pack iontophoresis-cats famose-cxl_zurich_2014

EVALUATION OF PACK-CXL AFTER

IONTOPHORESISFOR THE TREATMENT OF MELTING KERATITIS

IN 10 CATS

Dr Frank Famose – Toulouse - France

Pierre Roy – Paris - FranceZürich – december 6th, 2014

PACK-CXL Valuable tx for

melting keratitis

Sedation

Shortening of the

procedure

Iontophoresis

Application of a constant electric

current to enhance penetration

of a ionized substance through a

tissue

Aim of this study

To evaluate the clinical outcome

of feline melting keratitis

treated by accelerated CXL

after iontophoresis of riboflavin

Inclusion criteria

Cats

Corneal melting

Minimal Corneal

thickness > 300 µm

Protocol

Riboflavine

impregnation

Exposition

UVA 365 nm

Post-CXL

treatment

RF 0,1% (Ricrolin +TM)

Iontophoresis

5 min 1mA/min

30 mW/cm²

3 min

5,4J/cm²

TobrexTM BID

7 days

Accelerated protocol

(KXLTM – Avedro)

Follow-up

Inclusion D1 D4 D8 D15 D31

Pain (0-7) and clinical (0-18) scores

Ulceration and infiltration surfaces

0

2

4

6

8

10

12

D1 D4 D8 D15 D31

Evolution ofAverage scores

Clinical score Pain score

0

5

10

15

20

25

30

35

D1 D4 D8 D15 D31

Evolution of Average surfaces (mm²)

Ulcer surface Infiltration surface

Discussion : efficacy

Reduction of clinical

and pain score

Complete Epithelial

healing

Resolution of corneal melting

Duration of treatment ?

Instillation

30 min

Iontophoresis

5 min

Irradiation

30 min

Accelerated CXL

3-10 min

Conventional protocol

Duration > 1 hourIonto + acc. CXL protocol

Duration < 20 min.

Conclusion: IONTOPHORESIS

Results similar to

conventional instillation

Resolution of corneal melting

No adverse reaction or pain

Reduction of

procedure duration

frankfamose@gmail.com