this article and any supplementary material should be cited as follows: nitz jc, perrier j, cook p....

This article and any supplementary material should be cited as follows: Nitz JC, Perrier J, Cook P. In-vivo trial results of a novel ultrasonic cough stimulator. J Rehabil Res Dev. 2012;49(9):1421–30. http://dx.doi.org/10.1682/JRRD.2011.07.0121

Slideshow ProjectDOI:10.1682/JRRD.2011.07.0121JSP

In-vivo trial results of a novel ultrasonic cough stimulator

Jennifer C. Nitz, PhD, MPhty, BPhty; John Perrier, BPhty;

Peter Cook, MBBS, FANZCA, FCICM

This article and any supplementary material should be cited as follows: Nitz JC, Perrier J, Cook P. In-vivo trial results of a novel ultrasonic cough stimulator. J Rehabil Res Dev. 2012;49(9):1421–30. http://dx.doi.org/10.1682/JRRD.2011.07.0121

Slideshow ProjectDOI:10.1682/JRRD.2011.07.0121JSP

• Aim– Establish:• Whether ultrasound (US) stimulation can safely stimulate

cough.• Most efficient US frequency.• Whether single- or dual-sided stimulation is more

effective.

• Relevance– Ability to cough voluntarily is absent or diminished

in many clinical situations, which may predispose patients to or prolong respiratory diseases.

This article and any supplementary material should be cited as follows: Nitz JC, Perrier J, Cook P. In-vivo trial results of a novel ultrasonic cough stimulator. J Rehabil Res Dev. 2012;49(9):1421–30. http://dx.doi.org/10.1682/JRRD.2011.07.0121

Slideshow ProjectDOI:10.1682/JRRD.2011.07.0121JSP

Method• Applied stimulation with

CoughStim device to 15 nondisabled and 7 unable-to-cough volunteers:– Unilaterally: 8 frequencies

and 2 power levels.– Bilaterally: 2 frequencies

and 3 power levels.

This article and any supplementary material should be cited as follows: Nitz JC, Perrier J, Cook P. In-vivo trial results of a novel ultrasonic cough stimulator. J Rehabil Res Dev. 2012;49(9):1421–30. http://dx.doi.org/10.1682/JRRD.2011.07.0121

Slideshow ProjectDOI:10.1682/JRRD.2011.07.0121JSP

Results

• Nondisabled subjects– Cough stimulated:• 80% at 0.58 MHz and 9 W unilaterally.

• 75% at 0.58 MHz and 6 W bilaterally

• Unable-to-cough subjects– Cough stimulated:• 71% at 0.54 MHz and 6 W bilaterally.

This article and any supplementary material should be cited as follows: Nitz JC, Perrier J, Cook P. In-vivo trial results of a novel ultrasonic cough stimulator. J Rehabil Res Dev. 2012;49(9):1421–30. http://dx.doi.org/10.1682/JRRD.2011.07.0121

Slideshow ProjectDOI:10.1682/JRRD.2011.07.0121JSP

Conclusion

• CoughStim device:– Regularly and safely produced moderately strong

cough response in subjects with or without ability to cough.

– Produced this effect without causing undue discomfort.