associate editor : eric n. olson, ph.d

Associate Editor Eric N. Olson, Ph.D. Dr. Olson completed his doctorate in bio- chemistry at the Bow- man Gray School of Medicine of Wake Forest University in 1981. After a postdoc- toral fellowship at the Washington Univer- sity School of Medi- cine, he joined the faculty of The Uni- versity of Texas M. D. Anderson Cancer Center, Houston, in 1984. In 1995, he moved to The University of Texas Southwestern Medical Center at Dallas, where he is now professor and chairman of the Department of Molecular Biology; associate director and principal investigator of the Donald W. Reynolds Center for Cardiovascular Disease Research; and director of the Hamon Center for Basic Research in Cancer. He holds the Nancy B. and Jake L. Hamon Distinguished Chair in Basic Cancer Research at The University of Texas Southwestern Medical Center. Dr. Olson has been an established investigator of the American Heart Association, and his previous honors include the Edgar Haber Cardiovascular Research Award, The American Heart Association Basic Re- search Prize, and Gill Heart Institute Award for Outstanding Contributions to Cardiovascular Medicine. He is an elected member of the American Academy of Arts and Sciences and the National Academy of Sciences. He has documented his research in more than 200 scientific publications and serves on the editorial boards of many journals. Dr. Olson has discovered a series of developmental control genes that govern muscle cell identity and differentiation, some of which encode the regulatory proteins and signaling molecules that are also important for remodeling of the adult heart during pathologic cardiac enlargement and heart failure. He has indelibly marked the progress of genetics research by defining the molecular events that determine muscle cell destiny Ð whether they develop normally or abnormally. Dr. Olson's pioneering work on myogenic BHLH transcrip- tion factor elucidated a biologic system whereby a single regulatory factor could initiate the entire process of myogenesis. His characterization of MEF2 factors, GATA factors, cardiac BHLH factors, and many others, serves as the platform on which our understanding of cardiac myogenesis and developmental heart morpho- genesis has been built. In his most recent studies, Dr. Olson has taken genetic research an important step toward application, directing a study of the use of immunosuppressant drugs to prevent the formation of cardiac hypertrophy in genetically engineered mice. The mice exhibited the same progression from heart enlargement to heart failure to death as is observed in humans. This finding suggests a novel strategy to therapeutically target the myocardium, sparking the hope that this will lead to new and improved treatments for cardiac hypertrophy and heart failure. D 2002 Blackwell Publishing Inc. Journal of Experimental Therapeutics and Oncology Vol. 2 2002 67

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Page 1: Associate Editor : Eric N. Olson, Ph.D

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