this article and any supplementary material should be cited as follows: nitz jc, perrier j, cook p....

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This article and any supplementary material should be cited as follows: Nitz JC, Perrier J, Cook P. In-vivo trial results of a novel ultrasonic cough stimulator. J Rehabil Res Dev. 2012;49(9):1421–30. http://dx.doi.org/10.1682/JRRD.2011.07.0121 Slideshow Project DOI:10.1682/ JRRD.2011.07.0121JSP In-vivo trial results of a novel ultrasonic cough stimulator Jennifer C. Nitz, PhD, MPhty, BPhty; John Perrier, BPhty; Peter Cook, MBBS, FANZCA, FCICM

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Page 1: This article and any supplementary material should be cited as follows: Nitz JC, Perrier J, Cook P. In-vivo trial results of a novel ultrasonic cough stimulator

This article and any supplementary material should be cited as follows: Nitz JC, Perrier J, Cook P. In-vivo trial results of a novel ultrasonic cough stimulator. J Rehabil Res Dev. 2012;49(9):1421–30. http://dx.doi.org/10.1682/JRRD.2011.07.0121

Slideshow ProjectDOI:10.1682/JRRD.2011.07.0121JSP

In-vivo trial results of a novel ultrasonic cough stimulator

Jennifer C. Nitz, PhD, MPhty, BPhty; John Perrier, BPhty;

Peter Cook, MBBS, FANZCA, FCICM

Page 2: This article and any supplementary material should be cited as follows: Nitz JC, Perrier J, Cook P. In-vivo trial results of a novel ultrasonic cough stimulator

This article and any supplementary material should be cited as follows: Nitz JC, Perrier J, Cook P. In-vivo trial results of a novel ultrasonic cough stimulator. J Rehabil Res Dev. 2012;49(9):1421–30. http://dx.doi.org/10.1682/JRRD.2011.07.0121

Slideshow ProjectDOI:10.1682/JRRD.2011.07.0121JSP

• Aim– Establish:• Whether ultrasound (US) stimulation can safely stimulate

cough.• Most efficient US frequency.• Whether single- or dual-sided stimulation is more

effective.

• Relevance– Ability to cough voluntarily is absent or diminished

in many clinical situations, which may predispose patients to or prolong respiratory diseases.

Page 3: This article and any supplementary material should be cited as follows: Nitz JC, Perrier J, Cook P. In-vivo trial results of a novel ultrasonic cough stimulator

This article and any supplementary material should be cited as follows: Nitz JC, Perrier J, Cook P. In-vivo trial results of a novel ultrasonic cough stimulator. J Rehabil Res Dev. 2012;49(9):1421–30. http://dx.doi.org/10.1682/JRRD.2011.07.0121

Slideshow ProjectDOI:10.1682/JRRD.2011.07.0121JSP

Method• Applied stimulation with

CoughStim device to 15 nondisabled and 7 unable-to-cough volunteers:– Unilaterally: 8 frequencies

and 2 power levels.– Bilaterally: 2 frequencies

and 3 power levels.

Page 4: This article and any supplementary material should be cited as follows: Nitz JC, Perrier J, Cook P. In-vivo trial results of a novel ultrasonic cough stimulator

This article and any supplementary material should be cited as follows: Nitz JC, Perrier J, Cook P. In-vivo trial results of a novel ultrasonic cough stimulator. J Rehabil Res Dev. 2012;49(9):1421–30. http://dx.doi.org/10.1682/JRRD.2011.07.0121

Slideshow ProjectDOI:10.1682/JRRD.2011.07.0121JSP

Results

• Nondisabled subjects– Cough stimulated:• 80% at 0.58 MHz and 9 W unilaterally.

• 75% at 0.58 MHz and 6 W bilaterally

• Unable-to-cough subjects– Cough stimulated:• 71% at 0.54 MHz and 6 W bilaterally.

Page 5: This article and any supplementary material should be cited as follows: Nitz JC, Perrier J, Cook P. In-vivo trial results of a novel ultrasonic cough stimulator

This article and any supplementary material should be cited as follows: Nitz JC, Perrier J, Cook P. In-vivo trial results of a novel ultrasonic cough stimulator. J Rehabil Res Dev. 2012;49(9):1421–30. http://dx.doi.org/10.1682/JRRD.2011.07.0121

Slideshow ProjectDOI:10.1682/JRRD.2011.07.0121JSP

Conclusion

• CoughStim device:– Regularly and safely produced moderately strong

cough response in subjects with or without ability to cough.

– Produced this effect without causing undue discomfort.