antioxidants in cervical cancer chemopreventive and chemotherapeutic effects of polyphenols

7/28/2019 Antioxidants in Cervical Cancer Chemopreventive and Chemotherapeutic Effects of Polyphenols

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Highlights

*Keywords

*1. Introduction: cervical cancer

*2. HPV: structure, infection and transformation activity

*3. Oxidative stress and cervical cancer

*4. Antioxidants, chemoprevention and chemotherapy

*5. Polyphenols and cervical cancer

*

*

* 5.1. Curcumin and ferulic acid

*Table 1

*5.2. Epigallocatechin-3-gallate

*5.3. Resveratrol

*6. Clinical trial in cervical cancer

*7. Conclusions

*References

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Volume 1822, Issue 5, May

2012, Pages 737747

Antioxidants and Antioxidant Treatment in Disease

Edited By D.A. Butterfield and J.N. Keller

Cover image Review


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Antioxidants in cervical cancer: Chemopreventive and chemotherapeuticeffects of polyphenols ^

* F. Di Domenico â ,* C. Foppoli ^b ,* R. Coccia â ,* M. Perluigi â ^, Corresponding author contact

information ^, E-mail the corresponding author

* â Department of Biochemical Sciences, Sapienza University of Rome,P.le A. Moro, 5-00185 Rome, Italy

* ^b CNR Institute of Molecular Biology and Pathology, SapienzaUniversity of Rome, Rome, Italy

^Corresponding author contact information Corresponding author. Tel.: + 39 0649910900.

Received 27 August 2011Revised 5 October 2011Accepted 6 October 2011Available online 12 October 2011

* http://dx.doi.org/10.1016/j.bbadis.2011.10.005, How to Cite or Link

Using DOI

*Permissions & Reprints

View full textPurchase $31.50

1. Introduction: cervical cancer

2. HPV: structure, infection and transformation activity

3. Oxidative stress and cervical cancer

4. Antioxidants, chemoprevention and chemotherapy

5. Polyphenols and cervical cancer


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6. Clinical trial in cervical cancer

7. Conclusions

References

------------------------------------------------------------------------

Abstract

Cervical cancer lesions are a major threat to the health of women,representing the second most common cancer worldwide. The unanimouslyrecognized etiological factor in the causation of cervical cancer is theinfection with human papilloma virus (HPV). HPV infection, althoughnecessary, is not /per se/ sufficient to induce cancer. Other factorshave to be involved in the progression of infected cells to the fullneoplastic phenotype. Oxidative stress represents an interesting andunder-explored candidate as a promoting factor in HPV-initiatedcarcinogenesis. Oxidative stress is known to perturb the cellular redoxstatus thus leading to alteration of gene expression responses throughthe activation of several redox-sensitive transcription factors. This

signaling cascade affects both cell growth and cell death. The abilityof naturally occurring antioxidants to modulate cellular signaltransduction pathways, through the activation/repression of multipleredox-sensitive transcription factors, has been claimed for theirpotential therapeutic use as chemopreventive agents. Among thesecompounds, polyphenols have been found to be promising agents towardcervical cancer. In addition to acting as antioxidants, polyphenolsdisplay a wide variety of biological function including induction ofapoptosis, growth arrest, inhibition of DNA synthesis and modulation ofsignal transduction pathways. They can interfere with each stage ofcarcinogenesis initiation, promotion and progression to prevent cancerdevelopment. The present review discusses current knowledge of the majormolecular pathways, which are involved in HPV-driven cancerogenesis, and

the ability of polyphenols to modulate these pathways. By acting atspecific steps of viral transformation cascade, polyphenols have beendemonstrated to selectively inhibit tumor cell growth and may be apromising therapeutic tool for treatment of cervical cancer. Inaddition, recent results obtained in clinical trials using polyphenolsare also discussed. This article is part of a Special Issue entitled:Antioxidants and Antioxidant Treatment in Disease.

------------------------------------------------------------------------

Highlights

Cervical cancer is the second most common cancer among women worldwideand represents a major concern for public health. Oxidative stress isa candidate factor involved in the pathogenesis and progression ofcervical cancer. Polyphenols have been found to be promising agentstoward cervical cancer. In addition to act as antioxidants,polyphenols display a wide variety of biological functions. Polyphenols were demonstrated to inhibit the proliferation ofHPV-positive cancer cells.


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Keywords

* Cervical cancer;* HPV;* Polyphenol;* Apoptosis;* Oxidative stress

------------------------------------------------------------------------

Figures and tables from this article:

Full-size image (108 K)

Fig. 1. Molecular mechanisms of human papillomavirus-inducedcarcinogenesis. Oncogenic action of high-risk HPV E6 and E7oncoproteins is exerted through the inactivation of tumorsuppressors p53 and pRb, respectively. Abrogation of p53 by E6ensures cell survival by preventing apoptosis inactivation while pRbinactivation by E7 forces infected cells to remain in aproliferative state. The dark red box represent the target of actionof the polyphenols considered: C = curcumin; E = EGCG; R = resveratrol.

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Full-size image (62 K)

Fig. 2. Polyphenolic antioxidants. Chemical structure, propertiesand sources of curcumin (1,7-bis (4-hydroxy 3-methoxyphenyl)-1,6-heptadiene-3,5-dione), ferulic acid(3-methoxy-4-hydroxycinnamic acid), EGCG(epigallocatechin-3-gallate) and resveratrol(/trans/-3,5,4-trihydroxy-/trans/-stilbene).

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Table 1. Biochemical effects and molecular targets ofchemopreventive action of polyphenols (curcumin, ferulic acid, EGCG,and resveratrol) in cervical cancer models.

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This article is part of a Special Issue entitled: Antioxidants andAntioxidant Treatment in Disease.

^Corresponding author contact information Corresponding author. Tel.: + 39 0649910900.

Copyright 2011 Elsevier B.V. All rights reserved.

Bibliographic information


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