPark,PAMarianCarlson/ NewYork,NYDavidH.Price/ IowaCity,IA

Growth Control and ChromatinAcetylationC.DavidAllis/ Rochester,NYKevin Struhl / Boston, MARobert N. Eisenman / Seattle, WAMichael Grunstein / Los Angeles, CA

Regulationof Cell DeathAlbertS. Baldwin/ ChapelHill,NCCraigB.Thompson/ Chicago,IL

DevelopmentalBiologyand GeneRegulationBeverlyM.Emerson/ La lolla,CAKatiaGeorgopoulos/ Cambridge,MAFrank G. Grosveld / Rotterdam, The Netherlands

Signal to TranscriptionSteven L. McKnight / Dallas,TXDavid J. Mangelsdorf / Dallas,TXGregg L. Semenza/ Baltimore,MD

Gene Expression TechnologyStephen H. Friend / Seattle,WA

Additional Speakers to be Announced

Application Deadline: July 31, 1998

Information and Application Forms:American Association for Cancer ResearchPublic Ledger Building, Suite 826150 South Independence Mall WestPhiladelphia, PA 19106-3483215-440-9300 215-440-9313 (FAX)E-mail: meetings@aacr.org

Website: http://www.aacr.org

Four Essential Journals from the AACRPriorityreading forover 55 years - cited

more than any other journal in itsfield

CANCER RESEARCH

Vol.58, 1998 (24 issues)ISSN0008-5472

Editor-in-Chief:

Carlo M.Croce. M.I).

•¿�State-of-the-artlaboratoryand

clinical investigations•¿�Advancesin Brief•¿�Selectedreviewarticles

Individualnonmembers: $495;OutsideU.S.:$585

Institutions:$795; OutsideU.S.:$925Institutional subscriptions include a subscription toClinical Cancer Research. Available only is acombined subscription. Proceedings of the AACRis included in individual mmmember and institutional

subscriptions to Cancer Research

A major resource on the molecularbiology of cancer

CELL GROWTH& DIFFERENTIATION

Vol.9, 1998 (12 issues)ISSN1044-9523

Editor-in-Chief:Joseph R.Nevins,Ph.D.

•¿�Significant,originalresearchon themolecular biologyof cell growthanddifferentiation,particularlyas itrelates to oncogenesis

•¿�Selectedreviewarticles•¿�Meeting reports

Individual nonmembers: $120;OutsideU.S.:$160

Institutions:$325; OutsideU.S.:$365

A unique journal spanningthree vital fields

CANCER EPIDEMIOLOGY,BIOMARKERS & PREVENTION

Vol.7,1998 (12 issues)ISSN1055-9965

Eilitor-in-Chief:

Frederick P. Li, M.D.

An exciting forum for clinicaland translational cancer research

CLINICAL CANCER RESEARCH

Vol.4, 1998 (12 issues)ISSN1078-0432

Kditor-in-Cbief:

John Mendelsohn,M.D.

ORDER TODAY!

Members, American Associationfor (lancer Research:Contactthe-AACRfor special rates at(215) 440-9300; FAX(215) 440-9313.

MembersreceivediePmceedingsof theAACRwithoutchargeas a fringebenefitoftheirmembership.

Institutions: Purchase all four journals and save 1S% offthe total subscription price, excluding postage outside I'.S.

Canada: Uld ~% (ÃŒSTto all orders. MI): Add state sales lax.

•¿�Originalresearch on the epidemiologyand preventionof cancer in humans

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