ANTIMICROBIAL AGENTS ANDCHEMOTHERAPYVOLUME 31 * DECEMBER 1987 * NUMBER 12

Robert C. Moellering, Jr.,Editor in Chief (1990)

New England Deaconess HospitalBoston, Mass.Michael Barza, Editor (1990)New England Medical Center

HospitalsBoston, Mass.Lawrence E. Bryan, Editor (1992)University of CalgaryCalgary, Alberta, Canada

Jack M. Gwaltney, Jr., Editor (1990)University of Virginia School ofMedicine

CharlottesvilleGeorge A. Jacoby, Jr., Editor (1990)Massachusetts General HospitalBoston

Christine C. Sanders, Editor (1989)Creighton University School ofMedicine

Omaha, Neb.John A. Washington II, Editor (1991)Cleveland Clinic FoundationCleveland, OhioPeter G. Welling, Editor (1988)Warner-Lambert Co.Ann Arbor, Mich.

EDITORIAL BOARDVincent T. Andriole (1987)Bascom F. Anthony (1988)Gordon L. Archer (1989)George R. Aronoff (1989)Richard H. Baltz (1987)Rashmi H. Barbhaiya (1989)Arthur L. Barry (1989)John G. Bartlett (1987)Arnold S. Bayer (1988)William M. Bennett (1987)Michel G. Bergeron (1989)Richard F. Bergstrom (1988)Karen K. Biron (1987)Gerald P. Bodey (1989)Arthur E. Brown (1987)Ward Bullock (1987)Tsun Chang (1989)Anthony Chow (1988)C. Glenn Cobbs (1989)Paul S. Cohen (1989)William A. Craig (1987)Naomi Datta (1987)Lawrence E. Day (1989)William E. Dismukes (1987)Susan M. Dorrbecker (1989)R. Gordon Douglas, Jr. (1989)John C. Drach (1987)George L. Drusano (1987)Theodore Eickhoff (1988)Gertrude B. Elion (1987)

George M. Eliopoulos (1988)Arthur English (1989)Robert J. Fass (1988)Stuart Feldman (1988)Sydney Finegold (1988)Martin Forbes (1989)Peter T. Frame (1988)John N. Galgiani (1987)Dale N. Gerding (1988)Anthony J. Glazko (1987)Irving H. Goldberg (1988)Thomas D. Gootz (1988)Stephen B. Greenberg (1989)Scott M. Hammer (1989)Margaret R. Hammerschlag (1989)Robert E. W. Hancock (1989)W. Lee Hand (1989)H. Hunter Handsfield (1989)Frederick G. Hayden (1987)Michael L. Higgins (1989)David C. Hooper (1987)Richard Hornick (1989)George Gee Jackson (1989)James H. Jorgensen (1987)William J. Jusko (1989)A. W. Karchmer (1988)Donald Kaye (1988)Mark S. Klempner (1989)George S. Kobayashi (1988)Donald J. Krogstad (1989)

Philip Todd Lavin (1989)Stephen A. Lerner (1989)Stuart B. Levy (1989)Joan Lusk (1989)R. Luthy (1989)Gerald L. Mandell (1989)Gary R. Matzke (1989)George H. McCracken (1987)Antone A. Medeiros (1987)Michael Miller (1987)Barbara E. Murray (1987)John D. Nelson (1989)Harold C. Neu (1989)Lawrence A. Pachla (1987)Joseph S. Pagano (1987)James E. Pennington (1989)T. J. Perun (1989)Lance R. Peterson (1988)W. H. G. Richards (1989)Glenn D. Roberts (1989)Richard Roberts (1988)Ian M. Rollo (1988)Allan Ronald (1987)John P. Rosazza (1989)Jon E. Rosenblatt (1988)Robert H. Rubin (1987)Merle Sande (1988)W. Eugene Sanders, Jr. (1987)W. Michael Scheld (1989)Jerome J. Schentag (1988)

Raymond F. Schinazi (1989)Fritz D. Schoenknecht (1989)F. C. Sciavolino (1988)William M. Shannon (1989)Charles Shipman, Jr. (1988)David M. Shlaes (1988)Robert W. Sidwell (1987)Herbert M. Sommers (1989)P. Frederick Sparling (1987)Harold Standiford (1988)David A. Stevens (1989)Stephen E. Straus (1987)R. Sutherland (1988)Morton N. Swartz (1988)Richard B. Sykes (1988)Francis P. Tally (1987)Fred C. Tenover (1988)Alexander Tomasz (1988)Roger D. Toothaker (1988)Francis L. S. Tse (1989)Richard J. Wallace, Jr. (1987)Michael Waring (1987)Bernard Weisblum (1988)Peter F. Weller (1989)Richard Wise (1989)John S. Wolfson (1987)David J. Wyler (1989)Lowell Young (1988)Pauline K. W. Yu (1988)

Helen R. Whiteley, Chairman, Publications BoardLinda M. Illig, Managing Editor, Journals

Kirk Jensen, Director of PublicationsCarol J. Neff, Production Editor

Antimicrobial Agents and Chemotherapy (ISSN 0066-4804), an interdisciplinary publication of the American Society for Microbiology,1913 I St., NW, Washington, DC 20006, is devoted to the dissemination of knowledge relating to all aspects of antimicrobial, antiparasitic, andanticancer agents and chemotherapy. Instructions to authors are published in the January issue each year; reprints are available from theeditors and the Publications Department. Antimicrobial Agents and Chemotherapy is published monthly, one volume per year. Thenonmember subscription price is $220 per year; single copies are $25. The member subscription price is $35 (foreign, $51 [air drop shipping])per year; single copies are $8. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or lateproofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM Publications Department, 1913 ISt., NW, Washington, DC 20006 (phone: 202 833-9680).Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after publication of

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Author IndexAdachi, Yoshikazu, 1935Allan, J. Davis, Jr., 1997Allen, Debra N., 1989Alsip, Steven G., 1874Anderson, Margaret, 1939Arakawa, Akira, 1935Arioli, Vittorio, 1961Aulicino, Taryn M., 2013

Baron, Patricia A., 1882Berkowitz, Leonard R., 2013Berti, Marisa, 1961Borovoy, Roberta, 1939Brandt, Carl D., 1882Brennan, Lori, 1939Bright, Gene, 1939Brisbane, Peter G., 1967Brisson-Noel, Anne, 1887Burch, Barbara, 1882Bure, Anne, 2018

Cassani, Giovanni, 1961Caufield, Page W., 1989Chambers, Henry F., 1919,

1982Chapman, John S., 1994Childers, Noel K., 1989Cimochowski, Caroline R.,

1948Cloud, Gretchen A., 1874Cornick, N. A., 2010Cotton, David B., 2015Courvalin, Patrice, 1887Craven, Philip C., 1874Crosa, Jorge H., 1955Currie-McCumber, Charlotte,

2007

Decazes, Jean M., 2018Dell, Dennis, 1909Denaro, Maurizio, 1961

Dismukes, William E., 1874DiVincenzo, C. A., 2002Dorman, Karen, 2015Drusano, G. L., 1892duBouchet, Lorraine, 2013Dureuil, Christine, 1925Duval, Jean, 1887

Eliopoulos, George M., 1997English, Arthur R., 1948

Faiella, James A., 1948Faro, Sebastian, 2015Feldman, Stuart, 2015Ferrari, Pietro, 1961Fink, Robert J., 1882Frazier, Donita L., 1929Furman, Phillip A., 1972

Galgiani, John N., 1867, 1874Gastaldo, Luciano, 1961Georgopapadakou, Nafsika

H., 1994Girard, Arthur, 1939Girard, Arthur E., 1948Girard, Dennis, 1948Goldstein, Beth P., 1961Gombert, Myles E., 2013Gootz, Thomas D., 1948Gorbach, S. L., 2010Graybill, John R., 1874Gunner, Lori A., 1897

Hackbarth, Corinne J., 1982Haskell, Suzanne L., 1948Hemming, Val G., 1882Hopfer, Roy L., 1897, 1901,

1978

Janik, Leslie J., 1967Juliano, Rudolph L., 1897,

1901

Kashiwazaki, Mamoru, 1935Kim, Hyun Wha, 1882Kitai, Kazuhisa, 1935Kitzis, Marie D., 2018Kobayashi, G. S., 2005Koga, Hironobu, 1904Krishnasami, Shanti, 1915Kron, Michael A., 2007Kunugita, Kiyohiko, 1935

Langlois, Alphonse J., 1972Lantz, Marilyn S., 1915Leclercq, Roland, 1887Le Goffic, Francois, 1925Lopez-Berestein, Gabriel,

1897, 1901, 1978Lucker, Peter W., 1909Lynch, M. J., 1892

Manousos, Mary, 1939Martens, Mark G., 2015Mason, Rachel, 1939McQueen, Teresa, 1901Medeiros, Antone A., 2007Medoff, G., 2005Mehta, Reeta, 1978Mehta, Reeta T., 1897, 1901Miller, Wayne H., 1972Mobley, H. L. T., 1892Modai, Jacques, 2018Moellering, Robert C., Jr.,

1997Moreau, Nicole, 1925

O'Keefe, J. P., 2002

Jacobus, N. V., 2010 Pallanza, Rosa, 1961

Pangon, Beatrice, 2018Parrott, Robert H., 1882Partos, Charles, 1909Pearson, David E., 1915Portmann, Renee, 1909Powell, M., 1871Prince, Gregory A., 1882

Ray, Teresa, 1915Reaman, Gregory, 1882Reiszner, Edina, 1997Retsema, James, 1939Retsema, James A., 1948Richards, Cynthia A., 1972Richman, Douglas D., 1879Riddle, Gerald D., 2015Ripamonti, Franca, 1961Riviere, J. Edmond, 1929Rodriguez, William, 1882

Schelkly, William, 1939Selva, Enrico, 1961Shatzer, K. L., 2002Shlaes, David M., 2007Spector, Thomas, 1972St. Clair, Marty H., 1972Stevens, David A., 1874Sugar, Alan M., 1874Suter, Karin, 1909

Tabary, Xavier, 1925Tate, Max E., 1967Tolmasky, Marcelo E., 1955Travis, S. J., 2005

Venezio, F. R., 2002

Warren, Richard F. O., 1967Weidekamm, Erhard, 1909Weinhold, Kent J., 1972Williams, J. D., 1871Wolff, Michel, 2018

ACKNOWLEDGMENT

The following persons served as invited special reviewers for the journal during 1987, and their help is greatly appreciated.

Charles A. Alford, Jr.Oswald G. BacaD. P. BaccanariJohan BakkenRobert M. BannatyneRobert F. BettsP. M. BlumbergH. BockbraderJohn BoyceD. BoydPatrick BrennonSam BroderN. BrotKenneth BrownKaren BushPeter CanonicoHenry ChambersTe-Wen ChangEdward ChaperonStephen ChartrandIan ChopraRichard ClarkSeth CohenW. ColburnJ. W. CostertonClyde CrumpackerThomas CurranGary V. Doern

Thomas DoughertyM. EldonLynn ElwellSuzanne U. EmersonBarry M. FarrDavid FeingoldJ. FerryA. ForsgrenK. P. FuPhilip FurmanDenise GallowayG. R. GermaineDonald GigerJoseph GloriosoJ. GodfreyBarry GoldinS. V. S. GollapudiSherwood L. GorbachJohn E. GreenleeJerome GroopmanDieter H. GroschelDonald GuineyL. GutmannGerri S. HallL. HarvathJack HawigerLeonid B. HeifetsJ. Owen Hendley

M. HenryWalter HughesPentti HuovinenMichael JacobsRussell JohnsonRichard T. KellyEarl R. KernA. KinkelVernon KnightD. J. LambethRoland A. LevandowskiR. C. LevesquePaul LiebowitzJames LipskyG. LoewenFrancis MacrinaH. MaehrY. MartinJoseph McDadeMark McKinlayColin McLarenLaura McMurryW. McNallyL. C. McPhailMartha MellencampWilliam H. MurphyR. H. NeubauerF. C. Neuhaus

S. OlsonMichael OttoJames ParkL. W. ParksJohn PennerPhilip PetersonAlain PhilipponA. P. PugsleyJack RemingtonD. ReynoldsDouglas RichmanM. RoggePrem SarinJulius SchachterPriscilla SchaefferE. SchiffmannC. A. SchnaitmanRobert SchooleyA. SelenRobert E. ShopeJohn SixbeyRobert SmibertArnold SmithJames SmithThomas F. SmithDavid R. SnydmanD. R. SollBrian Spratt

Walter StammVictor StollarCharles W. StrattonFrancis SzokaA. I. TauberDiane TaylorRaymond T. TestaClyde ThornsberryRichard R. TidwellJ. TkaczW. H. TraubRonald B. TurnerU. UllmannMartti VaaraK. VosbeckEdward E. WalshD. M. WellerHannah WexlerRichard J. WhitleyWashington WinnMurray WittnerGail WoodsT. WoolfS. WrightRobert YarchoanVictor L. Yu

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AUTHOR INDEX

VOLUME 31

Abel, Laurent, 518, 1632Abele, G., 76Adachi, Yoshikazu, 1935Adam, D., 935Adams, John, 1507Adams, Kenneth R., 259Adelman, Martin H., 605Adessi, G. L., 300Agabian, Nina, 37Agnelli, Giancarlo, 1609Aguirre, F., 151Alarc6n, Balbino, 1388Alborn, W. E., Jr., 1093Albrecht, Lisa M., 1461Alexander, Michael R., 815Allan, J. Davis, Jr., 1997Allen, Debra N., 1989Allen, N. E., 1093Allocati, Nerino, 1644Alon, U., 126Alonso, Jean-Michel, 523Alonso, Maria J., 357Al-Sabbagh, Ahmad, 1296Alsip, Steven G., 1874Alvarez, Emilio, 1675Anderson, Edwin L., 1140Anderson, Margaret, 1939Anderson, Ronald, 789Andremont, Antoine, 124, 404Andrews, J. M., 267, 1051Andriole, Vincent T., 1199Angehrn, Peter, 614Ant6n, Dora N., 1627Antonacci, Barry, 1756Aoki, Takashi, 1278, 1446Aoyama, Hiroshi, 1640Apicella, Michael A., 173Arai, Sumio, 1843Arakawa, Akira, 1935Araujo, Visi, 1383Archer, Gordon L., 1027,

1683Archibeque, Eric G., 114Arioli, Vittorio, 1961Arlet, Guillaume, 1283Arnold, Keith, 473Aronoff, Stephen C., 663Aronovitz, Gerson H., 903Arthur, Michel, 404Arvin, Ann M., 1722Ashby, J., 161, 1051Auckenthaler, Raymond, 1803Aulicino, Taryn M., 2013Aversa, Franco, 1126Avila, Angela, 447Avila, Josd L., 447Axler, David A., 794

Baba, Masanori, 337, 1613Babel, Karen, 1750Babiuk, L. A., 752Baca, Oswald G., 1079Bacchi, C. J., 1406Bach, Michael C., 1605Bacon, Teresa H., 1238Bailer, Robert, 1243Baker-Zander, Sharon A., 187Bakker-Woudenberg, Irma

A. J. M., 1809Baldelli, Franco, 1126

Balzarini, Jan, 1613Bansal, Madhu B., 619Baquero, Fernando, 665Barbhaiya, R. H., 55Barbhaiya, Rashmi H., 799Barker, Guy C., 1567Bar-Nun, S., 1798Baron, Ellen Jo, 954Baron, Patricia A., 1882Barredo, Josd L., 1675Barriere, Steven L., 527, 895,

1075Barry, A. L., 1514Barry, Arthur L., 343, 625,

818Barry, D. W., 1117Barshatzky, Marc R., 27Bartholomew, P. T., 1791Bartlett, Marilyn S., 1323Bartram, Julie, 1140Barza, M., 202Barza, Michael, 421, 485, 723Basset, Guy, 1312Bateman, Judith A., 622Bauchet, Jacqueline, 635Bauer, Larry A., 850Bayer, Arnold S., 70, 253,

1750Bazin, Hervd, 600Beale, Angela S., 1204Bean, Karen, 1507Beauchamp, Denis, 1816Beaudette, Fran E., 328Bedard, Jean, 1348Beggs, William H., 643Bellido, Francis, 1589Belshe, Robert B., 1140Benavente, Maria C., 132Ben-Gigi, Gila, 834Bennett, D. B., 570Bennett, Renee L., 643Benson, Constance A., 328Berant, M., 126Berens, R. L., 1406Berger, Stephen A., 352Berger-Bachi, Brigitte, 1033,

1039Bergeron, Michel G., 966,

1359, 1816Bergeron, Yves, 1816Berkowitz, Frank E., 946Berkowitz, Leonard R., 2013Berman, J. D., 111Bernadet, P., 575Bernard, Gordon R., 1689Bernstein, David I., 1285Bernstein, Jack M., 1285Berti, Marisa, 1961Betts, Robert F., 1183Beverley, Stephen M., 1575Bialer, Martin G., 954Bibler, Mark R., 207Black, William A., 470Blaser, Jurg, 1054Blaser, Martin J., 438Blum, M. Robert, 1722Blumberg, Richard S., 168Blumenfeld, Walter, 37Blumer, Jeffrey L., 663, 698Bobek, Miroslav, 368

Bochner, Felix, 638Bode, Robert B., 207Bodey, Gerald P., 11, 102,

650, 829Bodhidatta, Ladaporn, 438Boeck, LaVerne D., 1497Bogaerts, Jos, 434Boiron, Patrick, 244Boissinot, Maurice, 728Boldrini, Francesca, 1609Bollinger, M. R., 151Bolton, Sandra M., 1281Bonet, Montserrat, 1383Boni, Jurg, 1293Bonner, Daniel P., 219, 226,

1271Boon, Ronald J., 1204Borchardt, Ronald T., 1849Borcherding, David R., 1849Borner, K., 1491Borner, Klaus, 417, 1338Borovoy, Roberta, 1939Boscia, Jerome A., 458Bosso, John A., 1403Bothof, Theo, 191Bourgault, Anne-Marie, 1596Boutron, L., 899Bow, Eric J., 551Bower, Robert R., 1768Bowie, William R., 470Bowmer, M. I., 67Boyce, John M., 1426Boyd, Malcolm R., 1238Bradley, David E., 823Branch, Robert A., 1689Brandt, Carl D., 1143, 1882Brass, Corstiaan, 1343Bredberg, Anders, 774Brennan, Cynthia, 850Brennan, Lori, 1939Breyssens, Johan, 1429Briceland, Laurie L., 679Briggs, Barbara, 1497Bright, Gene, 1939Briheim, Gunnar, 763Brion, Nils, 518, 1632Brisbane, Peter G., 1967Brisson-Noel, Anne, 1887Britigan, Bradley E., 1507Brodie, Howard R., 1251Brooks, Robert G., 805Brown, Hannah R., 27Brown, James L., 1465Brown, Janice T., 1852Brumfitt, W., 1442Brummett, Robert E., 612Brun, Patrick, 1312Brunette, Elisa N., 37Brunham, Robert C., 1153Brunner, David P., 1727Brun-Pascaud, Monique, 978Bryan, L. E., 286, 1216, 1348Bryan, Larry E., 1438Bucaneve, Giampaolo, 1126,

1609Buck, Robert E., 238Buesching, William J., 951Bui, Rose H. Dang, 1143Bullock, Ward E., Jr., 207Burch, Barbara, 1143, 1882

Burckart, Gilbert J., 323Burdett, Vickers, 1648Bure, Anne, 518Bure, Anne, 1632, 2018Burger, Walter, 1069Burnette, Thimysta, 1251Burns, Jane L., 686Buscher, Karl-Heinz, 703Bush, Karen, 219, 1271Bustamante, Carlos, 1420Bustamante, Carlos I., 632,956

Butkiewicz, N. J., 21Byington, Roy, 168

Caillon, Jocelyne, 870Calderwood, Stephen B., 876Call, E. W., 1130Campbell, I. G., 1440Campello, Marta G., 665Campos, Jose, 1478Canepari, Pietro, 1618Canonico, Peter G., 986, 1194Cantoral, Jesds M., 1675Carandang, Gloria, 114Carbon, Claude, 518, 635,

1632Carlisle, Ricarda, 452Carrasco, Luis, 1388Casal, Manuel J., 132Casin, Isabelle M., 1283Cassani, Giovanni, 1961Caufield, Page W., 1989Cederberg, Donna M., 1251Cellini, Luigina, 1644Cerami, Alice T., 949Cesario, Thomas C., 114Chaffin, Donald O., 1478Chai, Yaachov, 1507Chamberland, Suzanne, 1438Chambers, Henry F., 1549,

1919, 1982Chan, David G. W., 470Chan, Lydia, 253Chang, Barbara J., 1281Chang, Chih-Wen, 1662Chang, Hernan R., 1147Chang, Te-Wen, 1135Chanson, Philippe, 635Chapman, John S., 1994Chapman, Sharon, 1722Chapman, W. L., Jr., 111Chappell, Leslie H., 1567Charnas, Robert, 1589Chaslus-Dancla, Elisabeth,

784, 1274Chastre, Jean, 1312Chattopadhyaya, Jyoti, 600Chau, Nguyen Phong, 635,

1632Chau, P. Y., 473Cheng, Nick, 1379Cheng, Yung-Chi, 368, 1355Chernichovsky, Dina, 834Cheung, Richard P. F., 389Childers, Noel K., 1989Chin, Nai-Xun, 463, 480, 505,

558Chisholm, David R., 238Chiu, Joseph, 114

i

ANTIMICROB. AGENTS CHEMOTHER.

Chiu, Peter J. S., 1756Choma, Nadia, 826Chou, Ting-Chao, 168, 1355Chow, Anthony W., 1379Chow, Raymond T., 108Christensen, J. Mark, 1787Christenson, John C., 1775Chu, Daniel T. W., 1768Chun, Yeon-Sook, 349Cimochowski, Caroline R.,

1948Claes, Paul J., 410Clair, B., 899Clair, Bernard, 1600Clark, Junius M., 226Cleary, P. P., 667Cleeland, Roy, 1502Clements, Mary Lou, 1470Cloud, Gretchen A., 1874Cluzel, Roger, 943Cobb, Edie, 1251Cobo, L. Michael, 6Cocchetto, David M., 1605Cohen, Myron S., 1507Cole, Martin, 1238Cole, Stewart T., 295Collet, Michel, 1288Comstock, Thomas J., 393Conner, Edward M., 1183Connor, James D., 1143, 1722Conte, John E., Jr., 333, 1585Contrepois, Alain, 518, 635,

1632Cooksey, R. C., 300Corey, Lawrence, 361Cornaglia, Giuseppe, 1618,

1651Cornere, Brian M., 42Cornick, N. A., 2010Corpet, Denis E., 587Cotton, David B., 2015Couchot, Kendra R., 335Coughter, Jerald P., 1027Courtieu, Andre-Louis, 870Courtney, James T., 467Courvalin, Patrice, 404, 784,

1021, 1274, 1887Cramer, C., 1514Craven, Philip C., 1874Crenshaw, Debra A., 698Creticos, Catherine M., 1285Crosa, Jorge H., 1955Crosby, Sondra S., 850Cuisinaud, Guy, 1255Cullmann, Wolfgang, 703Cundy, Kenneth R., 321Currie-McCumber, Charlotte,

2007Curry, J., 292Cushion, Melanie T., 197

Dahlgren, Claes, 763Dainelli, Benedetto, 1651Dalvi, Madhu, 226Dan, Michael, 352Daneo-Moore, L., 1150Dankner, Wayne, 1722Darabi, Ali, 81Daschner, F. D., 813Davidai, G., 126Davis, L. Gray, 1317Davis, Robin L., 720, 915Davis, Stephen, 1126

D'Costa, L. J., 67De Almeida, Antonio Eugenio

C. C., 617Debs, Robert J., 37Decazes, J. M., 899Decazes, Jean M., 2018de Cespedes, Gilda, 1394De Clercq, Erik, 337, 1225,

1431, 1613Deeter, Robert G., 925De Lerma, Carlota, 135Del Favero, Albano, 1126,

1609Dell, Dennis, 1909Dellinger, E. Patchen, 850de Miranda, Paulo, 1251de Mulder, Pieter, 191Denaro, Maurizio, 1961Deneke, C., 1231Denney, William D., 1689de Pauw, Ben, 191Deschaseaux, M. L., 300Desiderio, James V., 238Desmyter, Jan, 1613Desnottes, Jean Francois,

1665Deterding, J., 292De Uzeda, Milton, 617Devlin, Anne, 1420de Witte, Theo, 191Diaz, Pamela S., 1722Dick, Wolfgang, 703Dickson, Paul L., 389Diez, Bruno, 1675DiGiore, Charles, 84Di Girolamo, Arturo, 1644Dillon, Jo-Anne R., 1744DiPiro, Joseph T., 389Dismukes, William E., 1874Disney, Frank A., 903DiVincenzo, C. A., 2002Dix, Barbara A., 46, 614, 1502Dix, Richard D., 1006Docherty, John J., 1562Doern, Gary V., 1519Doi, Masayoshi, 1307, 1423Domart, Yves, 1600Domer, Judith E., 691Dong, Mei-yan, 1135Dorman, Karen, 2015Dougherty, Thomas J., 178Douglas, Robert M., 1263Drach, John C., 544Drouhet, Edouard, 244Drugeon, Henri B., 870Drusano, G. L., 1892Drusano, George L., 632, 860,

956, 1177, 1420Dubin, Donald T., 735, 883duBouchet, Lorraine, 2013Dudley, Michael N., 1782Dunn, James F., 647Dupont, Bertrand, 244Durack, David T., 6Dureuil, Christine, 1925Durkin, Michelle M., 1323Durrell, Diane E., 951Dutschman, Ginger E., 368Duval, Jean, 1887Dylewski, J., 67

Ebert, Steven C., 709Echeverria, Peter, 438

Echols, Roger M., 657Edelstein, M. A. C., 443Ederer, Mary N., 16Edlund, Charlotta, 1846Edwards, David J., 1461Edwards, W. A. Drew, 850Eilam, Yael, 834Elegbe, I. A., 1406Eliopoulos, G. M., 653, 1188Eliopoulos, George M., 139,

1997Ellis, M. N., 1117Ellis, M. Nixon, 1483Elmer, Gary W., 129Elting, Linda, 11Elvrum, Patricia, 1301Elwell, Lynn P., 274Emm, Thomas, 860English, Arthur R., 1948Ericson, Jon, 1782Eriksson, Bertil, 600Erlich, Kim S., 1006Eron, Lawrence J., 1137Escriva, Enrique, 1474Espinel-Ingroff, Ana, 1343Evans, Evan J., 605Evans, Robert, 1662Evans, Rosemary C., 889

Facinelli, Bruna, 1642Faiella, James A., 1948Fainstein, Victor, 11Falcoz, Christine, 1255Fanucchi, Michael P., 1355Farinotti, Robert, 978Faro, Sebastian, 2015Farolino, Denise A., 826Farolino, Denise F., 173Farr, Barry M., 1183Faruki, Hawazin, 461Fass, Robert J., 148, 1457Fava, Pilar, 1474Fehr, Thomas F., 1734Feinstein, Stuart A., 108Fekete, Thomas, 321Fekety, Robert, 527, 1075Feldman, Stuart, 2015Fernandes, Prabhavathi B.,

1243, 1768Fernandez, Ruben O., 1627Fernandez-Guerrero, Manuel,430

Fernandez-Roblas, R., 821Ferone, Robert, 274Ferran, Fernando, 1383Ferraresi, R., 1514Ferrari, Pietro, 1961Ferry, Nicole, 1255Fesik, Stephen W., 230Fetchick, Richard, 647Fick, Robert B., Jr., 815Fillastre, J. P., 575Fillastre, Jean Paul, 156Finegold, S. M., 443Fink, Robert J., 1882Finkhouse, Bradley D., 630Flaherty, John F., 264, 895Flepp, M., 354Fletcher, H., 1150Fleurette, Jean, 1665Floyd-Reising, Shirley, 640Fong, Ignatius W., 748Fontana, Roberta, 1618

Forbes, M., 1791Forgue, S. T., 55Forgue, S. Thomas, 799Forlenza, Susan W., 331Forney, Robert B., Jr., 1328Forrest, Alan, 860, 956, 1177,

1420Forsgren, Arne, 768, 774Foulds, George, 1703Fourtillan, Jean Bernard, 1312Fox, Jack J., 1355Fox, Kaye E., 612Foy, Jilanna M., 197Frame, Peter T., 207Francis, Anne B., 903Frank, Karl B., 1369Frank, U., 813Frankowski, Jeffrey J., 1461Fransen, L., 67Franti, Charles E., 1234Franzblau, Scott G., 780Frazier, Donita L., 1929Freeman, G. Andrew, 274Freer, Jack P., 375Freimer, Earl H., 1328Freudenberger, Joan, 46Frost, Eric H., 1288Funke, Phillip T., 46Furman, Phillip A., 844, 1972Furukawa, Mayumi, 1843Fyfe, J. A., 1117Fyfe, James A., 274, 1483

Gade, Eugene, 1243Gadebusch, Hans H., 949Gal, Peter, 292Galera, M. Carmen, 1474Galetto, David W., 1683Galgiani, John N., 1343, 1867,

1874Gambertoglio, John G., 264,

895Garau, Javier, 1474Garaud, Jean J., 1600Garaud, Jean-Jacques, 635Garcia-Bustos, Jose F., 178Garcia-Lobo, Juan M., 1266Garlando, F., 354Garson, Michelle L., 393Gasser, Thomas C., 709, 1010Gastaldo, Luciano, 1961Gatell, Jose M., 1383Gaudreau, Christiane L., 940Gee, R., 443Geist, Felicia C., 622Genzlinger, Gail, 544Georgopapadakou, Nafsika

H., 46, 614, 1069, 1994Geraci, Joseph E., 430Gerbaud, Guy, 784, 1021,

1274Gerding, D. N., 667Giamarellou, Helen, 959Gibbs, Paul, 1194Gibert, Claude, 1312, 1600Gibson, Gene A., 1718Gifford, G. A., 752Gilbert, Thierry, 88Gill, Charles, 949Gillis, Jacqueline M., 1046Gilman, Robert H., 949Girard, Arthur, 1939Girard, Arthur E., 1948

ii AUTHORINDEX

AUTHOR INDEX iii

Girard, Dennis, 1948Girard, Pierre-Marie, 978Giuliano, M., 202Giuliano, Marina, 723Glauser, Michel P., 539Gleason, C. R., 570Gleason, Carol R., 799Gleaves, Curt A., 1465Gleckman, Richard A., 1Gluzman, Ilya Y., 32Gmeiner, Jobst, 1106Godfrey, A. J., 1216Godfrey, Allan J., 1438Goering, Richard V., 1164Gold, Deborah, 361Goldfarb, Johanna, 663Goldstein, Beth P., 1961Golper, Thomas A., 1787Gombert, Myles E., 2013Gomez-Lus, Rafael, 1266Gonzalez, M. Eugenia, 1388Gooch, Grace F., 829Goodman, Larry J., 328Gootz, Thomas D., 1948Gorbach, S. L., 202, 1231,

2010Gorbach, Sherwood L., 723,

1135Gordin, Fred M., 398Gordon, Morris A., 1343Gorea, Alfred, 352Gosselin, Pierre, 966Granich, George G., 385Grasela, Thaddeus H., Jr.,

375Grasselli, Serena, 1609Graversen, Peder H., 709,

1010Gray, Lynn D., 335Graybill, John R., 647, 1874Graziani, Amy L., 1718Green, John L., 903Greenberg, R. N., 151Greenberg, Richard N., 610Gregoire, Sylvie L., 375Gregory, W. A., 1791Gresser-Burns, Mary, 16Gresser-Burns, Mary E., 1711Griggs, D. J., 161Grill, Susan P., 368Groner, Michael C., 1054Guerciolini, Roberto, 1126,

1609Guglielmo, B. Joseph, 264Guiyoule, Annie, 523Gunner, Lori A., 1897Gunther, Robert, 1234Guruswamy, Arthur, 1775Gwaltney, Jack M., Jr., 1183

Hachler, Herbert, 1033, 1039Hackbarth, Corinne, 1549Hackbarth, Corinne J., 1982Hadley, W. Keith, 117, 1579Hagler, Dan N., 207Hall, Edward M., 389Hamamoto, Yoshiaki, 907Hamana, Yoko, 1111Hamilton-Miller, J. M. T.,

1442Hammer, Scott M., 1046Hancock, R. E. W., 121Hancock, Robert E. W., 253

Hand, W. Lee, 660, 1553Hansen, Larissa A., 1017Hanson, Charles W., 1768Hanson, W. L., 111Hardy, Dwight, 1243Hardy, Dwight J., 1768Hare, R. S., 1514Haregewoin, Abebe, 207Harmenberg, J., 76Harper, Rita G., 954Harris, Jeffrey E., 207Hartshorn, Kevan L., 168Hartstein, Alan I., 1787Hashizume, Terutaka, 578Haskell, Suzanne L., 1948Hasobe, Masahide, 1849Hassan, Erkan, 1855Hassett, Daniel J., 1507Hastings, Robert C., 780Hathorn, James W., 971Havlichek, Daniel, 1529Hawkey, Peter M., 331Hayakawa, Isao, 325Hayden, Frederick G., 622,

1285Haynes, Jeremy, 331Hazumi, Nobuyoshi, 1100Healy, Daniel P., 393Hector, Richard F., 691Heeren, Roberta L., 461Heggen, Laura, 915Heilmann, H.-D., 935Helsel, Valerie L., 1457Hemming, Val G., 1882Hendricks, Melissa, 1739Hendrix, Holly L., 197Henry, Nancy K., 430Hensey, Dena M., 1768Herdewijn, Piet, 1613Hill, John A., 274Himes, Donna, 612Hindler, Janet A., 640Hines, David W., 328Hirai, Keiji, 582, 1640Hirano, Lance, 1750Hirose, Tohru, 854Hirsch, Martin S., 168, 839Hirschman, Shalom Z., 925Hiruma, Ryoichi, 379Ho, Dah Hsi, 102, 650, 829Ho, John L., 485Hobbs, J. N., Jr., 1093Hoeprich, Paul D., 1234Hoffken, G., 1491H6ffken, Gert, 1338Hofflin, Jesse M., 346, 492Hoffman, Howard E., 1140Holman, John W., 1553Holmes, Clifford J., 889Honore, Nadine, 295Hoogeterp, Jaap J., 930Hooper, David C., 1861Hopfer, Roy L., 1897, 1901,

1978Horaud, Thea, 1394Horn, Ruth, 1596Hosoya, Mitsuaki, 1225Hosutt, Jean A., 281Hottendorf, G. H., 570Howrie, Denise L., 323Huang, Alice S., 1293Hubscher, Ulrich, 1657Huffman, J. H., 1130

Hughes, Carolyn E., 643Humbert, G., 575Humbert, Guy, 156Huovinen, Pentti, 455, 1451Hussain, Musaddeq, 512

Ichimura, Hiroshi, 1483Ikeda, Yasushi, 865Imada, Akira, 1692Imamura, Masazumi, 325Improvisi, Luce, 244Inazawa, Kazuhiro, 1169Inderlied, Clark B., 1697Ingram-Drake, L., 443Inoue, Matsuhisa, 854, 1085,

1111Irikura, Tsutomu, 582Isaacs, Charles E., 27Ito, Yasuo, 854Ivanoff, Bernard, 1288lyobe, Shizuko, 582

Jackson, George Gee, 1285Jackson, J. E., 111Jacobson, Mark A., 1251Jacobus, N. V., 202, 1231,

2010Jacobus, Nilda V., 723Jaffe, Arthur, 663Ja Kang, Young, 991James, Andrew, 52Jane, Javier, 1474Janik, Leslie J., 1967Janin, Nicole, 1665Janssen, Jos, 191Jarlier, Vincent, 295Jay, Margaret A., 1323Jensen, Tim, 594Jenssen, Warren D., 735, 883Johnson, Constance M., 991Johnson, Margaret A., 1199Johnson, Russell C., 164Johnston, J. Linda, 1027, 1683Jokipii, Anssi M. M., 183Jokipii, Liisa, 183Jollick, Joseph D., 1465Joly, Bernard, 943Joly, Veronique, 518, 635,

1632Jones, Colina, 144Jones, Douglas H., 323Jones, R. N., 1514Jones, Ronald N., 343, 625,

818Joos, Beda, 1222Josse, S., 575Jouvenot, M., 300Juliano, Rudolph L., 1897,

1901Jupeau-Vessieres, Annie M.,

523Juvin, Marie-Emmanuelle, 870

Kaatz, Glenn W., 527, 1075Kager, Lars, 1846Kapell, Kathi S., 100Kaplan, Joan C., 839Kaplan, Raymond L., 328Kaplan, Sheldon L., 467Kappstein, I., 813Kappus, Elizabeth W., 811Karchmer, Adolf W., 876Karlstrom, A., 76

Kashiwazaki, Mamoru, 1935Kasik, John E., 815Kass, Edward H., 911Kato, Hideo, 854Kato, Takako, 1640Katsu, Kanemasa, 497Kawana, Fuyuhiko, 1225Kaye, Donald, 458Kayser, Fritz H., 1033, 1039Keal, Julie A., 638Keating, Michael, 11Keigher, Nancy, 826Keith, Dennis, 1069Keller, P. M., 1117Kemi, Masayuki, 578Kemmerich, Bernd, 417Kenal, Kathy A. F., 467Kende, Meir, 986, 1194Kennedy, D. J., 151Kennedy, Donald J., 610Kerkering, Thomas M., 1343Kernbaum, Serge, 978Kernutt, Ian, 1826Kessler, Harold A., 100Kessler, Robert E., 238Khan, Waheed N., 1703Kido, Yasuji, 1524Kim, C. Kurtis, 197Kim, Hong-Ki, 84Kim, Hyun W., 1143Kim, Hyun Wha, 1882Kim, Kwang Sik, 70King-Thompson, Neva, 1553Kirch, Andreas, 1338Kirkpatrick, B., 161, 1051Kit, Saul, 1483Kita, Yasuo, 1692Kitai, Kazuhisa, 1935Kitao, Tadatoshi, 1446Kitoh, Kyosuke, 497Kitzis, Marie D., 2018Klastersky, J., 1002, 1061Klein, R. S., 111, 1406Klesel, N., 1822Kline, Sandra S., 1328Klopman, Gilles, 1831Knapp, Cynthia C., 1332Knapp, J. S., 535Knick, Victoria B., 274Knirsch, Anthony K., 1703Kobasa, William D., 458Kobayashi, G. S., 2005Kobayashi, Nobuyuki, 1524Kodesch, F., 151Kodner, Carrie, 164Koeppe, Peter, 1338Koga, Hironobu, 1904Komatsu, Tetsuro, 578Kong, Xiang-bin, 1355Koren, Gideon, 52Korting, H. C., 1822Kotilainen, Pirkko, 455Koup, Jeffrey R., 720, 915Krasny, Harvey C., 1317Krawczyk, Steven H., 544Krishnasami, Shanti, 1915Krispin, Mayer, 352Krogstad, Donald J., 32, 385Kroll, Hein-Peter, 1106Kron, Michael A., 2007Krul, Annemiek M., 930Kuehn, Craig, 1359Kunugita, Kiyohiko, 1935

VOL . 31, 1987

ANTIMICROB. AGENTS CHEMOTHER.

Labarre, C., 920Labthavikul, Pompen, 463LaFollette, Greg, 264Lafont, Jean-Pierre, 784, 1274Lagorce, Maryse, 784, 1274Laine, Beth M., 312Lakings, Duane B., 1706Lally, Richard T., 16, 1711Lambe, Catherine U., 844Lambert, Thierry, 1021Lamothe, Frangois, 1596Lane, Timothy, 292Langlois, Alphonse J., 1972Lantz, Marilyn S., 1915Lapiguera, Amy, 84Lariviere, Louise A., 940Larson, E. L., 1572Larsson, A., 76, 317Lau, Alan H., 1662Laughon, B. E., 1572Lauzer, Jean C., 940Lawman, M. J. P., 752LeBlanc, Barbara, 102, 650LeBlanc, Donald J., 1301Le Bouguenec, Chantal, 1394Leclercq, Roland, 1887Lee, Stephen C., 667Le Goffic, Frangois, 1925Lehrman, S. Nusinoff, 1117Leibowitz, Michael J., 512Leitner, Felix, 238Lelievre-Pegorier, Martine, 88Lenard, John, 512Lentnek, Arnold L., 281Leroy, A., 575Leroy, Annie, 156Le Saux, Nicole M., 1153Letarte, Robert, 1761Leung, Y. K., 473Levenberg, Alexander, 352Levesque, Roger C., 728,

1761Levin, Myron J., 946, 1722Levinson, Mark E., 1831Levy, Hilton B., 986, 1194Levy, Stuart B., 1648, 1739Leying, Hermann, 1106Liao, Sam, 1317Licitra, Carmelo M., 805Lidbeck, Ann, 1846Lieberman, M., 21Liebman, Arnold, 1069Lietman, Paul S., 1317Likitnukul, Sasithorn, 81Lim, J., 21, 998Lim, Josephine, 84Lin, C., 21, 998Lin, Chin-Chung, 84Lin, Emil, 37Lin, Jung-Chung, 1431Lindborg, B., 76Lindmark, Ann, 831Linke, Michael J., 197Liu, Connie, 1014, 1210Lle6, Maria del Mar, 1618Lode, H., 1491Lode, Hartmut, 1338Loebenberg, D., 998Loebenberg, David, 1756Logan, Robert, 1497Longetti, Mauro, 1609Lopez-Berestein, Gabriel, 675,

1897, 1901, 1978

Lorber, R. R., 1514Louie, Thomas J., 551Lovelace, J. K., 111Lucain, Christine, 1589Lucker, Peter W., 1909Luengo, Jose M., 357Lukehart, Sheila A., 187Luna, Maria D., 132Luppen, K. L., 151Lupton, Harold W., 986, 1194Luthy, R., 354Luthy, Ruedi, 1222Lyman, Gary H., 135Lynch, M. J., 1414, 1892

Maass, L., 1822MacCulloch, Donald, 42MacDonald, K., 443Mace, Janice, 1143MacGregor, Rob Roy, 1718Macina, Orest T., 1831MacKeen, Patricia C., 93Mader, Jon T., 259Madiraju, Murty V. V. S.,

1727Madsen, Paul O., 709, 1010Maier, Karen A., 213Maksymiuk, Andrew, 11Malamy, Michael H., 1739Malinverni, Raffael, 539Malnick, Henry, 331Malouin, F., 286Manousos, Mary, 1939Manson, Jeanne M., 991Manuel, Christian, 1312Marchbanks, C. Randall,

1375Marchou, Bruno, 1589Marco, Aliceann, 84Marcon, Mario J., 951Marks, Melvin I., 630, 1775Marois, Yves, 1359Marr, J. J., 1406Martel, Alain Y., 966Martel, Jean-Louis, 1274Martens, Mark G., 2015Martin, Carlos, 1266Martin, J. L., 1117Martin, Juan F., 1675Mason, Rachel, 1939Matsen, John M., 1403Matsuda, Akira, 907Matsuda, Kouji, 1100Matsui, Toshio, 907Mattie, Herman, 930Mauro, Vincent F., 1328May, D. Gail, 1689McBride, Tom J., 1703McCann, P. P., 1406McCashion, Ruth N., 1414McCloskey, Richard V., 1164McCormick, Ellen M., 657McCracken, George H., Jr.,

81, 1296McCredie, Kenneth B., 11McDevitt, Joseph T., 281McDonald, Edith, 1243McFarland, Lynne V., 129McGowen, Jack, 321McGroarty, Estelle J., 230McHugh, Gail L., 1861McKee, James G., 1849McKenna, William, 1507

McKernan, Patricia A., 1369,1535

McMillian, Ray, 610McMurry, Laura M., 1648McQueen, Teresa, 1901McRipley, R. J., 1791Medearis, Donald N., Jr.,

1017Medeiros, Antone A., 1426,

2007Medoff, G., 2005Mee, B. J., 1440Mehta, Reeta T., 1897, 1901,

1978Meier, B., 354Meingassner, Josef G., 1365,

1558Mendelman, Paul M., 1478Mendelson, Meryl H., 925Menichetti, Francesco, 1126,

1609Menzies, Rosalie E., 42Mercier, Josee, 728Merlet-Benichou, Claudie, 88Merry, Joanne M., 1234Merzbach, D., 126Meugnier, Helene, 1665Meulemans, Alain, 88Meyerovitch, J., 982Meyers, Burt R., 925Michael, Katherine A., 389Michea-Hamzehpour, Mehri,

1803Michel, F., 920Michel, M. F., 535Michel, Marc F., 1809Michel-Briand, Y., 300Mieth, Hubert, 1365, 1558Miles, Helen B., 1263Milholland, Diane, 421Miller, G. H., 21, 998, 1514Miller, George H., 1756Miller, Michael H., 108Miller, Wayne H., 1972Milliken, Jeffery, 52Mills, John, 1006, 1251Minassian, Beatrice F., 219Miniter, Peggy M., 1199Minnefor, Anthony, 1183Mirelis, Beatriz, 1474Misiek, Martin, 238Misu, Tomoko, 1843Mitscher, Lester A., 1079Mitsuhashi, Susumu, 582, 854,

1085, 1111, 1640Mitsuyama, Junichi, 379Mitten, Joanne E., 213, 312Miyazaki, Teinosuke, 1843Mizen, Linda, 1826Mizojiri, Kenji, 1169Mobley, H. L. T., 1892Mochizuki, Akihiko, 713Modai, Jacques, 2018Moellering, Robert C., Jr.,

139, 653, 1188, 1997Mohler, Jacqueline, 635Montgomery, A. Bruce, 37Moon-McDermott, Lotus, 735Moore, Brian W., 1263Moore, Lynn V., 121Moore, Richard A., 121Mordenti, Joyce, 895Moreau, Nicole, 1925

Mori, Shuichi, 337Morin, Claude J., 1761Morrison, Louis T., 259Morse, Gene D., 173, 292Morthland, Virginia H., 1787Motoki, Yoshinobu, 1524Mougin, C., 300Moulin, B., 575Murakami, Kazuhisa, 1307,

1423Murray, Barbara E., 808, 1779Murray, Patrick R., 461Murray, R. J., 1130Mutschler, E., 1822Mylotte, Joseph M., 679

Nadler, Paul I., 1137Nagasu, Takeshi, 497Nairn, Dawn K., 292Najjar, Amjad, 808Nakagawa, Susumu, 1100Nakashima, Hideki, 907, 1524Nakaya, Rintaro, 713Nalin, David R., 949Nassiri, Reza, 544Nassos, Patricia S., 117, 1579Nathan, H. C., 1406Neftel, Klaus A., 1657Nenci, Giuseppe G., 1609Neu, Harold C., 463, 480,

505, 558Neu, Natalie M., 463, 558Neushul, Michael, 1524Ng, Eva Y., 1861Ng, Lai-King, 1669Ng, W. W. S., 473Nichols, Ronald Lee, 281Nicolas, Marie-Helene, 295Niles, Ann C., 461Nishino, Takeshi, 865Nolan, Linda L., 1542, 1734Nomura, Kazuhide, 1307,

1423Nord, Carl Erik, 831, 1846Nord, L. Dee, 1535Norikura, Ryo, 1169Norman, Dean C., 70Novak, Ervin, 1706Nsanze, H., 67Nugent, Kenneth M., 335Nusinoff-Lehrman, Sandra,

1483Nutter, Louise M., 368

Ober, Joseph D., 1855Oberg, Bo, 600O'Brien, Cheryl A., 698Ogashiwa, Mieko, 578Ogunariwo, Julius, 1438Ohm-Smith, Marilyn J., 1434Ohringer, Shari, 1271Ojo, Otegbola, 144Okabe, Hiroshi, 1169Okamoto, Seiki, 1111Okamura, Noboru, 713O'Keefe, J. P., 2002Okezaki, Eiichi, 854Okumoto, Yasuhiro, 578Olay, Transito, 1444Oleske, James, 1183Olschewski, Peter, 1338Olsen, Kurt, 81Olsen, Kurt D., 1296Olsen, Steven J., 226

iv AUTHORINDEX

AUTHOR INDEX v

Olson, Gary L., 614Opferkuch, Wolfgang, 703,

1106Ortenberg, Margareta, 1283Ortiz, Jose M., 1266Osada, Yasuaki, 325Ossari, Simon, 1288Osterhammel, Dorrit, 594Osterhammel, Poul, 594Ostrander, M., 21O'Sullivan, John F., 789Otsuka, Haruki, 1483Ouellette, Marc, 943, 966,

1021

Pachla, Lawrence A., 1157Pagano, Joseph S., 1431Pallanza, Rosa, 1961Pangon, Beatrice, 518, 1632Pangon, Beatrice, 2018Papahadjopoulos, Demetrios,

37Papp, E. A., 55Pardee, Arthur B., 774Park, Britt H., 1648, 1739Park, No-Hee, 349Parmegiani, Raulo M., 1756Parr, Thomas R., Jr., 121,

253, 1750Parrott, Robert H., 1143, 1882Parsonnet, Kathy Cadow, 911Partos, Charles, 1909Pasko, Mary T., 679Patel, Pravin C., 1761Patterson, Thomas F., 1199Pauluzzi, Sergio, 1126Pauwels, Rudi, 1613Pauze, Marielle, 1744Paxton, Linda M., 1706Pearson, David E., 1915Pechere, Jean-Claude, 1589,

1803Pechere, Jean-Claude F., 1147Pecquet, Sophie, 124Pedersen, Svend S., 594Peeters, Martine, 1288Peixoto, Maria Petrillo, 1575Pennington, James E., 417,

876Pepper, Karen, 1394Perfect, John R., 6Perol, Yvonne, 1283Perronne, Christian M., 539Person, Ingela, 831Person, Stanley, 93Pessolano, Tammy, 27Peters, Julius, 253Peterson, Arnold A., 230Petranyi, Gabor, 1365, 1558Petrie, Charles R., 1535Petrikkos, George, 959Petty, Brent G., 1317Philippon, Alain, 295

Philippon, Alain M., 523Phillips, Peter, 647Piccolomini, Raffaele, 1644Pichichero, Michael E., 903Piddock, L. J. V., 267Pierre, Catherine, 1600Pinnock, Carole B., 1263Pintar, Jill, 1243Piot, P., 67Piot, Peter, 434

Pitarangsi, Chittima, 438Pittman, K. A., 55Pittman, Kenneth A., 799Pizzo, Philip A., 971Plaisance, Karen, 860, 1177Plaisance, Karen I., 956, 1420Plummer, Frank A., 1153Pohlod, Donald, 1529Pohlod, Donald J., 104Polacheck, Itzhack, 834Polegre, Marfa A., 447Polk, Ron E., 393Pollock, Jerry J., 1562Pompei, Raffaello, 1651Ponte, C., 821Portmann, Renee, 1909Powell, Dwight A., 951Powell, M., 1841, 1871Pozet, Nicole, 1255Price, Donald L., 135Prieto, S., 821Prince, Gregory A., 1882Prince, Randall A., 815Prober, Charles, 52Prosser, Barbara La Tourette,

1502Ptachcinski, Richard J., 323Pujadas, Ramon, 1474Pursiano, Theresa A., 238

Queener, Sherry F., 1323Quero, A. M., 920Quinn, Thomas C., 811

Rabalais, Gerard P., 946Rabin, Harvey R., 1438Radov, L. A., 1130Radwanski, Elaine, 84Ramer, Nancy R., 1243, 1768Rao, K. V. B., 1406Ratner, Hilda B., 1014Ravagnan, Giampietro, 1644Ray, Paul H., 274Ray, Teresa, 1915Rayner, Eleanor, 551Reaman, Gregory, 1882Reed, Michael D., 663, 698Regamey, Patrick, 1803Regnier, B., 899Regnier, Bernard, 1600Reig, Milagro, 665Reilly, P. M., 151Reinhardt, J., 443Reiser, Jody, 1343Reiszner, E., 653, 1188Reiszner, Edina, 1997Remington, Jack S., 346, 492Renard, Christine, 410Renkonen, Olli-Veikko, 962Retsema, James, 1939Retsema, James A., 1948Revankar, Ganapathi R., 1535Richards, Cynthia A., 274,

1972Richman, Douglas D., 1879Riddle, Gerald D., 2015Rideout, Janet L., 274Rietiker, S., 354Riley, Timothy M., 1535Rill, Wayne L., 986, 1194Ripamonti, Franca, 1961Riviere, J. Edmond, 1929Roberts, Marilyn C., 1852

Robins, Roland K., 447, 1535Rocco, Laura E., 1317Rock, David T., 393Rodrfguez, Antonio, 1444Rodriguez, Fernando C., 132Rodriguez, William, 1882Rodriguez, William J., 1143,

1703Rojas, Tamara, 447Rolan, Paul E., 638Rolston, Kenneth V. I., 102,

650, 829Ronald, A. R., 67Ronald, Allan R., 1153Ronen, D., 1798Roon, Richard A., 720Rooney, J. F., 1117Roosendaal, Robert, 1809Rosenkranz, Herbert S., 1831Rossman, Pamela, 1069Rouse, Mark S., 430Roy, Paul H., 966Royez, M., 300Rubin, Marc, 971Rubin, Robert H., 1017Rubinstein, E., 982Ruby, C., 744Ruby, Carolyn, 964Ruden, U., 317Rudent, A., 920Rusnak, Michael G., 398Russell, Marie, 164Russo, Diane A., 1069Ryan, Philip, 1263Rybak, Michael J., 1461

Sachdeva, Meena, 1549Saeed, A. M. K., 151Saeed, Abdul M. K., 610Saez-Nieto, Juan A., 1478Sagara, Hiroko, 713Saha, Gita, 463Said, I., 1150Sakly, Rachid, 88Sako, Marcia U., 1478Salsitz, Barbara, 1137Samonis, George, 829Sanada, Minoru, 1100Sande, Merle A., 398Sanders, Christine C., 1164Sanders, W. Eugene, Jr., 1164SanMiguel, Juan Garcia, 1383Sanson-Le Pors, Marie-Jose,

1283Santamaria, M., 821Saravolatz, Louis, 1529Saravolatz, Louis D., 104Sarni, Melody Tortosa, 925Sassard, Jean, 1255Sato, Kenichi, 1640Satoh, Takafusa, 1446Satta, Giuseppe, 1618, 1651Savani, Dora V., 6Sawai, Tetsuo, 379Saxon, Barbara A., 1403Scavizzi, Maurice R., 523Schaberg, Dennis R., 527,

1075Schafer-Korting, M., 1822Schalla, W. O., 535Scheer, Robert R., 1137Schelkly, William, 1939Schentag, Jerome J., 375, 605

Schiff, Gilbert M., 1285Schinazi, Raymond F., 477Schindler, M., 813Schlesinger, Paul H., 32Schlosser, V., 813Schlossman, Stuart F., 768,

774Schmidt-Eisenlohr, E., 813Scholl, David R., 1465Schooley, Robert T., 168Schryvers, A. B., 286Schryvers, Anthony B., 1438Schulman, Marvin D., 744,964

Schwartz, J., 21, 998Schwind Summerill, Rosalie

A., 219Scott, Barbara A., 551Scribner, Ronald K., 630Scupp, Ronald, 1756Sears, Stephen D., 1470Segreti, John, 100, 328Selecky, Mark, 1750Seligsohn, Robert, 1662Selva, Enrico, 1961Serour, Francis, 352Shalit, Itam4r, 1775Shaokat, Soham, 943Sharma, Ram A., 368Shatzer, K. L., 2002Shaw, Carol E., 470Sheppard, Michael, 1483Sherman, L., 1798Shibamura, Seiichi, 325Shigeta, S., 76Shigeta, Shiro, 337, 1225Shipman, Charles, Jr., 544Shlaes, David M., 2007Shohet, I., 982Shungu, Daniel L., 949Shyu, W. C., 55Shyu, Wen Chyi, 799Sidwell, R. W., 1130Sieger, Barty E., 805Sievers, Bernd, 1338Silva, M., 1231Silverblatt, Fredric J., 1359Simbul, Moises, 748Singer, Sara C., 274Singlas, E., 899Sirot, Danielle, 943Sivonen, Aulikki, 962Skold, Ola, 60Slaney, Leslie A., 1153Slattery, John T., 1859Slee, A. M., 1791Smee, Donald F., 1369, 1535Smets, P., 920Smith, Arnold L., 686, 720,

915, 1478, 1859Smith, G. W., 1442Smith, James W., 1323Smith, Michelle, 638Smith, Roberts A., 1369, 1535Smith, Sandra A., 46, 1271Smith, Stuart W. G., 1567Smith, Susan D., 331Snipes, Wallace, 93Soldin, Steve, 52Soler, Paul, 1312S0lver, E., 317Somani, Pitambar, 1328Somerville, Margaret M., 104

VOL . 31, 1987

ANTIMICROB. AGENTS CHEMOTHER.

Sommadossi, Jean-Pierre, 452Somogyi, Andrew A., 638Soriano, E., 1383Soriano, F., 821Souza, Kathy S., 1861Sparling, P. Frederick, 1507Spector, Thomas, 1972Spiegel, Carol A., 249Spillner, G., 813Srulevitch-Chin, Elina, 925Standiford, Harold C., 860,

956, 1177, 1420Staneck, Joseph L., 207Stanforth, D;avid, 197Starzl, Thomas E., 323St. Clair,.Marty H., 844, 1972Stein, Daniel S., 1285Steinberg, Thomas- H., 660Stella, Felicia B.' 1549Stempel, David, 915Stern, Robert C., 698Stevens, David A., 1874Stevens, Dennis L., 213, 312Stevens, Donald L., 144Stevens, S. Edward, Jr., 93Stiles, Michael E., 1669Stolz, E., 535Stone, Benjamin B., 1054Strat-ton, Charles W., 1014,

1210, 1689Straube, Robert, 1722Straubinger, Robert M., 37Straus, S. E., 1117Streicher, S., 744Suerbaum, Sebastian, 1106Sugar, Alan M., 1874Sugeno, Koichi, 1169Sullender, Wayne M., 1722Sundqvist, A., 317Sundstrom, Lars, 60Suter, Karin, 1909Sutton, David, 1238Suzue, Seigo, 582Suzuki, Hitoshi, 1225Svendsen, Thor, 1507Swanson, Robert, 1243Swanson, Robert N., 1768Swartz, Morton N., 1861Swedberg, Gote, 306Sweet, Richard L., 1434Swierkosz, Ella M., 1465Sykes, Richard B., 219, 226Symchowicz, S., 998Symchowicz, Samson, 84Syrogiannopoulos, George A.,

1296Szoka, Francis C., Jr., 421

Tabary, Xavier, 1925Tack, Kenneth J., 375Takahashi, Atsushi, 1278Takahashi, Kiyobumi, 1355Takase, Zenjiro, 578

Takashima, Akira, 1169Tally, Francis P., 1739Talpey, William B., 903Tamisier, Laurence, 978Tanaka, Hideo, 1169Tanaka, Nobuo, 1100Tanaka, S. K., 1271Tanaka, S. Ken, 219Tancrede, Cyrille, 124Tanino, Teruo, 865Tate, Max E., 1967Tatem, Beverly, 1177Tauber, M. G., 354Taylor, David N., 438Taylor, Diane E., 823, 1669Taylor, Doris, 1502Tedder, Thomas F., 768, 774Teitz, Y., 1798Tello, Waldina Martinez, 434Tenover, Fred C., 1301Terenzi, Adelmo; 1126Terleckyj, Bohdan, 794Thadepalli, H., 619Thakker-Varia, Smita, 735,

883Thamlikitkul, Visanu, 207Thauvin, Claudie, 139Thomson, Angus W., 1567Thormar, Halldor, 27.Thornsberry, C., 1514Thormsberry, Clyde, 343Threlkeld, Norma, 81Tolmasky, Marcelo E., 1955Toothaker, Roger D., 1157,

1859Tostowaryk, Walter, 1744Townsend, Leroy B., 544Toy, Cindy, 1137Traserra, Jose, 1383Travis, S. J., 2005Trenholme, Gordon M., 100,

328Trouillet, Jean Louis, 1312Tsai, Yuan H., 238Tubert, Tracey, 1519Tulkens, Paul M., 410Turgeon, Fernand F., 940Turk, Steven R., 544

Ueda, Tohru, 907Utsui, Yukio, 1085

Valentino, D., 744Vallois, Jean-Marie, 518, 1632Van Caekenberghe, Dirk L.,

1429van den Berghe-van Raffe,

Marion, 1809Vandenbroucke, Arthur, 748Vandepitte, Jozef, 434Van der Auwera, P., 1002,

1061Vanderhaeghe, Hubert J., 410

van der Hoek, J. C. S., 535van der Willigen, A. H., 535van Furth, Ralph, 930van Joost, T., 535van Klingeren, B., 535van Vliet, H. J. A., 535Van Voris, Lee P., 1140Varaldo, Pietro E., 1642Vaziri, Nostratola, 114Venezio, F. R., 2002Venkataramanan, Raman, 323Verbist, L., 340Verbist, Ludo, 434Verhagen, C. Stans, 191Vicente, Maria V., 1444Vinayagamoorthy, T., 60Vink-van den Berg, Joke C.,

1809Visakorpi, Risto, 962Visnic, Debra A., 219Vogt, Markus W., 168Volpe, A., 1150Vrang, Lotta, 600

Wade, James C., 632, 1420Wagenvoort, J. H. T., 535Wagner, J., 1491Wahren, B., 76, 317Waits, V. B., 111Walsh, Maura, 811Walshe, John J., 173Walzer, Peter D., 197Wang, Wen-Lan L., 438Wanger, Audrey R., 1779Warchol, Mark, 612Warner, Susan C., 93Warren, R. P., 1130Warren, Richard F. O., 1967Washington, John A., II, 1332Watanabe, Kyoichi A., 1355Watanabe, Nao-Aki, 497Watts, Florence L., 1689Weber, Allan, 915Weber, David J., 876Weeks, Lyndell S., 1014, 1210Weidek-amm, Erhard, 1909Weinandt, W. J., 151Weinberg, Diane S., 226Weinhold, Kent J., 1972Weinstein, Melvin P., 735, 883Weir, Matthew, 860Weismeier, K., 935Weissberger, Barbara, 949Weisser, Jochen, 531Welch, David F., 1775Weller, Stephen, 1722Wennersten, C., 653, 1188Wennersten, Christine, 139Wexler, H., 443Wharton, Rayner C., 632White, Catherine A., 1859White, Roger L., 1375Whiting, John L., 1379

Whitley, Richard J., 1317Whitney, Rita R., 226Wick, Alexander, 614Wiedemann, Bernd, 531Wikler, Matthew A., 281Wiley, R., 1491Wilkinson, Brian J., 1727Willey, Sandra, 139Williams, J. D., 1841, 1871Williams, Keith, 191Williams, P. D., 570Williams, Paul, 758Williams-Warren, Judy, 915Willis, Randall C., 1535Wills, Robert J., 826Wilson, Eileen J., 1017.Wilson, Walter R., 430Winslade, Nancy E., 605Wise, R., 161, 267, 1051Woehrle, Roger, 1665Wolff, M., 899Wolff, Michel, 2018Wolfson, John S., 1861Wong, Sallene, 1348Wood, Debra L., 1137Woodnutt, Gary, 1826Woods, Gail L., 1332Woods, T. Mark, 264Woolfrey, Bert F., 16, 1711Wright, D. Scott, 1157Wright, John J., 1756Wuonola, M. A., 1791

Yajko, David M., 117, 1579Yamada, June K., 1697Yamaguchi, Akihito, 379Yamamoto, Naoki, 907, 1524Yamamoto, Yasumichi, 1843Yangco,.Bienvenido G., 135Yarosh-Tomaine, Taisa, 1756Yeaman, Michael R., 1079Yellin, A., 982Yih, Jennifer, 1750Yoshida, Tadashi, 1307, 1423Yoshimori, Takeo, 1169Yost, Richard L., 1375Young, Lowell S., 640, 1697Yousefi, Shookooh, 114Yukawa, Tadahiko, 1169Yvert, Francine, 1288

Zajac, I., 1791Zalisz, R., 920Zawada, M. J., 1791Zech, Paul Y., 1255Zeis, Birgit M., 789Zenebergh, Andree, 410Zimmerman, Thomas P., 274Zinner, Stephen H., 1054,

1782Zmijewski, Milton J., Jr., 1497Zolna, Lawrence E., 991

1.

VI AUTHORINDEX

SUBJECT INDEXVOLUME 31

A25822BC. albicans, 46

A40926comparative activity

teicoplanin and vancomycin, 1961N. gonorrhoeae, 1961

A47934biosynthesis, 1497S. toyocaensis product, 1497

A-56268B. catarrhalis, 343C. fetus, 328C. trachomatis, 100, 470Campylobacter spp., 343comparative activity

amoxicillin, cefaclor, clindamycin,erythromycin, and roxithromycin,463

ciprofloxacin, doxycycline, erythromy-cin, and trimethoprim-sulfametho-xazole, 100

clindamycin and erythromycin, 328clindamycin, erythromycin, and roxi-

thromycin, 343clindamycin, erythromycin, and van-

comycin, 640enterococci, 343H. influenzae, 463, 640, 1243L. monocytogenes, 328, 343Legionella spp., 640N. gonorrhoeae, 328, 343, 470, 640S. aureus, 328S. pneumoniae, 328S. pyogenes, 328staphylococci, 343, 640streptococci, 463, 640

A-56619comparative activityA-56620 and nafcillin, 259

osteomyelitis, 259S. aureus, 259[3H]thymidine incorporation of lympho-

cytes, 768A-56620Bacteroides spp., 619comparative activityA-56619 and nafcillin, 259

osteomyelitis, 259S. aureus, 259[3H]thymidine incorporation of lympho-

cytes, 768A-62254

comparative activityciprofloxacin, 1768difloxacin, 1768

ABPintracellular accumulation, 410

Acetylsalicylic acidinterferon, effect on, 114

Acinetobacter calcoaceticusNY-198, 854

Acquired immunodeficiency syndromeletter to the editor, 969M. avium, 1579M. avium complex, 1697M. avium-M. intracellulare, 969

Acremonium chrysogenumvaline uptake

methionine, interference by, 357Actinomadura antibiotic

A40926, 1961

Acyclovircombinations

herpes simplex virus, 477vidarabine, 477

cytomegalovirus, 317, 544herpes simplex virus, 361, 477, 946,

1722, 1865resistant, 1465type 2, 1483

letter to the editor, 1865minireview, 361pediatric infections, 1722pharmacokinetics, 1722varicella-zoster virus, 1722

Acyl coenzyme A:6-aminopenicillanic acidacyltransferase

P. chrysogenum, 1675(RS)-3-Adenin-9-yl-2-hydroxypropanoic

acid isobutyl esterrespiratory syncytial virus, 1225

Adenosine analogsEpstein-Barr virus, 1431

Adenovirus2-nor-cyclic GMP, 337(S)-9-(3-hydroxy-2-phosphonylmethoxy-

propyl)adenine, 337N10169, 1535

2"-O-AdenylyltransferaseR plasmid encoded, 667

Aeromonas hydrophilaR plasmid, 1278

Aeromonas salmonicidapolymyxin B nonapeptide, 1414

Aeromonas spp.ampicillin, 1281carbenicillin, 1281cefamandole, 1281chloramphenicol, 1281colistin, 1281gentamicin, 1281kanamycin, 1281mercuric chloride, 1281nalidixic acid, 1281rifampin, 1281spectinomycin, 1281streptomycin, 1281sulfisoxazole, 1281tetracycline, 1281ticarcillin, 1281tobramycin, 1281trimethoprim, 1281

Agar dilution plate count methodH. influenzae type b

ampicillin killing curve, 1711oxacillin, 16S. aureus, 16

Alanine aminopeptidaseexcretion

effects of gentamicin, vancomycin,and vancomycin-gentamicin, 1461

Alcoholic liver diseasemetronidazole

pharmacokinetics, 1662Alizarin redMobiluncus spp., 249

AM-833comparative activity

ceftriaxone, erythromycin, penicillin,spectinomycin, and tetracycline,1153

H. ducreyi, 1153

N. gonorrhoeae, 1153pharmacokinetics, 1909

Amantadineinfluenza A virus, 1470

Amdinocillin3-lactamase induction, 1164

Amifloxacincombinations

L. pneumophila, 1529rifampin, 1529

L. pneumophila, 1529N. asteroides, 2013[3H]thymidine incorporation of lympho-

cytes, 768Amikacin

auditory toxicity, 1383Citrobacter spp., 829combinations

ciprofloxacin, 1803imipenem, 632P. aeruginosa, 632, 1803pefloxacin, 1803peritonitis, 1803

K. pneumoniae resistance transposon,1955

M. avium, 117, 1579Morganella-Proteus-Providencia group,

1644N. asteroides, 2013pharmacokinetics, 570, 1061renal membrane binding, 570urinary tract infections, 1061, 1644

p-AminobenzoateL. major, 1575

Aminoglycosidesauditory toxicity, 1383intra-abdominal infections, 485minireview, 485pharmacokinetics, 570, 1855renal membrane binding, 570

AmoxicillinCapnocytophaga spp., 1283S. pyogenes mixed infection with S. au-

reus, 1204Amoxicillin-clavulanic acid

B. catarrhalis, 1519C. coli, 940C. jejuni, 940Capnocytophaga spp., 1283endometritis, 1434H. influenzae, 1871, 2018M. avium, 1579meningitis, 2018N. asteroides, 2013pelvic inflammatory disease, 1434S. pyogenes mixed infection with S. au-

reus, 1204Amphotericin B

C. albicans, 335C. tropicalis, 421Candida infection in neutropenic

patients, 11Candida spp., 1343, 1756, 1978combinationsCandida spp., 1978gramicidin NF, 1978gramicidin S, 1978pneumonia, 1775Rhizopus spp., 1775rifampin, 1775

comparative activity

vii

ANTIMICROB. AGENTS CHEMOTHER.

amphotericin B methyl ester and N-D-ornithyl amphotericin B methylester, 1756

fluconazole, 2005flucytosine and ketoconazole, 1343ketoconazole, 11

H. capsulatum, 2005histoplasmosis, 2005liposomal, 1978liposome intercalation, 421M. furfur, 951pharmacokinetics, 1234S. cerevisiae, 421yeasts, 1756

Amphotericin B methyl esterCandida spp., 1756comparative activity

amphotericin B and N-D-ornithyl am-photericin B methyl ester, 1756

pharmacokinetics, 1234yeasts, 1756

AmpicillinAeromonas spp., 1281B. catarrhalis, 1519C. pylori, 949Capnocytophaga spp., 1283chemiluminescence response by

leukocytes, 763Citrobacter spp., 829combinations

bismuth subcitrate, 1429C. pylori, 1429meningitis, 1703sulbactam, 1703

comparative activitycefamandole, 876chloramphenicol and moxalactam, 467chloramphenicol, enoxacin, and oflo-

xacin, 417Corynebacterium group D2, 821E. coli, 126

effect on resistance, 587endocarditis, 139H. influenzae, 417, 467H. influenzae type b, 1711high-performance liquid chromatogra-

phy, 1904K. aerogenes, 126M. avium, 1579meningitis, 467Mobiluncus spp., 249P. mirabilis, 126penetration into polymorphonuclear leu-

kocytes, 1904pharmacokinetics, 1904

meningitis, 1703platelet function, 467pneumonia, 417, 876S. faecalis, 139S. faecium, 1618T. hyodysenteriae, 1935

Anaerobic bacteriaFCE 22101, 831

Analytical methodscephalosporins, 1157minireview, 1157

AnsamycinM. avium, 117

AntibodiesmonoclonalTEM-1 P-lactamase, 1761

Antifungal agentsminireview, 1867

susceptibility testing, 1867Antiseptics

chlorhexidine gluconate, 1572comparative studies, 1572

Antiviral agentsgenetic engineering, 1293minireview, 1293

ApalcillinN. asteroides, 2013

Ara-sangivamycincytomegalovirus, 544

Ara-toyocamycincytomegalovirus, 544

Ara-tubercidincytomegalovirus, 544

Arthritis, pyogenicteicoplanin, 207

Aspergilliterbinafine, 1365

Auditory toxicityamikacin, 1383netilmicin, 1383risk factors, 1383tobramycin, 1383

Avermectinsbiosynthesis, 964methylation

defective S. avermitis mutants, 744Avian myeloblastosis virus

3'-azido-3'-deoxythymidine 5'-triphos-phate, 600

reverse transcriptase, 600reverse transcriptase inhibitors

sea algal sulfated polysaccharides,1524

AzasterolC. albicans, 46

3'-Azido-3'-deoxythymidinecombinations

granulocyte-macrophage colony-stimu-lating factor, 1046

human immunodeficiency virus, 1046Enterobacteriaceae, 274fungi, 274hematopoietic cell proliferation, 452human immunodeficiency virus type 1,

1879human immunodeficiency virus type 2,

1879mechanism of action, 274Mycobacterium spp., 274P. aeruginosa, 274Vibrio spp., 274

3'-Azido-3'-deoxythymidine 5'triphosphate

avian myeloblastosis virus, 6003'-Azido-3'-deoxythymidine triphosphatehuman immunodeficiency virus reverse

transcriptase, 1972Azidothymidine

combinationsinterferon, alpha A, 168

human immunodeficiency virus, 168, 839minireview, 839

Azithromycincomparative activity

amoxicillin, 1948cefaclor, 1948erythromycin, 1939, 1948

F. necrophorum, 1948gram-negative organisms, 1939H. influenzae, 1948L. monocytogenes, 1948

mode of action, 1939pharmacokinetics, 1948S. aureus, 1948S. enteritidis, 1948Streptococcus spp., 1948

AzlocillinCapnocytophaga spp., 331M. avium, 1579Morganella-Proteus-Providencia group,

1644urinary tract infections, 1644

AZTcombinationsgranulocyte-macrophage colony-stimu-

lating factor, 1046human immunodeficiency virus, 1046

hematopoietic cell proliferation, 452AztreonamCapnocytophaga spp., 331Citrobacter spp., 829colonization resistance, 723combinations

gentamicin and tobramycin, 1403P. aeruginosa, 1403P. cepacia, 1403

comparative activitycefoperazone, cefoxitin, and piperacil-

lin, 202E. coli cell envelope, 1106H. influenzae, 1871intestinal flora, 202M. avium, 1579Morganella-Proteus-Providencia group,

1644N. asteroides, 2013pharmacokinetics, 81urinary tract infections, 1644

BO-1165P-lactamase stability, 505comparative activity, 505

Bacillus megateriumLY146032, 1093

Bacillus subtilisenoxacin uptake, 1348

Bacteremiafebrile, granulocytopenic leukemia pa-

tients, 1126teicoplanin-amikacin-ceftazidime, 1126

Bacteroides fragiliscarbenicillin, 617cefazolin, 321cefazolin-clavulanic acid, 321cefazolin-sulbactam, 321cefotaxime, 2002cefotetan, 2002cefoxitin, 617, 2002ceftizoxime, 2002chloramphenicol, 617ciprofloxacin, 1791ciprofloxacin-cefotaxime, 1379ciprofloxacin-cefoxitin, 1379ciprofloxacin-clindamycin, 1379ciprofloxacin-metronidazole, 1379ciprofloxacin-mezlocillin, 1379clindamycin, 617desacetyl cefotaxime, 2002DuP 105, 1791DuP 721, 1791imipenem, 1791, 2002metronidazole, 617oxazolidinones, 1791pefloxacin, 1665

viii SUBJECT INDEX

SUBJECT INDEX ix

R plasmids, 1739R-3746, 1085T-2588, 1111tetracycline resistance determinant

mediation of E. coli resistance, 1739ticarcillin-clavulanic acid, 2002vancomycin, 1791

Bacteroides fragilis groupcefotaxime, 2002cefotetan, 2002cefoxitin, 1596, 2002ceftizoxime, 2002chloramphenicol, 1596clindamycin, 1596desacetyl cefotaxime, 2002imipenem, 1596, 2002moxalactam, 1596susceptibility testing, 1596ticarcillin, 1596ticarcillin-clavulanic acid, 2002

Bacteroides intermediusfibrinogen binding, 1915gingivitis, 1915tetracycline, 1915

Bacteroides spp.A-56620, 619cefmetazole, 2010CGP 31608, 267difloxacin, 619Lactobacillus antimicrobial substance,

1231resistance

macrolides-lincosamides-streptograminB, 665

BAY n 7133pharmacokinetics, 1234

Benzylpenicillingranulocytopenia, 930S. aureus, 930S. faecium, 1618

P2-Microglobulinexcretion

effects of gentamicin, vancomycin,and vancomycin-gentamicin, 1461

P-Lactamasesamdinocillin, 1164BO-1165, stability of, 505CGP 31608, 267DNA probes, 728E. cloacae

ceftriaxone resistance, 1589E. coli, 943enterococci, 1749H. influenzae, 286, 1841H. parainfluenzae, 966OHIO-1, 2007P. aeruginosa, 1750

ceftazidime resistance, 253R-3746, 1085S. aureus, 1426T-2588, 1111TEM type

isoelectric focusing, 300molecular hybridization, 300

TEM-1monoclonal antibodies, 1761

3-Lactamscefsulodin and ticarcillin

effect on tobramycin uptake in P. ae-ruginosa, 108

E. cloacae resistance, 295E. coli binding, 1271endocarditis, 1750

eucaryotic cells, 1657intracellular accumulation, 410M. morganii resistance, 379minireview, 1657N. gonorrhoeae

peptidoglycan alterations, 178P. aeruginosa, 1750

permeation, 1216Proteus spp. resistance, 379Providencia spp. resistance, 379S. faecium, 1618Y. enterocolitica, 523

Bifidobacterium spp.Lactobacillus antimicrobial substance,

1231Bioassays

pefloxacin, 1665Biofilms

antibiotic effects, measurement of, 1502E. coli, 1502

BiosynthesisA47934, 1497

Bismuth subcitratecombinations

ampicillin, cefaclor, difloxacin, eryth-romycin, metronidazole, minocy-cline, nifuroxazide, nitrofurantoin,norfloxacin, ofloxacin, oxolinicacid, polymyxin B, rifampin, andtobramycin, 1429

C. pylori, 1429BMY-28100

B. catarrhalis, 238C. difficile, 238C. perfringens, 238comparative activity

amoxicillin, amoxicillin-clavulanate,cefaclor, and cephalexin, 480

ampicillin, cefaclor, cephalexin, andvancomycin, 238

cefaclor and cephalexin, 630, 653E. coli, 480Enterobacteriaceae, 238gonococci, 653H. influenzae, 238, 480, 653K. pneumoniae, 653Klebsiella spp., 480L. monocytogenes, 238, 480N. gonorrhoeae, 238, 480P. acnes, 238pediatric infections, 630S. aureus, 238, 653S. epidermidis, 238S. saprophyticus, 238staphylococci, 480streptococci, 238, 480, 653

BMY-28142high-performance liquid chromatogra-

phy, 799high-pressure liquid chromatography, 55pharmacokinetics, 799

BO-1236comparative activity

cefoperazone, cefotaxime, and ceftazi-dime, 1100

gram-negative organisms, 1100P. aeruginosa, 1100

Borrelia burgdorfericeftriaxone, 164erythromycin, 164penicillin G, 164tetracycline, 164

Bovine herpesvirus type 1

interferon, alpha 1, 752Branhamella catarrhalis

A-56268, 343amoxicillin-clavulanate, 1519ampicillin, 1519BMY-28100, 238cefaclor, 1519cephalothin, 1519chloramphenicol, 1519erythromycin, 1519T-2588, 1111tetracycline, 1519trimethoprim-sulfamethoxazole, 1519

BRL 39123comparative activity

acyclovir, 1238cytomegalovirus, 1238herpes simplex virus type 1, 1238herpes simplex virus type 2, 1238varicella-zoster virus, 1238

BW A509UEnterobacteriaceae, 274fungi, 274mechanism of action, 274Mycobacterium spp., 274P. aeruginosa, 274Vibrio spp., 274

BW301UP. carinii, 1323

Campylobacter coliamoxicillin-clavulanic acid, 940cefamandole-clavulanic acid, 940cefotaxime-clavulanic acid, 940cefoxitin-clavulanic acid, 940cephalothin-clavulanic acid, 940clavulanic acid combinations, 940DNA probes, 1669moxalactam-clavulanic acid, 940penicillin G-clavulanic acid, 940R plasmids, 713, 1669tetracycline

resistance, 1669ticarcillin-clavulanic acid, 940

Campylobacter fetusA-56268, 328TE-031, 328

Campylobacter jejuniamoxicillin-clavulanic acid, 940cefamandole-clavulanic acid, 940cefotaxime-clavulanic acid, 940cefoxitin-clavulanic acid, 940cephalothin-clavulanic acid, 940clavulanic acid combinations, 940DNA probes, 1669moxalactam-clavulanic acid, 940penicillin G-clavulanic acid, 940R plasmids, 713, 1301, 1669tetracycline

resistance, 1669ticarcillin-clavulanic acid, 940

Campylobacter pyloriampicillin, 949, 1429bismuth subcitrate, 1429cefaclor, 1429cimetidine, 949difloxacin, 1429erythromycin, 949, 1429famotidine, 949gentamicin, 949imipenem, 949metronidazole, 1429minocycline, 1429

VOL . 31, 1987

ANTIMICROB. AGENTS CHEMOTHER.

nalidixic acid, 949nifuroxazide, 1429nitrofurantoin, 1429norfloxacin, 949, 1429ofloxacin, 1429oxolinic acid, 1429polymyxin B, 1429rifampin, 1429tetracycline, 949tobramycin, 1429

Campylobacter spp.A-56268, 343erythromycin, 438

Campylobacter-like organismskanamycin resistance

Enterobacteriaceae, gene acquisitionfrom, 1021

Cancer patientsminireview, 971neutropenia, therapy for, 971

Candida albicansA25822B, 46amphotericin B, 335azasterol, 46cerulenin, 46chlorpromazine, 834clotrimazole, 46, 1558, 1864econazole, 46immune response induction, 691ketoconazole, 46, 643

uptake, 244letter to the editor, 1864lipid biosynthesis, 46membrane integrity, 46miconazole, 46, 1558morphology, 335naftifine, 46nystatin, liposomal, 1897, 1901penicillin-tetracycline, 691terbinafine, 1558tolnaftate, 46trifluoperazine, 834trimethoprim-sulfamethoxazole, 691

Candida spp.amphotericin B, 11, 1343, 1756, 1978

liposomal, 1978amphotericin B methyl ester, 1756endophthalmitis, 6fluconazole, 6flucytosine, 1343gramicidin NF, 1978

liposomal, 1978gramicidin S, 1978

liposomal, 1978itraconazole, 6ketoconazole, 6, 11, 1343neutropenic patients, 11ofloxacin, 124N-D-ornithyl amphotericin B methyl es-

ter, 1756terbinafine, 1365

Candida tropicalisamphotericin B, 421

Capnocytophaga spp.amoxicillin, 1283amoxicillin-clavulanic acid, 1283ampicillin, 1283azlocillin, 331aztreonam, 331carbenicillin, 1283cefamandole, 1283cefoperazone, 1283cefotaxime, 331, 1283

cefoxitin, 1283ceftazidime, 331, 1283ceftizoxime, 331ceftriaxone, 331, 1283cefuroxime, 331cephalothin, 1283ciprofloxacin, 331, 1283imipenem, 331, 1283mezlocillin, 1283moxalactam, 331, 1283nalidixic acid, 1283norfloxacin, 331, 1283ofloxacin, 1283pefloxacin, 1283piperacillin, 331, 1283rosoxacin, 1283ticarcillin, 331trimethoprim, 331

CarbadoxT. hyodysenteriae, 1935

CarbenicillinAeromonas spp., 1281B. fragilis, 617Capnocytophaga spp., 1283M. avium, 1579Morganella-Proteus-Providencia group,

1644urinary tract infections, 1644

Carbodinerespiratory syncytial virus, 1225

Carrageenansherpes simplex virus type 1, 1388sea algal extract, 1524

Carumonampharmacokinetics, 1692

CathetersS. epidermidis biofilm, 889

CefaclorB. catarrhalis, 1519combinations

bismuth subcitrate, 1429C. pylori, 1429

comparative activitycefixime, 443CL 284,635, 443

Cefadroxilcomparative activity

penicillin, 903streptococcal pharyngitis, 903

CefamandoleAeromonas spp., 1281Capnocytophaga spp., 1283Citrobacter spp., 829combinations

C. coli, 940C. jejuni, 940clavulanic acid, 940

comparative activityampicillin, 876cefazolin, nafcillin, and vancomycin,

1919ceftriaxone, cephalothin, cephradine,

and methicillin, 42endocarditis, 1919oxacillin resistance phenotype, 1332pneumonia, 876S. epidermidis, 1332staphylococci, 42, 1919

CefazolinB. fragilis, 321combinations

B. fragilis, 321clavulanic acid, 321

sulbactam, 321comparative activity

cefamandole, nafcillin, and vancomy-cin, 1919

endocarditis, 1919high-performance liquid chromatogra-

phy, 1904hypothyroidism, 635Morganella-Proteus-Providencia group,

1644penetration into polymorphonuclear leu-

kocytes, 1904pharmacokinetics, 635, 1904

hemorrhagic shock, 389staphylococci, 1919urinary tract infections, 1644

Cefepimehigh-performance liquid chromatogra-

phy, 799pharmacokinetics, 799

Cefetametcomparative activity

ceftriaxone, erythromycin, penicillin,spectinomycin, and tetracycline,1153

cephalexin, 473H. ducreyi, 1153N. gonorrhoeae, 1153

Cefiximecomparative activity

cefaclor, 443H. influenzae, 1841

Cefmenoximecomparative activity

cefbuperazone and cefoperazone, 865cefotiam and ceftriaxone, 518

E. coli, 518endocarditis, 518M. avium, 1579N. asteroides, 2013P. vulgaris, 865pharmacokinetics, 518

CefmetazoleBacteroides spp., 2010Clostridium spp., 2010comparative activity

cefoxitin, clindamycin, metronidazole,penicillin, and piperacillin, 2010

endometritis, 1434gram-positive cocci, 2010pelvic inflammatory disease, 1434

Cefodizimegonorrhea, 1822N. gonorrhoeae, 1822pharmacokinetics, 1822

Cefonicidpharmacokinetics, 292testicular toxicity, 991

CefoperazoneCapnocytophaga spp., 1283Citrobacter spp., 829colonization resistance, 723combinations

pharmacokinetics, 264tobramycin, 264

comparative activityaztreonam, cefoxitin, and piperacillin,

202difloxacin and enoxacin, 458

E. aerogenes, 458endocarditis, 458intestinal flora, 202pharmacokinetics, 264, 925

x SUBJECT INDEX

SUBJECT INDEX xi

Cefotaximeactivity with human serum supplement,

818B. fragilis, 2002B. fragilis group, 2002Capnocytophaga spp., 331, 1283combinations

C. coli, 940C. jejuni, 940clavulanic acid, 940

comparative activityamoxycillin, doxycycline, and genta-

micin, 523critical concentration, 870hypoprothrombinemia, development of,

281leptospirosis, 1656letter to the editor, 1656M. avium, 1579N. gonorrhoeae, 1288peritonitis, 281pharmacokinetics, 323, 815, 1177pneumonia, 281S. aureus, 818S. faecium, 1618susceptibility testing, 1375uptake by human polymorphonuclear

leukocytes, 1553Y. enterocolitica, 523

Cefotaxime-desacetylcefotaximeactivity with human serum supplement,

818S. aureus, 818

CefotetanB. fragilis, 2002B. fragilis group, 2002disulfiram-type reactions, 1328endometritis, 1434hypoprothrombinemia, development of,

1328pelvic inflammatory disease, 1434

Cefotiamcomparative activitycefmenoxime and ceftriaxone, 518

E. coli, 518endocarditis, 518pharmacokinetics, 518

CefoximeK. pneumoniae, 758

CefoxitinB. fragilis, 617, 2002B. fragilis group, 15%, 2002Capnocytophaga spp., 1283colonization resistance, 723combinations

C. coli, 940C. jejuni, 940clavulanic acid, 940L. pneumophila, 1529rifampin, 1529

comparative activityaztreonam, cefoperazone, and pipera-

cillin, 202endometritis, 1434intestinal flora, 202L. pneumophila, 1529Mobiluncus spp., 249Morganella-Proteus-Providencia group,

1644pelvic inflammatory disease, 1434urinary tract infections, 1644

Cefpimizolehigh-performance liquid chromatogra-

phy, 1904penetration into polymorphonuclear leu-

kocytes, 1904pharmacokinetics, 1706, 1904

Cefpiramidehigh-performance liquid chromatogra-

phy, 1585pharmacokinetics, 1585

CefpiromeN. asteroides, 2013

Cefsulodincombinations

P. aeruginosa, 108[3H]tobramycin, 108

CeftazidimeCapnocytophaga spp., 331, 1283Citrobacter spp., 829combinations

cephalothin, 191ciprofloxacin, 1803clavulanic acid, 1750dicloxacillin, 1750endocarditis, 1750P. aeruginosa, 398, 1750, 1803pefloxacin, 1803peritonitis, 1803pneumonia, 398sulbactam, 1750tobramycin, 398

comparative activityceftazidime-cephalothin, 191ciprofloxacin, 1809

cystic fibrosis, 698dose ranging, 698endocarditis, 253febrile neutropenic patients, 191high-performance liquid chromatogra-

phy, 1904K. pneumoniae, 1809Morganella-Proteus-Providencia group,

1644N. asteroides, 2013open-heart surgery, 813osteomyelitis

gram-negative aerobic bacillary, 1605P. aeruginosa, 1605

resistance, 253penetration into polymorphonuclear leu-

kocytes, 1904pharmacokinetics, 813, 1904pneumonia, 1809Pseudomonas spp., 698urinary tract infections, 1644

Ceftetramecomparative activity

ceftriaxone, erythromycin, penicillin,spectinomycin, and tetracycline,1153

cephalexin, 473H. ducreyi, 1153N. gonorrhoeae, 1153

CeftizoximeB. fragilis, 2002B. fragilis group, 2002Capnocytophaga spp., 331Citrobacter spp., 829high-performance liquid chromatogra-

phy, 1904hypoprothrombinemia, development of,

281N. asteroides, 2013penetration into polymorphonuclear leu-

kocytes, 1904

peritonitis, 281pharmacokinetics, 323, 1904pneumonia, 281T. hyodysenteriae, 1935

Ceftriaxoneactivity with human serum supplement,

818B. burgdorferi, 164Capnocytophaga spp., 331, 1283chancroid, 67Citrobacter spp., 829comparative activitycefmenoxime and cefotiam, 518erythromycin, penicillin G, and tetra-

cycline, 164critical concentration, 870E. cloacae resistance, 1589E. coli, 518, 1632endocarditis, 518, 1632H. ducreyi, 67high-performance liquid chromatogra-

phy, 385Lyme disease, 164Morganella-Proteus-Providencia group,

1644N. asteroides, 2013pharmacokinetics, 385, 518S. aureus, 818staphylococci, 42urinary tract infections, 1644

CefuroximeCapnocytophaga spp., 331K. pneumoniae, 758Morganella-Proteus-Providencia group,

1644N. asteroides, 2013oxacillin resistance phenotype, 1332S. epidermidis, 1332urinary tract infections, 1644

Cefuroxime axetilurinary tract infections, 1442

Cephalexincomparative activity

ceftetrame (Ro 19-5247) and cefetamet(Ro 15-8074), 473

CephaloridineE. coli cell envelope, 1106

CephalosporinaseE. cloacae, 295

Cephalosporinsanalytical methods, 1157cross resistance

methicillin, 42CS-807, 1085E. coli, 126E-0702, 497high-performance liquid chromatogra-

phy, 1157K. aerogenes, 126minireview, 1157P. aeruginosa, 1438P. mirabilis, 126R-3746, 1085T-2588, 1111

CephalothinB. catarrhalis, 1519Capnocytophaga spp., 1283Citrobacter spp., 829combinations

C. coli, 940C. jejuni, 940ceftazidime, 191clavulanic acid, 940

VOL . 31, 1987

ANTIMICROB. AGENTS CHEMOTHER.

comparative activitycefamandole, ceftriaxone, cephradine,

and methicillin, 42febrile neutropenic patients, 191Mobiluncus spp., 249Staphylococcus spp., 42, 1457

Cephradinecomparative activity

cefamandole, ceftriaxone, cephalothin,and methicillin, 42

staphylococci, 42Cerulenin

C. albicans, 46CGP 31608

Bacteroides spp., 267P-lactamase stability, 558P-lactamases, 267Clostridium spp., 267comparative activity

aztreonam, cefotaxime, ceftazidime,imipenem, piperacillin, and SCH34343, 558

cefamandole, imipenem, nafcillin, andvancomycin, 1549

cefotaxime, ceftazidime, ciprofloxacin,gentamicin, imipenem, piperacil-lin, and SCH 34343, 1188

cefoxitin, ceftazidime, cefuroxime,imipenem, and SCH 34343, 267

E. cloacae, 1188E. coli, 267Enterobacteriaceae, 267, 1188enterococci, 1188H. influenzae, 267, 1188Neisseria spp., 267P. aeruginosa, 267, 558Pseudomonas spp., 1188S. aureus, 1549S. epidermidis, 1549S. marcescens, 1188S. pneumoniae, 267staphylococci, 267, 558, 1188streptococci, 1188

Chancroidceftriaxone, 67H. ducreyi, 67

Charcoalvancomycin, effect on clearance of, 720

Chlamydia trachomatisA-56268, 100, 470ciprofloxacin, 100clindamycin, 811CP-62,993, 811doxycycline, 100erythromycin, 100, 811Ro 15-8074, 470roxithromycin, 470TE-031, 100tetracycline, 811trimethoprim-sulfamethoxazole, 100

ChloramphenicolAeromonas spp., 1281B. catarrhalis, 1519B. fragilis, 617B. fragilis group, 1596C. burnetii, 1079C. perfringens, 213chemiluminescence response by

leukocytes, 763comparative activity

ampicillin and moxalactam, 467ampicillin, enoxacin, and ofloxacin,

417

gas gangrene, 213H. influenzae, 417, 467

uptake, 686high-performance liquid chromatogra-

phy, 1904high-pressure liquid chromatography,

686M. avium, 1579meningitis, 467Mobiluncus spp., 249penetration into polymorphonuclear leu-

kocytes, 1904pharmacokinetics, 1904platelet function, 467pneumonia, 417T. hyodysenteriae, 1935

Chlorhexidinemembrane transfer assay, 1989periodontopathogens, 1989

Chlorhexidine gluconateantiseptics

comparative studies, 1572Chloroquine

G. intestinalis, 672inoculum effect, 32letter to the editor, 672P. falciparum, 32

5-Chlorotubercidinrespiratory syncytial virus, 1225

ChlorpromazineC. albicans, 834C. neoformans, 834

ChlortetracyclineE. coli

effect on resistance, 587Cilastatin

combinationsimipenem, 1491respiratory tract and other infections,

1491Cimetidine

C. pylori, 949Cinoxacin

combinationsL. pneumophila, 1529rifampin, 1529

L. pneumophila, 1529N. asteroides, 2013

CiprofloxacinB. fragilis, 1791C. burnetii, 1079C. trachomatis, 100Capnocytophaga spp., 331, 1283Citrobacter spp., 829combinations

amikacin, 1803amikacin and imipenem, 959B. fragilis, 1379cefotaxime, cefoxitin, clindamycin,

metronidazole, and mezlocillin,1379

ceftazidime, 1803coumermycin Al, 539endocarditis, 430, 539enterococci, 430Fusobacterium spp., 1379gentamicin, 430imipenem, 632L. pneumophila, 1529P. aeruginosa, 632, 959, 1803penicillin, 430Peptostreptococcus spp., 1379peritonitis, 1803

piperacillin, 1803rifampin, 1529S. aureus, 539

comparative activityA-62254, 1768ceftazidime, 1809ciprofloxacin-gentamicin, ciprofloxa-

cin-penicillin, gentamicin, penicil-lin, and penicillin-gentamicin, 430

DuP 105 and DuP 721, 1791effect of medium, 657effect of pH, 657imipenem-cilastatin, 1491nalidixic acid, norfloxacin, and oxoli-

nic acid, 1651rifampin, tobramycin, and vancomy-

cin-rifampin, 657temafloxacin hydrochloride, 1768vancomycin, 527

continuous ambulatory peritoneal dialy-sis, 1787

Corynebacterium group D2, 821E. agglomerans, 1651E. coli, 657

cell envelope, 1106R-plasmid transfer, 531

endocarditis, 430, 527, 539Enterobacteriaceae, 151enterococci, 430high-performance liquid chromatogra-

phy, 709, 899joint infections, 151K. pneumoniae, 1809L. pneumophila, 1529M. avium, 117meningitis, bacterial, 899N. asteroides, 2013N. meningitidis, 962osteomyelitis, 151P. aeruginosa, 151, 657, 959, 1803P. putrefaciens, 1651peritonitis, 1803pharmacokinetics, 709, 805, 860, 899,

915, 956, 1075, 1177, 1782, 1787pneumonia, 1809Providencia spp., 1651pyrimidine synthesis, 774respiratory tract and other infections,

1491S. aureus, 151, 527, 539skin infections, 151soft tissue infections, 151, 805staphylococci, 657, 1651, 1791streptococci, 1651, 1791[3H]thymidine incorporation of lympho-

cytes, 768urinary tract infections, 148, 354

Citrobacter freundiiR-3746, 1085

Citrobacter spp.amikacin, 829ampicillin, 829aztreonam, 829cefamandole, 829cefoperazone, 829ceftazidime, 829ceftizoxime, 829ceftriaxone, 829cephalothin, 829ciprofloxacin, 829enoxacin, 829gentamicin, 829imipenem, 829

xii SUBJECT INDEX

SUBJECT INDEX xiii

netilmicin, 829piperacillin, 829Timentin, 829

CL 284,635comparative activity

cefaclor, 443Clavulanic acid

combinationsamoxicillin, cefamandole, cefotaxime,

cefoxitin, cephalothin, moxalac-tam, penicillin G, and ticarcillin,940

B. fragilis, 321C. coli, 940C. jejuni, 940cefazolin, 321ceftazidime, 1750endocarditis, 1750P. aeruginosa, 1750

ClindamycinB. fragilis, 617B. fragilis group, 1596C. perfringens, 213, 312C. trachomatis, 811combinations

C. perfringens, 312gas gangrene, 312L. pneumophila, 1529penicillin, 312rifampin, 1529

comparative activityclindamycin-penicillin, metronidazole,

metronidazole-penicillin, penicil-lin, and rifampin, 312

CP-62,993, erythromycin, and tetracy-cline, 811

metronidazole, penicillin, and rifam-pin, 213

encephalitis, 492endometritis, 1434gas gangrene, 213, 312high-performance liquid chromatogra-

phy, 1904L. pneumophila, 1529M. avium, 1579Mobiluncus spp., 249pelvic inflammatory disease, 1434penetration into polymorphonuclear leu-

kocytes, 1904phagocytosis-stimulated uptake, 660pharmacokinetics, 1904Staphylococcus spp., 1457Toxoplasma spp., 492

Clofaziminecomparative activity

phenazine derivatives, 789M. avium, 117M. leprae, 780mycobacteria, 789prooxidative activity, 789rapid in vitro metabolic screen, 780

Clonorchiasisletter to the editor, 1291praziquantel, 135, 1291

ClorobiocinE. coli topoisomerase I, 1925

Clostridium difficileBMY-28100, 238erythromycin-clindamycin resistance,

1039homology with S. aureus Tn551, 1039

LY146032, 1135calcium supplementation, 461

metronidazole, 183pefloxacin, 1665S. boulardii, suppression by, 129tetracycline resistancehomology with S. faecalis Tn916, 1033

tinidazole, 183Clostridium perfringensBMY-28100, 238chloramphenicol, 213clindamycin, 213, 312clindamycin-penicillin, 312gas gangrene, 213, 312metronidazole, 213, 312metronidazole-penicillin, 312penicillin, 213, 312rifampin, 213, 312T-2588, 1111tetracycline, 213toxin production, 213

Clostridium spp.cefmetazole, 2010CGP 31608, 267Lactobacillus antimicrobial substance,

1231LY146032, 625

ClotrimazoleC. albicans, 46, 1864letter to the editor, 1864

Coccidioides immitisketocoqazole, 1874

ColistinAeromonas spp., 1281Mobiluncus spp., 249

Colonic microfloraenoxacin, 1846norfloxacin, 1846

Colonization resistanceaztreonam, 723cefoperazone, 723cefoxitin, 723piperacillin, 723

Computer Automated Structure Evaluationquinolones, 1831

Conjunctivitis, neonatalerythromycin ophthalmic ointment, 954

Continuous ambulatory peritoneal dialysisciprofloxacin, 1787peritonitis, 889

Cordycepin triphosphateL. mexicana, 1734

CoronavirusN10169, 1535

Corticotropinadrenal response with itraconazole, 647

Corynebacterium group D2ampicillin, 821ciprofloxacin, 821erythromycin, 821gentamicin, 821josamycin, 821norfloxacin, 821ofloxacin, 821teicoplanin, 821vancomycin, 821

CoumermycinN. asteroides, 2013

Coumermycin Alcombinations

ciprofloxacin, 539endocarditis, 539S. aureus, 539

endocarditis, 539S. aureus, 539

Coxiella burnetiichloramphenicol, 1079ciprofloxacin, 1079difloxacin, 1079doxycycline, 1079erythromycin, 1079gentamicin, 1079nalidixic acid, 1079novobiocin, 1079oxolinic acid, 1079penicillin G, 1079polymyxin B, 1079rifampin, 1079streptomycin, 1079sulfamethoxazole, 1079tetracycline, 1079trimethoprim, 1079

CP-62,993C. trachomatis, 811comparative activity

amoxicillin, 1948cefaclor, 1948clindamycin, erythromycin, and tetra-

cycline, 811erythromycin, 1939, 1948

F. necrophorum, 1948gram-negative organisms, 1939H. influenzae, 1948L. monocytogenes, 1948mode of action, 1939pharmacokinetics, 1948S. aureus, 1948S. enteritidis, 1948Streptococcus spp., 1948

Critical concentration assessmentcefotaxime, 870ceftriaxone, 870

Cryptococcus neoformanschlorpromazine, 834trifluoperazine, 834

CS-807R-3746 prodrug, 1085

5-Cyano-l-,B-D-ribofuranosylimidazole-4-carboxamide

respiratory syncytial virus, 12255-Cyanoimidazole-4-carboxamide

respiratory syncytial virus, 1225(+)-Cyclaradine

herpes simplex virus, 21(+ )-Cyclaradine-5 '-esters

pharmacokinetics, 9982'-nor-Cyclic GMP

adenovirus, 337CycloserineMobiluncus spp., 249

Cyclosporin AS. mansoni, 1567

Cystic fibrosisceftazidime, 698ciprofloxacin, 915P. aeruginosa, 594, 1403

cephalosporins, 1438P. cepacia, 1403tobramycin, high-dose, 594

Cytomegalovirusacyclovir, 317, 544ara-sangivamycin, 544ara-toyocamycin, 544ara-tubercidin, 544BRL 39123, 12382'-deoxysangivamycin, 544DHBG, 317DHPG, 1017

VOL . 31, 1987

ANTIMICROB. AGENTS CHEMOTHER.

9-(1-3-dihydroxy-2-propoxymethyl)gua-nine, 1017

9-(3,4-dihydroxybutyl)guanine, 317ganciclovir, 544HBG, 3179-(4-hydroxy-3-hydroxymethylbut-1-yl)guanir

12389-(4-hydroxybutyl)guanine, 3179-(2-hydroxyethoxymethyl)guanine, 317N10169, 1535pyrrolo[2,3-dlpyrimidine nucleosides,

544sangivamycin, 544toyocamycin, 544tubercidin, 544

DapsoneL. major, 1575M. leprae, 780rapid in vitro metabolic screen, 780

3-Deazaguaninerespiratory syncytial virus, 1225

9-Deazainosinecombinations

DL-a-difluoromethylornithine, 1406T. brucei subsp. brucei, 1406

comparative activityallopurinol and pentavalent antimony,

111L. donovani, 111T. brucei subsp. brucei, 1406

3-Deazauridinerespiratory syncytial virus, 1225

Demethylavermectinsmethylation, 964

5'-Deoxy-5-fluorouridinerespiratory syncytial virus, 1225

2'-Deoxysangivamycincytomegalovirus, 544

Dermatophytesterbinafine, 1365

Desacetylcefotaximeactivity with human serum supplement,

818B. fragilis, 2002B. fragilis group, 2002pharmacokinetics, 815S. aureus, 818

Desciclovirpharmacokinetics, 1317

DHBGcytomegalovirus, 317

(S)-DHPAEpstein-Barr virus, 1431

DHPGcytomegalovirus, 1017

2-5-Diamidinoindolerespiratory syncytial virus, 1225

Dicloxacillincombinations

ceftazidime, 1750endocarditis, 1750P. aeruginosa, 1750

2',3'-Didehydro-2',3'-dideoxycytidinehuman immunodeficiency virus, 907

2',3'-Didehydro-2',3'-dideoxythymidinehuman immunodeficiency virus, 907

Dideoxynucleosideshuman immunodeficiency virus type 1,

1879human immunodeficiency virus type 2,

18792',3'-Dideoxynucleosides

combinationshuman immunodeficiency virus, 1613ribavirin, 1613

purinehuman immunodeficiency virus, 1613

ie, pyrimidinehuman immunodeficiency virus, 1613

visna virus, 1369Difloxacin

Bacteroides spp., 619C. burnetii, 1079combinations

bismuth subcitrate, 1429C. pylori, 1429

comparative activityA-62254, 1768cefoperazone and enoxacin, 458temafloxacin hydrochloride, 1768

E. aerogenes, 458endocarditis, 458

DL-a-Difluoromethylornithinecombinations

9-deazainosine, formycin B, and sine-fungin, 1406

T. brucei subsp. brucei, 1406Dihydrocyclosporin A derivatives

S. mansoni, 1567Dihydrofolate reductase

P. carinii, 13239-(1-3-Dihydroxy-2-propoxymethyl)guanine

cytomegalovirus, 1017hematopoietic cell proliferation, 452herpes simplex virusDNA and protein synthesis, 349

9-(3,4-Dihydroxybutyl)guaninecytomegalovirus, 317

(S)-9-(2,3-Dihydroxypropyl)adenineEpstein-Barr virus, 1431

N-(3-Dimethylaminopropyl)benzylpenicilli-namide ("4C labeled)

intracellular accumulation, 410Disinfectants

fungi, 794quantitative neutralization assay, 794

Disulfiram-type reactionscefotetan-associated, 1328

DNA gyraseE. coli, 1861, 1925ofloxacin, 325, 1861S-25930 stereoisomers, 1861

DNA hybridizationherpes simplex virus, acyclovir resistant,

1465DNA probes

P-lactamases, 728C. coli, 1669C. jejuni, 1669staphylococci, 1683

N-DodecylimidazoleS. cerevisiae, 512

Dose rangingceftazidime, 698

DoxycyclineC. burnetii, 1079C. trachomatis, 100combinations

L. pneumophila, 1529rifampin, 1529

L. pneumophila, 1529Staphylococcus spp., 1457

DuP 105B. fragilis, 1791comparative activity

ciprofloxacin, imipenem, andvancomycin, 1791

staphylococci, 1791streptococci, 1791

DuP 721B. fragilis, 1791comparative activity

ciprofloxacin, imipenem, andvancomycin, 1791

staphylococci, 1791streptococci, 1791

E-0702E. coli incorporation, 497

EconazoleC. albicans, 46

Edwardsiella tardaR plasmid, 1278

EM 49E. coli, 230S. typhimurium, 230

Empyema, pleuralgentamicin, 982

Encephalitisclindamycin, 492herpes simplex virus, 1006immunoglobulin, human, 1006Toxoplasma species, 492

Endocarditisampicillin, 13913-lactams, 1750cefamandole, 1919cefazolin, 1919cefmenoxime, 518cefoperazone, 458cefotiam, 518ceftazidime, 253ceftazidime-clavulanic acid, 1750ceftazidime-dicloxacillin, 1750ceftazidime-sulbactam, 1750ceftriaxone, 518, 1632ciprofloxacin, 430, 527, 539ciprofloxacin-coumermycin Al, 539coumermycin Al, 539coumermycin Al-ciprofloxacin, 539difloxacin, 458E. aerogenes, 458E. coli, 518, 1632enoxacin, 458enterococci, 430fosfomycin-gentamicin, 1444fosfomycin-vancomycin, 1444nafcillin, 1919P. aeruginosa, 253, 1750

impermeability variants, 70penicillin V, 1474S. aureus, 527, 539, 1444S. faecalis, 139S. sanguis, 1474staphylococci, 1919teicoplanin, 207vancomycin, 527, 1919

Endometritisamoxicillin-clavulanic acid, 1434cefmetazole, 1434cefotetan, 1434cefoxitin, 1434clindamycin, 1434imipenem, 1434mezlocillin, 1434

EndophthalmitisCandida spp., 6fluconazole, 6

xiv SUBJECT INDEX

SUBJECT INDEX xv

itraconazole, 6ketoconazole, 6

EnoxacinB. subtilis, uptake by, 1348Citrobacter spp., 829colonic microflora, 1846combinations

L. pneumophila, 1529rifampin, 1529

comparative activityampicillin, chloramphenicol, and oflo-

xacin, 417cefoperazone and difloxacin, 458norfloxacin, 1846

E. aerogenes, 458E. coli

R-plasmid transfer, 531uptake by, 1348

endocarditis, 458gonorrhea, 535H. influenzae, 417L. pneumophila, 1529N. asteroides, 2013N. gonorrhoeae, 535pharmacokinetics, 748, 1054

food intake, 638pneumonia, 417[3H]thymidine incorporation of lympho-

cytes, 768Enterobacter aerogenes

cefoperazone, 458difloxacin, 458endocarditis, 458enoxacin, 458

Enterobacter agglomeransciprofloxacin, 1651

Enterobacter cloacae,B-lactam resistance, 295P-lactamase, 1589ceftriaxone resistance, 1589cephalosporinase, 295CGP 31608, 1188R-3746, 1085resistance, P-lactam, 295

EnterobacteriaR plasmid, 60

EnterobacteriaceaeA-56620, 1023'-azido-3'-deoxythymidine, 274BMY-28100, 238BW A509U, 274Campylobacter-like organism resistance

acquisition, 1021CGP 31608, 267, 1188ciprofloxacin, 102, 151difloxacin, 102enoxacin, 102erythromycin resistance, 404gene probes, 404ICI 193428, 1997ICI 194008, 1997Lactobacillus antimicrobial substance,

1231ofloxacin, 124pefloxacin, 1665S-25930, 102S-25932, 102T-2588, 1111tigemonam, 219

EnterococciA-56268, 343ampicillin, 10143-lactamases, 1749

CGP 31608, 1188ciprofloxacin, 430, 1014endocarditis, 430LY146032, 625, 1014, 1749LY146032-gentamicin, 1749LY146032-streptomycin, 1749R-3746, 1085trimethoprim-sulfamethoxazole, 808Vancocin, 333vancomycin, 333, 1014

Enterococcus faecalisR plasmids, 1394resistance markers, 1394

Epstein-Barr virusadenosine analogs, 1431(S)-DHPA, 1431(S)-9-(2,3-dihydroxypropyl)adenine, 1431(S)-HPMPA, 1431(S)-9-(3-hydroxy-2-phosphonylmethoxy-

propyl)adenine, 14319-(2-phosphonylmethoxyethyl)adenine,

1431PMEA, 1431

ErythromycinB. burgdorferi, 164B. catarrhalis, 1519C. burnetii, 1079C. pylori, 949C. trachomatis, 100, 811Campylobacter spp., 438combinationsbismuth subcitrate, 1429C. pylori, 1429L. pneumophila, 1529rifampin, 1529

comparative activityceftriaxone, penicillin G, and tetracy-

cline, 164clindamycin, CP-62,993, and tetracy-

cline, 811conjunctivitis, neonatal, 954Corynebacterium group D2, 821Enterobacteriaceae resistance, 404granulocytopenia, 930H. influenzae, 1243L. pneumophila, 1529Lyme disease, 164M. avium, 1579M. pneumoniae, 1843Mobiluncus spp., 249ophthalmic ointment, 954S. aureus, 930Staphylococcus spp., 1457

Escherichia coliampicillin, 126, 587,B-lactam binding, 12711-lactamase, 943biofilm

antibiotic effects, measurement of,1502

BMY-28100, 480cefmenoxime, 518cefotiam, 518ceftriaxone, 518, 1632cell envelope

aztreonam, 1106cephaloridine, 1106ciprofloxacin, 1106, 1106imipenem, 1106moxalactam, 1106

cephalosporins, 126CGP 31608, 267chlortetracycline, 587

ciprofloxacin, 657core-lipid A phosphates, 230DNA gyrase, 1861E-0702 incorporation, 497effect of drugs on resistance characteris-

tics, 587EM 49, 230endocarditis, 518, 1632enoxacin uptake, 1348imipenem-cilastatin, 578intrauterine infections, 578Lactobacillus antimicrobial substance,

1231lipopolysaccharide, 230meningitis, 1296nitrofurantoin, 126norfloxacin resistance, 1640ofloxacin, 1861outer membrane penetration

(2,3)-methylenepenams, 1994polymyxin B, 230prolonged exposure, 911pyelonephritis, 226R plasmid, 784, 943, 1266, 1274, 1301,

1440, 1739R-plasmid transfer inhibition

ciprofloxacin, 531enoxacin, 531norfloxacin, 531ofloxacin, 531pipemidic acid, 531

R-3746, 1085resistance patterns, 911Ro 13-5478, 614Ro 14-9578, 614S-25930 stereoisomers, 1861streptomycin, 587susceptibility patterns, 126T-2588, 1111tetracycline resistance

S. faecalis determinant, 1648B. fragilis determinant, 1739

ticarcillin-clavulanic acid, 1296tigemonam, 226topoisomerase I

clorobiocin, 1925novobiocin, 1925pefloxacin, 1925quinolones, 1925

trimethoprim-sulfamethoxazole, 126EthionamideM. leprae, 780rapid in vitro metabolic screen, 780

5'-Ethynylthymidineherpes simplex virus, 368

Evans blueMobiluncus spp., 249

Fabricsilver-coated nylon fiber

antibacterial activity, 93Famotidine

C. pylori, 949Fatty acids

viruses, enveloped, 27FCE 22101

anaerobic bacteria, 831comparative activity

bacitracin, benzylpenicillin, cefoxitin,chloramphenicol, clindamycin,fusidic acid, imipenem, metroni-dazole, piperacillin, and vancomy-cin, 831

VOL . 31, 1987

ANTIMICROB. AGENTS CHEMOTHER.

FEAUcomparative activity

2'-fluoro-5-methyl-1-p-D-arabinofu-ranosyluracil (FMAU), 1355

herpes simplex virus, 1355Fleroxacincomparative activity

ceftriaxone, erythromycin, penicillin,spectinomycin, and tetracycline,1153

H. ducreyi, 1153N. gonorrhoeae, 1153pharmacokinetics, 1010, 1909

FlomoxefS. aureus, 1307

FluconazoleCandida spp., 6comparative activity

amphotericin B, 2005itraconazole and ketoconazole, 6

endophthalmitis, 6H. capsulatum, 2005histoplasmosis, 2005

FlucytosineCandida spp., 1343comparative activity

amphotericin B and ketoconazole,1343

M. furfur, 951pharmacokinetics, 1234

Flumequine[3Hlthymidine incorporation of lympho-

cytes, 7682'-Fluoro-5-ethyl-l-,-D-arabinofuranosylur-

acilcomparative activity

2'-fluoro-5-methyl-l-3-D-arabinofu-ranosyluracil (FMAU), 1355

herpes simplex virus, 1355Fluoroquinolones

P. aeruginosa resistance, 1803Folate

L. major, 1575Formycin A triphosphate

L. mexicana, 1734Formycin Bcombinations

DL-a-difluoromethylornithine, 1406T. brucei subsp. brucei, 1406

T. brucei subsp. brucei, 1406Fosfomycincombinations

endocarditis, 1444gentamicin and vancomycin, 1444S. aureus, 1444

Fungi3'-azido-3'-deoxythymidine, 274BW A509U, 274disinfectants, 794

FurazolidoneG. intestinalis, 672letter to the editor, 672T. hyodysenteriae, 1935

Fusobacterium necrophorumazithromycin, 1948CP-62,993, 1948

Fusobacterium spp.ciprofloxacin-cefotaxime, 1379ciprofloxacin-cefoxitin, 1379ciprofloxacin-clindamycin, 1379ciprofloxacin-metronidazole, 1379ciprofloxacin-mezlocillin, 1379

Ganciclovircytomegalovirus, 544herpes simplex virus, 844DNA and protein synthesis, 349

pharmacokinetics, 1251Gas gangrene

C. perfringens, 312clindamycin, 213, 312clindamycin-penicillin, 312metronidazole, 213, 312metronidazole-penicillin, 312penicillin, 213, 312rifampin, 213, 312

Gene probeserythromycin-resistant Enterobacteria-

ceae, 404Genetic engineering

antiviral agents, 1293minireview, 1293

GentamicinAeromonas spp., 1281C. burnetii, 1079C. pylori, 949Citrobacter spp., 829combinations

aztreonam, 1403endocarditis, 1444enterococci, 1749fosfomycin, 1444L. pneumophila, 1529LY146032, 1749oxacillin, pefloxacin, and vancomycin,

1457P. aeruginosa, 679, 1403P. cepacia, 1403pharmacokinetics, 1461piperacillin, 679rifampin, 1529S. aureus, 1444Staphylococcus spp., 1457vancomycin, 1461

Corynebacterium group D2, 821empyema, pleural, 982hypothyroidism, 635L. pneumophila, 1529M. avium, 117P. aeruginosa, 679pharmacokinetics, 88, 389, 635, 850, 982,

1929alanine aminopeptidase excretion,

146132-microglobulin excretion, 1461hydrocortisone succinate, influence of,

1816pneumonia, 850serum bactericidal rate assay, 679Staphylococcus spp., 1457T. hyodysenteriae, 1935

Giardia intestinalischloroquine, 672furazolidone, 672letter to the editor, 672metronidazole, 672paromomycin, 672pyrimethamine, 672tinidazole, 672

GingivitisB. intermedius, 1915tetracycline, 1915

2'-nor-cGMPrespiratory syncytial virus, 1225

GonococciBMY-28100, 653

Gonorrheacefodizime, 1822enoxacin, 535norfloxacin, 434thiamphenicol, 434

Gramicidin NFcombinations

amphotericin B, 1978Candida spp., 1978

liposomal, 1978Gramicidin S

combinationsamphotericin B, 1978Candida spp., 1978

liposomal, 1978Gram-negative bacteria

azithromycin, 1939CP-62,993, 1939

Gram-positive bacteriaLY146032, 455

Granulocyte-macrophage colony-stimu-lating factor

combinations3'-azido-3'-deoxythymidine, 1046AZT, 1046human immunodeficiency virus, 1046

Granulocytopeniabenzylpenicillin, 930erythromycin, 930rifampin, 930

Guanine analogsLeishmania spp., 447Trypanosoma spp., 447

Guanosine analogsLeishmania spp., 447Trypanosoma spp., 447

Habekacinpharmacokinetics, 575

Haemophilus ducreyiAM-833, 1153cefetamet, 1153cefetrame, 1153ceftriaxone, 67chancroid, 67fleroxacin, 1153Ro 15-8074, 1153Ro 19-5247, 1153Ro 23-6240, 1153T-2588, 1153

Haemophilus influenzaeA-56268, 463, 640, 1243amoxicillin-clavulanate, 1871, 2018ampicillin, 417, 467azithromycin, 1948aztreonam, 1871P-lactamase, 286, 1841BMY-28100, 238, 480, 653cefixime, 1841CGP 31608, 267, 1188chloramphenicol, 417, 467

uptake, 686CP-62,993, 1948enoxacin, 417erythromycin, 1243imipenem, 1871meningitis, 467, 2018moxalactam, 467ofloxacin, 417platelet function, 467pneumonia, 417R plasmid, 286R-3746, 1085

xvi SUBJECT INDEX

SUBJECT INDEX xvii

T-2588, 1111TE-031, 640tigemonam, 219

Haemophilus influenzae type bagar dilution plate count method, 1711ampicillin killing curve, 1711meningitis, 1296ticarcillin-clavulanic acid, 1296

Haemophilus parainfluenzaeP-lactamase, 966R plasmid, 966

HBGcytomegalovirus, 317

Hematopoietic progenitor cells3'-azido-3'-deoxythymidine, 452AZT, 4529-(1,3-dihydroxy-2-propoxymethyl)guanine,

452Hemorrhagic shock

cefazolin pharmacokinetics, 389gentamicin pharmacokinetics, 389

Herpes, genitalinterferon, 1137

Herpes simplex virusacyclovir, 361, 477, 946, 1722, 1865

resistance, 1465acyclovir-vidarabine, 477(+)-cyclaradine, 219-(1,3-dihydroxy-2-propoxymethyl)guanine,

349DNA hybridization, 1465DNA synthesis, 349encephalitis, 10065'-ethynylthymidine, 368FEAU, 13552'-fluoro-5-ethyl-1-,-D-arabinofuranosyl-

uracil, 1355ganciclovir, 349, 8449-(1,3-hydroxy-2-propoxymethyl)guanine,

946immunoglobulin, human, 1006letter to the editor, 1865minireview, 361N10169, 1535protein synthesis, 349Sch 31172, 21vidarabine, 477

Herpes simplex virus type 1BRL 39123, 1238carrageenan, 1388histidine peptides, 15629-(4-hydroxy-3-hydroxymethylbut-1-yl)guan-

ine, 1238Herpes simplex virus type 2

acyclovir, 1483BRL 39123, 1238histidine peptides, 15629-(4-hydroxy-3-hydroxymethylbut-1-yl)guan-

ine, 1238thymidine kinase

nucleotide sequence changes with acy-clovir treatment, 1483

thymidine kinase, altered, 1117HerpesvirusesBRL 39123, 12389-(4-hydroxy-3-hydroxymethylbut-1-yl)guan-

ine, 1238type 1, bovine

interferon, alpha 1, 7522,3,5,6,7,8-Hexahydro-2-phenyl-8,8-dime-

thoxy-imidazo[1,2a]pyridinemurine hepatitis virus, 1130

High-performance liquid chromatography

ampicillin, 1904BMY-28142, 799cefazolin, 1904cefepime, 799cefpimizole, 1904cefpiramide, 1585ceftazidime, 1904ceftizoxime, 1904ceftriaxone, 385chloramphenicol, 1904ciprofloxacin, 709, 899clindamycin, 1904isoniazid, 1904lincomycin, 1904metronidazole, 1662mezlocillin, 895, 899penetration of agents into polymorpho-

nuclear leukocytes, 1904piperacillin, 1904rifampin, 1904trimethoprim, 1904

High-pressure liquid chromatographyBMY-28142, 55chloramphenicol uptake, 686teicoplanin, 1222vancomycin, 610

Histidine peptidesherpes simplex virus type 1, 1562herpes simplex virus type 2, 1562

Histoplasma capsulatumamphotericin B, 2005fluconazole, 2005

Histoplasmosisamphotericin B, 2005fluconazole, 2005

2HM-HBGvaricella zoster virus, 76

(S)-HPMPAEpstein-Barr virus, 1431respiratory syncytial virus, 1225

Human immunodeficiency virus3'-azido-3'-deoxythymidine-granulocyte-

macrophage colony-stimulating fac-tor, 1046

azidothymidine, 839azidothymidine plus alpha A interferon,

168AZT-granulocyte-macrophage colony-

stimulating factor, 10462',3'-didehydro-2',3'-dideoxycytidine,

9072',3'-didehydro-2',3'-dideoxythymidine,

907interferon (alpha A) plus azidothymi-

dine, 168minireview, 839purnne

2',3'-dideoxynucleosides-pyrimidine2',3'-dideoxynucleosides, 1613

reverse transcriptase3'-azido-3'-deoxythymidine triphos-

phate, 1972reverse transcriptase inhibitors

sea algal sulfated polysaccharides,1524

ribavirin-purine2',3'-dideoxynucleosides, 1613

ribavirin-pyrimidine 2',3'-dideoxynucleo-sides, 1613

visna virus model, 1369Human immunodeficiency virus type 1

3'-azido-3'-deoxythymidine, 1879dideoxynucleosides, 1879

Human immunodeficiency virus type 23'-azido-3'-deoxythymidine, 1879dideoxynucleosides, 1879

Hydrocortisone succinateinfluence on gentamicin pharmacokine-

tics, 1816RS-9-[4-Hydroxy-2(hydroxymethyl)butyl]guanine

varicella-zoster virus, 76(S)-9-(3-Hydroxy-2-phosphonylmethoxy-

propyl)adenineadenovirus, 337Epstein-Barr virus, 1431respiratory syncytial virus, 1225

9-(1,3-Hydroxy-2-propoxymethyl)guanineherpes simplex virus, 946

9-(4-Hydroxy-3-hydroxymethylbut-1-yl)guaninecomparative activity

acyclovir, 1238cytomegalovirus, 1238herpes simplex virus type 1, 1238herpesviruses, 1238varicella-zoster virus, 1238

9-(2-Hydroxy-1,3,2-dioxaphosphorinan-5-yl)oxymethyl guanine P-oxide

respiratory syncytial virus, 12259-(4-Hydroxybutyl)guanine

cytomegalovirus, 3179-(2-Hydroxyethoxymethyl)guanine

cytomegalovirus, 317Hypoprothrombinemia

cefotetan-associated, 1328development

cefotaxime, 281ceftizoxime, 281moxalactam, 281peritonitis, 281pneumonia, 281

Hypothyroidismcefazolin, 635gentamicin, 635

ICI 193428comparative activity

cefotaxime, cefpirome, ceftazidime,and piperacillin, 1997

Enterobacteriaceae, 1997P. aeruginosa, 1997P. maltophilia, 1997

ICI 194008comparative activity

cefotaxime, cefpirome, ceftazidime,and piperacillin, 1997

Enterobacteriaceae, 1997P. aeruginosa, 1997P. maltophilia, 1997

ImipenemB. fragilis, 1791, 2002B. fragilis group, 1596, 2002C. pylori, 949Capnocytophaga spp., 331, 1283Citrobacter spp., 829combinations

amikacin, 632cilastatin, 1491ciprofloxacin, 632P. aeruginosa, 632respiratory tract and other infections,

1491comparative activity

amoxycillin, doxycycline, and genta-micin, 523

DuP 105 and DuP 721, 1791E. coli cell envelope, 1106

VOL . 31, 1987

ANTIMICROB. AGENTS CHEMOTHER.

endometritis, 1434H. influenzae, 1871M. avium, 117Mobiluncus spp., 249Morganella-Proteus-Providencia group,

1644N. asteroides, 2013P. aeruginosa resistance, 703, 1892pelvic inflammatory disease, 1434pharmacokinetics, 1420staphylococci, 1791streptococci, 1791uptake by human polymorphonuclear

leukocytes, 1553urinary tract infections, 1644Y. enterocolitica, 523

Imipenem-cilastatincomparative activity

ampicillin, 578ciprofloxacin, 1491

E. coli, 578intrauterine infections, 578pharmacokinetics, 1718respiratory tract and other infections,

1491S. faecalis, 578

Immunoglobulin, humanencephalitis, 1006herpes simplex virus, 1006

Immunoglobulin, intravenousrespiratory syncytial virus, 1882

Influenza Aamantadine, 1470N10169, 1535ribavirin, 1285

Influenza BIN10169, 1535ribavirin, 1285

Influenza virusesRU 41821, 920

Infusaid Drug Pump Model 100vancomycin, 610

Interferonacetylsalicylic acid, effect of, 114alpha 1

bovine herpesvirus type 1, 752P. haemolytica, 752

alpha Aazidothymidine, 168combinations, 168human immunodeficiency virus, 168

gammacombinations, 346roxithromycin, 346T. gondii, 346

herpes, genital, 1137Intestinal flora

aztreonam, 202cefoperazone, 202cefoxitin, 202piperacillin, 202

Intra-abdominal infectionsaminoglycosides, 485minireview, 485

Intrauterine infectionsE. coli, 578imipenem-cilastatin, 578S. faecalis, 578

Iodinemembrane transfer assay, 1989periodontopathogens, 1989

Isoelectric focusingP-lactamases, TEM type, 300

Isoniazidhigh-performance liquid chromatogra-

phy, 1904penetration into polymorphonuclear leu-

kocytes, 1904pharmacokinetics, 1904

Itraconazoleadrenal response to corticotropin, 647Candida spp., 6comparative activity

fluconazole and ketoconazole, 6endophthalmitis, 6

Joint infectionsciprofloxacin, 151

JosamycinCorynebacterium group D2, 821M. pneumoniae, 1843Mobiluncus spp., 249

KanamycinAeromonas spp., 1281Campylobacter-like organism resistance

from Enterobacteriaceae, 1021N. gonorrhoeae, 1288

KetoconazoleC. albicans, 46, 643

uptake in, 244C. immitis, 1874Candida infection in neutropenic

patients, 11Candida spp., 6, 1343comparative activity

amphotericin B, 11amphotericin B and flucytosine, 1343fluconazole and itraconazole, 6

endophthalmitis, 6M. furfur, 951pharmacokinetics, 1234, 1874

Kinetic dilution modelscorrection for bacterial loss, 1859

KitasamycinM. pneumoniae, 1843

Klebsiella aerogenesampicillin, 126cephalosporins, 126nitrofurantoin, 126susceptibility patterns, 126trimethoprim-sulfamethoxazole, 126

Klebsiella pneumoniaeamikacin resistance transposon, 1955ampicillin resistance, 1955BMY-28100, 653cefoxime, 758ceftazidime, 1809cefuroxime, 758ciprofloxacin, 1809kanamycin resistance, 1955plasmids, 1955pneumonia, 1809surface hydrophobicity, 758tigemonam, 226tobramycin resistance, 1955

Klebsiella spp.BMY-28100, 480R-3746, 1085

Lactobacillus antimicrobial substanceBacteroides spp., 1231Bifidobacterium spp., 1231Clostridium spp., 1231E. coli, 1231Enterobacteriaceae, 1231

Lactobacillus spp., 1231Pseudomonas spp., 1231Staphylococcus spp., 1231Streptococcus spp., 1231

Lactobacillus spp.antimicrobial substance, 1231

Legionella pneumophilaamifloxacin, 1529amifloxacin-rifampin, 1529cefoxitin, 1529cefoxitin-rifampin, 1529cinoxacin, 1529cinoxacin-rifampin, 1529ciprofloxacin, 1529ciprofloxacin-rifampin, 1529clindamycin, 1529clindamycin-rifampin, 1529doxycycline, 1529-doxycycline-rifampin, 1529enoxacin, 1529enoxacin-rifampin, 1529erythromycin, 1529erythromycin-rifampin, 1529gentamicin, 1529gentamicin-rifampin, 1529rifampin, 1529rosoxacin, 1529rosoxacin-rifampin, 1529thienamycin, 1529thienamycin-rifampin, 1529trimethoprim-sulfamethoxazole, 1529trimethoprim-sulfamethoxazole-rifampin,

1529Legionella spp.

A-56268, 640TE-031, 640

Leishmania donovaniallopurinol, 1119-deazainosine, 111Glucantime, 111pentavalent antimony, 111Pentostam, 111purine analogs, 111

Leishmania majordapsone, 1575medium additivesp-aminobenzoate, 1575folate, 1575thymidine, 1575

methotrexate, 1575sulfamoxole, 1575sulfaquinoxaline, 1575sulfonamides, 1575

Leishmania mexicanacordycepin triphosphate, 1734formycin A triphosphate, 1734RNA polymerase, 1734

Leishmania spp.guanine analogs, 447guanosine analogs, 447sinefungin, 1542

Leprosyclofazimine, 780dapsone, 780ethionamide, 780rifampin, 780

Leptospirosiscefotaxime, 1656letter to the editor, 1656

Letters to the editoracquired immunodeficiency syndrome,a 9c

acyclovir, 1865

xviii SUBJECT INDEX

SUBJECT INDEX xix

C. albicans, 1864cefotaxime, 1656chloroquine, 672clonorchiasis, 1291clotrimazole, 1864furazolidone, 672G. intestinalis, 672herpes simplex virus, 1865leptospirosis, 1656M. avium-M. intracellulare, 969M. leprae, 134, 671metronidazole, 672nalidixic acid, 837ofloxacin, 671paromomycin, 672pefloxacin, 671plasmids, resistance, 1155praziquantel, 1291pyrimethamine, 672rifabutin, 134rifampin, 134rifapentine, 134S. dysenteriae, 837tinidazole, 672trimethoprim-sulfamethoxazole, 837

LeucomycinM. pneumoniae, 1843

Leukemia patients, febrileteicoplanin-amikacin-ceftazidime, 1126

Lincomycinhigh-performance liquid chromatogra-

phy, 1904penetration into polymorphonuclear leu-

kocytes, 1904pharmacokinetics, 1904T. hyodysenteriae, 1935

LincosamideStaphylococcus resistance, 1887

LipopolysaccharidesE. coli, 230S. typhimurium, 230

Liposomesantimicrobial carriers, 675minireview, 675nystatin formulation, 1897, 1901

Listeria monocytogenesA-56268, 328, 343azithromycin, 1948BMY-28100, 238, 480CP-62,993, 1948TE-031, 328

LY146032B. megaterium, 1093C. difficile, 461, 1135calcium supplementation, 461Clostridium spp., 625combinations

ceftriaxone, gentamicin, and imipe-nem, 1199

enterococci, 1749gentamicin, 1749S. faecalis, 1199streptomycin, 1749

comparative activityampicillin, ciprofloxacin, and

vancomycin, 1014ampicilli'n, clindamycin, erythromycin,

imipenem, metronidazole, pipera-cillin, rifampin, and vancomycin,455

ampicillin, oxacillin, and vancomycin,340

cefamandole, cefazolin; cefuroxime,

ciprofloxacin, methicillin, andvancomycin, 1210

ceftriaxone, ciprofloxacin, gentamicin,imipenem, LY146032-ceftriaxone,LY146032-gentamicin, LY146032-imipenem, and vancomycin, 1199

teicoplanin and vancomycin, 625enterococci, 625, 1014, 1749gram-positive bacteria, 455peptidoglycan biosynthesis, 1093S. aureus, 1093S. faecalis, 1199staphylococci,'340, 625, 1210streptococci, 340susceptibility testing, 625

Lyme diseaseceftriaxone, 164erythromycin, 164penicillin G, 164tetrac'ycline, 164

Macrolides-lincosamides-streptogramin BBacteroides species resistance, 665C. difficile resistancehomology with S. aureus Tn551, 1039

resistanceS. aureus, 735staphylococci, 883streptococci, 735, 883

Malassezia furfuramphotericin B, 951flucytosine, 951ketoconazole, 951miconazole, 951terbinafine, 1365

Membrane transfer assayoral microorganisms, 1989

Meningitisamoxicillin-clavulanic acid, 2018ampicillin, 467ampicillin-sulbactam, 1703chloramphenicol, 467E. coli, 1296H. influenzae, 467, 2018H. influenzae type b, 1296moxalactam, 467platelet function, 467sulbactam-ampicillin, 1703ticarcillin-clavulanic acid, 1296

Mercuric chlorideAeromonas spp., 1281

Methicillincomparative activity

cefamandole, ceftriaxone, cephalothin,and cephradine, 42

S. faecium, 1618staphylococci, 42

Methionineinterference in valine uptakeA. chrysogenum, 357

MethotrexateL. major, 1575

(2,3)-MethylenepenamsE. coli outer membrane penetration,

1994penicillin-binding proteins, 1069

N-Methylisatin-,-4',4'-diethylthiosemicar-bazone

Moloney leukemia virus, 17983-Methylquercetine

respiratory syncytial virus, 1225N-Methyltetrazolethiol

pharmacokinetics, 1169

3'-C-Methyluridinerespiratory syncytial virus, 1225

MetronidazoleB. fragilis, 617C. difficile, 183C. perfringens, 213, 312combinationsbismuth subcitrate, 1429C. perfringens, 312C. pylori, 1429gas gangrene, 312penicillin, 312

comparative activityclindamycin, clindamycin-penicillin,

metronidazole-penicillin, penicil-lin, and rifampin, 312

clindamycin, penicillin, and rifampin,213

tinidazole, 183G. intestinalis, 672gas gangrene, 213, 312high-performance liquid chromatogra-

phy, 1662letter to the editor, 672Mobiluncus spp., 249P. anaerobius, 183pharmacokinetics

alcoholic liver disease, 1662T. hyodysenteriae, 1935uptake by human polymorphonuclear

leukocytes, 1553MezlocillinCapnocytophaga spp., 1283endometritis, 1434high-performance liquid chromatogra-

phy, 895pelvic inflammatory disease, 1434pharmacokinetics, 895, 2015

Miconazole.C. albicans, 46M. furfur, 951

Microsporum caniseconazole, 1558griseofulvin, 1558terbinafine, 1558tolnaftate, 1558

Minireviewsacyclovir, 361aminoglycosides

intra-abdominal infections, 485antifungal agents, 1867antiviral agents, 1293azidothymidine, 8391-lactams

eucaryotic cells, 1657cephalosporins

analytical methods, 1157genetic engineering, 1293herpes simplex virus, 361human immunodeficiency virus, 839liposomes as antimicrobial carriers, 675neutropenic cancer patients, therapy for,

971susceptibility testing, 1867trimethoprim resistance, 1451urinary tract infections, 1

Minocyclinecombinations

bismuth subcitrate, 1429C. pylori, 1429

N. asteroides, 2013Mobiluncus spp.

alizarin red, 249

VOL . 31, 1987

ANTIMICROB. AGENTS CHEMOTHER.

ampicillin, 249cefoxitin, 249cephalothin, 249chloramphenicol, 249clindamycin, 249colistin, 249cycloserine, 249erythromycin, 249Evans blue, 249imipenem, 249josamycin, 249metronidazole, 249moxalactam, 249nalidixic acid, 249neomycin, 249Nile blue A, 249rifampin, 249sodium fluoride, 249tetracycline, 249tinidazole, 249tobramycin, 249vancomycin, 249virginiamycin, 249

Molecular hybridizationP-lactamases, TEM type, 300

Moloney leukemia virusN-methylisatin-P-4',4'-diethylthiosemi-

carbazone, 1798Monensin

T. hyodysenteriae, 1935Monoglycerides

viruses, enveloped, 27Morganella morganii

P-lactams, 379porins, 379R-3746, 1085

Morganella-Proteus-Providencia groupamikacin, 1644azlocillin, 1644aztreonam, 1644carbenicillin, 1644cefazolin, 1644cefoxitin, 1644ceftazidime, 1644ceftriaxone, 1644cefuroxime, 1644imipenem, 1644piperacillin, 1644temocillin, 1644tobramycin, 1644urinary tract infections, 1644

MoxalactamB. fragilis group, 1596Capnocytophaga spp., 331, 1283combinations

C. coli, 940C. jejuni, 940clavulanic acid, 940

comparative activityampicillin and chloramphenicol, 467

E. coli cell envelope, 1106H. influenzae, 467hypoprothrombinemia, development of,

281meningitis, 467Mobiluncus spp., 249peritonitis, 281pharmacokinetics, 1169platelet function, 467pneumonia, 281

Murine hepatitis virus2,3,5,6,7,8-hexahydro-2-phenyl-8,8-dime-

thoxy-imidazo[1,2a]pyridine, 1130

PR-879-317A, 1130Mycobacterium avium

acquired immune deficiency syndrome,1579

amikacin, 117, 1579amoxicillin-clavulanic acid, 1579ampicillin, 1579ansamycin, 117azlocillin, 1579aztreonam, 1579carbenicillin, 1579cefmenoxime, 1579cefotaxime, 1579chloramphenicol, 1579ciprofloxacin, 117clindamycin, 1579clofazimine, 117erythromycin, 1579gentamicin, 117imipenem, 117inhibition versus killing, therapeutic im-

plications of, 117nitrofurantoin, 1579oxacillin, 1579penicillin, 117rifabutine, 117tetracycline, 1579vancomycin, 1579

Mycobacterium avium complexacquired immunodeficiency syndrome,

1697susceptibility testing, 1697

Mycobacterium avium-M. intracellulareacquired immunodeficiency syndrome,

969letter to the editor, 969

Mycobacterium lepraeclofazimine, 780dapsone, 780ethionamide, 780letter to the editor, 134, 671ofloxacin, 671pefloxacin, 671rifabutin, 134rifampin, 134, 780rifapentine, 134

Mycobacterium spp.3'-azido-3'-deoxythymidine, 274BW A509U, 274clofazimine, 789ticarcillin-clavulanic acid, 132

Mycoplasma pneumoniaeerythromycin, 1843josamycin, 1843kitasamycin, 1843leucomycin, 1843rokitamycin, 1843

N10169 (pyrazolo[3,4-dlpyrimidine nucleo-side analog)

adenovirus, 1535coronavirus, 1535cytomegalovirus, 1535herpes simplex virus, 1535influenza A virus, 1535influenza B virus, 1535paramyxovirus, 1535picornavirus, 1535reovirus, 1535vaccinia virus, 1535vesicular stomatitis virus, 1535visna virus, 1535

Nafcillin

comparative activityA-56619 and A-56620, 259cefamandole, cefazolin, and vancomy-

cin, 1919endocarditis, 1919osteomyelitis, 259S. aureus, 259

penicillin-binding protein 2a, 1982staphylococci, 1919

NaftifineC. albicans, 46

Nalidixic acidAeromonas spp., 1281C. burnetii, 1079C. pylori, 949Capnocytophaga spp., 1283comparative activity

trimethoprim-sulfamethoxazole, 837letter to the editor, 837Mobiluncus spp., 249S. dysenteriae, 837selective gut contamination in neutrope-

nia, 551Neisseria gonorrhoeae

A40926, 1961A-56268, 328, 343, 470, 640AM-833, 1153P-lactams, 178BMY-28100, 238, 480cefetamet, 1153cefodizime, 1822cefotaxime, 1288ceftetrame, 1153changing susceptibility patterns, 1288enoxacin, 535fleroxacin, 1153kanamycin, 1288norfloxacin, 434penicillin, 1288peptidoglycan alterations, 178Ro 15-8074, 470, 1153Ro 19-5247, 470, 1153Ro 23-6240, 1153spectinomycin, 1288streptonigrin, 1507

resistance, 1507susceptibility testing, 1744T-2588, 1111, 1153TE-031, 328, 640tetracycline, 1288thiamphenicol, 434tigemonam, 219

Neisseria meningitidiscarrier rate, 962ciprofloxacin, 962penicillin G resistant, 1478R plasmid, 1642sulfonamide resistance, 1642susceptibility testing, 1478

Neisseria spp.CGP 31608, 267

NeomycinMobiluncus spp., 249

Neplanocin Aanalogs with reduced cytotoxicity

vaccinia virus, 1849respiratory syncytial virus, 1225

Neplanocin Crespiratory syncytial virus, 1225

Netilmicinauditory toxicity, 1383Citrobacter spp., 829P. aeruginosa, 1514

xx SUBJECT INDEX

SUBJECT INDEX xxi

pharmacokinetics, 605, 1054susceptibility testing

cation supplements, 1514P. aeruginosa, 1514

Neutropenic patientsCandida spp.

amphotericin B, 11ketoconazole, 11

ceftazidime, 191ceftazidime-cephalothin, 191selective gut decontamination

nalidixic acid, 551trimethoprim-sulfamethoxazole, 551

Nifuroxazidecombinations

bismuth subcitrate, 1429C. pylori, 1429

Nile blue AMobiluncus spp., 249

NitrocefinP. cepacia outer membrane permeabil-

ity, 121Nitrofurantoincombinations

bismuth subcitrate, 1429C. pylori, 1429

E. coli, 126K. aerogenes, 126M. avium, 1579P. mirabilis, 126

Nocardia asteroidesamifloxacin, 2013amikacin, 2013amoxicillin-clavulanic acid, 2013apalcillin, 2013aztreonam, 2013cefmenoxime, 2013cefpirome, 2013ceftazidime, 2013ceftizoxime, 2013ceftriaxone, 2013cefuroxime, 2013cinoxacin, 2013ciprofloxacin, 2013coumermycin, 2013enoxacin, 2013imipenem, 2013minocycline, 2013ofloxacin, 2013ticarcillin-clavulanic acid, 2013WIN 35439, 2013

NorfloxacinC. pylori, 949Capnocytophaga spp., 331, 1283colonic microflora, 1846combinationsbismuth subcitrate, 1429C. pylori, 1429

comparative activityenoxacin, 1846thiamphenicol, 434

Corynebacterium group D2, 821E. coli

resistance, 1640R-plasmid transfer, 531

gonorrhea, 434N. gonorrhoeae, 434pharmacokinetics, 352resistant P. aeruginosa mutants, 582[3H]thymidine incorporation of lympho-

cytes, 768Novobiocin

C. burnetii, 1079

E. coli topoisomerase I, 1925NY-198A. calcoaceticus, 854comparative activity

norfloxacin, ofloxacin, and pipemidicacid, 854

P. maltophilia, 854Nystatin

C. albicans, 1897, 1901liposomal formulation, 1897toxicity, 1897, 1901

OfloxacinCandida spp., 124Capnocytophaga spp., 1283combinationsbismuth subcitrate, 1429C. pylori, 1429theophylline, 375

comparative activityampicillin, chloramphenicol, and eno-

xacin, 417ciprofloxacin and norfloxacin, 325

Corynebacterium group D2, 821DNA gyrase, 325, 1861E. coli, 1861

R-plasmid transfer, 531Enterobacteriaceae, 124H. influenzae, 417letter to the editor, 671M. leprae, 671N. asteroides, 2013pharmacokinetics, 156, 1338pneumonia, 417[3H]thymidine incorporation of lympho-

cytes, 768Olaquindox

T. hyodysenteriae, 1935Open-heart surgery

ceftazidime, 813Ophthalmic ointment

conjunctivitis, neonatal, 954erythromycin, 954

Oral microorganismschlorhexidine, 1989iodine, 1989membrane transfer assay, 1989periodontal disease, 1989sodium fluoride, 1989stannous fluoride, 1989

N-D-Ornithyl amphotericin B methyl esterCandida spp., 1756comparative activity

amphotericin B and amphotericin Bmethyl ester, 1756

yeasts, 1756Osteomyelitis

A-56619, 259A-56620, 259ceftazidime, 1605ciprofloxacin, 151gram-negative aerobic bacilli, 1605nafcillin, 259P. aeruginosa, 1605S. aureus, 259teicoplanin, 207

Ototoxicityteichomycin A2, 612

Oxacillincombinations

gentamicin, pefloxacin, and rifampin,1457

Staphylococcus spp., 1457

M. avium, 1579S. aureus

agar dilution plate count method, 16Staphylococcus spp., 1457

OxazolidinonesB. fragilis, 1791comparative activity

ciprofloxacin, imipenem, andvancomycin, 1791

staphylococci, 1791streptococci, 1791

Oxolinic acidC. burnetii, 1079combinationsbismuth subcitrate, 1429C. pylori, 1429

OxytetracyclineT. hyodysenteriae, 1935

Paldimycincomparative activityvancomycin, 650

staphylococci, 104streptococci, 104

ParamyxovirusN10169, 1535

ParomomycinG. intestinalis, 672letter to the editor, 672

Pasteurella haemolyticainterferon, alpha 1, 752

Pasteurella piscicidaR plasmid, 1278

Pediatric infectionsBMY-28100, 630herpes simplex virus

acyclovir, 1722respiratory syncytial virus, 1882streptococcal pharyngitis, 903sultamicillin, 663varicella-zoster virus

acyclovir, 1722PefloxacinB. fragilis, 1665bioassay, 1665C. difficile, 1665Capnocytophaga spp., 1283combinations

amikacin, 1803ceftazidime, 1803gentamicin, oxacillin, rifampin, and

vancomycin, 1457P. aeruginosa, 1803peritonitis, 1803piperacillin, 1803Staphylococcus spp., 1457

E. coli topoisomerase I, 1925Enterobacteriaceae, 1665letter to the editor, 671M. leprae, 671P. aeruginosa, 1803peritonitis, 1803Staphylococcus spp., 1457streptococci, 1665[3H]thymidine incorporation of lympho-

cytes, 768Pelvic inflammatory disease

amoxicillin-clavulanic acid, 1434cefmetazole, 1434cefotetan, 1434cefoxitin, 1434clindamycin, 1434imipenem, 1434

VOL . 31, 1987

ANTIMICROB. AGENTS CHEMOTHER.

mezlocillin, 1434Penicillin

C. albicans, 691C. perfringens, 213, 312combinations

C. perfringens, 312clindamycin, 312gas gangrene, 312metronidazole, 312tetracycline, 691

comparative activitycefadroxil, 903clindamycin, clindamycin-penicillin,

metronidazole, metronidazole-penicillin, and rifampin, 312

clindamycin, metronidazole, and ri-fampin, 213

gas gangrene, 213, 312M. avium, 117(2,3)-methylenepenams

E. coli, 1994N. gonorrhoeae, 1288S. faecium tolerance, 1150streptococcal pharyngitis, 903

Penicillin GB. burgdorferi, 164C. burnetii, 1079chemiluminescence response by

leukocytes, 763combinations

C. coli, 940C. jejuni, 940clavulanic acid, 940

comparative activityceftriaxone, erythromycin, and tetra-

cycline, 164derivative

14C-labeled N-(3-dimethylaminoprop-yl)benzylpenicillinamide, 410

intracellular accumulation, 410Lyme disease, 164N. meningitidis, resistant, 1478

Penicillin Vendocarditis, 1474S. sanguis, 1474

Penicillin-binding proteins(2,3)-methylenepenams, 1069S. aureus, 1307, 1423

effect of NaCI and nafcillin, 1982methicillin resistance, 1727

S. faecium, 1618staphylococci, 1919

Penicillium chrysogenumacyl coenzyme A:6-aminopenicillanic

acid acyltransferase, 1675Pentamidine aerosol

P. carinii, 37, 978pneumonia, 978

Peptidoglycan biosynthesisLY146032, 1093

Peptostreptococcus anaerobiusmetronidazole, 183tinidazole, 183

Peptostreptococcus spp.ciprofloxacin-cefotaxime, 1379ciprofloxacin-cefoxitin, 1379ciprofloxacin-clindamycin, 1379ciprofloxacin-metronidazole, 1379ciprofloxacin-mezlocillin, 1379

Periodontopathogenschlorhexidine, 1989iodine, 1989membrane transfer assay, 1989

sodium fluoride, 1989stannous fluoride, 1989

Peritonitiscatheter-associated biofllm, 889cefotaxime, 281ceftizoxime, 281ciprofloxacin, 1803ciprofloxacin-amikacin, 1803ciprofloxacin-ceftazidime, 1803ciprofloxacin-piperacillin, 1803hypoprothrombinemia, development of,

281moxalactam, 281P. aeruginosa, 1803pefloxacin, 1803pefloxacin-amikacin, 1803pefloxacin-ceftazidime, 1803pefloxacin-piperacillin, 1803S. epidermidis, 889vancomycin, 889

Phagocytosisclindamycin uptake, 660rifampin uptake, 660

Pharmacokineticsacyclovir, 1722AM-833, 1909amikacin, 570, 1061aminoglycosides, 570, 1855amphotericin B, 1234

methyl ester, 1234an:picillin, 1904

meningitis, 1703azithromycin, 1948aztreonam, 81BAY n 7133, 1234BMY-28142, 799carumonam, 1692cefazolin, 635, 1904

hemorrhagic shock, 389cefepime, 799cefmenoxime, 518cefodizime, 1822cefonicid, 292cefoperazone, 264, 925cefoperazone-tobramycin, 264cefotaxime, 323, 815, 1177cefotiam, 518cefpimizole, 1706, 1904cefpiramide, 1585ceftazidime, 813, 1904ceftizoxime, 323, 1904ceftriaxone, 385, 518chloramphenicol, 1904ciprofloxacin, 709, 805, 860, 899, 915,

956, 1075, 1177, 1782, 1787clindamycin, 1904CP-62,993, 1948(+)-cyclaradine-5'-esters, 998desacetylcefotaxime, 815desciclovir, 1317enoxacin, 748, 1054food intake, 638

fleroxacin, 1010, 1909flucytosine, 1234ganciclovir, 1251gentamicin, 635, 850, 982, 1461, 1929

fetal exposure in guinea pigs, 88hemorrhagic shock, 389hydrocortisone succinate, influence of,

1816habekacin, 575imipenem, 1420imipenem-cilastatin, 1718

isoniazid, 1904ketoconazole, 1234, 1874lincomycin, 1904N-methyltetrazolethiol, 1169metronidazole

alcoholic liver disease, 1662mezlocillin, 895, 2015moxalactam, 1169netilmicin, 605, 1054norfloxacin, 352ofloxacin, 156, 1338piperacillin, 1904, 2015rifampin, 1904rimantadine, 826, 1140Ro 23-6240, 161, 1010, 1909roxithromycin, 1051, 1312Sch 34343, 84sulbactam

meningitis, 1703teicoplanin, 207, 1222, 1255, 1600theophylline-ofloxacin, 375ticarcillin-clavulanic acid, 935, 1296,

1826Timentin, 935, 1826tobramycin, 264, 605, 850

E. coli pyelonephritis, influence of,1359

tobramycin-cefoperazone, 264trimethoprim, 1904vancomycin, 173, 393, 610, 1075, 1461,

1689plus activated charcoal, 720preterm infants, 52

vancomycin-gentamicin, 1461Pharyngitis

cefadroxil, 903pediatric infections, 903penicillin, 903streptococcal, 903

Phenazineprooxidative activities of derivatives,

789Phenazine-1-carboxylic acid

revised structure, 1967Phenothiazines

C. albicans, 834C. neoformans, 834

Phosphonoformatevisna virus, 1369

9-(2-Phosphonylmethoxyethyl)adenineEpstein-Barr virus, 1431

PicomavirusN10169, 1535

Pipemidic acidE. coli R-plasmid transfer, 531[3H]thymidine incorporation of lympho-

cytes, 768PiperacillinCapnocytophaga spp., 331, 1283Citrobacter spp., 829colonization resistance, 723combinations

ciprofloxacin, 1803P. aeruginosa, 1803pefloxacin, 1803peritonitis, 1803

comparative activityaztreonam, cefoperazone, and cefoxi-

tin, 202high-performance liquid chromatogra-

phy, 1904intestinal flora, 202Morganella-Proteus-Providencia group,

xxii SUBJECT INDEX

SUBJECT INDEX xxiii

1644penetration into polymorphonuclear leu-

kocytes, 1904pharmacokinetics, 1904, 2015urinary tract infections, 1644

Piritrexim isethionateP. carinii, 1323

Plasmidsletter to the editor, 1155OHIO-1, 2007resistance, 1155, 2007A. hydrophila, 1278, 1281A. sobria, 12812"-O-adenylyltransferase, 667B. fragilis, 1739C. coli, 713, 1669C. jejuni, 713, 1301, 1669E. coli, 531, 784, 943, 1266, 1274,

1301, 1440, 1739E. faecalis, 1394E. tarda, 1278enterobacteria, 60H. influenzae, 286H. parainfluenzae, 966K. pneumoniae, 1955N. meningitidis, 1642P. piscicida, 1278S. aureus, 735staphylococci, 1027, 1683streptococci, 735sulfonamide, 306tellurite, 823V. anguillarum, 1446

Plasmodium falciparumchloroquineinoculum effect, 32

Platelet functionampicillin, 467chloramphenicol, 467H. influenzae, 467meningitis, 467moxalactam, 467

PMEAEpstein-Barr virus, 1431

Pneumocystis cariniiBW301U, 1323dihydrofolate reductase, 1323pentamidine aerosol, 37, 978piritrexim isethionate, 1323pneumonia, 978

histology, 197quantitation, 197

trimetrexate, 1323Pneumonia

amphotericin B, 1775amphotericin B-rifampin, 1775ampicillin, 417, 876cefamandole, 876cefotaxime, 281ceftazidime, 398, 1809ceftazidime-tobramycin, 398ceftizoxime, 281chloramphenicol, 417ciprofloxacin, 1809enoxacin, 417gentamicin, 850H. influenzae, 417hypoprothrombinemia, development of,

281K. pneumoniae, 1809moxalactam, 281ofloxacin, 417P. aeruginosa, 398

P. carinii, 978histology, 197quantitation, 197

pentamidine aerosol, 978Rhizopus spp., 1775tobramycin, 398, 850tobramycin-ceftazidime, 398

Poly(ICLC)combinations

ribavirin, 986Rift Valley fever virus, 986

Rift Valley fever virus, 986, 1194Polymorphonuclear leukocytes

antibiotic penetration, 1904antibiotic uptake

cefotaxime, 1553imipenem, 1553metronidazole, 1553roxithromycin, 1553RU 965, 1553trimethoprim, 1553

formylmethionyl-leucyl-phenylalanine-induced chemiluminescence

ampicillin, 763chloramphenicol, 763penicillin G, 763

Polymyxin BC. burnetii, 1079combinations

bismuth subcitrate, 1429C. pylori, 1429

E. coli, 230S. typhimurium, 230

Polymyxin B nonapeptideA. salmonicida, 1414

PorinsM. morganii resistance, 379Proteus spp. resistance, 379Providencia spp. resistance, 379

PR-879-317Amurine hepatitis virus, 1130

Praziquantelclonorchiasis, 135, 1291letter to the editor, 1291

Prooxidative activityclofazidime, 789

Propionibacterium acnesBMY-28100, 238

Proteus mirabilisampicillin, 126cephalosporins, 126nitrofurantoin, 126susceptibility patterns, 126trimethoprim-sulfamethoxazole, 126

Proteus spp.1-lactams, 379porins, 379pyelonephritis, 226R-3746, 1085tigemonam, 226

Proteus vulgariscefmenoxime, 865

Providencia rettgeriR-3746, 1085

Providencia spp.3-lactams, 379

ciprofloxacin, 1651porins, 379

Pseudomonas aeruginosaA-56620, 102amikacin-ciprofloxacin, 9593'-azido-3'-deoxythymidine, 274aztreonam-gentamicin, 1403

aztreonam-tobramycin, 1403P-lactamases, 253, 1750P-lactams, 1750BO-1236, 1100BW A509U, 274cefsulodin-[3H]tobramycin, 108ceftazidime, 398, 1605

resistance, 253ceftazidime-clavulanic acid, 1750ceftazidime-dicloxacillin, 1750ceftazidime-sulbactam, 1750ceftazidime-tobramycin, 398cephalosporins, 1438CGP 31608, 267, 558ciprofloxacin, 102, 151, 657, 959, 1803ciprofloxacin-amikacin, 959, 1803ciprofloxacin-ceftazidime, 1803ciprofloxacin-imipenem, 959ciprofloxacin-piperacillin, 1803cystic fibrosis, 1403, 1438difloxacin, 102endocarditis, 70, 253, 1750enoxacin, 102fluoroquinolone resistance, 1803gentamicin, 679gentamicin-piperacillin, 679ICI 193428, 1997ICI 194008, 1997imipenem resistance, 703, 1892imipenem-amikacin, 632imipenem-ciprofloxacin, 632, 959impermeability variants, 70netilmicin, 1514norfloxacin-resistant mutants, 582osteomyelitis, 1605pefloxacin, 1803pefloxacin-amikacin, 1803pefloxacin-ceftazidime, 1803pefloxacin-piperacillin, 1803peritonitis, 1803pneumonia, 398porn channel penetration

P-lactams, 1216S-25930, 102S-25932, 102serum bactericidal rate assay, 679susceptibility testing

cation supplements, 1514netilmicin, 1514

ticarcillin-[3H]tobramycin, 108tobramycin, 398, 594tobramycin-ceftazidime, 398

Pseudomonas cepaciaaztreonam-gentamicin, 1403aztreonam-tobramycin, 1403cystic fibrosis, 1403nitrocefin

outer membrane permeability, 121Pseudomonasfluorescens 2-79 (NRRL B-

15132)phenazine antibiotic, revised structure

for, 1967Pseudomonas maltophilia

ICI 193428, 1997ICI 194008, 1997NY-198, 854

Pseudomonas putrefaciensciprofloxacin, 1651

Pseudomonas spp.ceftazidime, 698CGP 31608, 1188Lactobacillus antimicrobial substance,

1231

VOL. 31, 1987

ANTIMICROB. AGENTS CHEMOTHER.

Pulmonary infectionsvancomycin, 1689

Purine 2',3'-dideoxynucleosidescombinationshuman immunodeficiency virus, 1613ribavirin, 1613

Purine analogsL. donovani, 111

PyelonephritisE. coli, 226Proteus sp., 226tigemonam, 226

Pyrazofurinrespiratory syncytial virus, 1225

Pyrazolo[3,4-d]pyrimidine nucleoside ana-logs

adenovirus, 1535coronavirus, 1535cytomegalovirus, 1535herpes simplex virus, 1535influenza A virus, 1535influenza B virus, 1535N10169, 1535paramyxovirus, 1535picornavirus, 1535reovirus, 15354(5H)-oxo-1-1-D-ribofuranosylpyrazolo-

[3,4-d]pyrimidine-3-thiocarboxamide,1535

vaccinia virus, 1535vesicular stomatitis virus, 1535visna virus, 1535

PyrimethamineG. intestinalis, 672letter to the editor, 672

Pyrimidine 2',3'-dideoxynucleosidescombinationshuman immunodeficiency virus, 1613ribavirin, 1613

Pyrimidine synthesisciprofloxacin, 774

Pyrrolo[2,3-d]pyrimidine nucleosidescytomegalovirus, 544

QuinolonesComputer Automated Structure Evalua-

tion, 1831E. coli topoisomerase I, 1925

R-3746B. fragilis, 1085,-lactamases, 1085C. freundii, 1085comparative activity

amoxicillin, cefaclor, cefixime, andT-2525, 1085

E. cloacae, 1085E. coli, 1085enterococci, 1085H. influenzae, 1085Klebsiella spp., 1085M. morganii, 1085P. rettgeri, 1085Proteus spp., 1085S. marcescens, 1085staphylococci, 1085streptococci, 1085

ReovirusN10169, 1535

Resistance patternsE. coli, 911

Respiratory syncytial virus(RS)-3-adenin-9-yl-2-hydroxypropanoic

acid isobutyl ester, 1225carbodine, 12255-chlorotubercidin, 12255-cyano-l-,-D-ribofuranosylimidazole-4-

carboxamide, 12255-cyanoimidazole4carboxamide, 12253-deazaguanine, 12253-deazauridine, 12255'-deoxy-5-fluorouridine, 12252,5-diamidinoindole, 12252'-nor-cGMP, 1225(S)-HPMPA, 1225(S)-9-(3-hydroxy-2-phosphonylmethoxy-

propyl)adenine, 12259-(2-hydroxy-1,3,2-dioxaphosphorinan-5-

yl)oxymethyl guanine P-oxide, 1225immunoglobulin, intravenous, 18823-methylquercetine, 12253'-C-methyluridine, 1225neplanocin A, 1225neplanocin C, 1225pediatric infections, 1882pyrazofurin, 1225ribavirin, 1225ribavirin aerosolexposure of primary care personnel,

1143thiosemicarbazone R, 1225tubercidin, 1225xylotubercidin, 1225

Respiratory tract infectionsciprofloxacin, 1491imipenem-cilastatin, 1491

Reverse transcriptaseavian myeloblastosis virus

inhibition by sea algal sulfated poly-saccharides, 1524

human immunodeficiency virus3'-azido-3'-deoxythymidine triphos-

phate, 1972inhibition by sea algal sulfated poly-

saccharides, 1524Rhinovirus

zinc acetate lozenges, 1263zinc gluconate lozenges, 1183zinc salts, 622

Rhizopus spp.amphotericin B, 1775amphotericin B-rifampin, 1775pneumonia, 1775

Ribavirinaerosol

exposure of primary care personnel,1143

combinationshuman immunodeficiency virus, 1613poly(ICLC), 986purine 2',3'-dideoxynucleosides, 1613pyrimidine 2',3'-dideoxynucleosides,

1613Rift Valley fever virus, 986

influenza A, 1285influenza B, 1285respiratory syncytial virus, 1225visna virus, 1369

4(5H)-oxo-1--3-D-Ribofuranosylpyrazolo-[3,4-dlpyrimidine-3-thiocarboxamide

adenovirus, 1535coronavirus, 1535cytomegalovirus, 1535herpes simplex virus, 1535influenza A virus, 1535influenza B virus, 1535

paramyxovirus, 1535picornavirus, 1535reovirus, 1535vaccinia virus, 1535vesicular stomatitis virus, 1535visna virus, 1535

Rifabutincomparative activity

rifapentine and rifampin, 134letter to the editor, 134M. leprae, 134

RifabutineM. avium, 117

RifampinAeromonas spp., 1281C. burnetii, 1079C. perfringens, 213, 312combinations

amifloxacin, cefoxitin, cinoxacin, ci-profloxacin, clindamycin, doxycy-cline, enoxacin, erythromycin,gentamicin, rosoxacin, thienamy-cin, and trimethoprim-sulfameth-oxazole, 1529

amphotericin B, 1775bismuth subcitrate, 1429C. pylori, 1429L. pneumophila, 1529oxacillin, pefloxacin, and vancomycin,

1457pneumonia, 1775Rhizopus spp., 1775staphylococci, 1002, 1457teicoplanin, 1002

comparative activityclindamycin, clindamycin-penicillin,

metronidazole, metronidazole-penicillin, and penicillin, 312

clindamycin, metronidazole, and peni-cillin, 213

gas gangrene, 213, 312granulocytopenia, 930high-performance liquid chromatogra-

phy, 1904L. pneumophila, 1529M. leprae, 780Mobiluncus spp., 249penetration into polymorphonuclear leu-

kocyte's, 1904phagocytosis-stimulated uptake, 660pharmacokinetics, 1904rapid in vitro metabolic screen, 780S. aureus, 930Staphylococcus spp., 1457

Rifapentinecomparative activity

rifabutin and rifampin, 134letter to the editor, 134M. leprae, 134

Rift Valley fever viruspoly(ICLC), 986, 1194poly(ICLC)-ribavirin, 986

Rimantadinepharmacokinetics, 826, 1140

Ristocetincomparative activity

teicoplanin, 1609RNA polymerase

L. mexicana, 1734Ro 13-5478

E. coli, 614S. aureus, 614

Ro 14-9578

xxiv SUBJECT INDEX

SUBJECT INDEX xxv

E. coli, 614S. aureus, 614

Ro 15-8074C. trachomatis, 470comparative activity

ceftriaxone, erythromycin, penicillin,spectinomycin, and tetracycline,1153

cephalexin, 473H. ducreyi, 1153N. gonorrhoeae, 470, 11$3

Ro 19-5247comparative activity

ceftriaxone, erythromycin, penicillin,spectinormycin, and tetracycline,1153

cephalexin, 473H. ducreyi, 1153N. gonorrhoeae, 470, 1153

Ro 23-6240comparative activity

ceftriaxone, erythromycin, penicillin,spectinomycin, and tetracycline,1153

H. ducreyi, 1153N. gonorrhoeae, 1153pharmacokinetics, 161, 1010, 1909

RokitamnycinM. pneumoniae, 1843

RosoxacinCapnocytophaga spp., 1283

RoxithromycinC. trachomatis, 470combinations

interferon, gamma, 346T. gondii, 346

pharmacokinetics, 1051, 1312syphilis, 187T. gondii, 346, 1147T. pallidum, 187uptake by human polymorphonuclear

leukocytes, 1553Roxoxacin

combinationsL. pneumophila, 1529rifampin, 1529

L. pneumophila, 1529RU 965

uptake by human polymorphonuclearleukocytes, 1553

RU 41821bronchoalveolar cell induction, 920influenza virus, 920

S-25930comparative activity

A-56620, ciprofloxacin, difloxacin, andenoxacin, 102

Enterobacteriaceae, 102P. aeruginosa, 102stereoisomersDNA gyrase, 1861E. coli, 1861

S-25932comparative activity

A-56620, ciprofloxacin, difloxacin, andenoxacin, 102

Enterobacteriaceae, 102P. aeruginosa, 102

Saccharomyces boulardiiC. difficile suppression, 129

Saccharomyces cerevisiaeamphotericin B, 421

N-dodecylimidazole, 512Salmonella enteritidis

azithromycin, 1948CP-62,993, 1948

Salmonella typhimuriumcore-lipid A phosphates, 230EM 49, 230lipopolysaccharides, 230polymyxin B, 230ribosomal streptomycin resistance, 1627streptomycin, 1627

Sangivamycincytomegalovirus, 544

Sch 31172herpes simplex virus, 21

Sch 34343pharmacokinetics, 84

Schistosoma mansonicyclosporin A, 1567dihydrocyclosporin A derivatives, 1567

Serratia marcescensCGP 31608, 1188R-3746, 1085

Serum bactericidal rate assaygentamicin, 679gentamicin-piperacillin, 679P. aeruginosa, 679

Shigella dysenteriaeletter to the editor, 837nalidixic acid, 837trimethoprim-sulfamethoxazole, 837

Silver-coated nylon fiberantibacterial activity, 93

Sinefungincombinations

DL-a-difluoromethylornithine, 1406T. brucei subsp. brucei, 1406

Leishmania spp., 1542T. brucei subsp. brucei, 1406

Skin infectionsciprofloxacin, 151sultamicillin, 663

Sodium fluoridemembrane transfer assay, 1989Mobiluncus spp., 249periodontopathogens, 1989

Soft tissue infectionsciprofloxacin, 151, 805sultamicillin, 663teicoplanin, 207

SpectinomycinAeromonas spp., 1281N. gonorrhoeae, 1288

Sporothrix schenckiiterbinafine, 1365

Stannous fluoridemembrane transfer assay, 1989periodontopathogens, 1989

StaphylococciA-56268, 343, 640BMY-28100, 480cefamandole, 42, 1919cefazolin, 1919ceftriaxone, 42cephalothin, 42cephradine, 42CGP 31608, 267, 558, 1188ciprofloxacin, 657, 1651, 1791coagulase negativeDNA probes, 1683R plasmid, 1683trimethoprim resistance, 1683

DuP 105, 1791

DuP 721, 1791endocarditis, 1919imipenem, 1791LY146032, 340, 625, 1210macrolides-lincosamides-streptogramin B

resistance, 883methicillin, 42nafcillin, 1919oxazolidinones, 1791paldimycin, 104penicillin-binding proteins, 1919R plasmid, 1027R-3746, 1085TE-031, 640teicoplanin, 1002teicoplanin-rifampin, 1002U-70138F, 104vancomycin, 1791, 1919

Staphylococcus aureusA-56268, 328A-56619, 259A-56620, 259azithromycin, 1948benzylpenicillin, 930P-lactamase, 1426BMY-28100, 238, 653cefamandole, 1549cefotaxime, 818cefotaxime-desacetylcefotaxime, 818ceftriaxone, 818CGP 31608, 1549ciprofloxacin, 151, 527, 539ciprofloxacin-coumermycin Al, 539coumermycin Al, 539coumermycin Al-ciprofloxacin, 539CP-62,993, 1948desacetylcefotaxime, 818endocarditis, 527, 539, 1444erythromycin, 930flomoxef, 1307fosfomycin-gentamicin, 1444fosfomycin-vancomycin, 1444imipenem, 1549LY146032, 1093macrolides-lincosamides-streptogramin B

resistance, 735methicillin resistance

penicillin-binding proteins, 1727nafcillin, 259, 1549osteomyelitis, 259oxacillin

agar dilution plate count method, 16penicillin-binding proteins, 1307, 1423,

1727effect of NaCl and nafcillin, 1982

R plasmid, 735rifampin, 930Ro 13-5478, 614Ro 14-9578, 614TE-031, 328Vancocin, 333vancomycin, 333, 527, 1549

Staphylococcus epidermidisBMY-28100, 238catheter-associated biofilm, 889cefamandole, 1332, 1549cefuroxime, 1332CGP 31608, 1549imipenem, 1549nafcillin, 1549peritonitis, 889trimethoprim-sulfamethoxazole, 144

thymidine added to medium, 144

VOL . 31, 1987

ANTIMICROB. AGENTS CHEMOTHER.

Vancocin, 333vancomycin, 333, 889, 1549

Staphylococcus saprophyticusBMY-28100, 238

Staphylococcus spp.cephalothin, 1457clindamycin, 1457doxycycline, 1457erythromycin, 1457gentamicin, 1457Lactobacillus antimicrobial substance,

1231lincosamide resistance, 1887oxacillin, 1457oxacillin-gentamicin, 1457oxacillin-pefloxacin, i457oxacillin-rifampin, 1457pefloxacin, 1457pefloxacin-gentamicin, 1457pefloxacin-rifampin, 1457rifampin, 1457trimethoprim-sulfamethoxazole, 1457vancomycin, 1457vancomycin-gentamicin, 1457vancomycin-pefloxacin, 1457vancomycin-rifampin, 1457

StreptococciA-56268, 463, 640azithromycin, 1948BMY-28100, 238, 480, 653CGP 31608, 1188CP-62,993, 1948ciprofloxacin, 1651, 1791DuP 105, 1791DuP 721, 1791imipenem, 1791Lactobacillus antimicrobial substance,

1231LY146032, 340macrolides-lincosamides-streptogramin B

resistance, 735, 883oxazolidinones, 1791paldimycin, 104pefloxacin, 1665R plasmid, 735R-3746, 1085T-2588, 1111TE-031, 640U-70138F, 104Vancocin, 333vancomycin, 333, 1791

Streptococcus (Enterococcus) faeciumampicillin, 1618benzylpenicillin, 1618P-lactams, 1618cefotaxime, 1618methicillin, 1618penicillin-binding proteins, 1618

Streptococcus faecalisampicillin, 139endocarditis, 139imipenem-cilastatin, 578intrauterine infections, 578LY146032, 1199tetracycline resistance, 1648

Streptococcus faeciumpenicillin tolerance, 1150

Streptococcus pneumoniaeA-56268, 328CGP 31608, 267TE-031, 328

Streptococcus pyogenesA-56268, 328

amoxicillin, 1204amoxicillin-clavulanic acid, 1204mixed infection with S. aureus, 1204TE-031, 328

Streptococcus sanguisendocarditis, 1474penicillin V, 1474

Streptomyces avermitilisavermectin methylation defective, 744avermectins, 964

Sireptomyces toyocaensisproduct A47934, 1497

StreptomycinAeromonas spp., 1281C. burnetii, 1079combinations

enterococci, 1749LY146032, 1749

E. colieffect on resistance, 587

ribosomally resistant S. typhimurium,1627

StreptonigrinN. gonorrhoeae, 1507role of extracellular iron in action, 1507

Sulbactamcombinations

ampicillin, 1703B. fragilis, 321cefazolin, 321ceftazidime, 1750endocarditis, 1750meningitis, 1703P. aeruginosa, 1750

pharmacokineticsmeningitis, 1703

SulfamethoxazoleC. burnetii, 1079

SulfamoxoleL. major, 1575

SulfaquinoxalineL. major, 1575

SulfisoxazoleAeromonds spp., 1281

SulfonamidesL. major, 1575N. meningitidis resistance, 1642resistance, plasmid-mediated, 306

Sultamicillincomparative activity

cloxacillin, 663pediatric infections, 663skin infections, 663soft tissue infections, 663

Susceptibility testingantifungal agents, 1867B. fragilis group, 15%6cefotaxime, 1375LY146032, 625M. avium complex, 1697minireview, 1867N. gonorrhoeae, 1744N. meningitidis, penicillin G resistant,

1478Syphilis

roxithromycin, 187RU 965, 187

T-2588B. catarrhalis, 1111B. fragilis, 11111-lactamase, 1111C. perfringens, 1111

comparative activityamoxicillin, cefaclor, and cephalexin,

1111ceftriaxone, erythromycin, penicillin,

spectinomycin, and tetracycline,1153

E. coli, 1111Enterobacteriaceae, 1111H. ducreyi, 1153H. influenzae, 1111N. gonorrhoeae, 1111, 1153streptococci, 1111

TE-031C. fetus, 328C. trachomatis, 100comparative activity

ciprofloxacin, doxycycline, erythromy-cin, and trimethoprim-sulfameth-oxazole, 100

clindamycin and erythromycin, 328clindamycin, erythromycin, and van-

comycin, 640H. influenzae, 640L. monocytogenes, 328Legionella spp., 640N. gonorrhoeae, 328, 640S. aureus, 328S. pneumoniae, 328S. pyogenes, 328staphylococci, 640streptococci, 640

Teichomycin A2ototoxicity, 612

Teicoplaninarthritis, pyogenic, 207blood coagulation, 1609combinations

amikacin-ceftazidime, 1126febrile, granulocytopenic leukemia pa-

tients, 1126rifampin, 1002staphylococci, 1002

comparative activityristocetin, 1609

Corynebacterium group D2, 821endocarditis, 207high-pressure liquid chromatography,

1222osteomyelitis, 207pharmacokinetics, 207, 1222, 1255, 1600platelet function, 1609soft tissue infections, 207staphylococci, 1002thrombophlebitis, septic, 207

Telluriteresistance plasmid, 823

TEM-1 ,B-lactamasemonoclonal antibodies, 1761

Temafloxacin hydrochloridecomparative activity

difloxacin and ciprofloxacin, 1768Temocillin

Morganella-Proteus-Providencia group,1644

urinary tract infections, 1644Terbinafine

aspergilli, 1365C. albicans, 1558Candida spp., 1365comparative activity

clotrimazole, econazole, griseofulvin,ketoconazole, miconazole, andtolnaftate, 1558

xxvi SUBJECT INDEX

SUBJECT INDEX xxvii

dermatophytes, 1365M. canis, 1558M. furfur, 1365S. schenckii, 1365T. mentagrophytes, 1558

Testicular toxicitycefonicid, 991

TetracyclineAeromonas spp., 1281B. burgdorferi, 164B. catarrhalis, 1519B. fragilis resistance, 1739B. intermedius fibrinogen binding, 1915C. albicans, 691C. burnetii, 1079C. coli resistance, 1669C. difficile resistancehomology with S. faecalis Tn91C, 1033

C. jejuni resistance, 1669C. perfringens, 213C. pylori, 949C. trachomatis, 811combinations

penicillin, 691comparative activity

ceftriaxone, erythromycin, and peni-cillin G, 164

clindamycin, CP-62,993, and erythro-mycin, 811

E. coliresistance, 1739S. faecalis resistance determinant,

1648gas gangrene, 213gingivitis, 1915Lyme disease, 164M. avium, 1579Mobiluncus spp., 249N. gonorrhoeae, 1288resistance determinant

S. faecalis, 1648U. urealyticum, 1852

S. faecalisresistance determinant, 1648

Theophyllinecombinations

ofloxacin, 375pharmacokinetics, 375

Thiamphenicolcomparative activity

norfloxacin, 434gonorrhea, 434N. gonorrhoeae, 434

Thienamycincombinations

L. pneumophila, 1529rifampin, 1529

L. pneumophila, 1529Thiopeptin

T. hyodysenteriae, 1935Thiosemicarbazone R

respiratory syncytial virus, 1225Thrombophlebitis, septic

teicoplanin, 207[3H]thymidine

incorporation of lymphocytesA-56619, 768A-56620, 768amifloxacin, 768ciprofloxacin, 768enoxacin, 768flumequine, 768norfloxacin, 768

ofloxacin, 768pefloxacin, 768pipemidic acid, 768

ThymidineL. major, 1575S. epidermidis

trimethoprim-sulfamethoxazole, 144Thymidine kinase

alteredherpes simplex virus type 2, 1117

herpes simplex virus type 2nucleotide sequence changes with acy-

clovir treatment, 1483Thymidine kinase inhibitors

5'-ethynylthymidineherpes simplex virus, 368

TiamulinT. hyodysenteriae, 1935

TicarcillinAeromonas spp., 1281B. fragilis group, 1596Capnocytophaga spp., 331combinations

C. coli, 940C. jejuni, 940clavulanic acid, 132, 940Mycobacterium spp., 132P. aeruginosa, 108[3H]tobramycin, 108

Ticarcillin-clavulanic acidB. fragilis, 2002B. fragilis group, 2002E. coli, 12%H. influenzae type b, 1296meningitis, 12%N. asteroides, 2013pharmacokinetics, 935, 12%, 1826

Tigemonamcomparative activity

amoxicillin, cefaclor, and cephalexin,226

amoxicillin-clavulanic acid, cefaclor,cefixime, cefuroxime, norfloxacin,trimethoprim-sulfamethoxazole,219

E. coli, 226Enterobacteriaceae, 219H. influenzae, 219K. pneumoniae, 226N. gonorrhoeae, 219Proteus sp., 226pyelonephritis, 226

TimentinCitrobacter spp., 829pharmacokinetics, 935, 1826

TinidazoleC. difficile, 183comparative activity

metronidazole, 183G. intestinalis, 672letter to the editor, 672Mobiluncus spp., 249P. anaerobius, 183

TobramycinAeromonas spp., 1281auditory toxicity, 1383combinations

aztreonam, 1403bismuth subcitrate, 1429C. pylori, 1429cefoperazone, 264ceftazidime, 398P. aeruginosa, 398, 1403

P. cepacia, 1403pharmacokinetics, 264pneumonia, 398

cystic fibrosis, 594effect of 3-lactams on uptake in P. aeru-

ginosa, 108Mobiluncus spp., 249Morganella-Proteus-Providencia group,

1644P. aeruginosa, 108, 594pharmacokinetics, 264, 605, 850, 1359pneumonia, 850toxicity, 594urinary tract infections, 1644

TolnaftateC. albicans, 46

TopoisomerasesE. coli, 1925

Toxoplasma gondiiinterferon, gamma, 346roxithromycin, 346, 1147roxithromycin-gamma interferon, 346

Toxoplasma speciesclindamycin, 492encephalitis, 492

Toyocamycincytomegalovirus, 544

Treponema hyodysenteriaeampicillin, 1935carbadox, 1935ceftizoxime, 1935chloramphenicol, 1935furazolidone, 1935gentamicin, 1935lincomycin, 1935metronidazole, 1935monensin, 1935olaquindox, 1935oxytetracycline, 1935thiopeptin, 1935tiamulin, 1935tylosin, 1935virginiamycin, 1935

Treponema pallidumroxithromycin, 187RU 965, 187

Trichophyton mentagrophyteseconazole, 1558griseofulvin, 1558ketoconazole, 1558terbinafine, 1558tolnaftate, 1558

TrifluoperazineC. albicans, 834C. neoformans, 834

TrimethoprimAeromonas spp., 1281C. burnetii, 1079Capnocytophaga spp., 331high-performance liquid chromatogra-

phy, 1904penetration into polymorphonuclear leu-

kocytes, 1904pharmacokinetics, 1904resistance

minireview, 1451plasmid-bome, 60staphylococci, 1683

uptake by human polymorphonuclearleukocytes, 1553

Trimethoprim-sulfamethoxazoleB. catarrhalis, 1519C. albicans, 691

VOL. 31, 1987

ANTIMICROB. AGENTS CHEMOTHER.

C. trachomatis, 100combinations

L. pneumophila, 1529rifampin, 1529

comparative activitynalidixic acid, 837

E. coli, 126enterococci, 808K. aerogenes, 126L. pneumophila, 1529letter to the editor, 837P. mirabilis, 126S. dysenteriae, 837S. epidermidis, 144selective gut contamination in neutrope-

nia, 551Staphylococcus spp., 1457thymidine added to medium

S. epidermidis, 144Trimetrexate

P. carinii, 1323Trypanosoma brucei subsp. brucei

9-deazainosine, 1406DL-a-difluoromethylornithine, 1406formycin B, 1406sinefungin, 1406

Trypanosoma spp.guanine analogs, 447guanosine analogs, 447

Tubercidincytomegalovirus, 544respiratory syncytial virus, 1225

TylosinT. hyodysenteriae, 1935

U-70138Fcomparative activity

vancomycin, 650staphylococci, 104streptococci, 104

Upper respiratory tract infectionszinc acetate lozenges, 1263

Ureaplasma urealyticumtetracycline resistance gene, 1852

Urinary tract infectionsamikacin, 1061, 1644azlocillin, 1644aztreonam, 1644carbenicillin, 1644cefazolin, 1644cefoxitin, 1644ceftazidime, 1644ceftriaxone, 1644cefuroxime, 1644cefuroxime axetil, 1442ciprofloxacin, 148, 354imipenem, 1644minireview, 1Morganella-Proteus-Providencia group,

1644piperacillin, 1644

temocillin, 1644tobramycin, 1644treatment duration, 1

Uropathogenssusceptibility patterns, 126

Vaccinia virusN10169, 1535neplanocin A analogs with reduced cyto-

toxicity, 1849ValineA. chrysogenum, 357

Vancocincomparative activity

vancomycin, 333enterococci, 333S. aureus, 333S. epidermidis, 333streptococci, 333

VancomycinB. fragilis, 1791catheter-associated biofilm, 889combinations

endocarditis, 1444fosfomycin, 1444gentamicin, 1461gentamicin, pefloxacin, and rifampin,

1457pharmacokinetics, 1461S. aureus, 1444Staphylococcus spp., 1457

comparative activitycefamandole, cefazolin, and nafcillin,

1919ciprofloxacin, 527DuP 105 and DuP 721, 1791Vancocin, 333

Corynebacterium group D2, 821effect of activated charcoal on clearance,

720endocarditis, 527, 1919enterococci, 333high-pressure liquid chromatography,

610Infusaid Drug Pump Model 100, 610M. avium, 1579Mobiluncus spp., 249peritonitis, 889pharmacokinetics, 52, 173, 393, 610, 720,

1075, 1689alanine aminopeptidase excretion,

1461Pb2-microglobulin excretion, 1461

preterm infants, 52pulmonary infections, 1689S. aureus, 333, 527S. epidermidis, 333, 889staphylococci, 1791, 1457, 1919streptococci, 333, 1791

Varicella-zoster virusacyclovir, 1722

BRL 39123, 12382HM-HBG, 76(RS)-9-[4-hydroxy-2(hydroxymethyl)butyl]-

guanine, 769-(4-hydroxy-3-hydroxymethylbut-1-yl)-

guanine, 1238Vesicular stomatitis virusN10169, 1535

Vibrio anguillarumR plasmid, 1446

Vibrio spp.3'-azido-3'-deoxythymidine, 274BW A509U, 274

Vidarabinecombinations

acyclovir, 477herpes simplex virus, 477

herpes simplex virus, 477VirginiamycinMobiluncus spp., 249T. hyodysenteriae, 1935

Viruses, envelopedfatty acids, 27monoglycerides, 27

Visna virus2'-3'-dideoxynucleosides, 1369human immunodeficiency virus, model

for, 1369N10169, 1535phosphonoformate, 1369ribavirin, 1369

WIN 35439N. asteroides, 2013

X-Staticantibacterial activity, 93

Xylotubercidinrespiratory syncytial virus, 1225

Yeastsamphotericin B, 1756amphotericin B methyl ester, 1756N-D-ornithyl amphotericin B methyl es-

ter, 1756Yersinia enterocoliticaamoxycillin, 523I-lactams, 523cefotaxime, 523doxycycline, 523gentamicin, 523imipenem, 523

Zinc acetate lozengesrhinovirus, 1263upper respiratory tract infections, 1263

Zinc gluconate lozengesrhinovirus, 1183

Zinc saltsrhinovirus, 622

xxviii SUBJECT INDEX