assessment & management orla dunlea surgical resident
TRANSCRIPT
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Assessment & ManagementOrla Dunlea
Surgical Resident
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It is common 80 Australians die each week from colon
cancer 1/12 of us will be diagnosed with it in our
lifetime
It is preventable 90% is treatable if detected early enough Currently <40% is detected in the early
stages
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M=F
Peak incidence at 65 years
Family history
Ulcerative colitis x 8-10 years
History of polyps
Fibre intake? (Proposed by Burkitt – Irish)
Aspirin reduces risk
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Morphological term – protrudes from the bowel wall into the lumen
Pedunculated Sessile
Tubulovillous Most common type Pedunculated
Tubular Least malignant potential Polyps found in FAP
Villous Most malignant potential Frond-like Mucus-secreting which
may be presenting complaint or low K+
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Right sided Anaemia
RIF mass
Don’t tend to cause obstruction (unless the ileocaecal valve is involved) as diameter is greater than left & stool is more liquid
Presentation with mets Obstructive jaundice – nodes compressing porta hepaticus Ureteric or duodenal obstruction – retroperitoneal lymph nodes Weight loss, anorexia, hepatomegaly due to liver mets
Left sided Change in bowel habit
PR bleeding
Tenesmus (lower rectal lesion)
Pericolic abscess – erodes through the bowel wall, LIF pain, tender & swinging pyrexia
Large bowel obstruction – acute presentation
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Signs of anaemia Weight loss Abdo exam
Normal Palpable mass Hepatomegaly due to mets Ascites
PR exam Mass Local extension into pouch of douglas Amount of fixation to local structures FOB
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Bloods CEA HB LFTs
Barium enema
Colonoscopy Visualise tumour Biopsy tumour Look for other
tumours/polyps +/- stenting if palliative
If histology confirmed Imaging
U/S for liver Mets CT thorax/abdo/pelvis with contrast for staging MRI /endoanal U/S for rectal CA (if MRI incompatible)
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Apple core lesion
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Stage of cancer – is it operable?
QOL & life expectancy prior to surgery
Does the patient want surgery?
Suitable for anaesthetic- anaesthetic review
Co-morbidities – IHD, DM, COPD etc
Are risks of complications too high?
Nutrition and ability to heal
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Routine bloods – FBC, U&Es, LFTs, Coag
Group & cross match CEA for baseline CXR Consent +/-bowel prep NPO Catheter IVABs TEDS
(Radiotherapy) (Chemotherapy) (Stoma education) (Stoma
positioning) (PFTs) (Echo/cardiac
mibi/ coronary angio)
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Caecal & R colon tumours
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Proximal or mid-transverse colon tumours
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Splenic flexure and left colon tumours
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Sigmoid tumours
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Low rectal tumours, FAP
Permanent stoma
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Hartman’s procedure with formation of a stoma
If present acutely
If anastomotic healing doubtful
~50% will be reversed
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HNPCC
FAP
Multiple tumours
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Early Bleeding Infection Perforation Local structure damage – ureters, bladder, spleen,
duodenum Anastomotic leak or breakdown Wound infection Wound dehiscence Sepsis & multiorgan failure Stoma problems TPN
Late Diarrhoea due to short bowel syndrome Impotence – pelvic parasympathetic nerve damage Small bowel obstruction
Adhesions 2nd radiotherapy
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Duke’s A Bowel wall only No nodes No mets 75% 5 year survival
Duke’s B Through muscularis
propria No nodes No mets 55% 5 year survival
Duke’s C C1
Node positive but only around tumour & not distal
40% 5 year survival C2
Node positive up to proximal resection margin
20% 5 year survival
Duke’s D Distant metastasis
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T = Tumour T1 – Invasion into submucosa (connective tissue & glands) T2 – Invasion into muscularis propria (muscles layers) T3 – Invasion into subserosa T4 – Invasion to local organ or structures +/- visceral
peritoneum
N = Nodes N0 - No lymph node invasion N1 – spread to 1-3 regional lymph nodes N2 - >4 regional lymph nodes
M = Metastasis M0 – No mets M1 – Distant mets
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Lymphatic spread to mesenteric & then para-aortic nodes
In the blood to the liver
Unusually to bone, lung or brain
Absence or presence of liver mets most important factor in
determining prognosis!!!
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5-Fluorouracil +/- Leucovorin
Following resection of stage 3, +/- stage 2
Metastatic disease
Radiation may be used in rectal cancer to reduce the size of the lesion & allow preservation of sphincter
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CEA levels
Colonoscopy
CT thorax/abdo/pelvis
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Hereditary non-polyposis colorectal cancer (HNPCC)
Lynch syndrome 1 – hereditary colon cancer Lynch syndrome 2 – hereditary colon cancer +
increased risk of other GIT or reproductive tumours
Familial adenomatous polyposis (FAP)
Unknown mutations
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DNA mismatch repair gene mutation (several different chromosome locations)
Autosomal dominant – 50% chance of offspring having mutation
Polyps become malignant over 2-3 years (compared to 8-10 years for non hereditary colon cancer)
70-80% lifetime chance of getting colon cancer
Lynch syndrome 2 increased risk of endometrial, ovarian, upper urinary tract & stomach
Treatment Colectomy with ileo-rectal anastomosis Colectomy & permanent ileostomy
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Used to identify people at risk of HNPCC >3 more relatives with HNPCC-related cancer 2 successive generations At least 1 of the cancers diagnosed <50 years FAP has been excluded
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Rare 100% penetrance Autosomal dominant Deletion on chromosome 5 (adenomatous
polyposis coli gene) Extra-intestinal features – BORED
Brain tumours Osteomas Retinal pigment hypertrophy Epidermal cysts Dentition abnormality
Treatment Panproctocolectomy & ileostomy
Good for screening as present in ~95% people with gene
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National screening programme if >50 years
Home FOB test – send off – GP contacted if positive
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Polyps with the most potential to become malignant are tubulovillous polyps – T or F
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Mr Murphy is a 69 year old man who has noticed passage of blood with stools over the last week – please take a history. What investigations would you like to perform?
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Post-operative patient with a stoma Ostomy = Surgically created opening connecting
an internal organ to the surface of the body Stoma = The opening of the ostomy
Stoma important for exams Ileostomy Colostomy Ileal-conduit
EXTREMELY COMMON FOR LONG
CASES!!!!!!
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Ileostomy To protect a distal at
risk anastomosis Distal bowel rest for
Crohn’s Permanent after
panproctocolectomy
Colostomy To protect a distal at
risk anastomosis Perforation, infection
or ischaemia means an anastomosis would not heal & may be performed at later date
Permanent after abdomino-perineal resection
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1. Stoma itself2. Stoma surroundings3. Stoma bag
1. Stoma itself Where is it? How many lumens? Type of spout Does it look healthy?
2. Stoma surroundings Skin Scars Patient general health
3. Stoma bag What kind of bag? What’s in the bag?
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1. Stoma itself Where is it?
How many lumens?
Type of spout
Does it look healthy?
RIF = ileostomy, left = colostomy – but beware
2 = may be loop ileostomy (temporary)
Flush with skin = colostomy, spouted= ileostomy (or prolapsing colostomy!)
Ischaemic? Prolapsing? Retracted? Stenosed?
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2. Stoma surroundings Skin
Scars
Patient general health
Rash, necrosis, parastomal hernia
Previous surgeries, previous stoma sites
Young =UC or Crohn’s, dehydrated looking = high stoma output, cachexic = palliative stoma
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3. Stoma bag What kind of bag?
What’s in the bag?
Tap & transparent = post-op for output measurements. Non-transparent no tap = long-term
Greenish fluid = ileostomy
Brownish = colostomy
Yellow = ileal-conduit
Any mucus or blood?
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Choosing a site Stoma nurse Important for success of the stoma post-op Assess site when sitting, standing Avoid
Previous scars/wound site Belt line Bony prominence Umbilicus Skin crease Obesity poses problems
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1. Stoma itself
2. Area surrounding stoma
3. Living with a stoma
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1. Stoma itself Ischaemia Retraction Prolapse Obstruction Stenosis
2. Area surrounding stoma Leakage Hernia Skin irritation (ileostomy) Fistula (Crohn’s)
3. Living with a stoma Increased output/short gut syndrome (electrolytes,
dehydration) Psychological/psychosexual – especially if odour
(charcoal filter helps) Kidney & gall stones (if terminal ileum
diseased/sacrificed)
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“From little things, big things grow”
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N Engl J Med. 2010 Jan 7;362(1):85; author reply 85.Screening for colorectal cancer. Mohammed F.
Lancet. 2009 Mar 7;373(9666):790-2.Rectal cancer: optimum treatment leads to optimum results. Madoff RD.