Annual MeetingNovember 6, 2015

Austin, TX

AGENDA• Welcome Dr. Steven Warach

• Summary of Accomplishments Dr. Steven Warach

• NASCare Dr. Mark Goldberg

• V-STOP II Dr. Jane Anderson

• LESTER Dr. Teddy Wu•

• American Heart Go Red Women Network Grant (and other plans)

• Stroke Data Mapping Project Christy Ankrom

• Public comments

Lone Star Stroke Consortium (LSS)Primary ObjectivesTo improve the lives of Texans at risk for or suffering stroke. To establish a state-wide clinical research network linking academic health institutions with proven expertise in stroke research to community stroke centers. To conduct patient-centered research and therapeutic trials within Texas aimed at the prevention and treatment of stroke.

FundingLSS is funded from the Texas State Legislature through DSHSOpportunities to leverage State funding for external grants in support of specific projects are being pursued.

Lone Star Stroke Consortium

Operations and Structures Member Organizations

Baylor College of MedicineSeton Healthcare FamilyTexas Tech Health Sciences CenterTexas Council on Cardiovascular Disease and StrokeUniversity of Texas Health Sciences Center HoustonUniversity of Texas Health Sciences Center San AntonioUniversity of Texas Southwestern Medical CenterUniversity of Texas System

Lone Star Stroke Consortium

Operations and Structures Executive Committee (EC)

Baylor College of Medicine - KentSeton Healthcare Family - WarachTexas Tech Health Sciences Center – Cruz-FloresTexas Council on Cardiovascular Disease and Stroke - RutledgeUniversity of Texas Health Sciences Center Houston - SavitzUniversity of Texas Health Sciences Center San Antonio - BreyUT Southwestern Medical Center - GoldbergUniversity of Texas System - HurnAt Large - Grotta

Lone Star Stroke Consortium

Operations and StructuresHub Coordinating Center – Principal Investigator

Baylor College of Medicine - KentSeton Healthcare Family - WarachUniversity of Texas Health Sciences Center Houston - SavitzUniversity of Texas Health Sciences Center San Antonio - BreyUniversity of Texas Southwestern Medical Center – Goldberg

• Five Hub Coordinating Centers• Four Spoke Centers per Hub identified• 25 Total enrolling research centers

Lone Star Stroke Hubs and SpokesHUB: Baylor College of Medicine

CHRISTUS Hospital-St. ElizabethValley Baptist Medical Center- HarlingenSt. Luke’s WoodlandsSt. Luke’s Hospital at The Vintage

HUB:UT Southwestern Medical CenterMethodist Dallas Medical CenterMethodist Mansfield Medical CenterGood Shepherd Medical Center - MarshallCHRISTUS St. Michael Hospital – Atlanta

Lone Star Stroke Hubs and Spokes• HUB: Seton Healthcare Family - Austin

Seton Medical Center Williamson – Round RockSeton Medical Center Hays - KyleSt. Joseph Regional Health Center – BryanProvident Hospital – Waco

• HUB: UT Health Science Center San AntonioSt. Luke’s Baptist HospitalCHRISTUS Santa Rosa Hospital-Westover HillsCHRISTUS Santa Rosa Hospital – New BraunfelsTexas Tech University Medical Center of El Paso

Lone Star Stroke Hubs and Spokes

HUB: The University Of Texas Health Science Center at Houston

Citizens Medical Center- VictoriaMemorial Hermann – SouthwestMemorial Hermann Memorial City HospitalHuntsville Memorial HospitalBaptist Hospitals of Southeast Texas Beaumont Hospital

Lone Star Stroke Hubs and SpokesHUB: Baylor College of MedicineCHRISTUS Hospital-St. ElizabethValley Baptist Medical Center- HarlingenSt. Luke’s WoodlandsSt. Luke’s Hospital at The Vintage

HUB:UT Southwestern Medical CenterMethodist Dallas Medical CenterMethodist Mansfield Medical CenterGood Shepherd Medical Center - MarshallCHRISTUS St. Michael Hospital – Atlanta

Lone Star Stroke ConsortiumOperations and StructuresHow New Projects Begin

Pilot studies – Proposed to and Approved by Executive Committee

Full studies Approved by Executive Committee and then External Advisory Committee (EAC)

Dr. Karen Johnston – University of VirginiaDr. Jeffrey Saver – UCLADr. Maria Aguilar – Mayo ClinicDr. David Hess – Georgia Regents University

Lone Star Stroke Progress• Lone Star Stroke has met its milestone driven deliverables as

specified in the DSHS contract

• Activity at five Hubs and 21 spoke partner sites has begun.

• The LSS research network serves annually more than seven thousand Texans with stroke and cerebrovascular disease. These patients comprise the population screened for inclusion in LSS clinical studies.

• Four clinical research projects have been approved forward by the External Advisory Committee and are in progress

Lone Star Stroke Progress • The LSS was selected to make a presentation to the recent 2015

International Stroke Conference of the American Heart Association, the world’s largest gathering of stroke researchers

• LSS Hub UTHSC Houston was named Regional Coordinating Center for the NIH StrokeNet clinical trials network and LSS centers are sites in StrokeNet, assuring a steady pipeline of externally funded studies into Lone Star Stroke.

• LSS administrative coordinating core has been established at the Austin Hub and the data management core at the UTHSC Houston Hub.

www.lonestarstroke.org• Website and newsletter to disseminate information• Publications and Contributions of LSS investigators

Active StudiesCLOTBUST-ER. Status: completed. Lone Star Stroke participated in this world-wide clinical trial that evaluated a Texas technology to assess whether ultrasound delivered into a clot improves the efficacy of tPA therapy for stroke. Lone Star Stroke sites enrolled 26 patients, 9 by telemedicine, about 5% of all patients. The study was halted and analyses are on-going to determine whether any subgroups of patients benefited.

• NASCare • V-STOP II• LESTER