an overview of gene regulationfire.biol.wwu.edu/cmoyer/zztemp_fire/biol345_w10/last...
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An Overview of Gene Regulation
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Genetic elements involved in regulation of the lac operong p
RN b d rRNA binding site
f l l f f Attenuation: fine scale control after initiation of transcription
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Leader peptide rich in pathway AAsLeader peptide rich in pathway AAs
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Leader encoded by domains 1 & 2y
Ribosome stalls waiting for TrpDomain 2:3 stem-loop forms
No termination!
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Ribosome encounters no waitingDomain 3:4 stem-loop formsD ma n t m p f rm
Termination occurs due to inverted repeats and polyuridine!p p y
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Attenuation: Th t f th tThe rest of the story
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Global Control Systemsy