innovation for impact: a collaborative venture>90% fail in the first 5 years 95% of all medical...

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1

Innovation for Impact: A Collaborative Venture

Kristian R. Olson MD, MPH, DTM&H

CIMIT Global Health Initiative Program Leader

Clinician Educator MGH; MGH Center for Global Health

Harvard Medical School

10 September, 2010

2

To enhance the

effectiveness of health care providers

in low-income

settings with sustainable

technologies and enabling training

Mission

3

19,943

1,178449 195

3,560

670

5,000

10,000

15,000

20,000

Technology Technology

+ Health

Technology

+ Health +

International

Technology Technology

+ Health

Technology

+ Health +

International

Source: Guidestar & Innovations in International Health at MIT

Standard Technology Initiatives Appropriate Technology

Initiatives

Landscape of Health and Technology

4

>90% Fail in the First 5 years

95% of all medical equipment in

resource-limited settings are donated

Source: Malkin, R. Design of Health Care Technologies in the Developing World. Annu. Rev. Biomed. Eng. 2007.

5

Invention, Adoption, and Access are essential

Components of “Innovation”

Adapted from:Laura Frost & Michael Reich, Access, Harvard U. Press; 2008.

AFFORDABILITY

Government

Affordability

Non-

Governmental

Agency

Affordability

End-user

Affordability

ADOPTABILITY

Global Adoption

National

Adoption

Provider

Adoption

End-User

Adoption

AVAILABILITY

Manufacturing

Forecasting

Procurement

Distribution

Delivery

Architecture

Access

Innovation

6

Building Capacity

7

Technology Serving as a

Marker for Medical Sophistication

8

Local Evaluation and Participatory Development is Essential for Accuracy and End User Ownership

9

Collaborative Team Building for

Prototype Development

10

A ‘Need Doesn’t Equal a Market”

Creative Innovation is Necessary

Source: CIMIT and Design that Matters

11

Clinical Users

Prospective

Buyers Manufacturers

and Distributors

Technology

Innovators

Partnerships are Essential for

Sustainable Device Development.

12

HIV Monitoring Through Lensless

Imaging for Point-of-Care Testing

Source: Demirci Lab (BAMM), Harvard Medical School

*

*=Charge-Coupled Device

13

Column with DNA bound.

Source: Klapperich Lab, Boston University and Innovations in International Health at MIT

SNAP: System for Nucleic Acid Processing

14Source: Pollock, N, Diagnostics for All, Boston, MA.

Colorimetric Cellulose Based Point-of-Care

Testing of Liver Injury

15

7 Key Barriers to Effective

Global Health Technology Innovation:

1) Addressing the right question

2) Lack of a clear path to market (and capacity to

weather the development timeline)

3) Product management capacity and tech transfer

4) Inadequate and unprepared infrastructure

5) Clarity of target product profiles and associated incremental benefit (technology choice)

6) Regulatory approval and multiple National Regulatory Authorities

7) Accurate forecasting

16

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